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P41732 (TSN7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-7

Short name=Tspan-7
Alternative name(s):
Cell surface glycoprotein A15
Membrane component chromosome X surface marker 1
T-cell acute lymphoblastic leukemia-associated antigen 1
Short name=TALLA-1
Transmembrane 4 superfamily member 2
CD_antigen=CD231
Gene names
Name:TSPAN7
Synonyms:A15, DXS1692E, MXS1, TM4SF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in cell proliferation and cell motility.

Subunit structure

Interacts with herpes simplex virus 1 (HHV-1) UL35. Ref.8

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.

Involvement in disease

Mental retardation, X-linked 58 (MRX58) [MIM:300210]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence caution

The sequence BAA01501.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA06191.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentMembrane
   DiseaseDisease mutation
Mental retardation
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processviral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Tetraspanin-7
PRO_0000219248

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 4024Helical; Potential
Topological domain41 – 5616Extracellular Potential
Transmembrane57 – 7519Helical; Potential
Topological domain76 – 8611Cytoplasmic Potential
Transmembrane87 – 11226Helical; Potential
Topological domain113 – 213101Extracellular Potential
Transmembrane214 – 23421Helical; Potential
Topological domain235 – 24915Cytoplasmic Potential

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential

Natural variations

Natural variant531E → K. Ref.7
Corresponds to variant rs17851592 [ dbSNP | Ensembl ].
VAR_037905
Natural variant1271A → T. Ref.7
Corresponds to variant rs17851593 [ dbSNP | Ensembl ].
VAR_037906
Natural variant1721P → H in MRX58. Ref.5
VAR_009259

Experimental info

Sequence conflict1361E → K in CAB65594. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P41732 [UniParc].

Last modified November 16, 2001. Version 2.
Checksum: F2CF4517DB388173

FASTA24927,574
        10         20         30         40         50         60 
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL IAENSTNAPY 

        70         80         90        100        110        120 
VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL AELVAGISGF VFRHEIKDTF 

       130        140        150        160        170        180 
LRTYTDAMQT YNGNDERSRA VDHVQRSLSC CGVQNYTNWS TSPYFLEHGI PPSCCMNETD 

       190        200        210        220        230        240 
CNPQDLHNLT VAATKVNQKG CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF 


ITANQYEMV 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily."
Emi N., Kitaori K., Seto M., Ueda R., Saito H., Takahashi T.
Immunogenetics 37:193-198(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Peripheral blood lymphocyte.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily."
Takagi S., Fujikawa K., Imai T., Fukuhara N., Fukudome K., Minegishi M., Tsuchiya S., Konno T., Hinuma Y., Yoshie O.
Int. J. Cancer 61:706-715(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-249.
Tissue: Peripheral blood.
[5]"A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation."
Zemni R., Bienvenu T., Vinet M.C., Sefiani A., Carrie A., Billuart P., McDonell N., Couvert P., Francis F., Chafey P., Fauchereau F., Friocourt G., desPortes V., Cardona A., Frints S., Meindl A., Brandau O., Ronce N. expand/collapse author list , Moraine C., Bokhoven H.V., Ropers H.-H., Sudbrak R., Kahn A., Fryns J.-P., Beldjord C., Chelly J.
Nat. Genet. 24:167-170(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MRX58 HIS-172.
[6]"Homo sapiens transmembrane 4 superfamily member 2 (TM4SF2, tetraspanins), mRNA."
Wang H., Gao X., Huang Y., Han J.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-53 AND THR-127.
Tissue: Brain.
[8]"Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein."
Wang L., Liu L., Che Y., Wang L., Jiang L., Dong C., Zhang Y., Li Q.
Virol. J. 7:156-156(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HHV-1 UL35.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10653 mRNA. Translation: BAA01501.1. Different initiation.
AK312343 mRNA. Translation: BAG35264.1.
CH471141 Genomic DNA. Translation: EAW59437.1.
D29808 mRNA. Translation: BAA06191.1. Different initiation.
AJ250562 expand/collapse EMBL AC list , AJ250563, AJ250564, AJ250565, AJ250566, AJ250567, AJ250568 Genomic DNA. Translation: CAB65594.1.
AB062057 mRNA. Translation: BAB55825.1.
AB062057 mRNA. Translation: BAB55824.1.
CH471141 Genomic DNA. Translation: EAW59438.1.
BC018036 mRNA. Translation: AAH18036.1.
CCDSCCDS14248.1.
PIRI39368.
RefSeqNP_004606.2. NM_004615.3.
UniGeneHs.441664.

3D structure databases

ProteinModelPortalP41732.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112957. 4 interactions.
IntActP41732. 2 interactions.
MINTMINT-1379586.
STRING9606.ENSP00000367743.

Protein family/group databases

TCDB8.A.40.1.2. the tetraspanin (tetraspanin) family.

PTM databases

PhosphoSiteP41732.

Polymorphism databases

DMDM17380550.

Proteomic databases

MaxQBP41732.
PaxDbP41732.
PRIDEP41732.

Protocols and materials databases

DNASU7102.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378482; ENSP00000367743; ENSG00000156298.
GeneID7102.
KEGGhsa:7102.
UCSCuc004deg.4. human.

Organism-specific databases

CTD7102.
GeneCardsGC0XP038420.
HGNCHGNC:11854. TSPAN7.
HPACAB062566.
HPA003140.
MIM300096. gene.
300210. phenotype.
neXtProtNX_P41732.
Orphanet777. X-linked non-syndromic intellectual disability.
PharmGKBPA36555.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274015.
HOGENOMHOG000230656.
HOVERGENHBG107306.
InParanoidP41732.
KOK06571.
OrthoDBEOG73BVDM.
PhylomeDBP41732.
TreeFamTF352891.

Gene expression databases

ArrayExpressP41732.
BgeeP41732.
CleanExHS_TSPAN7.
GenevestigatorP41732.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTSPAN7. human.
GeneWikiTSPAN7.
GenomeRNAi7102.
NextBio27785.
PROP41732.
SOURCESearch...

Entry information

Entry nameTSN7_HUMAN
AccessionPrimary (citable) accession number: P41732
Secondary accession number(s): B2R5W7 expand/collapse secondary AC list , D3DWB1, Q8WVG5, Q9UEY9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 16, 2001
Last modified: July 9, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries