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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gsdA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (gsdA)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (AN10233), 6-phosphogluconate dehydrogenase, decarboxylating (AN3954.2), 6-phosphogluconate dehydrogenase, decarboxylating (ANIA_03954)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63NADPBy similarity1
Binding sitei164NADP; via carbonyl oxygenBy similarity1
Binding sitei164SubstrateBy similarity1
Binding sitei232SubstrateBy similarity1
Binding sitei251SubstrateBy similarity1
Active sitei256Proton acceptorBy similarity1
Binding sitei350SubstrateBy similarity1
Binding sitei384SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 36NADPBy similarity8

GO - Molecular functioni

  • glucose-6-phosphate dehydrogenase activity Source: AspGD
  • NADP binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:gsdA
Synonyms:g6pD
ORF Names:AN2981
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VI
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681031 – 511Glucose-6-phosphate 1-dehydrogenaseAdd BLAST511

Proteomic databases

PRIDEiP41764

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00010099

Structurei

3D structure databases

ProteinModelPortaliP41764
SMRiP41764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 198Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000046192
InParanoidiP41764
KOiK00036
OMAiVEICVYE
OrthoDBiEOG092C2MOH

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P41764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATIARAEE QQNGSTVELK DDTVIVVLGA SGDLAKKKTF PALFGLFRNK
60 70 80 90 100
FLPKGIKIVG YARTQMDHNE YLKRVRSYIK TPTKEIEEQL NSFCELCTYI
110 120 130 140 150
SGQYDQDDSF KNLAKHLEEI EKNQKEQNRV FYMALPPSVF ITVSEQLKRN
160 170 180 190 200
CYPKNGVARI IVEKPFGKDL QSSRDLQKAL EPNWKEEEIF RIDHYLGKEM
210 220 230 240 250
VKNILIMRFG NEFFNATWNR HHIDNVQITF KEPFGTEGRG GYFDEFGIIR
260 270 280 290 300
DVMQNHLLQV LTLLAMERPI SFSAEDIRDE KVRVLRAMDP IQPKDVIIGQ
310 320 330 340 350
YGRSLDGSKP AYKEDDTVPQ DSRCPTFCAL VAHIKNERWD GVPFIMKAGK
360 370 380 390 400
ALNEQKTEIR IQFKDVTSGI FKDIPRNELV IRVQPNESVY IKMNSKLPGL
410 420 430 440 450
SMQTVVTELD LTYRRRFSDL KIPEAYESLI LDALKGDHSN FVRDDELDAS
460 470 480 490 500
WRMFTPLLHY LDDNKEIIPM EYPYGSRGPS VLDDFTASYG YKFSDAAGYQ
510
WPLTHTTPNR L
Length:511
Mass (Da):58,977
Last modified:November 1, 1997 - v2
Checksum:i66BC15B72878A475
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 20Missing in CAA58825 (Ref. 1) Curated6
Sequence conflicti76 – 85RSYIKTPTKE → DTLRPRQRK in CAA58825 (Ref. 1) Curated10
Sequence conflicti352L → LP in CAA58825 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84001 Genomic DNA Translation: CAA58825.1
X77830 Genomic DNA Translation: CAA54841.1
AACD01000051 Genomic DNA Translation: EAA63552.1
BN001306 Genomic DNA Translation: CBF83624.1
RefSeqiXP_660585.1, XM_655493.1

Genome annotation databases

EnsemblFungiiCADANIAT00010099; CADANIAP00010099; CADANIAG00010099
EAA63552; EAA63552; AN2981.2
GeneIDi2874290
KEGGiani:AN2981.2

Similar proteinsi

Entry informationi

Entry nameiG6PD_EMENI
AccessioniPrimary (citable) accession number: P41764
Secondary accession number(s): C8VIZ3, Q5B8Z9, Q92408
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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