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Protein

Nitrogen regulation protein NR(I)

Gene

glnG

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system NtrB/NtrC involved in the activation of nitrogen assimilatory genes such as GlnA. NtrC is phosphorylated by NtrB and interacts with sigma-54.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi168 – 175ATPPROSITE-ProRule annotation8
Nucleotide bindingi231 – 240ATPPROSITE-ProRule annotation10
DNA bindingi445 – 464H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Nitrogen fixation, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen regulation protein NR(I)
Gene namesi
Name:glnG
Synonyms:ntrC
Ordered Locus Names:STM4005
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000811671 – 469Nitrogen regulation protein NR(I)Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP41789.
PRIDEiP41789.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4005.

Structurei

Secondary structure

1469
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Beta strandi11 – 14Combined sources4
Helixi15 – 23Combined sources9
Turni24 – 27Combined sources4
Beta strandi33 – 36Combined sources4
Helixi38 – 42Combined sources5
Beta strandi43 – 45Combined sources3
Beta strandi51 – 53Combined sources3
Beta strandi56 – 58Combined sources3
Turni59 – 61Combined sources3
Helixi66 – 72Combined sources7
Beta strandi73 – 76Combined sources4
Beta strandi78 – 81Combined sources4
Turni88 – 90Combined sources3
Beta strandi91 – 93Combined sources3
Beta strandi98 – 101Combined sources4
Helixi108 – 121Combined sources14
Beta strandi390 – 392Combined sources3
Helixi402 – 414Combined sources13
Turni415 – 417Combined sources3
Helixi421 – 440Combined sources20
Turni441 – 443Combined sources3
Helixi447 – 451Combined sources5
Helixi456 – 468Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DC7NMR-A1-124[»]
1DC8NMR-A1-124[»]
1J56NMR-A1-124[»]
1KRWNMR-A1-124[»]
1KRXNMR-A1-124[»]
1NTCNMR-A/B380-469[»]
1NTRNMR-A1-124[»]
ProteinModelPortaliP41789.
SMRiP41789.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41789.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST115
Domaini140 – 369Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST230

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation
Contains 1 sigma-54 factor interaction domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.
KOiK07712.
OMAiGHSPVQV.
PhylomeDBiP41789.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR010114. Sig_transdc_resp-reg_NtrC.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01818. ntrC. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRGIVWVVD DDSSIRWVLE RALAGAGLTC TTFENGNEVL AALASKTPDV
60 70 80 90 100
LLSDIRMPGM DGLALLKQIK QRHPMLPVII MTAHSDLDAA VSAYQQGAFD
110 120 130 140 150
YLPKPFDIDE AVALVERAIS HYQEQQQPRN IEVNGPTTDM IGEAPAMQDV
160 170 180 190 200
FRIIGRLSRS SISVLINGES GTGKELVAHA LHRHSPRAKA PFIALNMAAI
210 220 230 240 250
PKDLIESELF GHEKGAFTGA NTIRQGRFEQ ADGGTLFLDE IGDMPLDVQT
260 270 280 290 300
RLLRVLADGQ FYRVGGYAPV KVDVRIIAAT HQNLERRVQE GKFREDLFHR
310 320 330 340 350
LNVIRIHLPP LRERREDIPR LARHFLQVAA RELGVEAKLL HPETETALTR
360 370 380 390 400
LAWPGNVRQL ENTCRWLTVM AAGQEVLIQD LPGELFEAST PDSPSHLPPD
410 420 430 440 450
SWATLLAQWA DRALRSGHQN LLSEAQPELE RTLLTTALRH TQGHKQEAAR
460
LLGWGRNTLT RKLKELGME
Length:469
Mass (Da):52,271
Last modified:January 23, 2002 - v2
Checksum:i25D3100A2D707E05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150V → L in CAA59425 (PubMed:7602583).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85104 Genomic DNA. Translation: CAA59425.1.
AE006468 Genomic DNA. Translation: AAL22844.1.
PIRiS53024.
RefSeqiNP_462885.1. NC_003197.1.
WP_001188783.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22844; AAL22844; STM4005.
GeneIDi1255531.
KEGGistm:STM4005.
PATRICi32386882. VBISalEnt20916_4221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85104 Genomic DNA. Translation: CAA59425.1.
AE006468 Genomic DNA. Translation: AAL22844.1.
PIRiS53024.
RefSeqiNP_462885.1. NC_003197.1.
WP_001188783.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DC7NMR-A1-124[»]
1DC8NMR-A1-124[»]
1J56NMR-A1-124[»]
1KRWNMR-A1-124[»]
1KRXNMR-A1-124[»]
1NTCNMR-A/B380-469[»]
1NTRNMR-A1-124[»]
ProteinModelPortaliP41789.
SMRiP41789.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4005.

Proteomic databases

PaxDbiP41789.
PRIDEiP41789.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22844; AAL22844; STM4005.
GeneIDi1255531.
KEGGistm:STM4005.
PATRICi32386882. VBISalEnt20916_4221.

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.
KOiK07712.
OMAiGHSPVQV.
PhylomeDBiP41789.

Miscellaneous databases

EvolutionaryTraceiP41789.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR010114. Sig_transdc_resp-reg_NtrC.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01818. ntrC. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTRC_SALTY
AccessioniPrimary (citable) accession number: P41789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2002
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.