Reviewed,
UniProtKB/Swiss-Prot P41760 (PGK1_TRYCO)
Last modified
June 16, 2009.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phosphoglycerate kinase, cytosolic EC=2.7.2.3 | |||||
| Gene names |
| |||||
| Organism | Trypanosoma congolense | |||||
| Taxonomic identifier | 5692 [NCBI] | |||||
| Taxonomic lineage | Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Nannomonas |
Protein attributes
| Sequence length | 420 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. |
| Pathway | Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. |
| Subunit structure | Monomer. |
| Subcellular location | |
| Sequence similarities | Belongs to the phosphoglycerate kinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 420 | 420 | Phosphoglycerate kinase, cytosolic | PRO_0000145867 | |||||
Regions | |||||||||
| Nucleotide binding | 375 – 378 | 4 | ATP By similarity | ||||||
| Region | 24 – 26 | 3 | Substrate binding By similarity | ||||||
| Region | 62 – 65 | 4 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 39 | 1 | Substrate By similarity | ||||||
| Binding site | 135 | 1 | Substrate By similarity | ||||||
| Binding site | 172 | 1 | Substrate By similarity | ||||||
| Binding site | 223 | 1 | ATP By similarity | ||||||
| Binding site | 345 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense." Parker H.L., Hill T., Alexander K.A., Murphy N.B., Fish W.R., Parsons M. Mol. Biochem. Parasitol. 69:269-279(1995) [PubMed: 7770090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IL3000. |
Cross-references
Sequence databases | |
|---|---|
| L37337 Genomic DNA. Translation: AAC37222.1. L37337 Genomic DNA. Translation: AAC37223.1. L37336 Genomic DNA. Translation: AAC37224.1. L37336 Genomic DNA. Translation: AAC37225.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 16PK based on UniProtKB P07378. |
| SMR | P41760. Positions 5-419. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.7.2.3. 95989. |
Family and domain databases | |
| InterPro | IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit. |
| PANTHER | PTHR11406. PGK. 1 hit. |
| Pfam | PF00162. PGK. 1 hit. [Graphical view] |
| PRINTS | PR00477. PHGLYCKINASE. |
| PROSITE | PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PGK1_TRYCO | ||||||||
| Accession | Primary (citable) accession number: P41760 Secondary accession number(s): P41761 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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