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Protein

Atrial natriuretic peptide receptor 3

Gene

Npr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: BHF-UCL
  • natriuretic peptide receptor activity Source: UniProtKB
  • peptide hormone binding Source: BHF-UCL
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
  • cAMP-mediated signaling Source: GO_Central
  • negative regulation of adenylate cyclase activity Source: RGD
  • negative regulation of smooth muscle cell proliferation Source: RGD
  • osteoclast proliferation Source: UniProtKB
  • pancreatic juice secretion Source: RGD
  • phosphatidylinositol-mediated signaling Source: RGD
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • positive regulation of nitric-oxide synthase activity Source: BHF-UCL
  • positive regulation of urine volume Source: UniProtKB
  • regulation of blood pressure Source: UniProtKB
  • regulation of osteoblast proliferation Source: UniProtKB
  • skeletal system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Atrial natriuretic peptide receptor 3
Alternative name(s):
Atrial natriuretic peptide clearance receptor
Atrial natriuretic peptide receptor type C
Short name:
ANP-C
Short name:
ANPR-C
Short name:
NPR-C
Gene namesi
Name:Npr3
Synonyms:Npr-c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3196. Npr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 477ExtracellularSequence analysisAdd BLAST437
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 535CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • integral component of plasma membrane Source: BHF-UCL
  • intracellular Source: GOC
  • membrane Source: RGD
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000001237327 – 40Sequence analysisAdd BLAST14
ChainiPRO_000001237441 – 535Atrial natriuretic peptide receptor 3Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi103 ↔ 131By similarity
Disulfide bondi208 ↔ 256By similarity
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi389N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi468InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP41740.
PRIDEiP41740.

PTM databases

iPTMnetiP41740.
PhosphoSitePlusiP41740.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019184.
GenevisibleiP41740. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025966.

Structurei

3D structure databases

ProteinModelPortaliP41740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ANF receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00440000033872.
HOGENOMiHOG000236252.
HOVERGENiHBG060145.
InParanoidiP41740.
KOiK12325.
OMAiFQVAYED.
OrthoDBiEOG091G04YV.
PhylomeDBiP41740.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR001170. ANPR/GUC.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
[Graphical view]
PRINTSiPR00255. NATPEPTIDER.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00458. ANF_RECEPTORS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLLLFTFS ACVLLARALL AGGASSGGGD TGPGNRRRER EALAAQKIEV
60 70 80 90 100
LVLLPRDDSY LFSLARVRPA IEYALRSVEG NGTGRKLLPP GTRFQVAYED
110 120 130 140 150
SDCGNRALFS LVDRVAAARG AKPDLILGPV CEYAAAPVAR LASHWDLPML
160 170 180 190 200
SAGALAAGFQ HKDTEYSHLT RVAPAYAKMG EMMLALFRHH HWSRAALLYS
210 220 230 240 250
DDKLERNCYF TLEGVHEVFQ EEGLHTSAYN FDETKDLDLD DIVRYIQGSE
260 270 280 290 300
RVVIMCASGD TIRRIMLAVH RHGMTSGDYA FFNIELFNSS SYGDGSWKRG
310 320 330 340 350
DKHDFEAKQA YSSLQTVTLL RTAKPEFEKF SMEVKSSVEK QGLNEEDYVN
360 370 380 390 400
MFVEGFHDAI LLYVLALHEV LRAGYSKKDG GKIIQQTWNR TFEGIAGQVS
410 420 430 440 450
IDANGDRYGD FSVVAMTDTE AGTQEVIGDY FGKEGRFKMR SNVKYPWGSL
460 470 480 490 500
KLRIDETRIV EHTNSSPCKS CGLEESAVTG IVVGALLGAG LLMAFYFFRK
510 520 530
KYRITIERRN HQEESNIGKH RELREDSIRS HFSVA
Length:535
Mass (Da):59,728
Last modified:November 1, 1995 - v1
Checksum:i236272DCD2352C40
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120G → R in AAB35354 (PubMed:7554122).Curated1
Sequence conflicti124D → H in AAB35354 (PubMed:7554122).Curated1
Sequence conflicti137P → R in AAB35354 (PubMed:7554122).Curated1
Sequence conflicti240D → H in AAB35354 (PubMed:7554122).Curated1
Sequence conflicti243V → A in AAB35354 (PubMed:7554122).Curated1
Sequence conflicti268 – 269AV → VA in AAB35354 (PubMed:7554122).Curated2
Sequence conflicti293G → R in AAB35354 (PubMed:7554122).Curated1
Sequence conflicti298 – 300KRG → SRE in AAB35354 (PubMed:7554122).Curated3
Sequence conflicti363Y → H in AAB35354 (PubMed:7554122).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27339 mRNA. Translation: AAA41721.1.
S79624 mRNA. Translation: AAB35354.1.
PIRiA54155.
RefSeqiNP_037000.1. NM_012868.1.
UniGeneiRn.11297.

Genome annotation databases

EnsembliENSRNOT00000025966; ENSRNOP00000025966; ENSRNOG00000019184.
GeneIDi25339.
KEGGirno:25339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27339 mRNA. Translation: AAA41721.1.
S79624 mRNA. Translation: AAB35354.1.
PIRiA54155.
RefSeqiNP_037000.1. NM_012868.1.
UniGeneiRn.11297.

3D structure databases

ProteinModelPortaliP41740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025966.

PTM databases

iPTMnetiP41740.
PhosphoSitePlusiP41740.

Proteomic databases

PaxDbiP41740.
PRIDEiP41740.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025966; ENSRNOP00000025966; ENSRNOG00000019184.
GeneIDi25339.
KEGGirno:25339.

Organism-specific databases

CTDi4883.
RGDi3196. Npr3.

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00440000033872.
HOGENOMiHOG000236252.
HOVERGENiHBG060145.
InParanoidiP41740.
KOiK12325.
OMAiFQVAYED.
OrthoDBiEOG091G04YV.
PhylomeDBiP41740.

Miscellaneous databases

PROiP41740.

Gene expression databases

BgeeiENSRNOG00000019184.
GenevisibleiP41740. RN.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR001170. ANPR/GUC.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
[Graphical view]
PRINTSiPR00255. NATPEPTIDER.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00458. ANF_RECEPTORS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANPRC_RAT
AccessioniPrimary (citable) accession number: P41740
Secondary accession number(s): Q64156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Has low affinity for peptide hormones in the absence of bound chloride.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.