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P41597 (CCR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 151. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 2

Short name=C-C CKR-2
Short name=CC-CKR-2
Short name=CCR-2
Short name=CCR2
Alternative name(s):
Monocyte chemoattractant protein 1 receptor
Short name=MCP-1-R
CD_antigen=CD192
Gene names
Name:CCR2
Synonyms:CMKBR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection. Ref.14

Subunit structure

Binds to HIV-1 Tat. Interacts with ARRB1. Ref.10 Ref.11

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.13.

Induction

Up-regulated by CREB3. Ref.13

Post-translational modification

N-glycosylated. Ref.12

Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.

Polymorphism

Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
Sulfation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processJAK-STAT cascade

Traceable author statement Ref.9. Source: ProtInc

T-helper 17 cell chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

blood vessel remodeling

Inferred from sequence or structural similarity. Source: BHF-UCL

cellular calcium ion homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

cellular defense response

Traceable author statement PubMed 10201901. Source: ProtInc

cellular homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

chemokine-mediated signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

chemotaxis

Traceable author statement PubMed 10623817. Source: ProtInc

cytokine-mediated signaling pathway

Inferred from direct assay PubMed 15995708. Source: MGI

dendritic cell chemotaxis

Traceable author statement PubMed 16621978. Source: BHF-UCL

immune response

Traceable author statement PubMed 10751368. Source: ProtInc

inflammatory response

Traceable author statement PubMed 10623817. Source: ProtInc

innate immune response

Traceable author statement. Source: Reactome

negative regulation of adenylate cyclase activity

Traceable author statement Ref.3. Source: ProtInc

negative regulation of angiogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of eosinophil degranulation

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of type 2 immune response

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of CD8-positive, alpha-beta T cell extravasation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T cell activation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T cell chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T-helper 1 type immune response

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of alpha-beta T cell proliferation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of astrocyte chemotaxis

Inferred from direct assay PubMed 12271471. Source: BHF-UCL

positive regulation of cytosolic calcium ion concentration

Traceable author statement PubMed 9548499. Source: ProtInc

positive regulation of hematopoietic stem cell migration

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of immune complex clearance by monocytes and macrophages

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of inflammatory response

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interferon-gamma production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interleukin-2 production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of monocyte chemotaxis

Inferred from direct assay Ref.13. Source: UniProtKB

positive regulation of monocyte extravasation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of tumor necrosis factor biosynthetic process

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of vascular endothelial growth factor production

Inferred from sequence or structural similarity. Source: BHF-UCL

response to wounding

Traceable author statement Ref.1. Source: ProtInc

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15995708. Source: MGI

cytosol

Inferred from sequence or structural similarity. Source: BHF-UCL

dendrite

Inferred from sequence or structural similarity. Source: BHF-UCL

integral component of membrane

Traceable author statement PubMed 8530354. Source: ProtInc

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

neuronal cell body

Inferred from sequence or structural similarity. Source: BHF-UCL

perikaryon

Inferred from sequence or structural similarity. Source: BHF-UCL

perinuclear region of cytoplasm

Inferred from sequence or structural similarity. Source: BHF-UCL

plasma membrane

Inferred from direct assay Ref.13. Source: UniProtKB

   Molecular_functionC-C chemokine receptor activity

Inferred from electronic annotation. Source: InterPro

CCR2 chemokine receptor binding

Inferred from direct assay PubMed 15995708. Source: MGI

chemokine receptor activity

Traceable author statement PubMed 10623817. Source: ProtInc

protein homodimerization activity

Inferred from sequence or structural similarity. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P41597-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P41597-2)

The sequence of this isoform differs from the canonical sequence as follows:
     314-374: SLFHIALGCR...EASLQDKEGA → RYLSVFFRKH...TGEQEVSAGL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374C-C chemokine receptor type 2
PRO_0000069232

Regions

Topological domain1 – 4242Extracellular Potential
Transmembrane43 – 7028Helical; Name=1; Potential
Topological domain71 – 8010Cytoplasmic Potential
Transmembrane81 – 10020Helical; Name=2; Potential
Topological domain101 – 11414Extracellular Potential
Transmembrane115 – 13622Helical; Name=3; Potential
Topological domain137 – 15317Cytoplasmic Potential
Transmembrane154 – 17825Helical; Name=4; Potential
Topological domain179 – 20628Extracellular Potential
Transmembrane207 – 22620Helical; Name=5; Potential
Topological domain227 – 24317Cytoplasmic Potential
Transmembrane244 – 26825Helical; Name=6; Potential
Topological domain269 – 28517Extracellular Potential
Transmembrane286 – 30924Helical; Name=7; Potential
Topological domain310 – 37465Cytoplasmic Potential

Amino acid modifications

Modified residue261Sulfotyrosine Ref.12
Modified residue1391Phosphotyrosine; by JAK2 Ref.9
Glycosylation141N-linked (GlcNAc...) Potential
Disulfide bond32 ↔ 277
Disulfide bond113 ↔ 190

Natural variations

Alternative sequence314 – 37461SLFHI…DKEGA → RYLSVFFRKHITKRFCKQCP VFYRETVDGVTSTNTPSTGE QEVSAGL in isoform B.
VSP_001893
Natural variant451L → V.
Corresponds to variant rs4987052 [ dbSNP | Ensembl ].
VAR_020066
Natural variant641V → I Confers relative resistance to infection by HIV-1; delay in disease progression in African Americans but not in Caucasians. Ref.4 Ref.15 Ref.16
Corresponds to variant rs1799864 [ dbSNP | Ensembl ].
VAR_014339
Natural variant3551G → E. Ref.4
Corresponds to variant rs3918387 [ dbSNP | Ensembl ].
VAR_014340

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: F865E0D39E74CF0F

FASTA37441,915
        10         20         30         40         50         60 
MLSTSRSRFI RNTNESGEEV TTFFDYDYGA PCHKFDVKQI GAQLLPPLYS LVFIFGFVGN 

        70         80         90        100        110        120 
MLVVLILINC KKLKCLTDIY LLNLAISDLL FLITLPLWAH SAANEWVFGN AMCKLFTGLY 

       130        140        150        160        170        180 
HIGYFGGIFF IILLTIDRYL AIVHAVFALK ARTVTFGVVT SVITWLVAVF ASVPGIIFTK 

       190        200        210        220        230        240 
CQKEDSVYVC GPYFPRGWNN FHTIMRNILG LVLPLLIMVI CYSGILKTLL RCRNEKKRHR 

       250        260        270        280        290        300 
AVRVIFTIMI VYFLFWTPYN IVILLNTFQE FFGLSNCEST SQLDQATQVT ETLGMTHCCI 

       310        320        330        340        350        360 
NPIIYAFVGE KFRSLFHIAL GCRIAPLQKP VCGGPGVRPG KNVKVTTQGL LDGRGKGKSI 

       370 
GRAPEASLQD KEGA 

« Hide

Isoform B [UniParc].

Checksum: EA352636D724D470
Show »

