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P41774

- COX1_MYTED

UniProt

P41774 - COX1_MYTED

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Mytilus edulis (Blue mussel)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791Iron (heme A axial ligand)Curated
    Metal bindingi258 – 2581Copper BCurated
    Metal bindingi262 – 2621Copper BCurated
    Metal bindingi308 – 3081Copper BCurated
    Metal bindingi309 – 3091Copper BCurated
    Metal bindingi394 – 3941Iron (heme A3 axial ligand)Curated
    Metal bindingi396 – 3961Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiMytilus edulis (Blue mussel)
    Taxonomic identifieri6550 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Cytochrome c oxidase subunit 1PRO_0000183364Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki258 ↔ 2621'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP41774.
    SMRiP41774. Positions 22-512.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKMLKKEEM GGYGEVESWW RRWLWSTNHK DIGTLYLYSG VWGGLFGASL    50
    SLMIRMQLGH PGAVFLKSDW FYNVVVTTHA LMMIFFAVMP ILIEAFGNWL 100
    IPLLVGGKDM IYPRMNNLSY WLSPNALYLL MLSFSTDKGV GAGWTIYPPL 150
    SVYPYHSGPS MDVLIVSLHL AGLSSLVGAI NFASTNKNMP VLEMKGERAE 200
    LYVLSISVTA VLLIISIPVL GGGITMILFD RNFNTTFFDP AGGGDPVLFQ 250
    HLFWFFGHPE VYILILPAFG VMSKVIMHCS GKEAVFGLIG MVYAMIGIGG 300
    LGCMVWAHHM FTVGLNVDTR GYFSTATMVI AVPTGVKVFS WLATMAGSKF 350
    KMKPAAYWST GFLFLFTVGG LTGVLLSSAS MDVSLHDTYY VVAHFHYVLS 400
    MGAVFGVFCG LNHWLPNFVG VCFNKKWSKA HFMAMFFGVN TTFFPQHFLG 450
    LSGMPRRYMD YADIYAHWHW VSSYGSAVSF GSLMYFKFLL WEALVSQRGV 500
    VFSGGLCGEM DWAGTRDLYP GSKHVYSQLP FVWTNPYNTC ITYIYKKSRN 550
    Q 551
    Length:551
    Mass (Da):61,644
    Last modified:March 1, 2005 - v2
    Checksum:iE1D49E4CD4FC13C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY484747 Genomic DNA. Translation: AAT98405.1.
    PIRiS28757.
    RefSeqiYP_073343.1. NC_006161.1.

    Genome annotation databases

    GeneIDi2960249.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY484747 Genomic DNA. Translation: AAT98405.1 .
    PIRi S28757.
    RefSeqi YP_073343.1. NC_006161.1.

    3D structure databases

    ProteinModelPortali P41774.
    SMRi P41774. Positions 22-512.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2960249.

    Organism-specific databases

    CTDi 4512.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequences of the highly rearranged molluscan mitochondrial genomes of the scaphopod Graptacme eborea and the bivalve Mytilus edulis."
      Boore J.L., Medina M., Rosenberg L.A.
      Mol. Biol. Evol. 21:1492-1503(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "A novel mitochondrial genome organization for the blue mussel, Mytilus edulis."
      Hoffmann R.J., Boore J.L., Brown W.M.
      Genetics 131:397-412(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.

    Entry informationi

    Entry nameiCOX1_MYTED
    AccessioniPrimary (citable) accession number: P41774
    Secondary accession number(s): Q68SR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3