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P41751 (ALDH_ASPNG) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase

Short name=ALDDH
Short name=ALDH
EC=1.2.1.3
Gene names
Name:aldA
OrganismAspergillus niger
Taxonomic identifier5061 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Aldehyde dehydrogenase
PRO_0000056436

Regions

Nucleotide binding242 – 2476NAD By similarity

Sites

Active site2651Proton acceptor By similarity
Active site2991Nucleophile By similarity
Site1661Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P41751 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 47CA353FFD8A50E8

FASTA49753,809
        10         20         30         40         50         60 
MSDLFATITT PNGVKYEQPL GLFIDGEFVK GAEGKTFETI NPSNEKPIVA VHEATEKDVD 

        70         80         90        100        110        120 
TAVAAARKAF EGSWRQVTPS TRGRMLTKLA DLFERDAEIL ASIEALDNGK SITMAHGDIA 

       130        140        150        160        170        180 
GAAGCLRYYG GWADKIHGQT IDTNSETLNY TRHEPIGVCG QIIPWNFPLL MWAWKIGPAI 

       190        200        210        220        230        240 
ATGNTVVIKT AEQTPLSGLY AANVIKEAGI PAGVVNVISG FGRVAGSAIS HHMDIDKVAF 

       250        260        270        280        290        300 
TGSTLVGRTI LQAAAKSNLK KVTLELGGKS PNIVFNDADI DNAISWANFG IFYNHGQCCC 

       310        320        330        340        350        360 
AGSRILVQEG IYDKFIARLK ERALQNKVGD PFAKDTFQGP QVSQLQFDRI MEYIQHGKDA 

       370        380        390        400        410        420 
GATVAVGGER HGTEGYFIQP TVFTDVTSDM KINQEEIFGP VVTVQKFKDV EDAIKIGNST 

       430        440        450        460        470        480 
SYGLAAGIHT KDVTTAIRVS NALRAGTVWV NSYNLIQYQV PFGGFKESGI GRELGSYALE 

       490 
NYTQIKAVHY RLGDALF 

« Hide

References

[1]"Physical characterization of the aldehyde-dehydrogenase-encoding gene of Aspergillus niger."
O'Connell M.J., Kelly J.M.
Gene 84:173-180(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32351 Genomic DNA. Translation: AAA87596.1.

3D structure databases

ProteinModelPortalP41751.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP41751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1012.

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_ASPNG
AccessionPrimary (citable) accession number: P41751
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 13, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways