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Protein

Interleukin-1 beta

Gene

IL1B

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei170Important for interaction with integrinBy similarity1
Sitei178Important for interaction with integrinBy similarity1
Sitei189Important for interaction with integrinBy similarity1
Sitei203Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:IL1B
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152971 – 115By similarityAdd BLAST115
ChainiPRO_0000015298116 – 267Interleukin-1 betaAdd BLAST152

Interactioni

Subunit structurei

Monomer. Interacts with MEFV. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000005482

Structurei

3D structure databases

ProteinModelPortaliP41687
SMRiP41687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGSZ Eukaryota
ENOG410XU2E LUCA
HOGENOMiHOG000246399
HOVERGENiHBG007328
InParanoidiP41687
KOiK04519
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR003296 IL-1_beta
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR44849 PTHR44849, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVPELTSE MMAYYSDEND LFFEADGPEK MKGSLQNLSH SFLGDEGIQL
60 70 80 90 100
QISHQPDNKS LRHAVSVIVA MEKLKKISFA CSQPLQDEDL KSLFCCIFEE
110 120 130 140 150
EPIICDTWDD GFVCDAAIQS QDYTFRDISQ KSLVLSGSYE LRALHLNGQN
160 170 180 190 200
MNQQVVFRMS FVHGEENSKK IPVVLCIKKN NLYLSCVMKD GKPTLQLEML
210 220 230 240 250
DPKVYPKKKM EKRFVFNKTE IKGNVEFESS QFPNWYISTS QAEEMPVFLG
260
NTKGGQDITD FIMESAS
Length:267
Mass (Da):30,362
Last modified:November 1, 1995 - v1
Checksum:i781F9971E32F6AE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92060 mRNA Translation: AAA30814.1
RefSeqiNP_001070882.1, NM_001077414.1

Genome annotation databases

GeneIDi768274
KEGGifca:768274

Similar proteinsi

Entry informationi

Entry nameiIL1B_FELCA
AccessioniPrimary (citable) accession number: P41687
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health