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Protein

5-hydroxytryptamine receptor 2B

Gene

HTR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.8 Publications

GO - Molecular functioni

  • drug binding Source: UniProtKB
  • G-protein alpha-subunit binding Source: UniProtKB
  • G-protein coupled serotonin receptor activity Source: UniProtKB
  • GTPase activator activity Source: UniProtKB
  • neurotransmitter receptor activity Source: GO_Central
  • serotonin binding Source: UniProtKB

GO - Biological processi

  • activation of phospholipase C activity Source: UniProtKB
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: GO_Central
  • behavior Source: UniProtKB-KW
  • calcium-mediated signaling Source: UniProtKB
  • cardiac muscle hypertrophy Source: UniProtKB
  • cellular calcium ion homeostasis Source: UniProtKB
  • cellular response to temperature stimulus Source: UniProtKB
  • cGMP biosynthetic process Source: UniProtKB
  • chemical synaptic transmission Source: GO_Central
  • embryonic morphogenesis Source: UniProtKB
  • ERK1 and ERK2 cascade Source: UniProtKB
  • G-protein coupled receptor internalization Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • heart morphogenesis Source: UniProtKB
  • intestine smooth muscle contraction Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of autophagy Source: UniProtKB
  • negative regulation of cell death Source: UniProtKB
  • neural crest cell differentiation Source: UniProtKB
  • neural crest cell migration Source: UniProtKB
  • phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • phosphorylation Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of cytokine production Source: UniProtKB
  • positive regulation of cytokine secretion Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • positive regulation of MAP kinase activity Source: UniProtKB
  • positive regulation of nitric-oxide synthase activity Source: UniProtKB
  • positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • protein kinase C signaling Source: UniProtKB
  • regulation of behavior Source: UniProtKB
  • release of sequestered calcium ion into cytosol Source: UniProtKB
  • response to drug Source: UniProtKB
  • serotonin receptor signaling pathway Source: UniProtKB
  • vasoconstriction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135914-MONOMER.
ReactomeiR-HSA-390666. Serotonin receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP41595.

Protein family/group databases

TCDBi9.A.14.3.7. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 2B
Short name:
5-HT-2B
Short name:
5-HT2B
Alternative name(s):
Serotonin receptor 2B
Gene namesi
Name:HTR2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5294. HTR2B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56ExtracellularAdd BLAST56
Transmembranei57 – 79Helical; Name=1Add BLAST23
Topological domaini80 – 90CytoplasmicAdd BLAST11
Transmembranei91 – 113Helical; Name=2Add BLAST23
Topological domaini114 – 129ExtracellularAdd BLAST16
Transmembranei130 – 151Helical; Name=3Add BLAST22
Topological domaini152 – 171CytoplasmicAdd BLAST20
Transmembranei172 – 192Helical; Name=4Add BLAST21
Topological domaini193 – 216ExtracellularAdd BLAST24
Transmembranei217 – 239Helical; Name=5Add BLAST23
Topological domaini240 – 324CytoplasmicAdd BLAST85
Transmembranei325 – 345Helical; Name=6Add BLAST21
Topological domaini346 – 360ExtracellularAdd BLAST15
Transmembranei361 – 382Helical; Name=7Add BLAST22
Topological domaini383 – 481CytoplasmicAdd BLAST99

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • dendrite Source: GO_Central
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: UniProtKB
  • synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi132L → A: No effect on agonist binding. 1 Publication1
Mutagenesisi135D → A: Abolishes agonist binding. 1 Publication1
Mutagenesisi136V → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi139S → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi140T → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi208V → A: No effect on agonist binding. 1 Publication1
Mutagenesisi209L → A: No effect on agonist binding. 1 Publication1
Mutagenesisi211K → A: Impairs protein folding and stability. Strongly reduced cell surface expression. 1 Publication1
Mutagenesisi217F → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi218M → A: No effect on agonist binding. 1 Publication1
Mutagenesisi225A → S: No effect on agonist binding. 1 Publication1
Mutagenesisi337W → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi340F → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi344N → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi347L → A: No effect on agonist binding. 1 Publication1
Mutagenesisi348V → A: No effect on agonist binding. 1 Publication1
Mutagenesisi362L → A: No effect on agonist binding. 1 Publication1
Mutagenesisi363E → A: No effect on agonist binding. 1 Publication1
Mutagenesisi366V → A: No effect on agonist binding. 1 Publication1
Mutagenesisi370Y → A: Slightly decreases agonist binding. 1 Publication1

Organism-specific databases

DisGeNETi3357.
OpenTargetsiENSG00000135914.
PharmGKBiPA29554.

Chemistry databases

ChEMBLiCHEMBL1833.
DrugBankiDB00543. Amoxapine.
DB00714. Apomorphine.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB06016. Cariprazine.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB01242. Clomipramine.
DB00320. Dihydroergotamine.
DB01142. Doxepin.
DB00216. Eletriptan.
DB01049. Ergoloid mesylate.
DB01221. Ketamine.
DB00589. Lisuride.
DB00247. Methysergide.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01186. Pergolide.
DB00413. Pramipexole.
DB00268. Ropinirole.
DB00508. Triflupromazine.
DB01392. Yohimbine.
GuidetoPHARMACOLOGYi7.

Polymorphism and mutation databases

BioMutaiHTR2B.
DMDMi1168220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689531 – 4815-hydroxytryptamine receptor 2BAdd BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi128 ↔ 207PROSITE-ProRule annotation1 Publication
Disulfide bondi350 ↔ 353PROSITE-ProRule annotation1 Publication
Lipidationi397S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP41595.
PRIDEiP41595.

PTM databases

iPTMnetiP41595.
PhosphoSitePlusiP41595.

Expressioni

Tissue specificityi

Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.5 Publications

Gene expression databases

BgeeiENSG00000135914.
CleanExiHS_HTR2B.
GenevisibleiP41595. HS.

Organism-specific databases

HPAiCAB011448.
HPA012867.
HPA063658.

Interactioni

Subunit structurei

Interacts with MPDZ.2 Publications

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109589. 3 interactors.
MINTiMINT-444010.
STRINGi9606.ENSP00000258400.

Chemistry databases

BindingDBiP41595.

Structurei

Secondary structure

1481
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi54 – 63Combined sources10
Helixi65 – 81Combined sources17
Helixi83 – 85Combined sources3
Helixi88 – 106Combined sources19
Helixi108 – 111Combined sources4
Helixi113 – 116Combined sources4
Helixi127 – 158Combined sources32
Helixi165 – 187Combined sources23
Helixi189 – 193Combined sources5
Helixi211 – 225Combined sources15
Helixi227 – 248Combined sources22
Helixi314 – 349Combined sources36
Beta strandi351 – 353Combined sources3
Helixi355 – 381Combined sources27
Helixi385 – 394Combined sources10
Turni395 – 397Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IB4X-ray2.70A36-248[»]
A314-405[»]
4NC3X-ray2.80A36-248[»]
A314-405[»]
ProteinModelPortaliP41595.
SMRiP41595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 140Agonist binding6
Regioni337 – 341Agonist binding5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi152 – 154DRY motif; important for ligand-induced conformation changes3
Motifi212 – 215[DE]RFG motif; may stabilize a conformation that preferentially activates signaling via beta-arrestin family members4
Motifi376 – 380NPxxY motif; important for ligand-induced conformation changes and signaling5
Motifi479 – 481PDZ-binding3

Domaini

Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000240378.
HOVERGENiHBG107487.
InParanoidiP41595.
KOiK04157.
OMAiCDSCNQT.
OrthoDBiEOG091G06VI.
PhylomeDBiP41595.
TreeFamiTF316350.

Family and domain databases

InterProiIPR000482. 5HT2B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF31. PTHR24247:SF31. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00651. 5HT2BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSYRVSEL QSTIPEHILQ STFVHVISSN WSGLQTESIP EEMKQIVEEQ
60 70 80 90 100
GNKLHWAALL ILMVIIPTIG GNTLVILAVS LEKKLQYATN YFLMSLAVAD
110 120 130 140 150
LLVGLFVMPI ALLTIMFEAM WPLPLVLCPA WLFLDVLFST ASIMHLCAIS
160 170 180 190 200
VDRYIAIKKP IQANQYNSRA TAFIKITVVW LISIGIAIPV PIKGIETDVD
210 220 230 240 250
NPNNITCVLT KERFGDFMLF GSLAAFFTPL AIMIVTYFLT IHALQKKAYL
260 270 280 290 300
VKNKPPQRLT WLTVSTVFQR DETPCSSPEK VAMLDGSRKD KALPNSGDET
310 320 330 340 350
LMRRTSTIGK KSVQTISNEQ RASKVLGIVF FLFLLMWCPF FITNITLVLC
360 370 380 390 400
DSCNQTTLQM LLEIFVWIGY VSSGVNPLVY TLFNKTFRDA FGRYITCNYR
410 420 430 440 450
ATKSVKTLRK RSSKIYFRNP MAENSKFFKK HGIRNGINPA MYQSPMRLRS
460 470 480
STIQSSSIIL LDTLLLTENE GDKTEEQVSY V
Length:481
Mass (Da):54,298
Last modified:November 1, 1995 - v1
Checksum:iCDA4447ECDBA3B46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti452T → P in CAA85319 (PubMed:7926008).Curated1
Sequence conflicti477Q → R in AAH63123 (PubMed:15489334).Curated1

Polymorphismi

A variation at a single nucleotide base, which results in an erroneous stop codon and affects Gln-20, triggers non-sense mediated RNA decay, such that no HTR2B-receptor protein is expressed. It is associated with impulsive behavior and co-segregates with disorders characterized by impulsivity. However, the presence of this variant is not in itself sufficient to cause impulsive behavior: male sex, testosterone level, alcohol and stress exposure are other factors playing important roles.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06457445Q → E.1 PublicationCorresponds to variant rs78484969dbSNPEnsembl.1
Natural variantiVAR_064575173F → L.1 PublicationCorresponds to variant rs77570025dbSNPEnsembl.1
Natural variantiVAR_064576388R → W.1 PublicationCorresponds to variant rs77982984dbSNPEnsembl.1
Natural variantiVAR_055907421M → V.Corresponds to variant rs6736017dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77307 mRNA. Translation: CAA54513.1.
Z36748 mRNA. Translation: CAA85319.1.
AF156160, AF156158, AF156159 Genomic DNA. Translation: AAD39259.1.
AY136751 mRNA. Translation: AAN01277.1.
AC009407 Genomic DNA. Translation: AAX93128.1.
AK313741 mRNA. Translation: BAG36482.1.
CH471063 Genomic DNA. Translation: EAW70949.1.
BC063123 mRNA. Translation: AAH63123.1.
CCDSiCCDS2483.1.
PIRiS43687.
S49442.
RefSeqiNP_000858.3. NM_000867.4.
NP_001307687.1. NM_001320758.1.
UniGeneiHs.421649.

Genome annotation databases

EnsembliENST00000258400; ENSP00000258400; ENSG00000135914.
GeneIDi3357.
KEGGihsa:3357.
UCSCiuc002vro.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

On the spur of a whim - Issue 127 of March 2011

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77307 mRNA. Translation: CAA54513.1.
Z36748 mRNA. Translation: CAA85319.1.
AF156160, AF156158, AF156159 Genomic DNA. Translation: AAD39259.1.
AY136751 mRNA. Translation: AAN01277.1.
AC009407 Genomic DNA. Translation: AAX93128.1.
AK313741 mRNA. Translation: BAG36482.1.
CH471063 Genomic DNA. Translation: EAW70949.1.
BC063123 mRNA. Translation: AAH63123.1.
CCDSiCCDS2483.1.
PIRiS43687.
S49442.
RefSeqiNP_000858.3. NM_000867.4.
NP_001307687.1. NM_001320758.1.
UniGeneiHs.421649.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IB4X-ray2.70A36-248[»]
A314-405[»]
4NC3X-ray2.80A36-248[»]
A314-405[»]
ProteinModelPortaliP41595.
SMRiP41595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109589. 3 interactors.
MINTiMINT-444010.
STRINGi9606.ENSP00000258400.

Chemistry databases

BindingDBiP41595.
ChEMBLiCHEMBL1833.
DrugBankiDB00543. Amoxapine.
DB00714. Apomorphine.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB06016. Cariprazine.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB01242. Clomipramine.
DB00320. Dihydroergotamine.
DB01142. Doxepin.
DB00216. Eletriptan.
DB01049. Ergoloid mesylate.
DB01221. Ketamine.
DB00589. Lisuride.
DB00247. Methysergide.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01186. Pergolide.
DB00413. Pramipexole.
DB00268. Ropinirole.
DB00508. Triflupromazine.
DB01392. Yohimbine.
GuidetoPHARMACOLOGYi7.

Protein family/group databases

TCDBi9.A.14.3.7. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP41595.
PhosphoSitePlusiP41595.

Polymorphism and mutation databases

BioMutaiHTR2B.
DMDMi1168220.

Proteomic databases

PaxDbiP41595.
PRIDEiP41595.

Protocols and materials databases

DNASUi3357.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258400; ENSP00000258400; ENSG00000135914.
GeneIDi3357.
KEGGihsa:3357.
UCSCiuc002vro.4. human.

Organism-specific databases

CTDi3357.
DisGeNETi3357.
GeneCardsiHTR2B.
HGNCiHGNC:5294. HTR2B.
HPAiCAB011448.
HPA012867.
HPA063658.
MIMi601122. gene.
neXtProtiNX_P41595.
OpenTargetsiENSG00000135914.
PharmGKBiPA29554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000240378.
HOVERGENiHBG107487.
InParanoidiP41595.
KOiK04157.
OMAiCDSCNQT.
OrthoDBiEOG091G06VI.
PhylomeDBiP41595.
TreeFamiTF316350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135914-MONOMER.
ReactomeiR-HSA-390666. Serotonin receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP41595.

Miscellaneous databases

GeneWikii5-HT2B_receptor.
GenomeRNAii3357.
PROiP41595.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135914.
CleanExiHS_HTR2B.
GenevisibleiP41595. HS.

Family and domain databases

InterProiIPR000482. 5HT2B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF31. PTHR24247:SF31. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00651. 5HT2BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT2B_HUMAN
AccessioniPrimary (citable) accession number: P41595
Secondary accession number(s): B2R9D5
, Q53TI1, Q62221, Q6P523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  8. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.