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P41597

- CCR2_HUMAN

UniProt

P41597 - CCR2_HUMAN

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Protein

C-C chemokine receptor type 2

Gene

CCR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.1 Publication

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro
  2. CCR2 chemokine receptor binding Source: MGI
  3. chemokine receptor activity Source: ProtInc
  4. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. blood vessel remodeling Source: BHF-UCL
  2. cellular calcium ion homeostasis Source: BHF-UCL
  3. cellular defense response Source: ProtInc
  4. cellular homeostasis Source: BHF-UCL
  5. chemokine-mediated signaling pathway Source: BHF-UCL
  6. chemotaxis Source: ProtInc
  7. cytokine-mediated signaling pathway Source: MGI
  8. dendritic cell chemotaxis Source: BHF-UCL
  9. immune response Source: ProtInc
  10. inflammatory response Source: ProtInc
  11. innate immune response Source: Reactome
  12. JAK-STAT cascade Source: ProtInc
  13. negative regulation of adenylate cyclase activity Source: ProtInc
  14. negative regulation of angiogenesis Source: BHF-UCL
  15. negative regulation of eosinophil degranulation Source: BHF-UCL
  16. negative regulation of type 2 immune response Source: BHF-UCL
  17. positive regulation of alpha-beta T cell proliferation Source: BHF-UCL
  18. positive regulation of astrocyte chemotaxis Source: BHF-UCL
  19. positive regulation of CD8-positive, alpha-beta T cell extravasation Source: BHF-UCL
  20. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  21. positive regulation of hematopoietic stem cell migration Source: BHF-UCL
  22. positive regulation of immune complex clearance by monocytes and macrophages Source: BHF-UCL
  23. positive regulation of inflammatory response Source: BHF-UCL
  24. positive regulation of interferon-gamma production Source: BHF-UCL
  25. positive regulation of interleukin-2 production Source: BHF-UCL
  26. positive regulation of monocyte chemotaxis Source: UniProtKB
  27. positive regulation of monocyte extravasation Source: BHF-UCL
  28. positive regulation of T cell activation Source: BHF-UCL
  29. positive regulation of T cell chemotaxis Source: BHF-UCL
  30. positive regulation of T-helper 1 type immune response Source: BHF-UCL
  31. positive regulation of tumor necrosis factor biosynthetic process Source: BHF-UCL
  32. regulation of vascular endothelial growth factor production Source: BHF-UCL
  33. response to wounding Source: ProtInc
  34. T-helper 17 cell chemotaxis Source: BHF-UCL
  35. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_115897. Beta defensins.
REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 2
Short name:
C-C CKR-2
Short name:
CC-CKR-2
Short name:
CCR-2
Short name:
CCR2
Alternative name(s):
Monocyte chemoattractant protein 1 receptor
Short name:
MCP-1-R
CD_antigen: CD192
Gene namesi
Name:CCR2
Synonyms:CMKBR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1603. CCR2.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: BHF-UCL
  3. dendrite Source: BHF-UCL
  4. integral component of membrane Source: ProtInc
  5. integral component of plasma membrane Source: ProtInc
  6. neuronal cell body Source: BHF-UCL
  7. perikaryon Source: BHF-UCL
  8. perinuclear region of cytoplasm Source: BHF-UCL
  9. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi609423. phenotype.
PharmGKBiPA26167.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374C-C chemokine receptor type 2PRO_0000069232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Modified residuei26 – 261Sulfotyrosine1 Publication
Disulfide bondi32 ↔ 277
Disulfide bondi113 ↔ 190
Modified residuei139 – 1391Phosphotyrosine; by JAK21 Publication

Post-translational modificationi

N-glycosylated.1 Publication
Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP41597.
PRIDEiP41597.

PTM databases

PhosphoSiteiP41597.

Expressioni

Inductioni

Up-regulated by CREB3.1 Publication

Gene expression databases

BgeeiP41597.
CleanExiHS_CCR2.
ExpressionAtlasiP41597. baseline and differential.
GenevestigatoriP41597.

Organism-specific databases

HPAiCAB003793.

Interactioni

Subunit structurei

Binds to HIV-1 Tat. Interacts with ARRB1.2 Publications

Protein-protein interaction databases

DIPiDIP-5833N.
DIP-5839N.
MINTiMINT-5005983.
STRINGi9606.ENSP00000292301.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KADmodel-A1-343[»]
1KP1model-A1-343[»]
ProteinModelPortaliP41597.
SMRiP41597. Positions 2-314.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
BLAST
Topological domaini71 – 8010CytoplasmicSequence Analysis
Topological domaini101 – 11414ExtracellularSequence AnalysisAdd
BLAST
Topological domaini137 – 15317CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini179 – 20628ExtracellularSequence AnalysisAdd
BLAST
Topological domaini227 – 24317CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini269 – 28517ExtracellularSequence AnalysisAdd
BLAST
Topological domaini310 – 37465CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 7028Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei81 – 10020Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei154 – 17825Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei207 – 22620Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei244 – 26825Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei286 – 30924Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP41597.
KOiK04177.
OMAiGWKNFHT.
OrthoDBiEOG738051.
PhylomeDBiP41597.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P41597-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSTSRSRFI RNTNESGEEV TTFFDYDYGA PCHKFDVKQI GAQLLPPLYS
60 70 80 90 100
LVFIFGFVGN MLVVLILINC KKLKCLTDIY LLNLAISDLL FLITLPLWAH
110 120 130 140 150
SAANEWVFGN AMCKLFTGLY HIGYFGGIFF IILLTIDRYL AIVHAVFALK
160 170 180 190 200
ARTVTFGVVT SVITWLVAVF ASVPGIIFTK CQKEDSVYVC GPYFPRGWNN
210 220 230 240 250
FHTIMRNILG LVLPLLIMVI CYSGILKTLL RCRNEKKRHR AVRVIFTIMI
260 270 280 290 300
VYFLFWTPYN IVILLNTFQE FFGLSNCEST SQLDQATQVT ETLGMTHCCI
310 320 330 340 350
NPIIYAFVGE KFRSLFHIAL GCRIAPLQKP VCGGPGVRPG KNVKVTTQGL
360 370
LDGRGKGKSI GRAPEASLQD KEGA
Length:374
Mass (Da):41,915
Last modified:November 1, 1995 - v1
Checksum:iF865E0D39E74CF0F
GO
Isoform B (identifier: P41597-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-374: SLFHIALGCR...EASLQDKEGA → RYLSVFFRKH...TGEQEVSAGL

Show »
Length:360
Mass (Da):41,064
Checksum:iEA352636D724D470
GO

Polymorphismi

Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIMi:609423].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451L → V.
Corresponds to variant rs4987052 [ dbSNP | Ensembl ].
VAR_020066
Natural varianti64 – 641V → I Confers relative resistance to infection by HIV-1; delay in disease progression in African Americans but not in Caucasians. 3 Publications
Corresponds to variant rs1799864 [ dbSNP | Ensembl ].
VAR_014339
Natural varianti355 – 3551G → E.1 Publication
Corresponds to variant rs3918387 [ dbSNP | Ensembl ].
VAR_014340

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei314 – 37461SLFHI…DKEGA → RYLSVFFRKHITKRFCKQCP VFYRETVDGVTSTNTPSTGE QEVSAGL in isoform B. 1 PublicationVSP_001893Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03882 mRNA. Translation: AAA19119.1.
U03905 mRNA. Translation: AAA19120.1.
D29984 mRNA. Translation: BAA06253.1.
U80924 Genomic DNA. Translation: AAC51637.1.
U80924 Genomic DNA. Translation: AAC51636.1.
AF545480 Genomic DNA. Translation: AAN16400.1.
AK292685 mRNA. Translation: BAF85374.1.
AK292920 mRNA. Translation: BAF85609.1.
U95626 Genomic DNA. Translation: AAB57791.1.
U95626 Genomic DNA. Translation: AAB57792.1.
CH471055 Genomic DNA. Translation: EAW64760.1.
BC074751 mRNA. Translation: AAH74751.1.
BC095540 mRNA. Translation: AAH95540.1.
BC126452 mRNA. Translation: AAI26453.1.
BC136396 mRNA. Translation: AAI36397.1.
CCDSiCCDS43078.1. [P41597-1]
CCDS46813.1. [P41597-2]
PIRiI38450.
JC2443.
RefSeqiNP_001116513.2. NM_001123041.2. [P41597-1]
NP_001116868.1. NM_001123396.1. [P41597-2]
UniGeneiHs.511794.
Hs.705362.

Genome annotation databases

EnsembliENST00000292301; ENSP00000292301; ENSG00000121807. [P41597-1]
ENST00000400888; ENSP00000383681; ENSG00000121807. [P41597-1]
ENST00000445132; ENSP00000399285; ENSG00000121807. [P41597-2]
GeneIDi729230.
KEGGihsa:729230.
UCSCiuc003cpm.4. human. [P41597-2]
uc003cpn.4. human. [P41597-1]

