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P41751

- ALDH_ASPNG

UniProt

P41751 - ALDH_ASPNG

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Protein
Aldehyde dehydrogenase
Gene
aldA
Organism
Aspergillus niger
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661Transition state stabilizer By similarity
Active sitei265 – 2651Proton acceptor By similarity
Active sitei299 – 2991Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi242 – 2476NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Short name:
ALDDH
Short name:
ALDH
Gene namesi
Name:aldA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Aldehyde dehydrogenase
PRO_0000056436Add
BLAST

Proteomic databases

PRIDEiP41751.

Structurei

3D structure databases

ProteinModelPortaliP41751.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41751-1 [UniParc]FASTAAdd to Basket

« Hide

MSDLFATITT PNGVKYEQPL GLFIDGEFVK GAEGKTFETI NPSNEKPIVA    50
VHEATEKDVD TAVAAARKAF EGSWRQVTPS TRGRMLTKLA DLFERDAEIL 100
ASIEALDNGK SITMAHGDIA GAAGCLRYYG GWADKIHGQT IDTNSETLNY 150
TRHEPIGVCG QIIPWNFPLL MWAWKIGPAI ATGNTVVIKT AEQTPLSGLY 200
AANVIKEAGI PAGVVNVISG FGRVAGSAIS HHMDIDKVAF TGSTLVGRTI 250
LQAAAKSNLK KVTLELGGKS PNIVFNDADI DNAISWANFG IFYNHGQCCC 300
AGSRILVQEG IYDKFIARLK ERALQNKVGD PFAKDTFQGP QVSQLQFDRI 350
MEYIQHGKDA GATVAVGGER HGTEGYFIQP TVFTDVTSDM KINQEEIFGP 400
VVTVQKFKDV EDAIKIGNST SYGLAAGIHT KDVTTAIRVS NALRAGTVWV 450
NSYNLIQYQV PFGGFKESGI GRELGSYALE NYTQIKAVHY RLGDALF 497
Length:497
Mass (Da):53,809
Last modified:November 1, 1995 - v1
Checksum:i47CA353FFD8A50E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32351 Genomic DNA. Translation: AAA87596.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32351 Genomic DNA. Translation: AAA87596.1 .

3D structure databases

ProteinModelPortali P41751.
ModBasei Search...

Proteomic databases

PRIDEi P41751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1012.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view ]
PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Physical characterization of the aldehyde-dehydrogenase-encoding gene of Aspergillus niger."
    O'Connell M.J., Kelly J.M.
    Gene 84:173-180(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiALDH_ASPNG
AccessioniPrimary (citable) accession number: P41751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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