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Protein

Bud site selection protein 6

Gene

BUD6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not essential for mitotic growth but is necessary for normal morphogenesis. Involved in the organization and/or function of the actin cytoskeleton.

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • actin binding Source: SGD
  • cytoskeletal regulatory protein binding Source: SGD
  • enzyme activator activity Source: SGD

GO - Biological processi

  • actin filament bundle assembly Source: SGD
  • astral microtubule organization Source: SGD
  • bipolar cellular bud site selection Source: SGD
  • budding cell apical bud growth Source: SGD
  • establishment of cell polarity Source: SGD
  • extrachromosomal circular DNA localization involved in cell aging Source: SGD
  • positive regulation of actin cytoskeleton reorganization Source: SGD
  • positive regulation of formin-nucleated actin cable assembly Source: SGD
  • pseudohyphal growth Source: SGD
  • regulation of actin nucleation Source: InterPro
  • regulation of protein localization Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32403-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Bud site selection protein 6
Alternative name(s):
Actin-interacting protein 3
Gene namesi
Name:BUD6
Synonyms:AIP3
Ordered Locus Names:YLR319C
ORF Names:L8543.5
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR319C
SGDiS000004311 BUD6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000650181 – 788Bud site selection protein 6Add BLAST788

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphothreonineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41697
PaxDbiP41697
PRIDEiP41697

PTM databases

iPTMnetiP41697

Interactioni

GO - Molecular functioni

  • actin binding Source: SGD
  • cytoskeletal regulatory protein binding Source: SGD

Protein-protein interaction databases

BioGridi31583, 173 interactors
DIPiDIP-880N
IntActiP41697, 7 interactors
MINTiP41697
STRINGi4932.YLR319C

Structurei

Secondary structure

1788
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi555 – 594Combined sources40
Helixi600 – 676Combined sources77
Helixi701 – 713Combined sources13
Helixi719 – 733Combined sources15
Turni734 – 737Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OKQX-ray2.04A549-688[»]
3ONXX-ray2.90A/B549-688[»]
4WYBX-ray3.49B/D/F/H/J/L/N/P/R/T/V/Y699-788[»]
ProteinModelPortaliP41697
SMRiP41697
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41697

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili573 – 628Sequence analysisAdd BLAST56

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000001134
InParanoidiP41697
OMAiNLACRAF
OrthoDBiEOG092C0X7Y

Family and domain databases

InterProiView protein in InterPro
IPR022782 AIP3-like_C
IPR005613 AIP3_C
PfamiView protein in Pfam
PF03915 AIP3, 1 hit
SMARTiView protein in SMART
SM00806 AIP3, 1 hit

Sequencei

Sequence statusi: Complete.

P41697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMAVDDPTY GTPKIKRTAS SSSSIETTVT KLLMSTKHLL QVLTQWSKGT
60 70 80 90 100
TSGRLVSDAY VQLGNDFKVV SKFFMHAKVD MSDVGDVPMA LRRVLEVTLR
110 120 130 140 150
EPPSDETLNK HLPKIREIIV TLLDKLKVKQ AILKNMQQEH RISVKSHHQQ
160 170 180 190 200
NPSFTSNLSL GSEGTREGTP LSSRKSSIVR DQRQSDSVEN SYGEKVNSTS
210 220 230 240 250
TGTPSAQSAE ATLTKPRTNI KQNLKSNNAP NASDDDDALS QLKKGTNLQR
260 270 280 290 300
RASKRYSAYH MAKLTNQSTT EAAAAAGLMT TPSPSMLHLE ETVRKSKLYG
310 320 330 340 350
NNNNDDDRNI NSAENKGKSI DDVSKASPLA KTPLPIENVR ASPRRLSSVV
360 370 380 390 400
TTSPDKAMNG TCPVFLRIGD KTKKCHVQLP TTKNALRLLF IERFAYSPGA
410 420 430 440 450
NSFPDIYIMD PQYGVFYELE ELNLLDIKEG FVIELKLEEN PNNTIKEFID
460 470 480 490 500
TVKMEISNSQ NDIIRHLKEM SFGSAISGKQ TEVLPQPGLE ANKHDLVGQN
510 520 530 540 550
KKDDDKTIKD IQYELGKIKQ VHNINRSNIN ETIFNILRKV DNFKSLSFSA
560 570 580 590 600
KNSSNRMYME KSQTELGDLS DTLLSKVDDL QDVIEIMRKD VAERRSQPAK
610 620 630 640 650
KKLETVSKDL ENAQADVLKL QEFIDTEKPH WKKTWEAELD KVCEEQQFLT
660 670 680 690 700
LQEELILDLK EDLGKALETF DLIKLCCEEQ EKNPSRSKSN PILPIMRPGT
710 720 730 740 750
FNQVREQVMV AVQSLNPDHD SRVEAIDKAE KMWEMERKLK ASNEFDDELE
760 770 780
NFVGNSNLKK SGGFEEVERI RKQKDEANLR AYFGPGFT
Length:788
Mass (Da):88,817
Last modified:November 1, 1995 - v1
Checksum:i4BAE8F541B8BDF1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti376Missing in AAB04948 (PubMed:9247651).Curated1
Sequence conflicti384 – 385NA → KP in AAB04948 (PubMed:9247651).Curated2
Sequence conflicti434E → A in AAB04948 (PubMed:9247651).Curated1
Sequence conflicti441P → S in AAB04948 (PubMed:9247651).Curated1
Sequence conflicti454M → I in AAB04948 (PubMed:9247651).Curated1
Sequence conflicti565 – 568ELGD → SH in AAB04948 (PubMed:9247651).Curated4
Sequence conflicti742S → T in AAB04948 (PubMed:9247651).Curated1
Sequence conflicti764 – 788FEEVE…GPGFT → LKK in AAB04948 (PubMed:9247651).CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38903 Genomic DNA Translation: AAB04948.1
U35668 Genomic DNA Translation: AAA79143.1
U20618 Genomic DNA Translation: AAB64514.1
BK006945 Genomic DNA Translation: DAA09628.1
PIRiS53397
RefSeqiNP_013423.1, NM_001182208.1

Genome annotation databases

EnsemblFungiiYLR319C; YLR319C; YLR319C
GeneIDi851029
KEGGisce:YLR319C

Similar proteinsi

Entry informationi

Entry nameiBUD6_YEAST
AccessioniPrimary (citable) accession number: P41697
Secondary accession number(s): D6VYW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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