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P41594

- GRM5_HUMAN

UniProt

P41594 - GRM5_HUMAN

Protein

Metabotropic glutamate receptor 5

Gene

GRM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641Glutamate1 Publication
    Binding sitei152 – 1521Glutamate1 Publication
    Binding sitei223 – 2231Glutamate1 Publication
    Binding sitei305 – 3051Glutamate1 Publication
    Binding sitei396 – 3961Glutamate1 Publication

    GO - Molecular functioni

    1. glutamate receptor activity Source: UniProtKB
    2. G-protein coupled receptor activity Source: UniProtKB

    GO - Biological processi

    1. activation of MAPKKK activity Source: Ensembl
    2. cognition Source: UniProt
    3. desensitization of G-protein coupled receptor protein signaling pathway Source: Ensembl
    4. G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
    5. learning Source: Ensembl
    6. locomotory behavior Source: Ensembl
    7. negative regulation of locomotion Source: Ensembl
    8. phospholipase C-activating G-protein coupled glutamate receptor signaling pathway Source: ProtInc
    9. positive regulation of long-term neuronal synaptic plasticity Source: Ensembl
    10. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RefGenome
    11. protein phosphorylation Source: Ensembl
    12. regulation of synaptic transmission, glutamatergic Source: RefGenome
    13. regulation of transcription, DNA-templated Source: Ensembl
    14. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    SignaLinkiP41594.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 5
    Short name:
    mGluR5
    Gene namesi
    Name:GRM5
    Synonyms:GPRC1E, MGLUR5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:4597. GRM5.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. astrocyte projection Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. dendritic shaft Source: Ensembl
    4. dendritic spine Source: Ensembl
    5. extracellular vesicular exosome Source: UniProt
    6. integral component of plasma membrane Source: UniProtKB
    7. plasma membrane Source: Reactome
    8. postsynaptic density Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi613 – 6131S → A or K: Increased constitutive signaling activity. 1 Publication
    Mutagenesisi614 – 6141S → D: Decreased constitutive signaling activity. 1 Publication
    Mutagenesisi665 – 6651K → A: Increased constitutive signaling activity. 1 Publication
    Mutagenesisi770 – 7701E → A: Increased constitutive signaling activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA28994.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 12121192Metabotropic glutamate receptor 5PRO_0000012932Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 99
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi241 ↔ 530By similarity
    Disulfide bondi276 ↔ 278
    Disulfide bondi365 ↔ 381
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi419 ↔ 426
    Glycosylationi445 – 4451N-linked (GlcNAc...)1 Publication
    Disulfide bondi511 ↔ 531By similarity
    Disulfide bondi515 ↔ 534By similarity
    Disulfide bondi537 ↔ 549By similarity
    Disulfide bondi552 ↔ 565By similarity
    Disulfide bondi644 ↔ 733
    Glycosylationi734 – 7341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP41594.
    PRIDEiP41594.

    PTM databases

    PhosphoSiteiP41594.

    Expressioni

    Gene expression databases

    ArrayExpressiP41594.
    BgeeiP41594.
    CleanExiHS_GRM5.
    GenevestigatoriP41594.

    Organism-specific databases

    HPAiHPA014096.

    Interactioni

    Subunit structurei

    The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109172. 4 interactions.
    IntActiP41594. 2 interactions.
    STRINGi9606.ENSP00000306138.

    Structurei

    Secondary structure

    1
    1212
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 313
    Beta strandi34 – 418
    Beta strandi49 – 513
    Turni52 – 554
    Turni62 – 654
    Helixi66 – 8116
    Beta strandi91 – 977
    Helixi102 – 11211
    Beta strandi143 – 1475
    Helixi152 – 16211
    Helixi163 – 1653
    Beta strandi169 – 1735
    Helixi177 – 1804
    Turni182 – 1843
    Beta strandi188 – 1925
    Helixi195 – 20814
    Beta strandi213 – 2197
    Helixi222 – 23514
    Turni236 – 2394
    Beta strandi241 – 2488
    Helixi254 – 26714
    Turni268 – 2703
    Beta strandi273 – 2775
    Helixi280 – 29314
    Beta strandi300 – 3034
    Turni307 – 3093
    Helixi311 – 3144
    Helixi318 – 3214
    Beta strandi325 – 3295
    Helixi335 – 3428
    Turni346 – 3483
    Helixi355 – 3639
    Turni387 – 3904
    Helixi397 – 41822
    Helixi427 – 4293
    Helixi434 – 4418
    Beta strandi445 – 4473
    Beta strandi449 – 4513
    Beta strandi453 – 4553
    Beta strandi466 – 47510
    Beta strandi479 – 48810
    Beta strandi491 – 4944

