Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P41736 (POTX_PARCV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poneratoxin

Short name=PoTX
Alternative name(s):
Pac-TX
OrganismParaponera clavata (Bullet ant) (Izuela)
Taxonomic identifier55425 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeParaponerinaeParaponera

Protein attributes

Sequence length25 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue. Ref.5

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 2525Poneratoxin
PRO_0000044538

Amino acid modifications

Modified residue251Arginine amide

Secondary structure

........ 25
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P41736 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: EEA403CC125E7BB0

FASTA252,757
        10         20 
FLPLLILGSL LMTPPVIQAI HDAQR 

« Hide

References

[1]"Pharmacological characterization and chemical fractionation of the venom of the ponerine ant, Paraponera clavata (F.)."
Piek T., Hue B., Mantel P., Nakajima T., Schmidt J.O.
Comp. Biochem. Physiol. 99C:481-486(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"Poneratoxin, neurotoxic pentacosapeptide from ant venom: synthetic, biological and conformational studies."
Konopinska D., Lombarska-Sliwinska D., Plech A., Rosinski G., Lisowski M.
(In) Schneider C.H., Eberles A.N. (eds.); Peptides 1992, pp.759-760, Escom Science Publishers, Leiden (1993)
Cited for: PROTEIN SEQUENCE, SYNTHESIS.
Tissue: Venom.
[3]"Poneratoxin, a novel peptide neurotoxin from the venom of the ant, Paraponera clavata."
Piek T., Duval A., Hue B., Karst H., Lapied B., Mantel P., Nakajima T., Pelhate M., Schmidt J.O.
Comp. Biochem. Physiol. 99C:487-495(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Tissue: Venom.
[4]"Poneratoxin, a new toxin from an ant venom, reveals an interconversion between two gating modes of the Na channels in frog skeletal muscle fibres."
Duval A., Malecot C.O., Pelhate M., Piek T.
Pflugers Arch. 420:239-247(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Tissue: Venom.
[5]"The effect of poneratoxin on neuromuscular transmission in the rat diaphragm."
Hendrich A.B., Mozrzymas J.W., Konopinska D., Scuka M.
Cell. Mol. Biol. Lett. 7:195-202(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Poneratoxin, a neurotoxin from ant venom. Structure and expression in insect cells and construction of a bio-insecticide."
Szolajska E., Poznanski J., Ferber M.L., Michalik J., Gout E., Fender P., Bailly I., Dublet B., Chroboczek J.
Eur. J. Biochem. 271:2127-2136(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, SYNTHESIS.

Web resources

Protein Spotlight

Princess Bala's sting - Issue 14 of September 2001

Cross-references

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1G92NMR-A1-25[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Other

EvolutionaryTraceP41736.

Entry information

Entry namePOTX_PARCV
AccessionPrimary (citable) accession number: P41736
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references