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P41736

- POTX_PARCV

UniProt

P41736 - POTX_PARCV

Protein

Poneratoxin

Gene
N/A
Organism
Paraponera clavata (Bullet ant) (Izuela)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue.1 Publication

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poneratoxin
    Short name:
    PoTX
    Alternative name(s):
    Pac-TX
    OrganismiParaponera clavata (Bullet ant) (Izuela)
    Taxonomic identifieri55425 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeParaponerinaeParaponera

    Subcellular locationi

    GO - Cellular componenti

    1. other organism postsynaptic membrane Source: UniProtKB-KW
    2. other organism presynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 2525PoneratoxinPRO_0000044538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Arginine amide

    Keywords - PTMi

    Amidation

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    Secondary structure

    1
    25
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 87
    Beta strandi11 – 133
    Turni16 – 183
    Helixi19 – 246

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1G92NMR-A1-25[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP41736.

    Sequencei

    Sequence statusi: Complete.

    P41736-1 [UniParc]FASTAAdd to Basket

    « Hide

    FLPLLILGSL LMTPPVIQAI HDAQR                              25
    Length:25
    Mass (Da):2,757
    Last modified:November 1, 1995 - v1
    Checksum:iEEA403CC125E7BB0
    GO

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Princess Bala's sting - Issue 14 of September 2001

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1G92 NMR - A 1-25 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P41736.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Pharmacological characterization and chemical fractionation of the venom of the ponerine ant, Paraponera clavata (F.)."
      Piek T., Hue B., Mantel P., Nakajima T., Schmidt J.O.
      Comp. Biochem. Physiol. 99C:481-486(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.
    2. "Poneratoxin, neurotoxic pentacosapeptide from ant venom: synthetic, biological and conformational studies."
      Konopinska D., Lombarska-Sliwinska D., Plech A., Rosinski G., Lisowski M.
      (In) Schneider C.H., Eberles A.N. (eds.); Peptides 1992, pp.759-760, Escom Science Publishers, Leiden (1993)
      Cited for: PROTEIN SEQUENCE, SYNTHESIS.
      Tissue: Venom.
    3. "Poneratoxin, a novel peptide neurotoxin from the venom of the ant, Paraponera clavata."
      Piek T., Duval A., Hue B., Karst H., Lapied B., Mantel P., Nakajima T., Pelhate M., Schmidt J.O.
      Comp. Biochem. Physiol. 99C:487-495(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Tissue: Venom.
    4. "Poneratoxin, a new toxin from an ant venom, reveals an interconversion between two gating modes of the Na channels in frog skeletal muscle fibres."
      Duval A., Malecot C.O., Pelhate M., Piek T.
      Pflugers Arch. 420:239-247(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Tissue: Venom.
    5. "The effect of poneratoxin on neuromuscular transmission in the rat diaphragm."
      Hendrich A.B., Mozrzymas J.W., Konopinska D., Scuka M.
      Cell. Mol. Biol. Lett. 7:195-202(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Poneratoxin, a neurotoxin from ant venom. Structure and expression in insect cells and construction of a bio-insecticide."
      Szolajska E., Poznanski J., Ferber M.L., Michalik J., Gout E., Fender P., Bailly I., Dublet B., Chroboczek J.
      Eur. J. Biochem. 271:2127-2136(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, SYNTHESIS.

    Entry informationi

    Entry nameiPOTX_PARCV
    AccessioniPrimary (citable) accession number: P41736
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3