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Reviewed, UniProtKB/Swiss-Prot P41680 (ADH1_PERMA)

Last modified November 25, 2008. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase A subunit
Gene names
Name: ADH1
Synonyms: ADH-1
OrganismPeromyscus maniculatus (Deer mouse)
Taxonomic identifier10042 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Neotominae › Peromyscus

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Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD(+) = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

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Ontologies

Keywords

   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 375374Alcohol dehydrogenase 1
PRO_0000160667

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding681Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1751Zinc 1; catalytic By similarity

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Sequences

Sequence LengthMass (Da)Tools
P41680-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: BA6878B0A071F901

FASTA37539,834
        10         20         30         40         50         60 
MSTAGKVIKC KAAVLWEPHK PFSIEDIEVA PPKAHEVRIK MVATGVCRSD DHVVSRSLAS 

        70         80         90        100        110        120 
PLPAVLGHEG AGIVESVGEG VTSVKPGDKV IPLFTPQCGK CRICKHPEYN LCMKNDLMQP 

       130        140        150        160        170        180 
RGTLLDGTSR FTCRGKAIHN FISTSTFSQY TVVDEMAVAK IDGASPLEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVKVAKV TPGSTCAVFG LGGVGLSVII GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CINPLDYSKP IQEVLQEMTD GGVDFSFEVI GRLDTMTSSL LSCHASCGVS VIVGVPPNAQ 

       310        320        330        340        350        360 
SLSVNPMSLL MGRSWKGAIF GGFKSKDSVP KLVTDFMAKK FPLEPLITHV LPFEKINEAF 

       370 
DLLRAGKSIR TVLTF

« Hide

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References

[1]"Molecular basis of the alcohol dehydrogenase-negative deer mouse. Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme class."
Zheng Y.W., Bey M., Liu H., Felder M.R.
J. Biol. Chem. 268:24933-24939(1993) [PubMed: 8227055] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

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Cross-references

Sequence databases

L15703 mRNA. Translation: AAA40591.1.
PIRA49107.

3D structure databases

HSSPHSSP built from PDB template 1HT0 based on UniProtKB P00326.
SMRP41680. Positions 2-375.
ModBaseSearch...

Phylogenomic databases

HOVERGENP41680.

Family and domain databases

InterProIPR013154. AlcDHase_GroES-like.
IPR002085. AlcDHase_SF_Zn.
IPR013149. AlcDHase_Zn-bd.
IPR002328. AlcDHase_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH1_PERMA
AccessionPrimary (citable) accession number: P41680
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 25, 2008
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents