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P41762

- PGKG_TRYCO

UniProt

P41762 - PGKG_TRYCO

Protein

Phosphoglycerate kinase, glycosomal

Gene

56PGK

Organism
Trypanosoma congolense
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481SubstrateBy similarity
    Binding sitei224 – 2241SubstrateBy similarity
    Binding sitei261 – 2611SubstrateBy similarity
    Binding sitei312 – 3121ATPBy similarity
    Binding sitei434 – 4341ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi464 – 4674ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase, glycosomal (EC:2.7.2.3)
    Gene namesi
    Name:56PGK
    OrganismiTrypanosoma congolense
    Taxonomic identifieri5692 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaNannomonas

    Subcellular locationi

    GO - Cellular componenti

    1. glycosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Glycosome, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Phosphoglycerate kinase, glycosomalPRO_0000145868Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP41762.
    SMRiP41762. Positions 14-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 353Substrate bindingBy similarity
    Regioni71 – 744Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1260. 2 hits.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 2 hits.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41762-1 [UniParc]FASTAAdd to Basket

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    MSHVTGVTSN IRIKKTIDDI WPLTAKRVLV RVDFNVPIQN GHITNDYRIR    50
    ATIPTIQRII DQGGICILLS HLGRPAGISM TTAVRDVRRR YHEAHFHDNK 100
    GKTAFFSVLP PEEKIKILAQ SSLREEATHI MPGVKSGKTI LFARLPEDEK 150
    KQLLMQYLDE KKDNGLPQLS VSAGYEEQYS LRPVAVRLAE LLGQHVYFAH 200
    DCMDAKMELS RLKRGNVMLL ENVRFYREED SKKEEEREAM AKVLASYGDI 250
    FVSDAFGTAH RDSATMTGIP KVLGHGAAGY LMEKEISYFS KVLGNPPRPL 300
    VAIVGGSKVS DKIQLLDNML QRIDYLLIGG AMAYTFLKAQ GHRIGTSMCE 350
    EDRLDLARSL LKKAEDRKVQ VLLPVDHVCH TEFKAVDTPV VTADADIPDG 400
    HMALDIGPKT IANYVETIGK CKSAIWNGPM GVFEMTPYSK GTFAVAKAMG 450
    DCTQKNGLMS IIGGGDSASA AEQSGEATRM SHVSTGGGAS LELLEGKTLP 500
    GVAILDDKE 509
    Length:509
    Mass (Da):55,963
    Last modified:November 1, 1995 - v1
    Checksum:iEA3FFD44B9426B3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37337 Genomic DNA. Translation: AAC37221.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37337 Genomic DNA. Translation: AAC37221.1 .

    3D structure databases

    ProteinModelPortali P41762.
    SMRi P41762. Positions 14-508.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 2 hits.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 2 hits.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense."
      Parker H.L., Hill T., Alexander K.A., Murphy N.B., Fish W.R., Parsons M.
      Mol. Biochem. Parasitol. 69:269-279(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: IL3000.

    Entry informationi

    Entry nameiPGKG_TRYCO
    AccessioniPrimary (citable) accession number: P41762
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3