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LMKX-ray2.44A/B18-505[»]
    4OO9X-ray2.60A569-836[»]
    ProteinModelPortaliP41594.
    SMRiP41594. Positions 26-833.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP41594.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 580559Extracellular1 PublicationAdd
    BLAST
    Topological domaini604 – 61310Cytoplasmic1 Publication
    Topological domaini637 – 6448Extracellular1 Publication
    Topological domaini668 – 69326Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini715 – 73723Extracellular1 PublicationAdd
    BLAST
    Topological domaini760 – 77213Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini796 – 7983Extracellular1 Publication
    Topological domaini821 – 1212392Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei581 – 60323Helical; Name=1Add
    BLAST
    Transmembranei614 – 63623Helical; Name=2Add
    BLAST
    Transmembranei645 – 66723Helical; Name=3Add
    BLAST
    Transmembranei694 – 71421Helical; Name=4Add
    BLAST
    Transmembranei738 – 75922Helical; Name=5Add
    BLAST
    Transmembranei773 – 79523Helical; Name=6Add
    BLAST
    Transmembranei799 – 82022Helical; Name=7Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni173 – 1753Glutamate binding
    Regioni805 – 8095Allosteric effector binding

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    HOGENOMiHOG000218636.
    HOVERGENiHBG107965.
    InParanoidiP41594.
    KOiK04604.
    OMAiAPLCSSY.
    OrthoDBiEOG7Z0JXG.
    PhylomeDBiP41594.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR000202. GPCR_3_mtglu_rcpt_5.
    IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF10606. GluR_Homer-bdg. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01055. MTABOTROPC5R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: P41594-1) [UniParc]FASTAAdd to Basket

    Also known as: 5b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD     50
    KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 100
    HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG 150
    SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR 200
    AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS 250
    NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL 300
    LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH 350
    RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV 400
    INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS 450
    GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW 500
    SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK 550
    ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV 600
    FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG 650
    IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL 700
    ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL 750
    ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII 800
    TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG 850
    KSSSAASRSS SLVNLWKRRG SSGETLRYKD RRLAQHKSEI ECFTPKGSMG 900
    NGGRATMSSS NGKSVTWAQN EKSSRGQHLW QRLSIHINKK ENPNQTAVIK 950
    PFPKSTESRG LGAGAGAGGS AGGVGATGGA GCAGAGPGGP ESPDAGPKAL 1000
    YDVAEAEEHF PAPARPRSPS PISTLSHRAG SASRTDDDVP SLHSEPVARS 1050
    SSSQGSLMEQ ISSVVTRFTA NISELNSMML STAAPSPGVG APLCSSYLIP 1100
    KEIQLPTTMT TFAEIQPLPA IEVTGGAQPA AGAQAAGDAA RESPAAGPEA 1150
    AAAKPDLEEL VALTPPSPFR DSVDSGSTTP NSPVSESALC IPSSPKYDTL 1200
    IIRDYTQSSS SL 1212
    Length:1,212
    Mass (Da):132,469
    Last modified:October 1, 1996 - v2
    Checksum:iA3C73606681C6A25
    GO
    Isoform 1 (identifier: P41594-2) [UniParc]FASTAAdd to Basket

    Also known as: 5a

    The sequence of this isoform differs from the canonical sequence as follows:
         877-908: Missing.

    Show »
    Length:1,180
    Mass (Da):128,874
    Checksum:i3DBACB2E8B341647
    GO
    Isoform 3 (identifier: P41594-3) [UniParc]FASTAAdd to Basket

    Also known as: 5d

    The sequence of this isoform differs from the canonical sequence as follows:
         896-1165: Missing.

    Show »
    Length:942
    Mass (Da):105,432
    Checksum:iEF45A35CADD56535
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei877 – 90832Missing in isoform 1. 1 PublicationVSP_002030Add
    BLAST
    Alternative sequencei896 – 1165270Missing in isoform 3. 1 PublicationVSP_047710Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28538 mRNA. Translation: BAA05891.1.
    D28539 mRNA. Translation: BAA05892.1.
    AY608336 mRNA. Translation: AAT37960.1.
    AP000626 Genomic DNA. No translation available.
    AP001482 Genomic DNA. No translation available.
    AP001828 Genomic DNA. No translation available.
    AP003120 Genomic DNA. No translation available.
    AP006214 Genomic DNA. No translation available.
    AP006215 Genomic DNA. No translation available.
    S64316 mRNA. Translation: AAD13954.1.
    CCDSiCCDS44694.1. [P41594-1]
    CCDS8283.1. [P41594-2]
    PIRiJC2131.
    JC2132.
    RefSeqiNP_000833.1. NM_000842.4. [P41594-2]
    NP_001137303.1. NM_001143831.2. [P41594-1]
    XP_006718891.1. XM_006718828.1. [P41594-1]
    XP_006718892.1. XM_006718829.1. [P41594-1]
    XP_006718893.1. XM_006718830.1. [P41594-2]
    UniGeneiHs.147361.
    Hs.616625.

