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Protein

Metabotropic glutamate receptor 5

Gene

GRM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64Glutamate1 Publication1
Binding sitei152Glutamate1 Publication1
Binding sitei223Glutamate1 Publication1
Binding sitei305Glutamate1 Publication1
Binding sitei396Glutamate1 Publication1

GO - Molecular functioni

  • glutamate receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • cognition Source: UniProtKB
  • G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  • learning Source: Ensembl
  • locomotory behavior Source: Ensembl
  • phospholipase C-activating G-protein coupled glutamate receptor signaling pathway Source: ProtInc
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • regulation of long-term neuronal synaptic plasticity Source: Ensembl
  • regulation of synaptic transmission, glutamatergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168959-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).
R-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
SignaLinkiP41594.
SIGNORiP41594.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 5
Short name:
mGluR5
Gene namesi
Name:GRM5
Synonyms:GPRC1E, MGLUR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4597. GRM5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 580Extracellular1 PublicationAdd BLAST559
Transmembranei581 – 603Helical; Name=1Add BLAST23
Topological domaini604 – 613Cytoplasmic1 Publication10
Transmembranei614 – 636Helical; Name=2Add BLAST23
Topological domaini637 – 644Extracellular1 Publication8
Transmembranei645 – 667Helical; Name=3Add BLAST23
Topological domaini668 – 693Cytoplasmic1 PublicationAdd BLAST26
Transmembranei694 – 714Helical; Name=4Add BLAST21
Topological domaini715 – 737Extracellular1 PublicationAdd BLAST23
Transmembranei738 – 759Helical; Name=5Add BLAST22
Topological domaini760 – 772Cytoplasmic1 PublicationAdd BLAST13
Transmembranei773 – 795Helical; Name=6Add BLAST23
Topological domaini796 – 798Extracellular1 Publication3
Transmembranei799 – 820Helical; Name=7Add BLAST22
Topological domaini821 – 1212Cytoplasmic1 PublicationAdd BLAST392

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • neuron projection Source: Ensembl
  • plasma membrane Source: Reactome
  • postsynaptic density Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi613S → A or K: Increased constitutive signaling activity. 1 Publication1
Mutagenesisi614S → D: Decreased constitutive signaling activity. 1 Publication1
Mutagenesisi665K → A: Increased constitutive signaling activity. 1 Publication1
Mutagenesisi770E → A: Increased constitutive signaling activity. 1 Publication1

Organism-specific databases

DisGeNETi2915.
OpenTargetsiENSG00000168959.
PharmGKBiPA28994.

Chemistry databases

ChEMBLiCHEMBL3227.
DrugBankiDB00659. Acamprosate.
DB06201. Rufinamide.
GuidetoPHARMACOLOGYi293.

Polymorphism and mutation databases

BioMutaiGRM5.
DMDMi1709020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001293221 – 1212Metabotropic glutamate receptor 5Add BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 99
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi241 ↔ 530By similarity
Disulfide bondi276 ↔ 278
Disulfide bondi365 ↔ 381
Glycosylationi378N-linked (GlcNAc...)Sequence analysis1
Glycosylationi382N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi419 ↔ 426
Glycosylationi445N-linked (GlcNAc...)1 Publication1
Disulfide bondi511 ↔ 531By similarity
Disulfide bondi515 ↔ 534By similarity
Disulfide bondi537 ↔ 549By similarity
Disulfide bondi552 ↔ 565By similarity
Disulfide bondi644 ↔ 733
Glycosylationi734N-linked (GlcNAc...)Sequence analysis1
Modified residuei861PhosphoserineBy similarity1
Modified residuei869Omega-N-methylarginineBy similarity1
Modified residuei925Omega-N-methylarginineBy similarity1
Modified residuei1018PhosphoserineBy similarity1
Modified residuei1020PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP41594.
PeptideAtlasiP41594.
PRIDEiP41594.

PTM databases

iPTMnetiP41594.
PhosphoSitePlusiP41594.

Expressioni

Gene expression databases

BgeeiENSG00000168959.
CleanExiHS_GRM5.
ExpressionAtlasiP41594. baseline and differential.
GenevisibleiP41594. HS.

Interactioni

Subunit structurei

The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity).By similarity

Protein-protein interaction databases

BioGridi109172. 8 interactors.
IntActiP41594. 4 interactors.
STRINGi9606.ENSP00000306138.

Chemistry databases

BindingDBiP41594.

Structurei

Secondary structure

11212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 31Combined sources3
Beta strandi34 – 41Combined sources8
Beta strandi49 – 51Combined sources3
Turni52 – 55Combined sources4
Turni62 – 65Combined sources4
Helixi66 – 81Combined sources16
Beta strandi91 – 97Combined sources7
Helixi102 – 112Combined sources11
Beta strandi143 – 147Combined sources5
Helixi152 – 162Combined sources11
Helixi163 – 165Combined sources3
Beta strandi169 – 173Combined sources5
Helixi177 – 180Combined sources4
Turni182 – 184Combined sources3
Beta strandi188 – 192Combined sources5
Helixi195 – 208Combined sources14
Beta strandi213 – 219Combined sources7
Helixi222 – 235Combined sources14
Turni236 – 239Combined sources4
Beta strandi241 – 248Combined sources8
Helixi254 – 267Combined sources14
Turni268 – 270Combined sources3
Beta strandi273 – 277Combined sources5
Helixi280 – 293Combined sources14
Beta strandi300 – 303Combined sources4
Turni307 – 309Combined sources3
Helixi311 – 314Combined sources4
Helixi318 – 321Combined sources4
Beta strandi325 – 329Combined sources5
Helixi335 – 342Combined sources8
Turni346 – 348Combined sources3
Helixi355 – 363Combined sources9
Turni387 – 390Combined sources4
Helixi397 – 418Combined sources22
Helixi427 – 429Combined sources3
Helixi434 – 441Combined sources8
Beta strandi445 – 447Combined sources3
Beta strandi449 – 451Combined sources3
Beta strandi453 – 455Combined sources3
Beta strandi466 – 475Combined sources10
Beta strandi479 – 488Combined sources10
Beta strandi491 – 494Combined sources4
Helixi569 – 575Combined sources7
Helixi579 – 603Combined sources25
Turni604 – 606Combined sources3
Helixi608 – 611Combined sources4
Helixi615 – 630Combined sources16
Helixi632 – 635Combined sources4
Helixi641 – 678Combined sources38
Helixi690 – 714Combined sources25
Helixi738 – 760Combined sources23
Turni761 – 763Combined sources3
Helixi766 – 793Combined sources28
Helixi798 – 817Combined sources20
Helixi819 – 827Combined sources9
Turni829 – 831Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LMKX-ray2.44A/B18-505[»]
4OO9X-ray2.60A569-836[»]
5CGCX-ray3.10A569-836[»]
5CGDX-ray2.60A569-836[»]
ProteinModelPortaliP41594.
SMRiP41594.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41594.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 175Glutamate binding3
Regioni805 – 809Allosteric effector binding5

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218636.
HOVERGENiHBG107965.
InParanoidiP41594.
KOiK04604.
OMAiLRPETNH.
OrthoDBiEOG091G177R.
PhylomeDBiP41594.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000202. GPCR_3_mtglu_rcpt_5.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01055. MTABOTROPC5R.
PR00593. MTABOTROPICR.
SMARTiSM01229. GluR_Homer-bdg. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P41594-1) [UniParc]FASTAAdd to basket
Also known as: 5b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD
60 70 80 90 100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW
110 120 130 140 150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG
160 170 180 190 200
SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR
210 220 230 240 250
AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS
260 270 280 290 300
NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL
310 320 330 340 350
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH
360 370 380 390 400
RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV
410 420 430 440 450
INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS
460 470 480 490 500
GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW
510 520 530 540 550
SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK
560 570 580 590 600
ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV
610 620 630 640 650
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG
660 670 680 690 700
IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL
710 720 730 740 750
ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL
760 770 780 790 800
ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII
810 820 830 840 850
TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG
860 870 880 890 900
KSSSAASRSS SLVNLWKRRG SSGETLRYKD RRLAQHKSEI ECFTPKGSMG
910 920 930 940 950
NGGRATMSSS NGKSVTWAQN EKSSRGQHLW QRLSIHINKK ENPNQTAVIK
960 970 980 990 1000
PFPKSTESRG LGAGAGAGGS AGGVGATGGA GCAGAGPGGP ESPDAGPKAL
1010 1020 1030 1040 1050
YDVAEAEEHF PAPARPRSPS PISTLSHRAG SASRTDDDVP SLHSEPVARS
1060 1070 1080 1090 1100
SSSQGSLMEQ ISSVVTRFTA NISELNSMML STAAPSPGVG APLCSSYLIP
1110 1120 1130 1140 1150
KEIQLPTTMT TFAEIQPLPA IEVTGGAQPA AGAQAAGDAA RESPAAGPEA
1160 1170 1180 1190 1200
AAAKPDLEEL VALTPPSPFR DSVDSGSTTP NSPVSESALC IPSSPKYDTL
1210
IIRDYTQSSS SL
Length:1,212
Mass (Da):132,469
Last modified:October 1, 1996 - v2
Checksum:iA3C73606681C6A25
GO
Isoform 1 (identifier: P41594-2) [UniParc]FASTAAdd to basket
Also known as: 5a

The sequence of this isoform differs from the canonical sequence as follows:
     877-908: Missing.

Show »
Length:1,180
Mass (Da):128,874
Checksum:i3DBACB2E8B341647
GO
Isoform 3 (identifier: P41594-3) [UniParc]FASTAAdd to basket
Also known as: 5d

The sequence of this isoform differs from the canonical sequence as follows:
     896-1165: Missing.

Show »
Length:942
Mass (Da):105,432
Checksum:iEF45A35CADD56535
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002030877 – 908Missing in isoform 1. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_047710896 – 1165Missing in isoform 3. 1 PublicationAdd BLAST270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28538 mRNA. Translation: BAA05891.1.
D28539 mRNA. Translation: BAA05892.1.
AY608336 mRNA. Translation: AAT37960.1.
AP000626 Genomic DNA. No translation available.
AP001482 Genomic DNA. No translation available.
AP001828 Genomic DNA. No translation available.
AP003120 Genomic DNA. No translation available.
AP006214 Genomic DNA. No translation available.
AP006215 Genomic DNA. No translation available.
S64316 mRNA. Translation: AAD13954.1.
CCDSiCCDS44694.1. [P41594-1]
CCDS8283.1. [P41594-2]
PIRiJC2131.
JC2132.
RefSeqiNP_000833.1. NM_000842.4. [P41594-2]
NP_001137303.1. NM_001143831.2. [P41594-1]
XP_006718891.1. XM_006718828.3. [P41594-1]
XP_011541094.1. XM_011542792.1. [P41594-1]
XP_016873116.1. XM_017017627.1. [P41594-2]
UniGeneiHs.147361.
Hs.616625.

Genome annotation databases

EnsembliENST00000305432; ENSP00000305905; ENSG00000168959. [P41594-2]
ENST00000305447; ENSP00000306138; ENSG00000168959. [P41594-1]
ENST00000455756; ENSP00000405690; ENSG00000168959. [P41594-2]
GeneIDi2915.
KEGGihsa:2915.
UCSCiuc001pcq.4. human. [P41594-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28538 mRNA. Translation: BAA05891.1.
D28539 mRNA. Translation: BAA05892.1.
AY608336 mRNA. Translation: AAT37960.1.
AP000626 Genomic DNA. No translation available.
AP001482 Genomic DNA. No translation available.
AP001828 Genomic DNA. No translation available.
AP003120 Genomic DNA. No translation available.
AP006214 Genomic DNA. No translation available.
AP006215 Genomic DNA. No translation available.
S64316 mRNA. Translation: AAD13954.1.
CCDSiCCDS44694.1. [P41594-1]
CCDS8283.1. [P41594-2]
PIRiJC2131.
JC2132.
RefSeqiNP_000833.1. NM_000842.4. [P41594-2]
NP_001137303.1. NM_001143831.2. [P41594-1]
XP_006718891.1. XM_006718828.3. [P41594-1]
XP_011541094.1. XM_011542792.1. [P41594-1]
XP_016873116.1. XM_017017627.1. [P41594-2]
UniGeneiHs.147361.
Hs.616625.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LMKX-ray2.44A/B18-505[»]
4OO9X-ray2.60A569-836[»]
5CGCX-ray3.10A569-836[»]
5CGDX-ray2.60A569-836[»]
ProteinModelPortaliP41594.
SMRiP41594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109172. 8 interactors.
IntActiP41594. 4 interactors.
STRINGi9606.ENSP00000306138.

Chemistry databases

BindingDBiP41594.
ChEMBLiCHEMBL3227.
DrugBankiDB00659. Acamprosate.
DB06201. Rufinamide.
GuidetoPHARMACOLOGYi293.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP41594.
PhosphoSitePlusiP41594.

Polymorphism and mutation databases

BioMutaiGRM5.
DMDMi1709020.

Proteomic databases

PaxDbiP41594.
PeptideAtlasiP41594.
PRIDEiP41594.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305432; ENSP00000305905; ENSG00000168959. [P41594-2]
ENST00000305447; ENSP00000306138; ENSG00000168959. [P41594-1]
ENST00000455756; ENSP00000405690; ENSG00000168959. [P41594-2]
GeneIDi2915.
KEGGihsa:2915.
UCSCiuc001pcq.4. human. [P41594-1]

Organism-specific databases

CTDi2915.
DisGeNETi2915.
GeneCardsiGRM5.
HGNCiHGNC:4597. GRM5.
MIMi604102. gene.
neXtProtiNX_P41594.
OpenTargetsiENSG00000168959.
PharmGKBiPA28994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218636.
HOVERGENiHBG107965.
InParanoidiP41594.
KOiK04604.
OMAiLRPETNH.
OrthoDBiEOG091G177R.
PhylomeDBiP41594.
TreeFamiTF313240.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168959-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).
R-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
SignaLinkiP41594.
SIGNORiP41594.

Miscellaneous databases

ChiTaRSiGRM5. human.
EvolutionaryTraceiP41594.
GenomeRNAii2915.
PROiP41594.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168959.
CleanExiHS_GRM5.
ExpressionAtlasiP41594. baseline and differential.
GenevisibleiP41594. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000202. GPCR_3_mtglu_rcpt_5.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01055. MTABOTROPC5R.
PR00593. MTABOTROPICR.
SMARTiSM01229. GluR_Homer-bdg. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRM5_HUMAN
AccessioniPrimary (citable) accession number: P41594
Secondary accession number(s): Q6J164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.