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P41732

- TSN7_HUMAN

UniProt

P41732 - TSN7_HUMAN

Protein

Tetraspanin-7

Gene

TSPAN7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (16 Nov 2001)
      Previous versions | rss
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    Functioni

    May be involved in cell proliferation and cell motility.

    GO - Biological processi

    1. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction

    Protein family/group databases

    TCDBi8.A.40.1.2. the tetraspanin (tetraspanin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-7
    Short name:
    Tspan-7
    Alternative name(s):
    Cell surface glycoprotein A15
    Membrane component chromosome X surface marker 1
    T-cell acute lymphoblastic leukemia-associated antigen 1
    Short name:
    TALLA-1
    Transmembrane 4 superfamily member 2
    CD_antigen: CD231
    Gene namesi
    Name:TSPAN7
    Synonyms:A15, DXS1692E, MXS1, TM4SF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:11854. TSPAN7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Mental retardation, X-linked 58 (MRX58) [MIM:300210]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti172 – 1721P → H in MRX58. 1 Publication
    VAR_009259

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi300210. phenotype.
    Orphaneti777. X-linked non-syndromic intellectual disability.
    PharmGKBiPA36555.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249Tetraspanin-7PRO_0000219248Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP41732.
    PaxDbiP41732.
    PRIDEiP41732.

    PTM databases

    PhosphoSiteiP41732.

    Expressioni

    Tissue specificityi

    Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.

    Gene expression databases

    ArrayExpressiP41732.
    BgeeiP41732.
    CleanExiHS_TSPAN7.
    GenevestigatoriP41732.

    Organism-specific databases

    HPAiCAB062566.
    HPA003140.

    Interactioni

    Subunit structurei

    Interacts with herpes simplex virus 1 (HHV-1) UL35.1 Publication

    Protein-protein interaction databases

    BioGridi112957. 4 interactions.
    IntActiP41732. 2 interactions.
    MINTiMINT-1379586.
    STRINGi9606.ENSP00000367743.

    Structurei

    3D structure databases

    ProteinModelPortaliP41732.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 5616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 8611CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini113 – 213101ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 24915CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 4024HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7519HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 11226HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274015.
    HOGENOMiHOG000230656.
    HOVERGENiHBG107306.
    InParanoidiP41732.
    KOiK06571.
    OrthoDBiEOG73BVDM.
    PhylomeDBiP41732.
    TreeFamiTF352891.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41732-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL    50
    IAENSTNAPY VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL 100
    AELVAGISGF VFRHEIKDTF LRTYTDAMQT YNGNDERSRA VDHVQRSLSC 150
    CGVQNYTNWS TSPYFLEHGI PPSCCMNETD CNPQDLHNLT VAATKVNQKG 200
    CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF ITANQYEMV 249
    Length:249
    Mass (Da):27,574
    Last modified:November 16, 2001 - v2
    Checksum:iF2CF4517DB388173
    GO

    Sequence cautioni

    The sequence BAA01501.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA06191.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti136 – 1361E → K in CAB65594. (PubMed:10655063)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531E → K.1 Publication
    Corresponds to variant rs17851592 [ dbSNP | Ensembl ].
    VAR_037905
    Natural varianti127 – 1271A → T.1 Publication
    Corresponds to variant rs17851593 [ dbSNP | Ensembl ].
    VAR_037906
    Natural varianti172 – 1721P → H in MRX58. 1 Publication
    VAR_009259

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10653 mRNA. Translation: BAA01501.1. Different initiation.
    AK312343 mRNA. Translation: BAG35264.1.
    CH471141 Genomic DNA. Translation: EAW59437.1.
    D29808 mRNA. Translation: BAA06191.1. Different initiation.
    AJ250562
    , AJ250563, AJ250564, AJ250565, AJ250566, AJ250567, AJ250568 Genomic DNA. Translation: CAB65594.1.
    AB062057 mRNA. Translation: BAB55825.1.
    AB062057 mRNA. Translation: BAB55824.1.
    CH471141 Genomic DNA. Translation: EAW59438.1.
    BC018036 mRNA. Translation: AAH18036.1.
    CCDSiCCDS14248.1.
    PIRiI39368.
    RefSeqiNP_004606.2. NM_004615.3.
    UniGeneiHs.441664.

