Reviewed, UniProtKB/Swiss-Prot P41760 (PGK1_TRYCO)

Names and origin

Protein names

Recommended name:
    Phosphoglycerate kinase, cytosolic
    EC=2.7.2.3

Gene names

Name:	C1PGK
AND
Name:	C2PGK

Organism

Trypanosoma congolense

Taxonomic identifier

5692 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Nannomonas

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.
Subunit structure	Monomer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Phosphoglycerate kinase, cytosolic		PRO_0000145867
Regions
	Nucleotide binding	375 – 378	4	ATP By similarity
	Region	24 – 26	3	Substrate binding By similarity
	Region	62 – 65	4	Substrate binding By similarity
Sites
	Binding site	39	1	Substrate By similarity
	Binding site	135	1	Substrate By similarity
	Binding site	172	1	Substrate By similarity
	Binding site	223	1	ATP By similarity
	Binding site	345	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41760-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 0FE519E5EC184061	FASTA	420	44,897
	10 20 30 40 50 60 MTLNEKKSIN ECDLKGKKTL VRVDFNVPVK GGVITNDYRI RSALPTIQKV LNEGGSCILM 70 80 90 100 110 120 SHLGRPKGIS ISEAAAVRSA GKVPGYEEAA TLRPVAQRLG ELLSKPVVFA PDCLDAADVV 130 140 150 160 170 180 KKMSPGDVVL LENVRFYREE GSKKEEEREA MAKVLASYGD IFVSDAFGTA HRDSATMTGI 190 200 210 220 230 240 PKVLGHGAAG YLMEKEISYF SKVLGNPPRP LVAIVGGSKV SDKIQLLDNM LQRIDYLLIG 250 260 270 280 290 300 GAMAYTFLKA QGHRIGTSMC EEDRLDLARS LLKKAEDRKV QVLLPVDHVC HTEFKAVDTP 310 320 330 340 350 360 VVTADADIPD GHMALDIGPK TIANYVETIG KCKSAIWNGP MGVFEMTPYS KGTFAVAKAM 370 380 390 400 410 420 GDCTQKNGLM SIIGGGDSAS AAEQSGEATR MSHVSTGGGA SLELLEGKTL PGVAILDEKV

References

[1]

"Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense." Parker H.L., Hill T., Alexander K.A., Murphy N.B., Fish W.R., Parsons M. Mol. Biochem. Parasitol. 69:269-279(1995) [PubMed: 7770090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IL3000.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L37337 Genomic DNA. Translation: AAC37222.1. L37337 Genomic DNA. Translation: AAC37223.1. L37336 Genomic DNA. Translation: AAC37224.1. L37336 Genomic DNA. Translation: AAC37225.1.
3D structure databases
HSSP	HSSP built from PDB template 16PK based on UniProtKB P07378.
SMR	P41760. Positions 5-419.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.2.3. 95989.
Family and domain databases
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
PANTHER	PTHR11406. PGK. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PRINTS	PR00477. PHGLYCKINASE.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK1_TRYCO

Accession

Primary (citable) accession number: P41760
Secondary accession number(s): P41761

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)