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P41764

- G6PD_EMENI

UniProt

P41764 - G6PD_EMENI

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gsdA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631NADPBy similarity
    Binding sitei164 – 1641NADP; via carbonyl oxygenBy similarity
    Binding sitei164 – 1641SubstrateBy similarity
    Binding sitei232 – 2321SubstrateBy similarity
    Binding sitei251 – 2511SubstrateBy similarity
    Active sitei256 – 2561Proton acceptorBy similarity
    Binding sitei350 – 3501SubstrateBy similarity
    Binding sitei384 – 3841SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 368NADPBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: ASPGD
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:gsdA
    Synonyms:g6pD
    ORF Names:AN2981
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VI

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: ASPGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Glucose-6-phosphate 1-dehydrogenasePRO_0000068103Add
    BLAST

    Proteomic databases

    PRIDEiP41764.

    Structurei

    3D structure databases

    ProteinModelPortaliP41764.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni194 – 1985Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046192.
    KOiK00036.
    OMAiHAFTESS.
    OrthoDBiEOG7TXKRP.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41764-1 [UniParc]FASTAAdd to Basket

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    MSATIARAEE QQNGSTVELK DDTVIVVLGA SGDLAKKKTF PALFGLFRNK    50
    FLPKGIKIVG YARTQMDHNE YLKRVRSYIK TPTKEIEEQL NSFCELCTYI 100
    SGQYDQDDSF KNLAKHLEEI EKNQKEQNRV FYMALPPSVF ITVSEQLKRN 150
    CYPKNGVARI IVEKPFGKDL QSSRDLQKAL EPNWKEEEIF RIDHYLGKEM 200
    VKNILIMRFG NEFFNATWNR HHIDNVQITF KEPFGTEGRG GYFDEFGIIR 250
    DVMQNHLLQV LTLLAMERPI SFSAEDIRDE KVRVLRAMDP IQPKDVIIGQ 300
    YGRSLDGSKP AYKEDDTVPQ DSRCPTFCAL VAHIKNERWD GVPFIMKAGK 350
    ALNEQKTEIR IQFKDVTSGI FKDIPRNELV IRVQPNESVY IKMNSKLPGL 400
    SMQTVVTELD LTYRRRFSDL KIPEAYESLI LDALKGDHSN FVRDDELDAS 450
    WRMFTPLLHY LDDNKEIIPM EYPYGSRGPS VLDDFTASYG YKFSDAAGYQ 500
    WPLTHTTPNR L 511
    Length:511
    Mass (Da):58,977
    Last modified:November 1, 1997 - v2
    Checksum:i66BC15B72878A475
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 206Missing in CAA58825. 1 PublicationCurated
    Sequence conflicti76 – 8510RSYIKTPTKE → DTLRPRQRK in CAA58825. 1 PublicationCurated
    Sequence conflicti352 – 3521L → LP in CAA58825. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84001 Genomic DNA. Translation: CAA58825.1.
    X77830 Genomic DNA. Translation: CAA54841.1.
    AACD01000051 Genomic DNA. Translation: EAA63552.1.
    BN001306 Genomic DNA. Translation: CBF83624.1.
    RefSeqiXP_660585.1. XM_655493.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00010099; CADANIAP00010099; CADANIAG00010099.
    GeneIDi2874290.
    KEGGiani:AN2981.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84001 Genomic DNA. Translation: CAA58825.1 .
    X77830 Genomic DNA. Translation: CAA54841.1 .
    AACD01000051 Genomic DNA. Translation: EAA63552.1 .
    BN001306 Genomic DNA. Translation: CBF83624.1 .
    RefSeqi XP_660585.1. XM_655493.1.

    3D structure databases

    ProteinModelPortali P41764.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P41764.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00010099 ; CADANIAP00010099 ; CADANIAG00010099 .
    GeneIDi 2874290.
    KEGGi ani:AN2981.2.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046192.
    KOi K00036.
    OMAi HAFTESS.
    OrthoDBi EOG7TXKRP.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Schaap P.J., Muller Y., Visser J.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. van den Broek P., Goosen T., Wennekes B., van den Broek H.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: WG096.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    4. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiG6PD_EMENI
    AccessioniPrimary (citable) accession number: P41764
    Secondary accession number(s): C8VIZ3, Q5B8Z9, Q92408
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3