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P41739 (ARNT_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aryl hydrocarbon receptor nuclear translocator

Short name=ARNT protein
Alternative name(s):
Dioxin receptor, nuclear translocator
Hypoxia-inducible factor 1-beta
Short name=HIF-1-beta
Short name=HIF1-beta
Gene names
Name:Arnt
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length800 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia By similarity.

Subunit structure

Heterodimer with HIF1A By similarity. Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with NOCA7 and TACC3 By similarity.

Subcellular location

Nucleus.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 2 PAS (PER-ARNT-SIM) domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

AhrP417382EBI-1162920,EBI-1162880

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 800799Aryl hydrocarbon receptor nuclear translocator
PRO_0000127121

Regions

Domain89 – 14254bHLH
Domain161 – 23575PAS 1
Domain349 – 41971PAS 2
Domain424 – 46744PAC
Compositional bias99 – 1024Poly-Arg
Compositional bias503 – 51816Poly-Gln

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue771Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P41739 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: CD71FCDF2C23BF34

FASTA80088,221
        10         20         30         40         50         60 
MAATTANPEM TSDVPSLGPT IASGNPGPGI QGGGAVVQRA IKRRSGLDFD DEGEVNSKFL 

        70         80         90        100        110        120 
RCDDEQMCND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS 

       130        140        150        160        170        180 
ALARKPDKLT ILRMAVSHMK SLRGTGNTST DGSYKPSFLT DQELKHLILE AADGFLFIVS 

       190        200        210        220        230        240 
CETGRVVYVS DSVTPVLNQP QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK 

       250        260        270        280        290        300 
TGTVKKEGQQ SSMRMCMGSR RSFICRMRCG TSSVDPVSMN RLSFLRNRCR NGLGSVKEGE 

       310        320        330        340        350        360 
PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN CTDMSNICQP 

       370        380        390        400        410        420 
TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC HPEDQQLLRD SFQQVVKLKG 

       430        440        450        460        470        480 
QVLSVMFRFR AKNREWLWMR TSSFTFQNPY SDEMSIFICT NTNVKNSSQE PRPTLSNTIQ 

       490        500        510        520        530        540 
RSQLGPTTNL SLEMGTGVLA SRQQQQQQQQ QQQQQQQQTE LDMVPGRDGL ASYSHSQVSV 

       550        560        570        580        590        600 
QPVATAGSEH SKPLEKSEGL FVQDRDPRFS EIYPNISADQ SKGLSSSTVP ATQQLFSQGS 

       610        620        630        640        650        660 
SFPPNPRPAE NFRNSGLTPP VTIVQPSSSA GQILAQISRH SNLTQGSAPT WTSSTRPGFS 

       670        680        690        700        710        720 
AQLPTQATAK TRSSQFGVNN FQTSSSFSAM SLPGAPTASP STAAYPTLPN RGSNFPPETG 

       730        740        750        760        770        780 
QTTGQFQTRT AEGVGVWPQW QGQQPHHRSS SNEQHVQPTS AQPSSQPEVF QEMLSMLGDQ 

       790        800 
SNTYNNEEFP DLTMFPPFSE 

« Hide

References

[1]Drutel G., Kathmann M., Heron A., Schwartz J.C., Arrang J.-M.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
[2]"Tissue specific expression of the rat Ah-receptor and ARNT mRNAs."
Carver L.A., Hogenesch J.B., Bradfield C.A.
Nucleic Acids Res. 22:3038-3044(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 96-453.
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U61184 mRNA. Translation: AAB03811.1.
U08986 mRNA. Translation: AAA56896.1.
PIRS58376.
RefSeqNP_036912.1. NM_012780.1.
UniGeneRn.10520.

3D structure databases

ProteinModelPortalP41739.
SMRP41739. Positions 354-470.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid247282. 1 interaction.
IntActP41739. 1 interaction.

PTM databases

PhosphoSiteP41739.

Proteomic databases

PRIDEP41739.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25242.
KEGGrno:25242.
UCSCRGD:2153. rat.

Organism-specific databases

CTD405.
RGD2153. Arnt.

Phylogenomic databases

eggNOGNOG293303.
HOVERGENHBG000164.
InParanoidP41739.
KOK09097.
PhylomeDBP41739.

Gene expression databases

GenevestigatorP41739.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSPR00785. NCTRNSLOCATR.
SMARTSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 4 hits.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio605831.
PROP41739.

Entry information

Entry nameARNT_RAT
AccessionPrimary (citable) accession number: P41739
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families