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Protein

Interleukin-6

Gene

IL6

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001558028 – 208Interleukin-6Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 74By similarity
Modified residuei77PhosphoserineBy similarity1
Disulfide bondi97 ↔ 107By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000022423.

Structurei

3D structure databases

ProteinModelPortaliP41683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOVERGENiHBG000471.
InParanoidiP41683.
KOiK05405.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFLSTSAFS PLAFSLGLLL VVATAFPTPG PLGGDATSNR LPLTSADKME
60 70 80 90 100
ELIKYILGKI SALKKEMCDN YNKCEDSKEA LAENNLNLPK LAEKDGCFQS
110 120 130 140 150
GFNQETCLTR ITTGLQEFQI YLKFLQDKYE GDEENAKSVY TSTNVLLQML
160 170 180 190 200
KRKGKNQDEV TIPVPTVEVG LQAKLQSQEE WLRHTTIHLT LRRLEDFLQF

SLRAVRIM
Length:208
Mass (Da):23,401
Last modified:November 1, 1995 - v1
Checksum:i93B4456B2989CA4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → N in AAA16620 (PubMed:8234373).Curated1
Sequence conflicti45S → P in AAA16620 (PubMed:8234373).Curated1
Sequence conflicti133E → K in AAA16620 (PubMed:8234373).Curated1
Sequence conflicti173 – 187AKLQS…RHTTI → LSCSHRRVAEAHNN in AAA16620 (PubMed:8234373).CuratedAdd BLAST15
Sequence conflicti200 – 201FS → LR in AAA16620 (PubMed:8234373).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16914 mRNA. Translation: AAA16620.1.
D13227 mRNA. Translation: BAA02507.1.
PIRiI46084.
RefSeqiNP_001009211.1. NM_001009211.1.

Genome annotation databases

GeneIDi493687.
KEGGifca:493687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16914 mRNA. Translation: AAA16620.1.
D13227 mRNA. Translation: BAA02507.1.
PIRiI46084.
RefSeqiNP_001009211.1. NM_001009211.1.

3D structure databases

ProteinModelPortaliP41683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000022423.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493687.
KEGGifca:493687.

Organism-specific databases

CTDi3569.

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOVERGENiHBG000471.
InParanoidiP41683.
KOiK05405.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL6_FELCA
AccessioniPrimary (citable) accession number: P41683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.