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P41762 (PGKG_TRYCO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase, glycosomal

EC=2.7.2.3
Gene names
Name:56PGK
OrganismTrypanosoma congolense
Taxonomic identifier5692 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaNannomonas

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Glycosome HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentGlycosome
Peroxisome
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentglycosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Phosphoglycerate kinase, glycosomal HAMAP-Rule MF_00145
PRO_0000145868

Regions

Nucleotide binding464 – 4674ATP By similarity
Region33 – 353Substrate binding By similarity
Region71 – 744Substrate binding By similarity

Sites

Binding site481Substrate By similarity
Binding site2241Substrate By similarity
Binding site2611Substrate By similarity
Binding site3121ATP By similarity
Binding site4341ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P41762 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: EA3FFD44B9426B3A

FASTA50955,963
        10         20         30         40         50         60 
MSHVTGVTSN IRIKKTIDDI WPLTAKRVLV RVDFNVPIQN GHITNDYRIR ATIPTIQRII 

        70         80         90        100        110        120 
DQGGICILLS HLGRPAGISM TTAVRDVRRR YHEAHFHDNK GKTAFFSVLP PEEKIKILAQ 

       130        140        150        160        170        180 
SSLREEATHI MPGVKSGKTI LFARLPEDEK KQLLMQYLDE KKDNGLPQLS VSAGYEEQYS 

       190        200        210        220        230        240 
LRPVAVRLAE LLGQHVYFAH DCMDAKMELS RLKRGNVMLL ENVRFYREED SKKEEEREAM 

       250        260        270        280        290        300 
AKVLASYGDI FVSDAFGTAH RDSATMTGIP KVLGHGAAGY LMEKEISYFS KVLGNPPRPL 

       310        320        330        340        350        360 
VAIVGGSKVS DKIQLLDNML QRIDYLLIGG AMAYTFLKAQ GHRIGTSMCE EDRLDLARSL 

       370        380        390        400        410        420 
LKKAEDRKVQ VLLPVDHVCH TEFKAVDTPV VTADADIPDG HMALDIGPKT IANYVETIGK 

       430        440        450        460        470        480 
CKSAIWNGPM GVFEMTPYSK GTFAVAKAMG DCTQKNGLMS IIGGGDSASA AEQSGEATRM 

       490        500 
SHVSTGGGAS LELLEGKTLP GVAILDDKE 

« Hide

References

[1]"Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense."
Parker H.L., Hill T., Alexander K.A., Murphy N.B., Fish W.R., Parsons M.
Mol. Biochem. Parasitol. 69:269-279(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IL3000.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L37337 Genomic DNA. Translation: AAC37221.1.

3D structure databases

ProteinModelPortalP41762.
SMRP41762. Positions 14-508.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 2 hits.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 2 hits.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGKG_TRYCO
AccessionPrimary (citable) accession number: P41762
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways