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Reviewed, UniProtKB/Swiss-Prot P41747 (ADH1_ASPFN)

Last modified November 24, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase I
Gene names
Name: adh1
ORF Names: AFLA_048690
OrganismAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifier332952 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

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Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Alcohol dehydrogenase 1
PRO_0000160716

Regions

Nucleotide binding178 – 1847NAD By similarity
Nucleotide binding271 – 2733NAD By similarity

Sites

Metal binding441Zinc 1; catalytic By similarity
Metal binding671Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1541Zinc 1; catalytic By similarity
Binding site2021NAD By similarity
Binding site2071NAD By similarity
Binding site3431NAD By similarity

Experimental info

Sequence conflict2631Missing in AAA32684. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P41747-1 [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: BA168DB43A17DFA9

FASTA35037,057
        10         20         30         40         50         60 
MSIPEMQWAQ VAEQKGGPLI YKQIPVPKPG PDEILVKVRY SGVCHTDLHA LKGDWPLPVK 

        70         80         90        100        110        120 
MPLVGGHEGA GVVVARGDLV TEFEIGDHAG LKWLNGSCLA CEFCKQADEP LCPNASLSGY 

       130        140        150        160        170        180 
TVDGTFQQYA IGKATHASKL PKNVPLDAVA PVLCAGITVY KGLKESGVRP GQTVAIVGAG 

       190        200        210        220        230        240 
GGLGSLALQY AKAMGIRVVA IDGGEEKQAM CEQLGAEAYV DFTKTQDLVA DVKAATPEGL 

       250        260        270        280        290        300 
GAHAVILLAV AEKPFQQAAE YVRSRGTVVA IGLPAGAFLR APVFNTVVRM INIKGSYVGN 

       310        320        330        340        350 
RQDGVEAVDF FARGLIKAPF KTAPLQDLPK IFELMEQGKI AGRYVLEIPE

« Hide

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References

« Hide 'large scale' references
[1]"The alcohol dehydrogenase gene adh1 is induced in Aspergillus flavus grown on medium conducive to aflatoxin biosynthesis."
Woloshuk C.P., Payne G.A.
Appl. Environ. Microbiol. 60:670-676(1994) [PubMed: 8135521] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V.S., Inman J.M., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

L27434 mRNA. Translation: AAA32684.1.
L27433 Genomic DNA. Translation: AAA32683.1.
EQ963483 Genomic DNA. Translation: EED46816.1.
RefSeqXP_002382996.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID7911686.
KEGGafv:AFLA_048690.

Enzyme and pathway databases

BRENDA1.1.1.1. 2238.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF08240. ADH_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH1_ASPFN
AccessionPrimary (citable) accession number: P41747
Secondary accession number(s): B8NRG4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 14, 2009
Last modified: November 24, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents