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Protein

Tetraspanin-7

Gene

TSPAN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell proliferation and cell motility.

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors

Protein family/group databases

TCDBi8.A.40.1.2 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-7
Short name:
Tspan-7
Alternative name(s):
Cell surface glycoprotein A15
Membrane component chromosome X surface marker 1
T-cell acute lymphoblastic leukemia-associated antigen 1
Short name:
TALLA-1
Transmembrane 4 superfamily member 2
CD_antigen: CD231
Gene namesi
Name:TSPAN7
Synonyms:A15, DXS1692E, MXS1, TM4SF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000156298.12
HGNCiHGNC:11854 TSPAN7
MIMi300096 gene
neXtProtiNX_P41732

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 40HelicalSequence analysisAdd BLAST24
Topological domaini41 – 56ExtracellularSequence analysisAdd BLAST16
Transmembranei57 – 75HelicalSequence analysisAdd BLAST19
Topological domaini76 – 86CytoplasmicSequence analysisAdd BLAST11
Transmembranei87 – 112HelicalSequence analysisAdd BLAST26
Topological domaini113 – 213ExtracellularSequence analysisAdd BLAST101
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 249CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked 58 (MRX58)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
See also OMIM:300210
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009259172P → H in MRX58. 1 PublicationCorresponds to variant dbSNP:rs104894951EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi7102
MalaCardsiTSPAN7
MIMi300210 phenotype
OpenTargetsiENSG00000156298
Orphaneti777 X-linked non-syndromic intellectual disability
PharmGKBiPA36555

Polymorphism and mutation databases

BioMutaiTSPAN7
DMDMi17380550

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192481 – 249Tetraspanin-7Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP41732
PaxDbiP41732
PeptideAtlasiP41732
PRIDEiP41732

PTM databases

iPTMnetiP41732
PhosphoSitePlusiP41732
SwissPalmiP41732

Expressioni

Tissue specificityi

Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.

Gene expression databases

BgeeiENSG00000156298
CleanExiHS_TSPAN7
ExpressionAtlasiP41732 baseline and differential
GenevisibleiP41732 HS

Organism-specific databases

HPAiCAB062566
CAB068245
HPA003140

Interactioni

Subunit structurei

Interacts with herpes simplex virus 1 (HHV-1) UL35.1 Publication

Protein-protein interaction databases

BioGridi112957, 7 interactors
IntActiP41732, 3 interactors
MINTiP41732
STRINGi9606.ENSP00000367743

Structurei

3D structure databases

ProteinModelPortaliP41732
SMRiP41732
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230656
HOVERGENiHBG107306
InParanoidiP41732
KOiK06571
PhylomeDBiP41732
TreeFamiTF352891

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

P41732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL
60 70 80 90 100
IAENSTNAPY VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL
110 120 130 140 150
AELVAGISGF VFRHEIKDTF LRTYTDAMQT YNGNDERSRA VDHVQRSLSC
160 170 180 190 200
CGVQNYTNWS TSPYFLEHGI PPSCCMNETD CNPQDLHNLT VAATKVNQKG
210 220 230 240
CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF ITANQYEMV
Length:249
Mass (Da):27,574
Last modified:November 16, 2001 - v2
Checksum:iF2CF4517DB388173
GO

Sequence cautioni

The sequence BAA01501 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA06191 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136E → K in CAB65594 (PubMed:10655063).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03790553E → K1 PublicationCorresponds to variant dbSNP:rs17851592Ensembl.1
Natural variantiVAR_037906127A → T1 PublicationCorresponds to variant dbSNP:rs17851593Ensembl.1
Natural variantiVAR_009259172P → H in MRX58. 1 PublicationCorresponds to variant dbSNP:rs104894951EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10653 mRNA Translation: BAA01501.1 Different initiation.
AK312343 mRNA Translation: BAG35264.1
CH471141 Genomic DNA Translation: EAW59437.1
D29808 mRNA Translation: BAA06191.1 Different initiation.
AJ250562
, AJ250563, AJ250564, AJ250565, AJ250566, AJ250567, AJ250568 Genomic DNA Translation: CAB65594.1
AB062057 mRNA Translation: BAB55825.1
AB062057 mRNA Translation: BAB55824.1
CH471141 Genomic DNA Translation: EAW59438.1
BC018036 mRNA Translation: AAH18036.1
CCDSiCCDS14248.1
PIRiI39368
RefSeqiNP_004606.2, NM_004615.3
UniGeneiHs.441664

Genome annotation databases

EnsembliENST00000378482; ENSP00000367743; ENSG00000156298
GeneIDi7102
KEGGihsa:7102
UCSCiuc004deg.5 human

Similar proteinsi

Entry informationi

Entry nameiTSN7_HUMAN
AccessioniPrimary (citable) accession number: P41732
Secondary accession number(s): B2R5W7
, D3DWB1, Q8WVG5, Q9UEY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 16, 2001
Last modified: May 23, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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