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P41739

- ARNT_RAT

UniProt

P41739 - ARNT_RAT

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Protein

Aryl hydrocarbon receptor nuclear translocator

Gene

Arnt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: RGD
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. signal transducer activity Source: InterPro

GO - Biological processi

  1. response to hypoxia Source: RGD
  2. response to toxic substance Source: RGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator
Short name:
ARNT protein
Alternative name(s):
Dioxin receptor, nuclear translocator
Hypoxia-inducible factor 1-beta
Short name:
HIF-1-beta
Short name:
HIF1-beta
Gene namesi
Name:Arnt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2153. Arnt.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. nucleus Source: RGD
  3. transcription factor complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 800799Aryl hydrocarbon receptor nuclear translocatorPRO_0000127121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP41739.

PTM databases

PhosphoSiteiP41739.

Expressioni

Gene expression databases

GenevestigatoriP41739.

Interactioni

Subunit structurei

Heterodimer with HIF1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with NOCA7 and TACC3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AhrP417382EBI-1162920,EBI-1162880

Protein-protein interaction databases

BioGridi247282. 1 interaction.
IntActiP41739. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP41739.
SMRiP41739. Positions 354-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 14254bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini161 – 23575PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini349 – 41971PAS 2PROSITE-ProRule annotationAdd
BLAST
Domaini424 – 46744PACAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi99 – 1024Poly-Arg
Compositional biasi503 – 51816Poly-GlnAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG293303.
HOVERGENiHBG000164.
InParanoidiP41739.
KOiK09097.
PhylomeDBiP41739.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 4 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41739-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATTANPEM TSDVPSLGPT IASGNPGPGI QGGGAVVQRA IKRRSGLDFD
60 70 80 90 100
DEGEVNSKFL RCDDEQMCND KERFARSDDE QSSADKERLA RENHSEIERR
110 120 130 140 150
RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST
160 170 180 190 200
DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP
210 220 230 240 250
QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ
260 270 280 290 300
SSMRMCMGSR RSFICRMRCG TSSVDPVSMN RLSFLRNRCR NGLGSVKEGE
310 320 330 340 350
PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN
360 370 380 390 400
CTDMSNICQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC
410 420 430 440 450
HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR AKNREWLWMR TSSFTFQNPY
460 470 480 490 500
SDEMSIFICT NTNVKNSSQE PRPTLSNTIQ RSQLGPTTNL SLEMGTGVLA
510 520 530 540 550
SRQQQQQQQQ QQQQQQQQTE LDMVPGRDGL ASYSHSQVSV QPVATAGSEH
560 570 580 590 600
SKPLEKSEGL FVQDRDPRFS EIYPNISADQ SKGLSSSTVP ATQQLFSQGS
610 620 630 640 650
SFPPNPRPAE NFRNSGLTPP VTIVQPSSSA GQILAQISRH SNLTQGSAPT
660 670 680 690 700
WTSSTRPGFS AQLPTQATAK TRSSQFGVNN FQTSSSFSAM SLPGAPTASP
710 720 730 740 750
STAAYPTLPN RGSNFPPETG QTTGQFQTRT AEGVGVWPQW QGQQPHHRSS
760 770 780 790 800
SNEQHVQPTS AQPSSQPEVF QEMLSMLGDQ SNTYNNEEFP DLTMFPPFSE
Length:800
Mass (Da):88,221
Last modified:November 1, 1997 - v2
Checksum:iCD71FCDF2C23BF34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61184 mRNA. Translation: AAB03811.1.
U08986 mRNA. Translation: AAA56896.1.
PIRiS58376.
RefSeqiNP_036912.1. NM_012780.1.
UniGeneiRn.10520.

Genome annotation databases

GeneIDi25242.
KEGGirno:25242.
UCSCiRGD:2153. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61184 mRNA. Translation: AAB03811.1 .
U08986 mRNA. Translation: AAA56896.1 .
PIRi S58376.
RefSeqi NP_036912.1. NM_012780.1.
UniGenei Rn.10520.

3D structure databases

ProteinModelPortali P41739.
SMRi P41739. Positions 354-470.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247282. 1 interaction.
IntActi P41739. 1 interaction.

PTM databases

PhosphoSitei P41739.

Proteomic databases

PRIDEi P41739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25242.
KEGGi rno:25242.
UCSCi RGD:2153. rat.

Organism-specific databases

CTDi 405.
RGDi 2153. Arnt.

Phylogenomic databases

eggNOGi NOG293303.
HOVERGENi HBG000164.
InParanoidi P41739.
KOi K09097.
PhylomeDBi P41739.

Miscellaneous databases

NextBioi 605831.
PROi P41739.

Gene expression databases

Genevestigatori P41739.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view ]
PRINTSi PR00785. NCTRNSLOCATR.
SMARTi SM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 4 hits.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Drutel G., Kathmann M., Heron A., Schwartz J.C., Arrang J.-M.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "Tissue specific expression of the rat Ah-receptor and ARNT mRNAs."
    Carver L.A., Hogenesch J.B., Bradfield C.A.
    Nucleic Acids Res. 22:3038-3044(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 96-453.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiARNT_RAT
AccessioniPrimary (citable) accession number: P41739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3