Polymorphism databases

DMDMi1168965.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03882 mRNA. Translation: AAA19119.1 .
U03905 mRNA. Translation: AAA19120.1 .
D29984 mRNA. Translation: BAA06253.1 .
U80924 Genomic DNA. Translation: AAC51637.1 .
U80924 Genomic DNA. Translation: AAC51636.1 .
AF545480 Genomic DNA. Translation: AAN16400.1 .
AK292685 mRNA. Translation: BAF85374.1 .
AK292920 mRNA. Translation: BAF85609.1 .
U95626 Genomic DNA. Translation: AAB57791.1 .
U95626 Genomic DNA. Translation: AAB57792.1 .
CH471055 Genomic DNA. Translation: EAW64760.1 .
BC074751 mRNA. Translation: AAH74751.1 .
BC095540 mRNA. Translation: AAH95540.1 .
BC126452 mRNA. Translation: AAI26453.1 .
BC136396 mRNA. Translation: AAI36397.1 .
CCDSi CCDS43078.1. [P41597-1 ]
CCDS46813.1. [P41597-2 ]
PIRi I38450.
JC2443.
RefSeqi NP_001116513.2. NM_001123041.2. [P41597-1 ]
NP_001116868.1. NM_001123396.1. [P41597-2 ]
UniGenei Hs.511794.
Hs.705362.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KAD model - A 1-343 [» ]
1KP1 model - A 1-343 [» ]
ProteinModelPortali P41597.
SMRi P41597. Positions 2-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5833N.
DIP-5839N.
MINTi MINT-5005983.
STRINGi 9606.ENSP00000292301.

Chemistry

BindingDBi P41597.
ChEMBLi CHEMBL4015.
GuidetoPHARMACOLOGYi 59.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P41597.

Polymorphism databases

DMDMi 1168965.

Proteomic databases

PaxDbi P41597.
PRIDEi P41597.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292301 ; ENSP00000292301 ; ENSG00000121807 . [P41597-1 ]
ENST00000400888 ; ENSP00000383681 ; ENSG00000121807 . [P41597-1 ]
ENST00000445132 ; ENSP00000399285 ; ENSG00000121807 . [P41597-2 ]
GeneIDi 729230.
KEGGi hsa:729230.
UCSCi uc003cpm.4. human. [P41597-2 ]
uc003cpn.4. human. [P41597-1 ]

Organism-specific databases

CTDi 729230.
GeneCardsi GC03P046356.
HGNCi HGNC:1603. CCR2.
HPAi CAB003793.
MIMi 601267. gene.
609423. phenotype.
neXtProti NX_P41597.
PharmGKBi PA26167.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148353.
GeneTreei ENSGT00760000118785.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P41597.
KOi K04177.
OMAi GWKNFHT.
OrthoDBi EOG738051.
PhylomeDBi P41597.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_115897. Beta defensins.
REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii CCR2.
GenomeRNAii 729230.
NextBioi 129620.
PROi P41597.
SOURCEi Search...

Gene expression databases

Bgeei P41597.
CleanExi HS_CCR2.
ExpressionAtlasi P41597. baseline and differential.
Genevestigatori P41597.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails."
    Charo I.F., Myers S.J., Herman A., Franci C., Connolly A.J., Coughlin S.R.
    Proc. Natl. Acad. Sci. U.S.A. 91:2752-2756(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor."
    Yamagami S., Tokuda Y., Ishii K., Tamaka H., Endo N.
    Biochem. Biophys. Res. Commun. 202:1156-1162(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking."
    Wong L.-M., Myers S.J., Tsou C.-L., Gosling J., Arai H., Charo I.F.
    J. Biol. Chem. 272:1038-1045(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. SeattleSNPs variation discovery resource
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-64 AND GLU-355.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus and Trachea.
  6. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
  9. "The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor."
    Mellado M., Rodriguez-Frade J.M., Aragay A., del Real G., Martin A.M., Vila-Coro A.J., Serrano A., Mayor F. Jr., Martinez-A C.
    J. Immunol. 161:805-813(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-139 BY JAK2.
  10. "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2."
    Aragay A.M., Mellado M., Frade J.M., Martin A.M., Jimenez-Sainz M.C., Martinez-A C., Mayor F. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB1.
  11. Cited for: INTERACTION WITH HIV-1 TAT.
  12. "Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region."
    Preobrazhensky A.A., Dragan S., Kawano T., Gavrilin M.A., Gulina I.V., Chakravarty L., Kolattukudy P.E.
    J. Immunol. 165:5295-5303(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SULFATION AT TYR-26, GLYCOSYLATION.
  13. "Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."
    Sung H.J., Kim Y.S., Kang H., Ko J.
    Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.
  14. "Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1)."
    Tan J.H., Ludeman J.P., Wedderburn J., Canals M., Hall P., Butler S.J., Taleski D., Christopoulos A., Hickey M.J., Payne R.J., Stone M.J.
    J. Biol. Chem. 288:10024-10034(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SULFATION.
  15. Cited for: VARIANT ILE-64.
  16. "Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression."
    Mummidi S., Ahuja S.S., Gonzalez E., Anderson S.A., Santiago E.N., Stephan K.T., Craig F.E., O'Connell P., Tryon V., Clark R.A., Dolan M.J., Ahuja S.K.
    Nat. Med. 4:786-793(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ILE-64.

Entry informationi

Entry nameiCCR2_HUMAN
AccessioniPrimary (citable) accession number: P41597
Secondary accession number(s): A0AVQ3, B2RMT0, Q4VBL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3