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P41694 (IGF2_NEOVI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Insulin-like growth factor II

Short name=IGF-II

Cleaved into the following 2 chains:

  1. Insulin-like growth factor II
  2. Preptin
Gene names
Name:IGF2
OrganismNeovison vison (American mink) (Mustela vison)
Taxonomic identifier452646 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeNeovison

Protein attributes

Sequence length129 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.

Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the insulin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 9268Insulin-like growth factor II
PRO_0000015722
Propeptide93 – ›129›37E peptide By similarity
PRO_0000015723
Peptide94 – 12734Preptin
PRO_0000370378

Regions

Region25 – 5228B
Region53 – 6513C
Region66 – 8621A
Region87 – 926D

Amino acid modifications

Disulfide bond33 ↔ 72 By similarity
Disulfide bond45 ↔ 85 By similarity
Disulfide bond71 ↔ 76 By similarity

Experimental info

Non-terminal residue1291

Sequences

Sequence LengthMass (Da)Tools
P41694 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: FD06661DAFB473D0

FASTA12914,437
        10         20         30         40         50         60 
MGVPMGKSLL APLTFLALAS CCFAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS 

        70         80         90        100        110        120 
RRSSRGIVEE CCFRSCDLAL LETYCATPAK SERDVSTPPT VLPDNFPRYP VGKFFQYDTW 


KQSAQRLRR 

« Hide

References

[1]"Insulin-like growth factor II in the mink (Mustela vison): determination of a cDNA nucleotide sequence and developmental regulation of its expression."
Ekstroem T.J., Baecklin B.M., Lindqvist Y., Engstroem W.
Gen. Comp. Endocrinol. 90:243-250(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S63459 mRNA. Translation: AAB27392.2.

3D structure databases

ProteinModelPortalP41694.
SMRP41694. Positions 25-92.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP41694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006137.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIGF2_NEOVI
AccessionPrimary (citable) accession number: P41694
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families