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Protein

Alcohol dehydrogenase 1

Gene

adh1

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi154Zinc 1; catalyticBy similarity1
Binding sitei202NADBy similarity1
Binding sitei207NADBy similarity1
Binding sitei343NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 184NADBy similarity7
Nucleotide bindingi271 – 273NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase I
Gene namesi
Name:adh1
ORF Names:AFLA_048690
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000001875 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AFLA_048690.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607161 – 350Alcohol dehydrogenase 1Add BLAST350

Proteomic databases

PRIDEiP41747.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP41747.
SMRiP41747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685.
KOiK13953.
OMAiEYKQIPV.
OrthoDBiEOG092C2Q8E.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P41747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPEMQWAQ VAEQKGGPLI YKQIPVPKPG PDEILVKVRY SGVCHTDLHA
60 70 80 90 100
LKGDWPLPVK MPLVGGHEGA GVVVARGDLV TEFEIGDHAG LKWLNGSCLA
110 120 130 140 150
CEFCKQADEP LCPNASLSGY TVDGTFQQYA IGKATHASKL PKNVPLDAVA
160 170 180 190 200
PVLCAGITVY KGLKESGVRP GQTVAIVGAG GGLGSLALQY AKAMGIRVVA
210 220 230 240 250
IDGGEEKQAM CEQLGAEAYV DFTKTQDLVA DVKAATPEGL GAHAVILLAV
260 270 280 290 300
AEKPFQQAAE YVRSRGTVVA IGLPAGAFLR APVFNTVVRM INIKGSYVGN
310 320 330 340 350
RQDGVEAVDF FARGLIKAPF KTAPLQDLPK IFELMEQGKI AGRYVLEIPE
Length:350
Mass (Da):37,057
Last modified:April 14, 2009 - v2
Checksum:iBA168DB43A17DFA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263Missing in AAA32684 (PubMed:8135521).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27434 mRNA. Translation: AAA32684.1.
L27433 Genomic DNA. Translation: AAA32683.1.
EQ963483 Genomic DNA. Translation: EED46816.1.
RefSeqiXP_002382996.1. XM_002382955.1.

Genome annotation databases

EnsemblFungiiEED46816; EED46816; AFLA_048690.
GeneIDi7911686.
KEGGiafv:AFLA_048690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27434 mRNA. Translation: AAA32684.1.
L27433 Genomic DNA. Translation: AAA32683.1.
EQ963483 Genomic DNA. Translation: EED46816.1.
RefSeqiXP_002382996.1. XM_002382955.1.

3D structure databases

ProteinModelPortaliP41747.
SMRiP41747.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP41747.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEED46816; EED46816; AFLA_048690.
GeneIDi7911686.
KEGGiafv:AFLA_048690.

Organism-specific databases

EuPathDBiFungiDB:AFLA_048690.

Phylogenomic databases

HOGENOMiHOG000294685.
KOiK13953.
OMAiEYKQIPV.
OrthoDBiEOG092C2Q8E.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_ASPFN
AccessioniPrimary (citable) accession number: P41747
Secondary accession number(s): B8NRG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 14, 2009
Last modified: May 10, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.