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P41597

- CCR2_HUMAN

UniProt

P41597 - CCR2_HUMAN

Protein

C-C chemokine receptor type 2

Gene

CCR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.1 Publication

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: InterPro
    2. CCR2 chemokine receptor binding Source: MGI
    3. chemokine receptor activity Source: ProtInc
    4. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. blood vessel remodeling Source: BHF-UCL
    2. cellular calcium ion homeostasis Source: BHF-UCL
    3. cellular defense response Source: ProtInc
    4. cellular homeostasis Source: BHF-UCL
    5. chemokine-mediated signaling pathway Source: BHF-UCL
    6. chemotaxis Source: ProtInc
    7. cytokine-mediated signaling pathway Source: MGI
    8. dendritic cell chemotaxis Source: BHF-UCL
    9. immune response Source: ProtInc
    10. inflammatory response Source: ProtInc
    11. innate immune response Source: Reactome
    12. JAK-STAT cascade Source: ProtInc
    13. negative regulation of adenylate cyclase activity Source: ProtInc
    14. negative regulation of angiogenesis Source: BHF-UCL
    15. negative regulation of eosinophil degranulation Source: BHF-UCL
    16. negative regulation of type 2 immune response Source: BHF-UCL
    17. positive regulation of alpha-beta T cell proliferation Source: BHF-UCL
    18. positive regulation of astrocyte chemotaxis Source: BHF-UCL
    19. positive regulation of CD8-positive, alpha-beta T cell extravasation Source: BHF-UCL
    20. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    21. positive regulation of hematopoietic stem cell migration Source: BHF-UCL
    22. positive regulation of immune complex clearance by monocytes and macrophages Source: BHF-UCL
    23. positive regulation of inflammatory response Source: BHF-UCL
    24. positive regulation of interferon-gamma production Source: BHF-UCL
    25. positive regulation of interleukin-2 production Source: BHF-UCL
    26. positive regulation of monocyte chemotaxis Source: UniProtKB
    27. positive regulation of monocyte extravasation Source: BHF-UCL
    28. positive regulation of T cell activation Source: BHF-UCL
    29. positive regulation of T cell chemotaxis Source: BHF-UCL
    30. positive regulation of T-helper 1 type immune response Source: BHF-UCL
    31. positive regulation of tumor necrosis factor biosynthetic process Source: BHF-UCL
    32. regulation of vascular endothelial growth factor production Source: BHF-UCL
    33. response to wounding Source: ProtInc
    34. T-helper 17 cell chemotaxis Source: BHF-UCL
    35. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Host-virus interaction

    Enzyme and pathway databases

    ReactomeiREACT_115897. Beta defensins.
    REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 2
    Short name:
    C-C CKR-2
    Short name:
    CC-CKR-2
    Short name:
    CCR-2
    Short name:
    CCR2
    Alternative name(s):
    Monocyte chemoattractant protein 1 receptor
    Short name:
    MCP-1-R
    CD_antigen: CD192
    Gene namesi
    Name:CCR2
    Synonyms:CMKBR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1603. CCR2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: BHF-UCL
    3. dendrite Source: BHF-UCL
    4. integral component of membrane Source: ProtInc
    5. integral component of plasma membrane Source: ProtInc
    6. neuronal cell body Source: BHF-UCL
    7. perikaryon Source: BHF-UCL
    8. perinuclear region of cytoplasm Source: BHF-UCL
    9. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi609423. phenotype.
    PharmGKBiPA26167.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374C-C chemokine receptor type 2PRO_0000069232Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Modified residuei26 – 261Sulfotyrosine2 Publications
    Disulfide bondi32 ↔ 277
    Disulfide bondi113 ↔ 190
    Modified residuei139 – 1391Phosphotyrosine; by JAK21 Publication

    Post-translational modificationi

    N-glycosylated.1 Publication
    Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

    Proteomic databases

    PaxDbiP41597.
    PRIDEiP41597.

    PTM databases

    PhosphoSiteiP41597.

    Expressioni

    Inductioni

    Up-regulated by CREB3.1 Publication

    Gene expression databases

    ArrayExpressiP41597.
    BgeeiP41597.
    CleanExiHS_CCR2.
    GenevestigatoriP41597.

    Organism-specific databases

    HPAiCAB003793.

