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P41731 (CD63_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD63 antigen
Alternative name(s):
CD_antigen=CD63
Gene names
Name:Cd63
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play some role in signal transduction pathways.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Lysosome membrane; Multi-pass membrane protein By similarity. Late endosome membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Strongly expressed in kidney.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 238237CD63 antigen
PRO_0000219217

Regions

Topological domain2 – 1110Cytoplasmic Potential
Transmembrane12 – 3221Helical; Potential
Topological domain33 – 5119Extracellular Potential
Transmembrane52 – 7221Helical; Potential
Topological domain73 – 819Cytoplasmic Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 203101Extracellular Potential
Transmembrane204 – 22421Helical; Potential
Topological domain225 – 23814Cytoplasmic Potential

Amino acid modifications

Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Ref.3
Glycosylation1501N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P41731 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: B57E47B31E13EED8

FASTA23825,767
        10         20         30         40         50         60 
MAVEGGMKCV KFLLYVLLLA FCACAVGLIA IGVAVQVVLK QAITHETTAG SLLPVVIIAV 

        70         80         90        100        110        120 
GAFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAV AIAGYVFRDQ VKSEFNKSFQ 

       130        140        150        160        170        180 
QQMQNYLKDN KTATILDKLQ KENNCCGASN YTDWENIPGM AKDRVPDSCC INITVGCGND 

       190        200        210        220        230 
FKESTIHTQG CVETIAIWLR KNILLVAAAA LGIAFVEVLG IIFSCCLVKS IRSGYEVM 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages."
Miyamoto M., Homma M., Hotta H.
Biochim. Biophys. Acta 1217:312-316(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon and Mammary gland.
[3]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-130.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16432 mRNA. Translation: BAA03904.1.
BC008108 mRNA. Translation: AAH08108.1.
BC012212 mRNA. Translation: AAH12212.1.
BC083161 mRNA. Translation: AAH83161.1.
PIRS43511.
RefSeqNP_001036045.1. NM_001042580.1.
NP_001269895.1. NM_001282966.1.
NP_031679.1. NM_007653.3.
UniGeneMm.371552.
Mm.416079.

3D structure databases

ProteinModelPortalP41731.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP41731. 2 interactions.

PTM databases

PhosphoSiteP41731.

Proteomic databases

PaxDbP41731.
PRIDEP41731.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026407; ENSMUSP00000026407; ENSMUSG00000025351.
ENSMUST00000105229; ENSMUSP00000100862; ENSMUSG00000025351.
GeneID12512.
KEGGmmu:12512.
UCSCuc007hou.1. mouse.

Organism-specific databases

CTD967.
MGIMGI:99529. Cd63.

Phylogenomic databases

eggNOGNOG268658.
HOVERGENHBG107306.
InParanoidP41731.
KOK06497.
OMAVTQGCGI.
OrthoDBEOG73BVDM.
TreeFamTF316345.

Gene expression databases

ArrayExpressP41731.
BgeeP41731.
CleanExMM_CD63.
GenevestigatorP41731.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281496.
PROP41731.
SOURCESearch...

Entry information

Entry nameCD63_MOUSE
AccessionPrimary (citable) accession number: P41731
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot