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Protein

Alcohol dehydrogenase 6

Gene

ADH6

Organism
Peromyscus maniculatus (North American deer mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi175Zinc 1; catalyticBy similarity1
Binding sitei224NADBy similarity1
Binding sitei229NADBy similarity1
Binding sitei370NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NADBy similarity6
Nucleotide bindingi293 – 295NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 6 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase 2
Short name:
ADH-2
Gene namesi
Name:ADH6
OrganismiPeromyscus maniculatus (North American deer mouse)
Taxonomic identifieri10042 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeNeotominaePeromyscus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606891 – 375Alcohol dehydrogenase 6Add BLAST375

Structurei

3D structure databases

ProteinModelPortaliP41681.
SMRiP41681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P41681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAGKVIRC KAAVLWKPGA PLTMEEIDVA PPKGKEVRVK MVAAGICGTD
60 70 80 90 100
IKSLDNKKLA PFCPIIMGHE GTGIVESVGE GVSTVKTGDK VIILCLPQCG
110 120 130 140 150
ECNTCLNSKN NICKEVRLSG THLTSEGNSR ITCKGKTTYQ YITTGTFSEY
160 170 180 190 200
IVIKEISVAK VDEDALLEKA CIIGCGFATG FGAAINSAKV SPGSTCAVFG
210 220 230 240 250
LGGVGLSVIM GCKAAGAARI IAVDTNKDKF AKAKTVGATE CIDPQDFEKP
260 270 280 290 300
IQQVLFDMMN DGADFTFEVT GNPETVETAL ASCHKDHGVC VIVGSLASWI
310 320 330 340 350
QLNINSHLFF SGRTLKGSVL GGWKTKEEIP KLVSDYTAKK FNLDPLITHT
360 370
LTLDKVNEAI QLMKNGQCIR CVLLP
Length:375
Mass (Da):39,828
Last modified:November 1, 1995 - v1
Checksum:iF0194982C94DE279
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15704 mRNA. Translation: AAA40592.1.
PIRiB49107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15704 mRNA. Translation: AAA40592.1.
PIRiB49107.

3D structure databases

ProteinModelPortaliP41681.
SMRiP41681.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000195.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH6_PERMA
AccessioniPrimary (citable) accession number: P41681
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.