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P41769

- PYRF_KLUMA

UniProt

P41769 - PYRF_KLUMA

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Kluyveromyces marxianus (Yeast) (Candida kefyr)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371SubstrateBy similarity
Active sitei93 – 931Proton donorPROSITE-ProRule annotation
Binding sitei217 – 2171SubstrateBy similarity
Binding sitei235 – 2351SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiKluyveromyces marxianus (Yeast) (Candida kefyr)
Taxonomic identifieri4911 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Orotidine 5'-phosphate decarboxylasePRO_0000134664Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP41769.
SMRiP41769. Positions 1-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 613Substrate bindingBy similarity
Regioni91 – 10010Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41769 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTKSYSERA AAHRSPVAAK LLNLMEEKKS NLCASLDVRK TAELLRLVEV
60 70 80 90 100
LGPYICLLKT HVDILEDFSF ENTIVPLKQL AEKHKFLIFE DRKFADIGNT
110 120 130 140 150
VKLQYTSGVY RIAEWSDITN AHGVTGAGIV AGLKQGAEEV TKEPRGLLML
160 170 180 190 200
AELSSKGSLA HGEYTRGTVE IAKSDKDFVI GFIAQNDMGG REEGYDWLIM
210 220 230 240 250
TPGVGLDDKG DALGQQYRTV DEVVAGGSDI IIVGRGLFAK GRDPVVEGER
260
YRKAGWDAYL KRVGRSA
Length:267
Mass (Da):29,295
Last modified:November 1, 1995 - v1
Checksum:i3B0281C40E3EE735
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21934 Genomic DNA. Translation: CAA79928.1.
PIRiS33964.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21934 Genomic DNA. Translation: CAA79928.1 .
PIRi S33964.

3D structure databases

ProteinModelPortali P41769.
SMRi P41769. Positions 1-265.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the URA3 gene of Kluyveromyces marxianus CBS 6556."
    Bergkamp R.J., Geerse R.H., Verbakel J.M., Planta R.J.
    Yeast 9:677-681(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26548 / CBS 6556 / NRRL Y-7571.

Entry informationi

Entry nameiPYRF_KLUMA
AccessioniPrimary (citable) accession number: P41769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3