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P41760

- PGK1_TRYCO

UniProt

P41760 - PGK1_TRYCO

Protein

Phosphoglycerate kinase, cytosolic

Gene

C1PGK

more
Organism
Trypanosoma congolense
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Binding sitei135 – 1351SubstrateBy similarity
    Binding sitei172 – 1721SubstrateBy similarity
    Binding sitei223 – 2231ATPBy similarity
    Binding sitei345 – 3451ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi375 – 3784ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase, cytosolic (EC:2.7.2.3)
    Gene namesi
    Name:C1PGK
    AND
    Name:C2PGK
    OrganismiTrypanosoma congolense
    Taxonomic identifieri5692 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaNannomonas

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Phosphoglycerate kinase, cytosolicPRO_0000145867Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP41760.
    SMRiP41760. Positions 5-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni62 – 654Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41760-1 [UniParc]FASTAAdd to Basket

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    MTLNEKKSIN ECDLKGKKTL VRVDFNVPVK GGVITNDYRI RSALPTIQKV    50
    LNEGGSCILM SHLGRPKGIS ISEAAAVRSA GKVPGYEEAA TLRPVAQRLG 100
    ELLSKPVVFA PDCLDAADVV KKMSPGDVVL LENVRFYREE GSKKEEEREA 150
    MAKVLASYGD IFVSDAFGTA HRDSATMTGI PKVLGHGAAG YLMEKEISYF 200
    SKVLGNPPRP LVAIVGGSKV SDKIQLLDNM LQRIDYLLIG GAMAYTFLKA 250
    QGHRIGTSMC EEDRLDLARS LLKKAEDRKV QVLLPVDHVC HTEFKAVDTP 300
    VVTADADIPD GHMALDIGPK TIANYVETIG KCKSAIWNGP MGVFEMTPYS 350
    KGTFAVAKAM GDCTQKNGLM SIIGGGDSAS AAEQSGEATR MSHVSTGGGA 400
    SLELLEGKTL PGVAILDEKV 420
    Length:420
    Mass (Da):44,897
    Last modified:November 1, 1995 - v1
    Checksum:i0FE519E5EC184061
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37337 Genomic DNA. Translation: AAC37222.1.
    L37337 Genomic DNA. Translation: AAC37223.1.
    L37336 Genomic DNA. Translation: AAC37224.1.
    L37336 Genomic DNA. Translation: AAC37225.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37337 Genomic DNA. Translation: AAC37222.1 .
    L37337 Genomic DNA. Translation: AAC37223.1 .
    L37336 Genomic DNA. Translation: AAC37224.1 .
    L37336 Genomic DNA. Translation: AAC37225.1 .

    3D structure databases

    ProteinModelPortali P41760.
    SMRi P41760. Positions 5-419.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense."
      Parker H.L., Hill T., Alexander K.A., Murphy N.B., Fish W.R., Parsons M.
      Mol. Biochem. Parasitol. 69:269-279(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: IL3000.

    Entry informationi

    Entry nameiPGK1_TRYCO
    AccessioniPrimary (citable) accession number: P41760
    Secondary accession number(s): P41761
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3