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P41739

- ARNT_RAT

UniProt

P41739 - ARNT_RAT

Protein

Aryl hydrocarbon receptor nuclear translocator

Gene

Arnt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein heterodimerization activity Source: RGD
    4. sequence-specific DNA binding transcription factor activity Source: InterPro
    5. signal transducer activity Source: InterPro

    GO - Biological processi

    1. response to hypoxia Source: RGD
    2. response to toxic substance Source: RGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aryl hydrocarbon receptor nuclear translocator
    Short name:
    ARNT protein
    Alternative name(s):
    Dioxin receptor, nuclear translocator
    Hypoxia-inducible factor 1-beta
    Short name:
    HIF-1-beta
    Short name:
    HIF1-beta
    Gene namesi
    Name:Arnt
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2153. Arnt.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. nucleus Source: RGD
    3. transcription factor complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 800799Aryl hydrocarbon receptor nuclear translocatorPRO_0000127121Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei77 – 771PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiP41739.

    PTM databases

    PhosphoSiteiP41739.

    Expressioni

    Gene expression databases

    GenevestigatoriP41739.

    Interactioni

    Subunit structurei

    Heterodimer with HIF1A By similarity. Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with NOCA7 and TACC3 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AhrP417382EBI-1162920,EBI-1162880

    Protein-protein interaction databases

    BioGridi247282. 1 interaction.
    IntActiP41739. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP41739.
    SMRiP41739. Positions 354-470.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini89 – 14254bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini161 – 23575PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini349 – 41971PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini424 – 46744PACAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi99 – 1024Poly-Arg
    Compositional biasi503 – 51816Poly-GlnAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG293303.
    HOVERGENiHBG000164.
    InParanoidiP41739.
    KOiK09097.
    PhylomeDBiP41739.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR001067. Nuc_translocat.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view]
    PRINTSiPR00785. NCTRNSLOCATR.
    SMARTiSM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 4 hits.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATTANPEM TSDVPSLGPT IASGNPGPGI QGGGAVVQRA IKRRSGLDFD    50
    DEGEVNSKFL RCDDEQMCND KERFARSDDE QSSADKERLA RENHSEIERR 100
    RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST 150
    DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP 200
    QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ 250
    SSMRMCMGSR RSFICRMRCG TSSVDPVSMN RLSFLRNRCR NGLGSVKEGE 300
    PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN 350
    CTDMSNICQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC 400
    HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR AKNREWLWMR TSSFTFQNPY 450
    SDEMSIFICT NTNVKNSSQE PRPTLSNTIQ RSQLGPTTNL SLEMGTGVLA 500
    SRQQQQQQQQ QQQQQQQQTE LDMVPGRDGL ASYSHSQVSV QPVATAGSEH 550
    SKPLEKSEGL FVQDRDPRFS EIYPNISADQ SKGLSSSTVP ATQQLFSQGS 600
    SFPPNPRPAE NFRNSGLTPP VTIVQPSSSA GQILAQISRH SNLTQGSAPT 650
    WTSSTRPGFS AQLPTQATAK TRSSQFGVNN FQTSSSFSAM SLPGAPTASP 700
    STAAYPTLPN RGSNFPPETG QTTGQFQTRT AEGVGVWPQW QGQQPHHRSS 750
    SNEQHVQPTS AQPSSQPEVF QEMLSMLGDQ SNTYNNEEFP DLTMFPPFSE 800
    Length:800
    Mass (Da):88,221
    Last modified:November 1, 1997 - v2
    Checksum:iCD71FCDF2C23BF34
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61184 mRNA. Translation: AAB03811.1.
    U08986 mRNA. Translation: AAA56896.1.
    PIRiS58376.
    RefSeqiNP_036912.1. NM_012780.1.
    UniGeneiRn.10520.

    Genome annotation databases

    GeneIDi25242.
    KEGGirno:25242.
    UCSCiRGD:2153. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61184 mRNA. Translation: AAB03811.1 .
    U08986 mRNA. Translation: AAA56896.1 .
    PIRi S58376.
    RefSeqi NP_036912.1. NM_012780.1.
    UniGenei Rn.10520.

    3D structure databases

    ProteinModelPortali P41739.
    SMRi P41739. Positions 354-470.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247282. 1 interaction.
    IntActi P41739. 1 interaction.

    PTM databases

    PhosphoSitei P41739.

    Proteomic databases

    PRIDEi P41739.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25242.
    KEGGi rno:25242.
    UCSCi RGD:2153. rat.

    Organism-specific databases

    CTDi 405.
    RGDi 2153. Arnt.

    Phylogenomic databases

    eggNOGi NOG293303.
    HOVERGENi HBG000164.
    InParanoidi P41739.
    KOi K09097.
    PhylomeDBi P41739.

    Miscellaneous databases

    NextBioi 605831.
    PROi P41739.

    Gene expression databases

    Genevestigatori P41739.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR001067. Nuc_translocat.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view ]
    PRINTSi PR00785. NCTRNSLOCATR.
    SMARTi SM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 4 hits.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Drutel G., Kathmann M., Heron A., Schwartz J.C., Arrang J.-M.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
    2. "Tissue specific expression of the rat Ah-receptor and ARNT mRNAs."
      Carver L.A., Hogenesch J.B., Bradfield C.A.
      Nucleic Acids Res. 22:3038-3044(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 96-453.
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiARNT_RAT
    AccessioniPrimary (citable) accession number: P41739
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3