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Protein

Poneratoxin

Gene
N/A
Organism
Paraponera clavata (Bullet ant) (Izuela)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue.1 Publication

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Poneratoxin
Short name:
PoTX
Alternative name(s):
Pac-TX
OrganismiParaponera clavata (Bullet ant) (Izuela)
Taxonomic identifieri55425 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeParaponerinaeParaponera

Subcellular locationi

GO - Cellular componenti

  1. other organism postsynaptic membrane Source: UniProtKB-KW
  2. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2525PoneratoxinPRO_0000044538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Arginine amide

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1
25
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 87Combined sources
Beta strandi11 – 133Combined sources
Turni16 – 183Combined sources
Helixi19 – 246Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G92NMR-A1-25[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41736.

Sequencei

Sequence statusi: Complete.

P41736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
FLPLLILGSL LMTPPVIQAI HDAQR
Length:25
Mass (Da):2,757
Last modified:November 1, 1995 - v1
Checksum:iEEA403CC125E7BB0
GO

Cross-referencesi

Web resourcesi

Protein Spotlight

Princess Bala's sting - Issue 14 of September 2001

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G92NMR-A1-25[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP41736.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Pharmacological characterization and chemical fractionation of the venom of the ponerine ant, Paraponera clavata (F.)."
    Piek T., Hue B., Mantel P., Nakajima T., Schmidt J.O.
    Comp. Biochem. Physiol. 99C:481-486(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.
  2. "Poneratoxin, neurotoxic pentacosapeptide from ant venom: synthetic, biological and conformational studies."
    Konopinska D., Lombarska-Sliwinska D., Plech A., Rosinski G., Lisowski M.
    (In) Schneider C.H., Eberles A.N. (eds.); Peptides 1992, pp.759-760, Escom Science Publishers, Leiden (1993)
    Cited for: PROTEIN SEQUENCE, SYNTHESIS.
    Tissue: Venom.
  3. "Poneratoxin, a novel peptide neurotoxin from the venom of the ant, Paraponera clavata."
    Piek T., Duval A., Hue B., Karst H., Lapied B., Mantel P., Nakajima T., Pelhate M., Schmidt J.O.
    Comp. Biochem. Physiol. 99C:487-495(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Tissue: Venom.
  4. "Poneratoxin, a new toxin from an ant venom, reveals an interconversion between two gating modes of the Na channels in frog skeletal muscle fibres."
    Duval A., Malecot C.O., Pelhate M., Piek T.
    Pflugers Arch. 420:239-247(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Tissue: Venom.
  5. "The effect of poneratoxin on neuromuscular transmission in the rat diaphragm."
    Hendrich A.B., Mozrzymas J.W., Konopinska D., Scuka M.
    Cell. Mol. Biol. Lett. 7:195-202(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Poneratoxin, a neurotoxin from ant venom. Structure and expression in insect cells and construction of a bio-insecticide."
    Szolajska E., Poznanski J., Ferber M.L., Michalik J., Gout E., Fender P., Bailly I., Dublet B., Chroboczek J.
    Eur. J. Biochem. 271:2127-2136(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, SYNTHESIS.

Entry informationi

Entry nameiPOTX_PARCV
AccessioniPrimary (citable) accession number: P41736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.