    Interactioni

    Subunit structurei

    Binds to HIV-1 Tat. Interacts with ARRB1.2 Publications

    Protein-protein interaction databases

    DIPiDIP-5833N.
    DIP-5839N.
    MINTiMINT-5005983.
    STRINGi9606.ENSP00000292301.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KADmodel-A1-343[»]
    1KP1model-A1-343[»]
    ProteinModelPortaliP41597.
    SMRiP41597. Positions 2-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini71 – 8010CytoplasmicSequence Analysis
    Topological domaini101 – 11414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 20628ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28517ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 37465CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 7028Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10020Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17825Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei207 – 22620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26825Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30924Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP41597.
    KOiK04177.
    OMAiGWKNFHT.
    OrthoDBiEOG738051.
    PhylomeDBiP41597.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002237. Chemokine_CCR2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01107. CHEMOKINER2.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: P41597-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSTSRSRFI RNTNESGEEV TTFFDYDYGA PCHKFDVKQI GAQLLPPLYS    50
    LVFIFGFVGN MLVVLILINC KKLKCLTDIY LLNLAISDLL FLITLPLWAH 100
    SAANEWVFGN AMCKLFTGLY HIGYFGGIFF IILLTIDRYL AIVHAVFALK 150
    ARTVTFGVVT SVITWLVAVF ASVPGIIFTK CQKEDSVYVC GPYFPRGWNN 200
    FHTIMRNILG LVLPLLIMVI CYSGILKTLL RCRNEKKRHR AVRVIFTIMI 250
    VYFLFWTPYN IVILLNTFQE FFGLSNCEST SQLDQATQVT ETLGMTHCCI 300
    NPIIYAFVGE KFRSLFHIAL GCRIAPLQKP VCGGPGVRPG KNVKVTTQGL 350
    LDGRGKGKSI GRAPEASLQD KEGA 374
    Length:374
    Mass (Da):41,915
    Last modified:November 1, 1995 - v1
    Checksum:iF865E0D39E74CF0F
    GO
    Isoform B (identifier: P41597-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         314-374: SLFHIALGCR...EASLQDKEGA → RYLSVFFRKH...TGEQEVSAGL

    Show »
    Length:360
    Mass (Da):41,064
    Checksum:iEA352636D724D470
    GO

    Polymorphismi

    Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIMi:609423].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451L → V.
    Corresponds to variant rs4987052 [ dbSNP | Ensembl ].
    VAR_020066
    Natural varianti64 – 641V → I Confers relative resistance to infection by HIV-1; delay in disease progression in African Americans but not in Caucasians. 3 Publications
    Corresponds to variant rs1799864 [ dbSNP | Ensembl ].
    VAR_014339
    Natural varianti355 – 3551G → E.1 Publication
    Corresponds to variant rs3918387 [ dbSNP | Ensembl ].
    VAR_014340

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei314 – 37461SLFHI…DKEGA → RYLSVFFRKHITKRFCKQCP VFYRETVDGVTSTNTPSTGE QEVSAGL in isoform B. 1 PublicationVSP_001893Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03882 mRNA. Translation: AAA19119.1.
    U03905 mRNA. Translation: AAA19120.1.
    D29984 mRNA. Translation: BAA06253.1.
    U80924 Genomic DNA. Translation: AAC51637.1.
    U80924 Genomic DNA. Translation: AAC51636.1.
    AF545480 Genomic DNA. Translation: AAN16400.1.
    AK292685 mRNA. Translation: BAF85374.1.
    AK292920 mRNA. Translation: BAF85609.1.
    U95626 Genomic DNA. Translation: AAB57791.1.
    U95626 Genomic DNA. Translation: AAB57792.1.
    CH471055 Genomic DNA. Translation: EAW64760.1.
    BC074751 mRNA. Translation: AAH74751.1.
    BC095540 mRNA. Translation: AAH95540.1.
    BC126452 mRNA. Translation: AAI26453.1.
    BC136396 mRNA. Translation: AAI36397.1.
    CCDSiCCDS43078.1. [P41597-1]
    CCDS46813.1. [P41597-2]
    PIRiI38450.
    JC2443.
    RefSeqiNP_001116513.2. NM_001123041.2. [P41597-1]
    NP_001116868.1. NM_001123396.1. [P41597-2]
    UniGeneiHs.511794.
    Hs.705362.

    Genome annotation databases

    EnsembliENST00000292301; ENSP00000292301; ENSG00000121807. [P41597-1]
    ENST00000400888; ENSP00000383681; ENSG00000121807. [P41597-1]
    ENST00000445132; ENSP00000399285; ENSG00000121807. [P41597-2]
    GeneIDi729230.
    KEGGihsa:729230.
    UCSCiuc003cpm.4. human. [P41597-2]
    uc003cpn.4. human. [P41597-1]

    Polymorphism databases

    DMDMi1168965.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CC chemokine receptors entry

    SeattleSNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03882 mRNA. Translation: AAA19119.1 .
    U03905 mRNA. Translation: AAA19120.1 .
    D29984 mRNA. Translation: BAA06253.1 .
    U80924 Genomic DNA. Translation: AAC51637.1 .
    U80924 Genomic DNA. Translation: AAC51636.1 .
    AF545480 Genomic DNA. Translation: AAN16400.1 .
    AK292685 mRNA. Translation: BAF85374.1 .
    AK292920 mRNA. Translation: BAF85609.1 .
    U95626 Genomic DNA. Translation: AAB57791.1 .
    U95626 Genomic DNA. Translation: AAB57792.1 .
    CH471055 Genomic DNA. Translation: EAW64760.1 .
    BC074751 mRNA. Translation: AAH74751.1 .
    BC095540 mRNA. Translation: AAH95540.1 .
    BC126452 mRNA. Translation: AAI26453.1 .
    BC136396 mRNA. Translation: AAI36397.1 .
    CCDSi CCDS43078.1. [P41597-1 ]
    CCDS46813.1. [P41597-2 ]
    PIRi I38450.
    JC2443.
    RefSeqi NP_001116513.2. NM_001123041.2. [P41597-1 ]
    NP_001116868.1. NM_001123396.1. [P41597-2 ]
    UniGenei Hs.511794.
    Hs.705362.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KAD model - A 1-343 [» ]
    1KP1 model - A 1-343 [» ]
    ProteinModelPortali P41597.
    SMRi P41597. Positions 2-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5833N.
    DIP-5839N.
    MINTi MINT-5005983.
    STRINGi 9606.ENSP00000292301.

    Chemistry

    BindingDBi P41597.
    ChEMBLi CHEMBL4015.
    GuidetoPHARMACOLOGYi 59.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P41597.

    Polymorphism databases

    DMDMi 1168965.

    Proteomic databases

    PaxDbi P41597.
    PRIDEi P41597.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292301 ; ENSP00000292301 ; ENSG00000121807 . [P41597-1 ]
    ENST00000400888 ; ENSP00000383681 ; ENSG00000121807 . [P41597-1 ]
    ENST00000445132 ; ENSP00000399285 ; ENSG00000121807 . [P41597-2 ]
    GeneIDi 729230.
    KEGGi hsa:729230.
    UCSCi uc003cpm.4. human. [P41597-2 ]
    uc003cpn.4. human. [P41597-1 ]

    Organism-specific databases

    CTDi 729230.
    GeneCardsi GC03P046356.
    HGNCi HGNC:1603. CCR2.
    HPAi CAB003793.
    MIMi 601267. gene.
    609423. phenotype.
    neXtProti NX_P41597.
    PharmGKBi PA26167.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148353.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P41597.
    KOi K04177.
    OMAi GWKNFHT.
    OrthoDBi EOG738051.
    PhylomeDBi P41597.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_115897. Beta defensins.
    REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CCR2.
    GenomeRNAii 729230.
    NextBioi 129620.
    PROi P41597.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41597.
    Bgeei P41597.
    CleanExi HS_CCR2.
    Genevestigatori P41597.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002237. Chemokine_CCR2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01107. CHEMOKINER2.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails."
      Charo I.F., Myers S.J., Herman A., Franci C., Connolly A.J., Coughlin S.R.
      Proc. Natl. Acad. Sci. U.S.A. 91:2752-2756(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor."
      Yamagami S., Tokuda Y., Ishii K., Tamaka H., Endo N.
      Biochem. Biophys. Res. Commun. 202:1156-1162(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking."
      Wong L.-M., Myers S.J., Tsou C.-L., Gosling J., Arai H., Charo I.F.
      J. Biol. Chem. 272:1038-1045(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. SeattleSNPs variation discovery resource
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-64 AND GLU-355.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus and Trachea.
    6. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
    9. "The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor."
      Mellado M., Rodriguez-Frade J.M., Aragay A., del Real G., Martin A.M., Vila-Coro A.J., Serrano A., Mayor F. Jr., Martinez-A C.
      J. Immunol. 161:805-813(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-139 BY JAK2.
    10. "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2."
      Aragay A.M., Mellado M., Frade J.M., Martin A.M., Jimenez-Sainz M.C., Martinez-A C., Mayor F. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB1.
    11. Cited for: INTERACTION WITH HIV-1 TAT.
    12. "Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region."
      Preobrazhensky A.A., Dragan S., Kawano T., Gavrilin M.A., Gulina I.V., Chakravarty L., Kolattukudy P.E.
      J. Immunol. 165:5295-5303(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SULFATION AT TYR-26, GLYCOSYLATION.
    13. "Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."
      Sung H.J., Kim Y.S., Kang H., Ko J.
      Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INDUCTION.
    14. "Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1)."
      Tan J.H., Ludeman J.P., Wedderburn J., Canals M., Hall P., Butler S.J., Taleski D., Christopoulos A., Hickey M.J., Payne R.J., Stone M.J.
      J. Biol. Chem. 288:10024-10034(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SULFATION.
    15. Cited for: VARIANT ILE-64.
    16. "Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression."
      Mummidi S., Ahuja S.S., Gonzalez E., Anderson S.A., Santiago E.N., Stephan K.T., Craig F.E., O'Connell P., Tryon V., Clark R.A., Dolan M.J., Ahuja S.K.
      Nat. Med. 4:786-793(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ILE-64.

    Entry informationi

    Entry nameiCCR2_HUMAN
    AccessioniPrimary (citable) accession number: P41597
    Secondary accession number(s): A0AVQ3, B2RMT0, Q4VBL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 156 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    8. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3