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P41774

- COX1_MYTED

UniProt

P41774 - COX1_MYTED

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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Mytilus edulis (Blue mussel)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Iron (heme A axial ligand)Curated
Metal bindingi258 – 2581Copper BCurated
Metal bindingi262 – 2621Copper BCurated
Metal bindingi308 – 3081Copper BCurated
Metal bindingi309 – 3091Copper BCurated
Metal bindingi394 – 3941Iron (heme A3 axial ligand)Curated
Metal bindingi396 – 3961Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiMytilus edulis (Blue mussel)
Taxonomic identifieri6550 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Cytochrome c oxidase subunit 1PRO_0000183364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki258 ↔ 2621'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP41774.
SMRiP41774. Positions 22-512.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence AnalysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence AnalysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence AnalysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence AnalysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence AnalysisAdd
BLAST
Transmembranei475 – 49521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41774-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMKMLKKEEM GGYGEVESWW RRWLWSTNHK DIGTLYLYSG VWGGLFGASL
60 70 80 90 100
SLMIRMQLGH PGAVFLKSDW FYNVVVTTHA LMMIFFAVMP ILIEAFGNWL
110 120 130 140 150
IPLLVGGKDM IYPRMNNLSY WLSPNALYLL MLSFSTDKGV GAGWTIYPPL
160 170 180 190 200
SVYPYHSGPS MDVLIVSLHL AGLSSLVGAI NFASTNKNMP VLEMKGERAE
210 220 230 240 250
LYVLSISVTA VLLIISIPVL GGGITMILFD RNFNTTFFDP AGGGDPVLFQ
260 270 280 290 300
HLFWFFGHPE VYILILPAFG VMSKVIMHCS GKEAVFGLIG MVYAMIGIGG
310 320 330 340 350
LGCMVWAHHM FTVGLNVDTR GYFSTATMVI AVPTGVKVFS WLATMAGSKF
360 370 380 390 400
KMKPAAYWST GFLFLFTVGG LTGVLLSSAS MDVSLHDTYY VVAHFHYVLS
410 420 430 440 450
MGAVFGVFCG LNHWLPNFVG VCFNKKWSKA HFMAMFFGVN TTFFPQHFLG
460 470 480 490 500
LSGMPRRYMD YADIYAHWHW VSSYGSAVSF GSLMYFKFLL WEALVSQRGV
510 520 530 540 550
VFSGGLCGEM DWAGTRDLYP GSKHVYSQLP FVWTNPYNTC ITYIYKKSRN

Q
Length:551
Mass (Da):61,644
Last modified:March 1, 2005 - v2
Checksum:iE1D49E4CD4FC13C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY484747 Genomic DNA. Translation: AAT98405.1.
PIRiS28757.
RefSeqiYP_073343.1. NC_006161.1.

Genome annotation databases

GeneIDi2960249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY484747 Genomic DNA. Translation: AAT98405.1 .
PIRi S28757.
RefSeqi YP_073343.1. NC_006161.1.

3D structure databases

ProteinModelPortali P41774.
SMRi P41774. Positions 22-512.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2960249.

Organism-specific databases

CTDi 4512.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequences of the highly rearranged molluscan mitochondrial genomes of the scaphopod Graptacme eborea and the bivalve Mytilus edulis."
    Boore J.L., Medina M., Rosenberg L.A.
    Mol. Biol. Evol. 21:1492-1503(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A novel mitochondrial genome organization for the blue mussel, Mytilus edulis."
    Hoffmann R.J., Boore J.L., Brown W.M.
    Genetics 131:397-412(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.

Entry informationi

Entry nameiCOX1_MYTED
AccessioniPrimary (citable) accession number: P41774
Secondary accession number(s): Q68SR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 1, 2005
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3