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Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (Smp_056970.3), Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase (Smp_056970.1), Glyceraldehyde-3-phosphate dehydrogenase (Smp_056970.4), Glyceraldehyde-3-phosphate dehydrogenase (Smp_056970.2)
  2. Phosphoglycerate kinase (Smp_018890), Phosphoglycerate kinase (PGK), Phosphoglycerate kinase (Smp_187370)
  3. no protein annotated in this organism
  4. Enolase (ENO)
  5. Pyruvate kinase (Smp_065610.1), Pyruvate kinase (Smp_065610.2), Pyruvate kinase (Smp_156360)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateBy similarity1
Binding sitei121SubstrateBy similarity1
Binding sitei169SubstrateBy similarity1
Binding sitei218ATPBy similarity1
Binding sitei311ATP; via carbonyl oxygenBy similarity1
Binding sitei342ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi371 – 374ATPBy similarity4

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • phosphoglycerate kinase activity Source: UniProtKB

GO - Biological processi

  • glycolytic process Source: UniProtKB
  • phosphorylation Source: UniProtKB

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458461 – 416Phosphoglycerate kinaseAdd BLAST416

Proteomic databases

PRIDEiP41759

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP41759
SMRiP41759
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 25Substrate bindingBy similarity3
Regioni62 – 65Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiKOG1367 Eukaryota
COG0126 LUCA
HOGENOMiHOG000227108
OrthoDBiEOG091G08S6

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 4 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P41759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSKLSISD VDLKGKRVLI RVDFNVPMKD GKVTNTQRIA AAIPTIKYAL
60 70 80 90 100
DKGAKSVVLM SHLGRPDGHK VDKYSLKPVC PEVSKLLGKE VTFLNDCVGP
110 120 130 140 150
DVVNACANPA PGSVFLLENL RFHVEEEGKG VSPTGEKTKA TADQIKAFSE
160 170 180 190 200
SLTKLGDVYV NDAFGTAHRA HASMVGCQLP QKACGFLMNK ELTYFAKALE
210 220 230 240 250
NPERPFLAIL GGAKVSDKIQ LINNMLDKVN ELIIGGGMAY TFLKQIHNMH
260 270 280 290 300
IGNSLFDAPG AEIVHKVMET AKAKNVAIHL PVDFVTADKF ADDANTEIRT
310 320 330 340 350
IQSGIADGWM GLDIGPKTIE EFSKVISRAK TIVWNGPMGV FEMDKFATGT
360 370 380 390 400
KAAMDEVVKA TKNGATTIIG GGDTATCCAK WDTEDKVSHV STGGGASLEL
410
LEGKQLPGVV ALTDAH
Length:416
Mass (Da):44,508
Last modified:November 1, 1995 - v1
Checksum:i28DB11837F7EF9CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36833 mRNA Translation: AAA93516.1

Genome annotation databases

EnsemblMetazoaiSmp_018890.1; Smp_018890.1:pep; Smp_018890
Smp_187370.1; Smp_187370.1:pep; Smp_187370
GeneDBiSmp_214060.1:pep

Similar proteinsi

Entry informationi

Entry nameiPGK_SCHMA
AccessioniPrimary (citable) accession number: P41759
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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