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P41760

- PGK1_TRYCO

UniProt

P41760 - PGK1_TRYCO

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Protein

Phosphoglycerate kinase, cytosolic

Gene

C1PGK

more
Organism
Trypanosoma congolense
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Binding sitei135 – 1351SubstrateBy similarity
Binding sitei172 – 1721SubstrateBy similarity
Binding sitei223 – 2231ATPBy similarity
Binding sitei345 – 3451ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi375 – 3784ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase, cytosolic (EC:2.7.2.3)
Gene namesi
Name:C1PGK
AND
Name:C2PGK
OrganismiTrypanosoma congolense
Taxonomic identifieri5692 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaNannomonas

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Phosphoglycerate kinase, cytosolicPRO_0000145867Add
BLAST

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP41760.
SMRiP41760. Positions 5-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni62 – 654Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41760-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLNEKKSIN ECDLKGKKTL VRVDFNVPVK GGVITNDYRI RSALPTIQKV
60 70 80 90 100
LNEGGSCILM SHLGRPKGIS ISEAAAVRSA GKVPGYEEAA TLRPVAQRLG
110 120 130 140 150
ELLSKPVVFA PDCLDAADVV KKMSPGDVVL LENVRFYREE GSKKEEEREA
160 170 180 190 200
MAKVLASYGD IFVSDAFGTA HRDSATMTGI PKVLGHGAAG YLMEKEISYF
210 220 230 240 250
SKVLGNPPRP LVAIVGGSKV SDKIQLLDNM LQRIDYLLIG GAMAYTFLKA
260 270 280 290 300
QGHRIGTSMC EEDRLDLARS LLKKAEDRKV QVLLPVDHVC HTEFKAVDTP
310 320 330 340 350
VVTADADIPD GHMALDIGPK TIANYVETIG KCKSAIWNGP MGVFEMTPYS
360 370 380 390 400
KGTFAVAKAM GDCTQKNGLM SIIGGGDSAS AAEQSGEATR MSHVSTGGGA
410 420
SLELLEGKTL PGVAILDEKV
Length:420
Mass (Da):44,897
Last modified:November 1, 1995 - v1
Checksum:i0FE519E5EC184061
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37337 Genomic DNA. Translation: AAC37222.1.
L37337 Genomic DNA. Translation: AAC37223.1.
L37336 Genomic DNA. Translation: AAC37224.1.
L37336 Genomic DNA. Translation: AAC37225.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37337 Genomic DNA. Translation: AAC37222.1 .
L37337 Genomic DNA. Translation: AAC37223.1 .
L37336 Genomic DNA. Translation: AAC37224.1 .
L37336 Genomic DNA. Translation: AAC37225.1 .

3D structure databases

ProteinModelPortali P41760.
SMRi P41760. Positions 5-419.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense."
    Parker H.L., Hill T., Alexander K.A., Murphy N.B., Fish W.R., Parsons M.
    Mol. Biochem. Parasitol. 69:269-279(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IL3000.

Entry informationi

Entry nameiPGK1_TRYCO
AccessioniPrimary (citable) accession number: P41760
Secondary accession number(s): P41761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3