P41786 (PRGK_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipoprotein PrgK

Gene names

Name:	prgK
Ordered Locus Names:	STM2871

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for invasion of epithelial cells. Could be involved in protein secretion.
Subcellular location	Cell outer membrane; Lipid-anchor Probable.
Sequence similarities	Belongs to the YscJ lipoprotein family.

Ontologies

Keywords
Biological process	Protein transport Transport Virulence
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW protein secretion Inferred from electronic annotation. Source: InterPro
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 252	235	Lipoprotein PrgK		PRO_0000018182
Regions
	Transmembrane	207 – 227	21	Helical; Potential
Amino acid modifications
	Lipidation	18	1	N-palmitoyl cysteine Potential
	Lipidation	18	1	S-diacylglycerol cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	P41786 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 2C0A6FC06667E256	FASTA	252	28,210
	10 20 30 40 50 60 MIRRYLYTFL LVMTLAGCKD KDLLKGLDQE QANEVIAVLQ MHNIEANKID SGKLGYSITV 70 80 90 100 110 120 AEPDFTAAVY WIKTYQLPPR PRVEIAQMFP ADSLVSSPRA EKARLYSAIE QRLEQSLQTM 130 140 150 160 170 180 EGVLSARVHI SYDIDAGENG RPPKPVHLSA LAVYERGSPL AHQISDIKRF LKNSFADVDY 190 200 210 220 230 240 DNISVVLSER SDAQLQAPGT PVKRNSFATS WIVLIILLSV MSAGFGVWYY KNHYARNKKG 250 ITADDKAKSS NE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion." Pegues D.A., Hantman M.J., Behlau I., Miller S.I. Mol. Microbiol. 17:169-181(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 14028s / SGSG 2262.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U21676 Genomic DNA. Translation: AAB60191.1.
AE006468 Genomic DNA. Translation: AAL21751.1.

PIR

S69786.

RefSeq

NP_461792.1. NC_003197.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2Y9J	electron microscopy	6.40	Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v	21-190	[»]

ProteinModelPortal

P41786.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-59554N.

STRING

99287.STM2871.

Proteomic databases

PaxDb

P41786.

PRIDE

P41786.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAL21751; AAL21751; STM2871.

GeneID

1254394.

KEGG

stm:STM2871.

PATRIC

32384430. VBISalEnt20916_3027.

Phylogenomic databases

eggNOG

COG4669.

HOGENOM

HOG000219450.

KO

K03222.

OMA

NISSKPM.

ProtClustDB

PRK15324.

Family and domain databases

InterPro

IPR003282. T3SS_HrcJ/YscJ.
IPR006182. YscJ_FliF.
[Graphical view]

Pfam

PF01514. YscJ_FliF. 1 hit.
[Graphical view]

PRINTS

PR01338. TYPE3OMKPROT.

TIGRFAMs

TIGR02544. III_secr_YscJ. 1 hit.

PROSITE

PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

PRGK_SALTY

Accession

Primary (citable) accession number: P41786

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program