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P41760 (PGK1_TRYCO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase, cytosolic

EC=2.7.2.3
Gene names
Name:C1PGK
AND
Name:C2PGK
OrganismTrypanosoma congolense
Taxonomic identifier5692 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaNannomonas

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Cytoplasm HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Phosphoglycerate kinase, cytosolic HAMAP-Rule MF_00145
PRO_0000145867

Regions

Nucleotide binding375 – 3784ATP By similarity
Region24 – 263Substrate binding By similarity
Region62 – 654Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1351Substrate By similarity
Binding site1721Substrate By similarity
Binding site2231ATP By similarity
Binding site3451ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P41760 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 0FE519E5EC184061

FASTA42044,897
        10         20         30         40         50         60 
MTLNEKKSIN ECDLKGKKTL VRVDFNVPVK GGVITNDYRI RSALPTIQKV LNEGGSCILM 

        70         80         90        100        110        120 
SHLGRPKGIS ISEAAAVRSA GKVPGYEEAA TLRPVAQRLG ELLSKPVVFA PDCLDAADVV 

       130        140        150        160        170        180 
KKMSPGDVVL LENVRFYREE GSKKEEEREA MAKVLASYGD IFVSDAFGTA HRDSATMTGI 

       190        200        210        220        230        240 
PKVLGHGAAG YLMEKEISYF SKVLGNPPRP LVAIVGGSKV SDKIQLLDNM LQRIDYLLIG 

       250        260        270        280        290        300 
GAMAYTFLKA QGHRIGTSMC EEDRLDLARS LLKKAEDRKV QVLLPVDHVC HTEFKAVDTP 

       310        320        330        340        350        360 
VVTADADIPD GHMALDIGPK TIANYVETIG KCKSAIWNGP MGVFEMTPYS KGTFAVAKAM 

       370        380        390        400        410        420 
GDCTQKNGLM SIIGGGDSAS AAEQSGEATR MSHVSTGGGA SLELLEGKTL PGVAILDEKV 

« Hide

References

[1]"Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense."
Parker H.L., Hill T., Alexander K.A., Murphy N.B., Fish W.R., Parsons M.
Mol. Biochem. Parasitol. 69:269-279(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IL3000.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L37337 Genomic DNA. Translation: AAC37222.1.
L37337 Genomic DNA. Translation: AAC37223.1.
L37336 Genomic DNA. Translation: AAC37224.1.
L37336 Genomic DNA. Translation: AAC37225.1.

3D structure databases

ProteinModelPortalP41760.
SMRP41760. Positions 5-419.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK1_TRYCO
AccessionPrimary (citable) accession number: P41760
Secondary accession number(s): P41761
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways