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Protein

Poneratoxin

Gene
N/A
Organism
Paraponera clavata (Bullet ant) (Izuela)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Poneratoxin
Short name:
PoTX
Alternative name(s):
Pac-TX
OrganismiParaponera clavata (Bullet ant) (Izuela)
Taxonomic identifieri55425 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataFormicoideaFormicidaeParaponerinaeParaponera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000445381 – 25PoneratoxinAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Arginine amide1 Publication1

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 8Combined sources7
Beta strandi11 – 13Combined sources3
Turni16 – 18Combined sources3
Helixi19 – 24Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G92NMR-A1-25[»]
SMRiP41736
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41736

Sequencei

Sequence statusi: Complete.

P41736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
FLPLLILGSL LMTPPVIQAI HDAQR
Length:25
Mass (Da):2,757
Last modified:November 1, 1995 - v1
Checksum:iEEA403CC125E7BB0
GO

Entry informationi

Entry nameiPOTX_PARCV
AccessioniPrimary (citable) accession number: P41736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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