    Genome annotation databases

    EnsembliENST00000305432; ENSP00000305905; ENSG00000168959. [P41594-2]
    ENST00000305447; ENSP00000306138; ENSG00000168959. [P41594-1]
    ENST00000455756; ENSP00000405690; ENSG00000168959. [P41594-2]
    GeneIDi2915.
    KEGGihsa:2915.
    UCSCiuc001pcq.3. human. [P41594-1]
    uc009yvm.3. human. [P41594-2]

    Polymorphism databases

    DMDMi1709020.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28538 mRNA. Translation: BAA05891.1 .
    D28539 mRNA. Translation: BAA05892.1 .
    AY608336 mRNA. Translation: AAT37960.1 .
    AP000626 Genomic DNA. No translation available.
    AP001482 Genomic DNA. No translation available.
    AP001828 Genomic DNA. No translation available.
    AP003120 Genomic DNA. No translation available.
    AP006214 Genomic DNA. No translation available.
    AP006215 Genomic DNA. No translation available.
    S64316 mRNA. Translation: AAD13954.1 .
    CCDSi CCDS44694.1. [P41594-1 ]
    CCDS8283.1. [P41594-2 ]
    PIRi JC2131.
    JC2132.
    RefSeqi NP_000833.1. NM_000842.4. [P41594-2 ]
    NP_001137303.1. NM_001143831.2. [P41594-1 ]
    XP_006718891.1. XM_006718828.1. [P41594-1 ]
    XP_006718892.1. XM_006718829.1. [P41594-1 ]
    XP_006718893.1. XM_006718830.1. [P41594-2 ]
    UniGenei Hs.147361.
    Hs.616625.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LMK X-ray 2.44 A/B 18-505 [» ]
    4OO9 X-ray 2.60 A 569-836 [» ]
    ProteinModelPortali P41594.
    SMRi P41594. Positions 26-833.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109172. 4 interactions.
    IntActi P41594. 2 interactions.
    STRINGi 9606.ENSP00000306138.

    Chemistry

    BindingDBi P41594.
    ChEMBLi CHEMBL3227.
    DrugBanki DB00659. Acamprosate.
    GuidetoPHARMACOLOGYi 293.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P41594.

    Polymorphism databases

    DMDMi 1709020.

    Proteomic databases

    PaxDbi P41594.
    PRIDEi P41594.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305432 ; ENSP00000305905 ; ENSG00000168959 . [P41594-2 ]
    ENST00000305447 ; ENSP00000306138 ; ENSG00000168959 . [P41594-1 ]
    ENST00000455756 ; ENSP00000405690 ; ENSG00000168959 . [P41594-2 ]
    GeneIDi 2915.
    KEGGi hsa:2915.
    UCSCi uc001pcq.3. human. [P41594-1 ]
    uc009yvm.3. human. [P41594-2 ]

    Organism-specific databases

    CTDi 2915.
    GeneCardsi GC11M088237.
    HGNCi HGNC:4597. GRM5.
    HPAi HPA014096.
    MIMi 604102. gene.
    neXtProti NX_P41594.
    PharmGKBi PA28994.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295200.
    HOGENOMi HOG000218636.
    HOVERGENi HBG107965.
    InParanoidi P41594.
    KOi K04604.
    OMAi APLCSSY.
    OrthoDBi EOG7Z0JXG.
    PhylomeDBi P41594.
    TreeFami TF313240.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    SignaLinki P41594.

    Miscellaneous databases

    ChiTaRSi GRM5. human.
    EvolutionaryTracei P41594.
    GenomeRNAii 2915.
    NextBioi 11555.
    PROi P41594.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41594.
    Bgeei P41594.
    CleanExi HS_GRM5.
    Genevestigatori P41594.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR000202. GPCR_3_mtglu_rcpt_5.
    IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF10606. GluR_Homer-bdg. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01055. MTABOTROPC5R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5."
      Minakami R., Katsuki F., Yamamoto T., Nakamura K., Sugiyama H.
      Biochem. Biophys. Res. Commun. 199:1136-1143(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Brain.
    2. Katsuki F.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Molecular cloning and characterization of human metabotropic glutamate receptor 5d; a splice variant with reduced desensitization properties."
      Levinthal C., Storjohann L., Hammerland L.G., Hung B.C.P., Krapcho K.J., Logan M.A., Smith D.L., Trovato R., Vanwagenen B.C., Stormannn T.M.
      Abstr. - Soc. Neurosci. 25:976-976(1999)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon."
      Minakami R., Katsuki F., Sugiyama H.
      Biochem. Biophys. Res. Commun. 194:622-627(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 860-952 (ISOFORM 2).
      Tissue: Brain.
    6. "Metabotropic glutamate receptor MGluR5 complexed with glutamate."
      Structural genomics consortium (SGC)
      Submitted (JUL-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 18-505 IN COMPLEX WITH GLUTAMATE, GLYCOSYLATION AT ASN-445, DISULFIDE BONDS.
    7. "Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain."
      Dore A.S., Okrasa K., Patel J.C., Serrano-Vega M., Bennett K., Cooke R.M., Errey J.C., Jazayeri A., Khan S., Tehan B., Weir M., Wiggin G.R., Marshall F.H.
      Nature 0:0-0(2014)
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 569-836 IN COMPLEX WITH ALLOSTERIC EFFECTOR, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, DISULFIDE BONDS, MUTAGENESIS OF SER-613; SER-614; LYS-665 AND GLU-770.

    Entry informationi

    Entry nameiGRM5_HUMAN
    AccessioniPrimary (citable) accession number: P41594
    Secondary accession number(s): Q6J164
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3