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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Mytilus edulis (Blue mussel)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Iron (heme A axial ligand)Curated1
Metal bindingi258Copper BCurated1
Metal bindingi262Copper BCurated1
Metal bindingi308Copper BCurated1
Metal bindingi309Copper BCurated1
Metal bindingi394Iron (heme A3 axial ligand)Curated1
Metal bindingi396Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiMytilus edulis (Blue mussel)
Taxonomic identifieri6550 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833641 – 551Cytochrome c oxidase subunit 1Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki258 ↔ 2621'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PRIDEiP41774.

Structurei

3D structure databases

ProteinModelPortaliP41774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMLKKEEM GGYGEVESWW RRWLWSTNHK DIGTLYLYSG VWGGLFGASL
60 70 80 90 100
SLMIRMQLGH PGAVFLKSDW FYNVVVTTHA LMMIFFAVMP ILIEAFGNWL
110 120 130 140 150
IPLLVGGKDM IYPRMNNLSY WLSPNALYLL MLSFSTDKGV GAGWTIYPPL
160 170 180 190 200
SVYPYHSGPS MDVLIVSLHL AGLSSLVGAI NFASTNKNMP VLEMKGERAE
210 220 230 240 250
LYVLSISVTA VLLIISIPVL GGGITMILFD RNFNTTFFDP AGGGDPVLFQ
260 270 280 290 300
HLFWFFGHPE VYILILPAFG VMSKVIMHCS GKEAVFGLIG MVYAMIGIGG
310 320 330 340 350
LGCMVWAHHM FTVGLNVDTR GYFSTATMVI AVPTGVKVFS WLATMAGSKF
360 370 380 390 400
KMKPAAYWST GFLFLFTVGG LTGVLLSSAS MDVSLHDTYY VVAHFHYVLS
410 420 430 440 450
MGAVFGVFCG LNHWLPNFVG VCFNKKWSKA HFMAMFFGVN TTFFPQHFLG
460 470 480 490 500
LSGMPRRYMD YADIYAHWHW VSSYGSAVSF GSLMYFKFLL WEALVSQRGV
510 520 530 540 550
VFSGGLCGEM DWAGTRDLYP GSKHVYSQLP FVWTNPYNTC ITYIYKKSRN

Q
Length:551
Mass (Da):61,644
Last modified:March 1, 2005 - v2
Checksum:iE1D49E4CD4FC13C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484747 Genomic DNA. Translation: AAT98405.1.
PIRiS28757.
RefSeqiYP_073343.1. NC_006161.1.

Genome annotation databases

GeneIDi2960249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484747 Genomic DNA. Translation: AAT98405.1.
PIRiS28757.
RefSeqiYP_073343.1. NC_006161.1.

3D structure databases

ProteinModelPortaliP41774.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP41774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2960249.

Organism-specific databases

CTDi4512.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_MYTED
AccessioniPrimary (citable) accession number: P41774
Secondary accession number(s): Q68SR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.