FASTA36041,064

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails."
Charo I.F., Myers S.J., Herman A., Franci C., Connolly A.J., Coughlin S.R.
Proc. Natl. Acad. Sci. U.S.A. 91:2752-2756(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor."
Yamagami S., Tokuda Y., Ishii K., Tamaka H., Endo N.
Biochem. Biophys. Res. Commun. 202:1156-1162(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking."
Wong L.-M., Myers S.J., Tsou C.-L., Gosling J., Arai H., Charo I.F.
J. Biol. Chem. 272:1038-1045(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]SeattleSNPs variation discovery resource
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-64 AND GLU-355.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus and Trachea.
[6]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
[9]"The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor."
Mellado M., Rodriguez-Frade J.M., Aragay A., del Real G., Martin A.M., Vila-Coro A.J., Serrano A., Mayor F. Jr., Martinez-A C.
J. Immunol. 161:805-813(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-139 BY JAK2.
[10]"Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2."
Aragay A.M., Mellado M., Frade J.M., Martin A.M., Jimenez-Sainz M.C., Martinez-A C., Mayor F. Jr.
Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARRB1.
[11]"HIV-1 Tat protein mimicry of chemokines."
Albini A., Ferrini S., Benelli R., Sforzini S., Giunciuglio D., Aluigi M.G., Proudfoot A.E.I., Alouani S., Wells T.N.C., Mariani G., Rabin R.L., Farber J.M., Noonan D.M.
Proc. Natl. Acad. Sci. U.S.A. 95:13153-13158(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HIV-1 TAT.
[12]"Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region."
Preobrazhensky A.A., Dragan S., Kawano T., Gavrilin M.A., Gulina I.V., Chakravarty L., Kolattukudy P.E.
J. Immunol. 165:5295-5303(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SULFATION AT TYR-26, GLYCOSYLATION.
[13]"Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."
Sung H.J., Kim Y.S., Kang H., Ko J.
Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INDUCTION.
[14]"Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1)."
Tan J.H., Ludeman J.P., Wedderburn J., Canals M., Hall P., Butler S.J., Taleski D., Christopoulos A., Hickey M.J., Payne R.J., Stone M.J.
J. Biol. Chem. 288:10024-10034(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SULFATION.
[15]"Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression."
Smith M.W., Dean M., Carrington M., Winkler C., Huttley G.A., Lomb D.A., Goedert J.J., O'Brien T.R., Jacobson L.P., Kaslow R., Buchbinder S., Vittinghoff E., Vlahov D., Hoots K., Hilgartner M.W., O'Brien S.J.
Science 277:959-965(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ILE-64.
[16]"Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression."
Mummidi S., Ahuja S.S., Gonzalez E., Anderson S.A., Santiago E.N., Stephan K.T., Craig F.E., O'Connell P., Tryon V., Clark R.A., Dolan M.J., Ahuja S.K.
Nat. Med. 4:786-793(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ILE-64.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03882 mRNA. Translation: AAA19119.1.
U03905 mRNA. Translation: AAA19120.1.
D29984 mRNA. Translation: BAA06253.1.
U80924 Genomic DNA. Translation: AAC51637.1.
U80924 Genomic DNA. Translation: AAC51636.1.
AF545480 Genomic DNA. Translation: AAN16400.1.
AK292685 mRNA. Translation: BAF85374.1.
AK292920 mRNA. Translation: BAF85609.1.
U95626 Genomic DNA. Translation: AAB57791.1.
U95626 Genomic DNA. Translation: AAB57792.1.
CH471055 Genomic DNA. Translation: EAW64760.1.
BC074751 mRNA. Translation: AAH74751.1.
BC095540 mRNA. Translation: AAH95540.1.
BC126452 mRNA. Translation: AAI26453.1.
BC136396 mRNA. Translation: AAI36397.1.
PIRI38450.
JC2443.
RefSeqNP_001116513.2. NM_001123041.2.
NP_001116868.1. NM_001123396.1.
UniGeneHs.511794.
Hs.705362.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1KADmodel-A1-343[»]
1KP1model-A1-343[»]
ProteinModelPortalP41597.
SMRP41597. Positions 2-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5833N.
DIP-5839N.
MINTMINT-5005983.
STRING9606.ENSP00000292301.

Chemistry

BindingDBP41597.
ChEMBLCHEMBL4015.
GuidetoPHARMACOLOGY59.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP41597.

Polymorphism databases

DMDM1168965.

Proteomic databases

PaxDbP41597.
PRIDEP41597.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292301; ENSP00000292301; ENSG00000121807. [P41597-1]
ENST00000400888; ENSP00000383681; ENSG00000121807. [P41597-1]
ENST00000445132; ENSP00000399285; ENSG00000121807. [P41597-2]
GeneID729230.
KEGGhsa:729230.
UCSCuc003cpm.4. human. [P41597-2]
uc003cpn.4. human. [P41597-1]

Organism-specific databases

CTD729230.
GeneCardsGC03P046356.
HGNCHGNC:1603. CCR2.
HPACAB003793.
MIM601267. gene.
609423. phenotype.
neXtProtNX_P41597.
PharmGKBPA26167.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148353.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP41597.
KOK04177.
OMAGWKNFHT.
OrthoDBEOG738051.
PhylomeDBP41597.
TreeFamTF330966.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressP41597.
BgeeP41597.
CleanExHS_CCR2.
GenevestigatorP41597.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCCR2.
GenomeRNAi729230.
NextBio129620.
PROP41597.
SOURCESearch...

Entry information

Entry nameCCR2_HUMAN
AccessionPrimary (citable) accession number: P41597
Secondary accession number(s): A0AVQ3, B2RMT0, Q4VBL2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries