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P41759

- PGK_SCHMA

UniProt

P41759 - PGK_SCHMA

Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381SubstrateBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Binding sitei169 – 1691SubstrateBy similarity
    Binding sitei218 – 2181ATPBy similarity
    Binding sitei311 – 3111ATP; via carbonyl oxygenBy similarity
    Binding sitei342 – 3421ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi371 – 3744ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. phosphoglycerate kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycolytic process Source: UniProtKB
    2. phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:PGK
    OrganismiSchistosoma mansoni (Blood fluke)
    Taxonomic identifieri6183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Phosphoglycerate kinasePRO_0000145846Add
    BLAST

    Proteomic databases

    PRIDEiP41759.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP41759.
    SMRiP41759. Positions 4-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 253Substrate bindingBy similarity
    Regioni62 – 654Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000227108.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41759-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLSKLSISD VDLKGKRVLI RVDFNVPMKD GKVTNTQRIA AAIPTIKYAL    50
    DKGAKSVVLM SHLGRPDGHK VDKYSLKPVC PEVSKLLGKE VTFLNDCVGP 100
    DVVNACANPA PGSVFLLENL RFHVEEEGKG VSPTGEKTKA TADQIKAFSE 150
    SLTKLGDVYV NDAFGTAHRA HASMVGCQLP QKACGFLMNK ELTYFAKALE 200
    NPERPFLAIL GGAKVSDKIQ LINNMLDKVN ELIIGGGMAY TFLKQIHNMH 250
    IGNSLFDAPG AEIVHKVMET AKAKNVAIHL PVDFVTADKF ADDANTEIRT 300
    IQSGIADGWM GLDIGPKTIE EFSKVISRAK TIVWNGPMGV FEMDKFATGT 350
    KAAMDEVVKA TKNGATTIIG GGDTATCCAK WDTEDKVSHV STGGGASLEL 400
    LEGKQLPGVV ALTDAH 416
    Length:416
    Mass (Da):44,508
    Last modified:November 1, 1995 - v1
    Checksum:i28DB11837F7EF9CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36833 mRNA. Translation: AAA93516.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36833 mRNA. Translation: AAA93516.1 .

    3D structure databases

    ProteinModelPortali P41759.
    SMRi P41759. Positions 4-414.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P41759.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000227108.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the gene for phosphoglycerate kinase from Schistosoma mansoni and characterization of its gene product."
      Lee K.W., Shalaby K.A., Thakur A., Medhat A.M., Karim A.M., Loverde P.T.
      Mol. Biochem. Parasitol. 71:221-231(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: NMRI.

    Entry informationi

    Entry nameiPGK_SCHMA
    AccessioniPrimary (citable) accession number: P41759
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3