    Genome annotation databases

    EnsembliENST00000378482; ENSP00000367743; ENSG00000156298.
    GeneIDi7102.
    KEGGihsa:7102.
    UCSCiuc004deg.4. human.

    Polymorphism databases

    DMDMi17380550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10653 mRNA. Translation: BAA01501.1 . Different initiation.
    AK312343 mRNA. Translation: BAG35264.1 .
    CH471141 Genomic DNA. Translation: EAW59437.1 .
    D29808 mRNA. Translation: BAA06191.1 . Different initiation.
    AJ250562
    , AJ250563 , AJ250564 , AJ250565 , AJ250566 , AJ250567 , AJ250568 Genomic DNA. Translation: CAB65594.1 .
    AB062057 mRNA. Translation: BAB55825.1 .
    AB062057 mRNA. Translation: BAB55824.1 .
    CH471141 Genomic DNA. Translation: EAW59438.1 .
    BC018036 mRNA. Translation: AAH18036.1 .
    CCDSi CCDS14248.1.
    PIRi I39368.
    RefSeqi NP_004606.2. NM_004615.3.
    UniGenei Hs.441664.

    3D structure databases

    ProteinModelPortali P41732.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112957. 4 interactions.
    IntActi P41732. 2 interactions.
    MINTi MINT-1379586.
    STRINGi 9606.ENSP00000367743.

    Protein family/group databases

    TCDBi 8.A.40.1.2. the tetraspanin (tetraspanin) family.

    PTM databases

    PhosphoSitei P41732.

    Polymorphism databases

    DMDMi 17380550.

    Proteomic databases

    MaxQBi P41732.
    PaxDbi P41732.
    PRIDEi P41732.

    Protocols and materials databases

    DNASUi 7102.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378482 ; ENSP00000367743 ; ENSG00000156298 .
    GeneIDi 7102.
    KEGGi hsa:7102.
    UCSCi uc004deg.4. human.

    Organism-specific databases

    CTDi 7102.
    GeneCardsi GC0XP038420.
    HGNCi HGNC:11854. TSPAN7.
    HPAi CAB062566.
    HPA003140.
    MIMi 300096. gene.
    300210. phenotype.
    neXtProti NX_P41732.
    Orphaneti 777. X-linked non-syndromic intellectual disability.
    PharmGKBi PA36555.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274015.
    HOGENOMi HOG000230656.
    HOVERGENi HBG107306.
    InParanoidi P41732.
    KOi K06571.
    OrthoDBi EOG73BVDM.
    PhylomeDBi P41732.
    TreeFami TF352891.

    Miscellaneous databases

    ChiTaRSi TSPAN7. human.
    GeneWikii TSPAN7.
    GenomeRNAii 7102.
    NextBioi 27785.
    PROi P41732.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41732.
    Bgeei P41732.
    CleanExi HS_TSPAN7.
    Genevestigatori P41732.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily."
      Emi N., Kitaori K., Seto M., Ueda R., Saito H., Takahashi T.
      Immunogenetics 37:193-198(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peripheral blood lymphocyte.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily."
      Takagi S., Fujikawa K., Imai T., Fukuhara N., Fukudome K., Minegishi M., Tsuchiya S., Konno T., Hinuma Y., Yoshie O.
      Int. J. Cancer 61:706-715(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-249.
      Tissue: Peripheral blood.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MRX58 HIS-172.
    6. "Homo sapiens transmembrane 4 superfamily member 2 (TM4SF2, tetraspanins), mRNA."
      Wang H., Gao X., Huang Y., Han J.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-53 AND THR-127.
      Tissue: Brain.
    8. "Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein."
      Wang L., Liu L., Che Y., Wang L., Jiang L., Dong C., Zhang Y., Li Q.
      Virol. J. 7:156-156(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HHV-1 UL35.

    Entry informationi

    Entry nameiTSN7_HUMAN
    AccessioniPrimary (citable) accession number: P41732
    Secondary accession number(s): B2R5W7
    , D3DWB1, Q8WVG5, Q9UEY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3