Reviewed, UniProtKB/Swiss-Prot P41654 (PUR6_METTH)

Names and origin

Protein names

Recommended name:
    Probable phosphoribosylaminoimidazole carboxylase
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:	purE
Ordered Locus Names:	MTH_1393

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Probable phosphoribosylaminoimidazole carboxylase		PRO_0000074992
Sites
	Binding site	11	1	Substrate By similarity
	Binding site	14	1	Substrate By similarity
	Binding site	41	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41654-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 502E0E964ECC7A65	FASTA	334	36,245
	10 20 30 40 50 60 MKPRVMILLG SASDFRIAEK AMEIFEELRI PYDLRVASAH RTHEKVKAIV SEAVKAGVEV 70 80 90 100 110 120 FIGIAGLSAH LPGMISANTH RPVIGVPVDV KLGGLDALFA CSQMPFPAPV ATVGVDRGEN 130 140 150 160 170 180 AAILAAQIIG IGDPGVRERV ADLRRGFYER VRRDECQVLN SIEGSYYAPL EVEMPPIGDK 190 200 210 220 230 240 VPSDSQDDPM VSVIPGSYSD MKIAKKTTMF LERMGISYDL NVISPIRYPE RFERYLEKME 250 260 270 280 290 300 NVKLFIAISG LSAHVTGAVV ALSDRPVIGV PCPLKMNGWD SLLSMINMPP GVPVGTVGVG 310 320 330 NGGNAAILAA EMLGIYDEKI ESRIKRIKSR SVKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence divergence of an archaebacterial gene cloned from a mesophilic and a thermophilic methanogen." Hamilton P.T., Reeve J.N. J. Mol. Evol. 22:351-360(1985) [PubMed: 3936936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Delta H.
[2]	"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X03250 Genomic DNA. Translation: CAA27010.1. AE000666 Genomic DNA. Translation: AAB85870.1. Different initiation.
PIR	D69052.
RefSeq	NP_276509.1.
3D structure databases
HSSP	HSSP built from PDB template 1O4V based on UniProtKB Q9WYS7.
ModBase	Search...
Protein-protein interaction databases
STRING	P41654.
Genome annotation databases
GeneID	1471110.
GenomeReviews	Gene locus MTH_1393 in contig AE000666_GR.
KEGG	mth:MTH1393.
NMPDR	fig|187420.1.peg.1364.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P41654.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH1393-MON.
BRENDA	4.1.1.21. 270.
Family and domain databases
InterPro	IPR000031. AIR_COase_core. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 2 hits.
PANTHER	PTHR23046. AIR_carboxyl. 1 hit.
Pfam	PF00731. AIRC. 2 hits. [Graphical view]
ProDom	PD002193. AIR_carboxyl. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01162. purE. 2 hits.
ProtoNet	Search...

Entry information

Entry name

PUR6_METTH

Accession

Primary (citable) accession number: P41654

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	September 1, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)