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Protein

Tetraspanin-7

Gene

TSPAN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell proliferation and cell motility.

GO - Biological processi

  1. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Protein family/group databases

TCDBi8.A.40.1.2. the tetraspanin (tetraspanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-7
Short name:
Tspan-7
Alternative name(s):
Cell surface glycoprotein A15
Membrane component chromosome X surface marker 1
T-cell acute lymphoblastic leukemia-associated antigen 1
Short name:
TALLA-1
Transmembrane 4 superfamily member 2
CD_antigen: CD231
Gene namesi
Name:TSPAN7
Synonyms:A15, DXS1692E, MXS1, TM4SF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:11854. TSPAN7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei17 – 4024HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 5616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei57 – 7519HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 8611CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei87 – 11226HelicalSequence AnalysisAdd
BLAST
Topological domaini113 – 213101ExtracellularSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Topological domaini235 – 24915CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked 581 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.

See also OMIM:300210
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721P → H in MRX58. 1 Publication
VAR_009259

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi300210. phenotype.
Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA36555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Tetraspanin-7PRO_0000219248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP41732.
PaxDbiP41732.
PRIDEiP41732.

PTM databases

PhosphoSiteiP41732.

Expressioni

Tissue specificityi

Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.

Gene expression databases

BgeeiP41732.
CleanExiHS_TSPAN7.
ExpressionAtlasiP41732. baseline and differential.
GenevestigatoriP41732.

Organism-specific databases

HPAiCAB062566.
CAB068245.
HPA003140.

Interactioni

Subunit structurei

Interacts with herpes simplex virus 1 (HHV-1) UL35.1 Publication

Protein-protein interaction databases

BioGridi112957. 4 interactions.
IntActiP41732. 2 interactions.
MINTiMINT-1379586.
STRINGi9606.ENSP00000367743.

Structurei

3D structure databases

ProteinModelPortaliP41732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274015.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230656.
HOVERGENiHBG107306.
InParanoidiP41732.
KOiK06571.
OrthoDBiEOG73BVDM.
PhylomeDBiP41732.
TreeFamiTF352891.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL
60 70 80 90 100
IAENSTNAPY VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL
110 120 130 140 150
AELVAGISGF VFRHEIKDTF LRTYTDAMQT YNGNDERSRA VDHVQRSLSC
160 170 180 190 200
CGVQNYTNWS TSPYFLEHGI PPSCCMNETD CNPQDLHNLT VAATKVNQKG
210 220 230 240
CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF ITANQYEMV
Length:249
Mass (Da):27,574
Last modified:November 16, 2001 - v2
Checksum:iF2CF4517DB388173
GO

Sequence cautioni

The sequence BAA01501.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA06191.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361E → K in CAB65594 (PubMed:10655063).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531E → K.1 Publication
Corresponds to variant rs17851592 [ dbSNP | Ensembl ].
VAR_037905
Natural varianti127 – 1271A → T.1 Publication
Corresponds to variant rs17851593 [ dbSNP | Ensembl ].
VAR_037906
Natural varianti172 – 1721P → H in MRX58. 1 Publication
VAR_009259

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10653 mRNA. Translation: BAA01501.1. Different initiation.
AK312343 mRNA. Translation: BAG35264.1.
CH471141 Genomic DNA. Translation: EAW59437.1.
D29808 mRNA. Translation: BAA06191.1. Different initiation.
AJ250562
, AJ250563, AJ250564, AJ250565, AJ250566, AJ250567, AJ250568 Genomic DNA. Translation: CAB65594.1.
AB062057 mRNA. Translation: BAB55825.1.
AB062057 mRNA. Translation: BAB55824.1.
CH471141 Genomic DNA. Translation: EAW59438.1.
BC018036 mRNA. Translation: AAH18036.1.
CCDSiCCDS14248.1.
PIRiI39368.
RefSeqiNP_004606.2. NM_004615.3.
UniGeneiHs.441664.

