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P41769 (PYRF_KLUMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismKluyveromyces marxianus (Yeast) (Candida kefyr)
Taxonomic identifier4911 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Orotidine 5'-phosphate decarboxylase
PRO_0000134664

Regions

Region59 – 613Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site371Substrate By similarity
Binding site2171Substrate By similarity
Binding site2351Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P41769 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 3B0281C40E3EE735

FASTA26729,295
        10         20         30         40         50         60 
MSTKSYSERA AAHRSPVAAK LLNLMEEKKS NLCASLDVRK TAELLRLVEV LGPYICLLKT 

        70         80         90        100        110        120 
HVDILEDFSF ENTIVPLKQL AEKHKFLIFE DRKFADIGNT VKLQYTSGVY RIAEWSDITN 

       130        140        150        160        170        180 
AHGVTGAGIV AGLKQGAEEV TKEPRGLLML AELSSKGSLA HGEYTRGTVE IAKSDKDFVI 

       190        200        210        220        230        240 
GFIAQNDMGG REEGYDWLIM TPGVGLDDKG DALGQQYRTV DEVVAGGSDI IIVGRGLFAK 

       250        260 
GRDPVVEGER YRKAGWDAYL KRVGRSA 

« Hide

References

[1]"Cloning and sequencing of the URA3 gene of Kluyveromyces marxianus CBS 6556."
Bergkamp R.J., Geerse R.H., Verbakel J.M., Planta R.J.
Yeast 9:677-681(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 26548 / CBS 6556 / NRRL Y-7571.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z21934 Genomic DNA. Translation: CAA79928.1.
PIRS33964.

3D structure databases

ProteinModelPortalP41769.
SMRP41769. Positions 1-265.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_KLUMA
AccessionPrimary (citable) accession number: P41769
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways