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P41759 (PGK_SCHMA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase
EC=2.7.2.3
Gene names
Name:PGK
OrganismSchistosoma mansoni (Blood fluke)
Taxonomic identifier6183 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.

Subunit structure

Monomer.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processglycolysis

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionATP binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphoglycerate kinase activity

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Phosphoglycerate kinase
PRO_0000145846

Regions

Nucleotide binding371 – 3744ATP By similarity
Region23 – 253Substrate binding By similarity
Region62 – 654Substrate binding By similarity

Sites

Binding site381Substrate By similarity
Binding site1211Substrate By similarity
Binding site1691Substrate By similarity
Binding site2181ATP By similarity
Binding site3111ATP; via carbonyl oxygen By similarity
Binding site3421ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P41759 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 28DB11837F7EF9CB

FASTA41644,508
        10         20         30         40         50         60 
MGLSKLSISD VDLKGKRVLI RVDFNVPMKD GKVTNTQRIA AAIPTIKYAL DKGAKSVVLM 

        70         80         90        100        110        120 
SHLGRPDGHK VDKYSLKPVC PEVSKLLGKE VTFLNDCVGP DVVNACANPA PGSVFLLENL 

       130        140        150        160        170        180 
RFHVEEEGKG VSPTGEKTKA TADQIKAFSE SLTKLGDVYV NDAFGTAHRA HASMVGCQLP 

       190        200        210        220        230        240 
QKACGFLMNK ELTYFAKALE NPERPFLAIL GGAKVSDKIQ LINNMLDKVN ELIIGGGMAY 

       250        260        270        280        290        300 
TFLKQIHNMH IGNSLFDAPG AEIVHKVMET AKAKNVAIHL PVDFVTADKF ADDANTEIRT 

       310        320        330        340        350        360 
IQSGIADGWM GLDIGPKTIE EFSKVISRAK TIVWNGPMGV FEMDKFATGT KAAMDEVVKA 

       370        380        390        400        410 
TKNGATTIIG GGDTATCCAK WDTEDKVSHV STGGGASLEL LEGKQLPGVV ALTDAH

« Hide

References

[1]"Cloning of the gene for phosphoglycerate kinase from Schistosoma mansoni and characterization of its gene product."
Lee K.W., Shalaby K.A., Thakur A., Medhat A.M., Karim A.M., Loverde P.T.
Mol. Biochem. Parasitol. 71:221-231(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: NMRI.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L36833 mRNA. Translation: AAA93516.1.

3D structure databases

ProteinModelPortalP41759.
SMRP41759. Positions 4-414.
ModBaseSearch...

Proteomic databases

PRIDEP41759.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000227108.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. PGK. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_SCHMA
AccessionPrimary (citable) accession number: P41759
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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