Genome annotation databases

EnsembliENST00000378482; ENSP00000367743; ENSG00000156298.
GeneIDi7102.
KEGGihsa:7102.
UCSCiuc004deg.4. human.

Polymorphism databases

DMDMi17380550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10653 mRNA. Translation: BAA01501.1. Different initiation.
AK312343 mRNA. Translation: BAG35264.1.
CH471141 Genomic DNA. Translation: EAW59437.1.
D29808 mRNA. Translation: BAA06191.1. Different initiation.
AJ250562
, AJ250563, AJ250564, AJ250565, AJ250566, AJ250567, AJ250568 Genomic DNA. Translation: CAB65594.1.
AB062057 mRNA. Translation: BAB55825.1.
AB062057 mRNA. Translation: BAB55824.1.
CH471141 Genomic DNA. Translation: EAW59438.1.
BC018036 mRNA. Translation: AAH18036.1.
CCDSiCCDS14248.1.
PIRiI39368.
RefSeqiNP_004606.2. NM_004615.3.
UniGeneiHs.441664.

3D structure databases

ProteinModelPortaliP41732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112957. 4 interactions.
IntActiP41732. 2 interactions.
MINTiMINT-1379586.
STRINGi9606.ENSP00000367743.

Protein family/group databases

TCDBi8.A.40.1.2. the tetraspanin (tetraspanin) family.

PTM databases

PhosphoSiteiP41732.

Polymorphism databases

DMDMi17380550.

Proteomic databases

MaxQBiP41732.
PaxDbiP41732.
PRIDEiP41732.

Protocols and materials databases

DNASUi7102.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378482; ENSP00000367743; ENSG00000156298.
GeneIDi7102.
KEGGihsa:7102.
UCSCiuc004deg.4. human.

Organism-specific databases

CTDi7102.
GeneCardsiGC0XP038420.
HGNCiHGNC:11854. TSPAN7.
HPAiCAB062566.
CAB068245.
HPA003140.
MIMi300096. gene.
300210. phenotype.
neXtProtiNX_P41732.
Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA36555.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274015.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230656.
HOVERGENiHBG107306.
InParanoidiP41732.
KOiK06571.
OrthoDBiEOG73BVDM.
PhylomeDBiP41732.
TreeFamiTF352891.

Miscellaneous databases

ChiTaRSiTSPAN7. human.
GeneWikiiTSPAN7.
GenomeRNAii7102.
NextBioi27785.
PROiP41732.
SOURCEiSearch...

Gene expression databases

BgeeiP41732.
CleanExiHS_TSPAN7.
ExpressionAtlasiP41732. baseline and differential.
GenevestigatoriP41732.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily."
    Emi N., Kitaori K., Seto M., Ueda R., Saito H., Takahashi T.
    Immunogenetics 37:193-198(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood lymphocyte.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily."
    Takagi S., Fujikawa K., Imai T., Fukuhara N., Fukudome K., Minegishi M., Tsuchiya S., Konno T., Hinuma Y., Yoshie O.
    Int. J. Cancer 61:706-715(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-249.
    Tissue: Peripheral blood.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MRX58 HIS-172.
  6. "Homo sapiens transmembrane 4 superfamily member 2 (TM4SF2, tetraspanins), mRNA."
    Wang H., Gao X., Huang Y., Han J.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-53 AND THR-127.
    Tissue: Brain.
  8. "Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein."
    Wang L., Liu L., Che Y., Wang L., Jiang L., Dong C., Zhang Y., Li Q.
    Virol. J. 7:156-156(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HHV-1 UL35.

Entry informationi

Entry nameiTSN7_HUMAN
AccessioniPrimary (citable) accession number: P41732
Secondary accession number(s): B2R5W7
, D3DWB1, Q8WVG5, Q9UEY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 16, 2001
Last modified: March 4, 2015
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.