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Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Neovison vison (American mink) (Mustela vison)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone, Mitogen
Biological processCarbohydrate metabolism, Glucose metabolism, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Cleaved into the following 2 chains:
Gene namesi
Name:IGF2
OrganismiNeovison vison (American mink) (Mustela vison)
Taxonomic identifieri452646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeNeovison

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001572225 – 92Insulin-like growth factor IIAdd BLAST68
PropeptideiPRO_000001572393 – ›129E peptideBy similarityAdd BLAST›37
PeptideiPRO_000037037894 – 127PreptinAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 72By similarity
Disulfide bondi45 ↔ 85By similarity
Disulfide bondi71 ↔ 76By similarity

Post-translational modificationi

Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-129 and Arg-92 to generate big-IGF2 and mature IGF2.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP41694.
SMRiP41694.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 52BAdd BLAST28
Regioni53 – 65CAdd BLAST13
Regioni66 – 86AAdd BLAST21
Regioni87 – 92D6

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188. IGF2_C. 1 hit.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41694-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPMGKSLL APLTFLALAS CCFAAYRPSE TLCGGELVDT LQFVCGDRGF
60 70 80 90 100
YFSRPASRVS RRSSRGIVEE CCFRSCDLAL LETYCATPAK SERDVSTPPT
110 120
VLPDNFPRYP VGKFFQYDTW KQSAQRLRR
Length:129
Mass (Da):14,437
Last modified:November 1, 1995 - v1
Checksum:iFD06661DAFB473D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1291

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63459 mRNA. Translation: AAB27392.2.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIGF2_NEOVI
AccessioniPrimary (citable) accession number: P41694
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families