SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P41759

- PGK_SCHMA

UniProt

P41759 - PGK_SCHMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphoglycerate kinase
Gene
PGK
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381Substrate By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei218 – 2181ATP By similarity
Binding sitei311 – 3111ATP; via carbonyl oxygen By similarity
Binding sitei342 – 3421ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi371 – 3744ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. phosphoglycerate kinase activity Source: UniProtKB

GO - Biological processi

  1. glycolytic process Source: UniProtKB
  2. phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Phosphoglycerate kinaseUniRule annotation
PRO_0000145846Add
BLAST

Proteomic databases

PRIDEiP41759.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP41759.
SMRiP41759. Positions 4-414.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 253Substrate binding By similarity
Regioni62 – 654Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000227108.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41759-1 [UniParc]FASTAAdd to Basket

« Hide

MGLSKLSISD VDLKGKRVLI RVDFNVPMKD GKVTNTQRIA AAIPTIKYAL    50
DKGAKSVVLM SHLGRPDGHK VDKYSLKPVC PEVSKLLGKE VTFLNDCVGP 100
DVVNACANPA PGSVFLLENL RFHVEEEGKG VSPTGEKTKA TADQIKAFSE 150
SLTKLGDVYV NDAFGTAHRA HASMVGCQLP QKACGFLMNK ELTYFAKALE 200
NPERPFLAIL GGAKVSDKIQ LINNMLDKVN ELIIGGGMAY TFLKQIHNMH 250
IGNSLFDAPG AEIVHKVMET AKAKNVAIHL PVDFVTADKF ADDANTEIRT 300
IQSGIADGWM GLDIGPKTIE EFSKVISRAK TIVWNGPMGV FEMDKFATGT 350
KAAMDEVVKA TKNGATTIIG GGDTATCCAK WDTEDKVSHV STGGGASLEL 400
LEGKQLPGVV ALTDAH 416
Length:416
Mass (Da):44,508
Last modified:November 1, 1995 - v1
Checksum:i28DB11837F7EF9CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36833 mRNA. Translation: AAA93516.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36833 mRNA. Translation: AAA93516.1 .

3D structure databases

ProteinModelPortali P41759.
SMRi P41759. Positions 4-414.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P41759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000227108.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of the gene for phosphoglycerate kinase from Schistosoma mansoni and characterization of its gene product."
    Lee K.W., Shalaby K.A., Thakur A., Medhat A.M., Karim A.M., Loverde P.T.
    Mol. Biochem. Parasitol. 71:221-231(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: NMRI.

Entry informationi

Entry nameiPGK_SCHMA
AccessioniPrimary (citable) accession number: P41759
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi