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P41751

- ALDH_ASPNG

UniProt

P41751 - ALDH_ASPNG

Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei166 – 1661Transition state stabilizerBy similarity
    Active sitei265 – 2651Proton acceptorPROSITE-ProRule annotation
    Active sitei299 – 2991NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi242 – 2476NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Short name:
    ALDDH
    Short name:
    ALDH
    Gene namesi
    Name:aldA
    OrganismiAspergillus niger
    Taxonomic identifieri5061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Aldehyde dehydrogenasePRO_0000056436Add
    BLAST

    Proteomic databases

    PRIDEiP41751.

    Structurei

    3D structure databases

    ProteinModelPortaliP41751.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view]
    PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41751-1 [UniParc]FASTAAdd to Basket

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    MSDLFATITT PNGVKYEQPL GLFIDGEFVK GAEGKTFETI NPSNEKPIVA    50
    VHEATEKDVD TAVAAARKAF EGSWRQVTPS TRGRMLTKLA DLFERDAEIL 100
    ASIEALDNGK SITMAHGDIA GAAGCLRYYG GWADKIHGQT IDTNSETLNY 150
    TRHEPIGVCG QIIPWNFPLL MWAWKIGPAI ATGNTVVIKT AEQTPLSGLY 200
    AANVIKEAGI PAGVVNVISG FGRVAGSAIS HHMDIDKVAF TGSTLVGRTI 250
    LQAAAKSNLK KVTLELGGKS PNIVFNDADI DNAISWANFG IFYNHGQCCC 300
    AGSRILVQEG IYDKFIARLK ERALQNKVGD PFAKDTFQGP QVSQLQFDRI 350
    MEYIQHGKDA GATVAVGGER HGTEGYFIQP TVFTDVTSDM KINQEEIFGP 400
    VVTVQKFKDV EDAIKIGNST SYGLAAGIHT KDVTTAIRVS NALRAGTVWV 450
    NSYNLIQYQV PFGGFKESGI GRELGSYALE NYTQIKAVHY RLGDALF 497
    Length:497
    Mass (Da):53,809
    Last modified:November 1, 1995 - v1
    Checksum:i47CA353FFD8A50E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32351 Genomic DNA. Translation: AAA87596.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32351 Genomic DNA. Translation: AAA87596.1 .

    3D structure databases

    ProteinModelPortali P41751.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P41751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1012.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view ]
    PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Physical characterization of the aldehyde-dehydrogenase-encoding gene of Aspergillus niger."
      O'Connell M.J., Kelly J.M.
      Gene 84:173-180(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiALDH_ASPNG
    AccessioniPrimary (citable) accession number: P41751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3