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Reviewed, UniProtKB/Swiss-Prot P41751 (ALDH_ASPNG)

Last modified June 16, 2009. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Aldehyde dehydrogenase
      Short name=ALDDH
      Short name=ALDH
    EC=1.2.1.3
Gene names
Name: aldA
OrganismAspergillus niger
Taxonomic identifier5061 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

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Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = an acid + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

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Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Aldehyde dehydrogenase
PRO_0000056436

Regions

Nucleotide binding242 – 2476NAD By similarity

Sites

Active site2651Proton acceptor By similarity
Active site2991Nucleophile By similarity
Site1661Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
P41751-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 47CA353FFD8A50E8

FASTA49753,809
        10         20         30         40         50         60 
MSDLFATITT PNGVKYEQPL GLFIDGEFVK GAEGKTFETI NPSNEKPIVA VHEATEKDVD 

        70         80         90        100        110        120 
TAVAAARKAF EGSWRQVTPS TRGRMLTKLA DLFERDAEIL ASIEALDNGK SITMAHGDIA 

       130        140        150        160        170        180 
GAAGCLRYYG GWADKIHGQT IDTNSETLNY TRHEPIGVCG QIIPWNFPLL MWAWKIGPAI 

       190        200        210        220        230        240 
ATGNTVVIKT AEQTPLSGLY AANVIKEAGI PAGVVNVISG FGRVAGSAIS HHMDIDKVAF 

       250        260        270        280        290        300 
TGSTLVGRTI LQAAAKSNLK KVTLELGGKS PNIVFNDADI DNAISWANFG IFYNHGQCCC 

       310        320        330        340        350        360 
AGSRILVQEG IYDKFIARLK ERALQNKVGD PFAKDTFQGP QVSQLQFDRI MEYIQHGKDA 

       370        380        390        400        410        420 
GATVAVGGER HGTEGYFIQP TVFTDVTSDM KINQEEIFGP VVTVQKFKDV EDAIKIGNST 

       430        440        450        460        470        480 
SYGLAAGIHT KDVTTAIRVS NALRAGTVWV NSYNLIQYQV PFGGFKESGI GRELGSYALE 

       490 
NYTQIKAVHY RLGDALF

« Hide

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References

[1]"Physical characterization of the aldehyde-dehydrogenase-encoding gene of Aspergillus niger."
O'Connell M.J., Kelly J.M.
Gene 84:173-180(1989) [PubMed: 2606357] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

M32351 Genomic DNA. Translation: AAA87596.1.

3D structure databases

HSSPHSSP built from PDB template 1O01 based on UniProtKB P05091.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.2.1.3. 277.

Family and domain databases

InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameALDH_ASPNG
AccessionPrimary (citable) accession number: P41751
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents