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P41762

- PGKG_TRYCO

UniProt

P41762 - PGKG_TRYCO

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Protein

Phosphoglycerate kinase, glycosomal

Gene
56PGK
Organism
Trypanosoma congolense
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481Substrate By similarity
Binding sitei224 – 2241Substrate By similarity
Binding sitei261 – 2611Substrate By similarity
Binding sitei312 – 3121ATP By similarity
Binding sitei434 – 4341ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi464 – 4674ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase, glycosomal (EC:2.7.2.3)
Gene namesi
Name:56PGK
OrganismiTrypanosoma congolense
Taxonomic identifieri5692 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaNannomonas

Subcellular locationi

Glycosome UniRule annotation

GO - Cellular componenti

  1. glycosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Glycosome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Phosphoglycerate kinase, glycosomalUniRule annotationPRO_0000145868Add
BLAST

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP41762.
SMRiP41762. Positions 14-508.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 353Substrate binding By similarity
Regioni71 – 744Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.1260. 2 hits.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 2 hits.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41762-1 [UniParc]FASTAAdd to Basket

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MSHVTGVTSN IRIKKTIDDI WPLTAKRVLV RVDFNVPIQN GHITNDYRIR    50
ATIPTIQRII DQGGICILLS HLGRPAGISM TTAVRDVRRR YHEAHFHDNK 100
GKTAFFSVLP PEEKIKILAQ SSLREEATHI MPGVKSGKTI LFARLPEDEK 150
KQLLMQYLDE KKDNGLPQLS VSAGYEEQYS LRPVAVRLAE LLGQHVYFAH 200
DCMDAKMELS RLKRGNVMLL ENVRFYREED SKKEEEREAM AKVLASYGDI 250
FVSDAFGTAH RDSATMTGIP KVLGHGAAGY LMEKEISYFS KVLGNPPRPL 300
VAIVGGSKVS DKIQLLDNML QRIDYLLIGG AMAYTFLKAQ GHRIGTSMCE 350
EDRLDLARSL LKKAEDRKVQ VLLPVDHVCH TEFKAVDTPV VTADADIPDG 400
HMALDIGPKT IANYVETIGK CKSAIWNGPM GVFEMTPYSK GTFAVAKAMG 450
DCTQKNGLMS IIGGGDSASA AEQSGEATRM SHVSTGGGAS LELLEGKTLP 500
GVAILDDKE 509
Length:509
Mass (Da):55,963
Last modified:November 1, 1995 - v1
Checksum:iEA3FFD44B9426B3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37337 Genomic DNA. Translation: AAC37221.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37337 Genomic DNA. Translation: AAC37221.1 .

3D structure databases

ProteinModelPortali P41762.
SMRi P41762. Positions 14-508.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 2 hits.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 2 hits.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense."
    Parker H.L., Hill T., Alexander K.A., Murphy N.B., Fish W.R., Parsons M.
    Mol. Biochem. Parasitol. 69:269-279(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IL3000.

Entry informationi

Entry nameiPGKG_TRYCO
AccessioniPrimary (citable) accession number: P41762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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