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P41593

- PTH1R_MOUSE

UniProt

P41593 - PTH1R_MOUSE

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Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

Pth1r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. parathyroid hormone receptor activity Source: MGI
  2. peptide hormone binding Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  2. aging Source: Ensembl
  3. bone mineralization Source: MGI
  4. bone resorption Source: MGI
  5. cell maturation Source: MGI
  6. cellular calcium ion homeostasis Source: MGI
  7. chondrocyte differentiation Source: MGI
  8. negative regulation of cell proliferation Source: MGI
  9. ossification Source: MGI
  10. osteoblast development Source: MGI
  11. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  12. positive regulation of cell proliferation Source: MGI
  13. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  14. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
  15. skeletal system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_250061. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alternative name(s):
PTH/PTHrP type I receptor
Short name:
PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name:
PTH1 receptor
Gene namesi
Name:Pth1r
Synonyms:Pthr, Pthr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:97801. Pth1r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 188162ExtracellularSequence AnalysisAdd
BLAST
Transmembranei189 – 21224Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini213 – 2197CytoplasmicSequence Analysis
Transmembranei220 – 23920Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini240 – 28243ExtracellularSequence AnalysisAdd
BLAST
Transmembranei283 – 30624Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini307 – 32014CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei321 – 34222Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini343 – 36119ExtracellularSequence AnalysisAdd
BLAST
Transmembranei362 – 38221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini383 – 40927CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei410 – 42819Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini429 – 44012ExtracellularSequence AnalysisAdd
BLAST
Transmembranei441 – 46323Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini464 – 591128CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. brush border membrane Source: Ensembl
  4. cytoplasm Source: Ensembl
  5. extracellular vesicular exosome Source: Ensembl
  6. integral component of plasma membrane Source: Ensembl
  7. intracellular Source: MGI
  8. nucleus Source: Ensembl
  9. receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 591565Parathyroid hormone/parathyroid hormone-related peptide receptorPRO_0000012846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 117By similarity
Disulfide bondi108 ↔ 148By similarity
Disulfide bondi131 ↔ 170By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP41593.
PRIDEiP41593.

PTM databases

PhosphoSiteiP41593.

Expressioni

Gene expression databases

BgeeiP41593.
GenevestigatoriP41593.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed by GNG2 and GNB1 (By similarity).By similarity

Protein-protein interaction databases

IntActiP41593. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP41593.
SMRiP41593. Positions 24-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi474 – 4774Important for interaction with G proteinsBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293423.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiP41593.
KOiK04585.
OMAiWIIQVPI.
OrthoDBiEOG7TF78W.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41593-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK
60 70 80 90 100
LLKEVLHTAA NIMESDKGWT PASTSGKPRK EKAPGKFYPE SKENKDVPTG
110 120 130 140 150
SRRRGRPCLP EWDNIVCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWEVVPGH NRTWANYSEC LKFMTNETRE REVFDRLGMI YTVGYSMSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK DAVLYSGFTL
260 270 280 290 300
DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG
360 370 380 390 400
CWDLSSGHKK WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLRST LVLVPLFGVH YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RAGLSLPLSP RLLPATTNGH SQLPGHAKPG APAIENETIP
560 570 580 590
VTMTVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M
Length:591
Mass (Da):66,372
Last modified:July 27, 2011 - v2
Checksum:iC2E6CCAF2ABAFEEF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 282DA → TS in AAA40011. (PubMed:8197183)Curated
Sequence conflicti464 – 4652Missing in AAA40011. (PubMed:8197183)Curated
Sequence conflicti500 – 5012VS → GA in CAA55536. (PubMed:7524627)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78936 mRNA. Translation: CAA55536.1.
L34611
, L34608, L34607, L34609, L34610 Genomic DNA. Translation: AAA40011.1.
BC051981 mRNA. Translation: AAH51981.1.
CCDSiCCDS52940.1.
PIRiI59297.
S44203.
RefSeqiNP_001077404.1. NM_001083935.1.
NP_001077405.1. NM_001083936.1.
NP_035329.2. NM_011199.2.
UniGeneiMm.3542.

Genome annotation databases

EnsembliENSMUST00000006005; ENSMUSP00000006005; ENSMUSG00000032492.
ENSMUST00000166716; ENSMUSP00000132064; ENSMUSG00000032492.
GeneIDi19228.
KEGGimmu:19228.
UCSCiuc009ruo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78936 mRNA. Translation: CAA55536.1 .
L34611
, L34608 , L34607 , L34609 , L34610 Genomic DNA. Translation: AAA40011.1 .
BC051981 mRNA. Translation: AAH51981.1 .
CCDSi CCDS52940.1.
PIRi I59297.
S44203.
RefSeqi NP_001077404.1. NM_001083935.1.
NP_001077405.1. NM_001083936.1.
NP_035329.2. NM_011199.2.
UniGenei Mm.3542.

3D structure databases

ProteinModelPortali P41593.
SMRi P41593. Positions 24-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P41593. 1 interaction.

Chemistry

BindingDBi P41593.
ChEMBLi CHEMBL1075300.
GuidetoPHARMACOLOGYi 331.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P41593.

Proteomic databases

PaxDbi P41593.
PRIDEi P41593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006005 ; ENSMUSP00000006005 ; ENSMUSG00000032492 .
ENSMUST00000166716 ; ENSMUSP00000132064 ; ENSMUSG00000032492 .
GeneIDi 19228.
KEGGi mmu:19228.
UCSCi uc009ruo.1. mouse.

Organism-specific databases

CTDi 5745.
MGIi MGI:97801. Pth1r.

Phylogenomic databases

eggNOGi NOG293423.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008248.
HOVERGENi HBG008318.
InParanoidi P41593.
KOi K04585.
OMAi WIIQVPI.
OrthoDBi EOG7TF78W.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_242871. G alpha (s) signalling events.
REACT_250061. Class B/2 (Secretin family receptors).

Miscellaneous databases

NextBioi 296024.
PROi P41593.
SOURCEi Search...

Gene expression databases

Bgeei P41593.
Genevestigatori P41593.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
PANTHERi PTHR12011:SF24. PTHR12011:SF24. 1 hit.
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes."
    Karperien M., van Dijk T.B., Hoeijmakers T., Cremers F., Abou-Samra A.-B., Boonstra J., de Laat S.W., Defize L.H.K.
    Mech. Dev. 47:29-42(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/HEHA.
  2. "Molecular cloning of the gene encoding the mouse parathyroid hormone/parathyroid hormone-related peptide receptor."
    McCuaig K.A., Clarke J.C., White J.H.
    Proc. Natl. Acad. Sci. U.S.A. 91:5051-5055(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPTH1R_MOUSE
AccessioniPrimary (citable) accession number: P41593
Secondary accession number(s): Q62119, Q80WU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3