P41736 (POTX_PARCV) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 66.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Poneratoxin Short name=PoTX Alternative name(s): Pac-TX |
| Organism | Paraponera clavata (Bullet ant) (Izuela) |
| Taxonomic identifier | 55425 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Vespoidea › Formicidae › Paraponerinae › Paraponera |
Protein attributes
| Sequence length | 25 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue. Ref.5 |
| Subcellular location | |
| Tissue specificity | Expressed by the venom gland. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Molecular function | Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Presynaptic neurotoxin Sodium channel inhibitor Toxin |
| PTM | Amidation |
| Technical term | 3D-structure Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular_component | other organism postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW other organism presynaptic membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular_function | sodium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Pharmacological characterization and chemical fractionation of the venom of the ponerine ant, Paraponera clavata (F.)." Piek T., Hue B., Mantel P., Nakajima T., Schmidt J.O. Comp. Biochem. Physiol. 99C:481-486(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom. |
| [2] | "Poneratoxin, neurotoxic pentacosapeptide from ant venom: synthetic, biological and conformational studies." Konopinska D., Lombarska-Sliwinska D., Plech A., Rosinski G., Lisowski M. (In) Schneider C.H., Eberles A.N. (eds.); Peptides 1992, pp.759-760, Escom Science Publishers, Leiden (1993) Cited for: PROTEIN SEQUENCE, SYNTHESIS. Tissue: Venom. |
| [3] | "Poneratoxin, a novel peptide neurotoxin from the venom of the ant, Paraponera clavata." Piek T., Duval A., Hue B., Karst H., Lapied B., Mantel P., Nakajima T., Pelhate M., Schmidt J.O. Comp. Biochem. Physiol. 99C:487-495(1991) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION. Tissue: Venom. |
| [4] | "Poneratoxin, a new toxin from an ant venom, reveals an interconversion between two gating modes of the Na channels in frog skeletal muscle fibres." Duval A., Malecot C.O., Pelhate M., Piek T. Pflugers Arch. 420:239-247(1992) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION. Tissue: Venom. |
| [5] | "The effect of poneratoxin on neuromuscular transmission in the rat diaphragm." Hendrich A.B., Mozrzymas J.W., Konopinska D., Scuka M. Cell. Mol. Biol. Lett. 7:195-202(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. |
| [6] | "Poneratoxin, a neurotoxin from ant venom. Structure and expression in insect cells and construction of a bio-insecticide." Szolajska E., Poznanski J., Ferber M.L., Michalik J., Gout E., Fender P., Bailly I., Dublet B., Chroboczek J. Eur. J. Biochem. 271:2127-2136(2004) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR, SYNTHESIS. |
Web resources
| Protein Spotlight Princess Bala's sting - Issue 14 of September 2001 |
Cross-references
Entry information
| Entry name | POTX_PARCV | ||||||||
| Accession | Primary (citable) accession number: P41736 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Animal Toxin Annotation Program | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |