Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P41751

- ALDH_ASPNG

UniProt

P41751 - ALDH_ASPNG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661Transition state stabilizerBy similarity
Active sitei265 – 2651Proton acceptorPROSITE-ProRule annotation
Active sitei299 – 2991NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi242 – 2476NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Short name:
ALDDH
Short name:
ALDH
Gene namesi
Name:aldA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Aldehyde dehydrogenasePRO_0000056436Add
BLAST

Proteomic databases

PRIDEiP41751.

Structurei

3D structure databases

ProteinModelPortaliP41751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41751-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDLFATITT PNGVKYEQPL GLFIDGEFVK GAEGKTFETI NPSNEKPIVA
60 70 80 90 100
VHEATEKDVD TAVAAARKAF EGSWRQVTPS TRGRMLTKLA DLFERDAEIL
110 120 130 140 150
ASIEALDNGK SITMAHGDIA GAAGCLRYYG GWADKIHGQT IDTNSETLNY
160 170 180 190 200
TRHEPIGVCG QIIPWNFPLL MWAWKIGPAI ATGNTVVIKT AEQTPLSGLY
210 220 230 240 250
AANVIKEAGI PAGVVNVISG FGRVAGSAIS HHMDIDKVAF TGSTLVGRTI
260 270 280 290 300
LQAAAKSNLK KVTLELGGKS PNIVFNDADI DNAISWANFG IFYNHGQCCC
310 320 330 340 350
AGSRILVQEG IYDKFIARLK ERALQNKVGD PFAKDTFQGP QVSQLQFDRI
360 370 380 390 400
MEYIQHGKDA GATVAVGGER HGTEGYFIQP TVFTDVTSDM KINQEEIFGP
410 420 430 440 450
VVTVQKFKDV EDAIKIGNST SYGLAAGIHT KDVTTAIRVS NALRAGTVWV
460 470 480 490
NSYNLIQYQV PFGGFKESGI GRELGSYALE NYTQIKAVHY RLGDALF
Length:497
Mass (Da):53,809
Last modified:November 1, 1995 - v1
Checksum:i47CA353FFD8A50E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32351 Genomic DNA. Translation: AAA87596.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32351 Genomic DNA. Translation: AAA87596.1 .

3D structure databases

ProteinModelPortali P41751.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P41751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1012.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view ]
PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Physical characterization of the aldehyde-dehydrogenase-encoding gene of Aspergillus niger."
    O'Connell M.J., Kelly J.M.
    Gene 84:173-180(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiALDH_ASPNG
AccessioniPrimary (citable) accession number: P41751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3