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P41593

- PTH1R_MOUSE

UniProt

P41593 - PTH1R_MOUSE

Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

Pth1r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. parathyroid hormone receptor activity Source: MGI
    2. peptide hormone binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    2. aging Source: Ensembl
    3. bone mineralization Source: MGI
    4. bone resorption Source: MGI
    5. cell maturation Source: MGI
    6. cellular calcium ion homeostasis Source: MGI
    7. chondrocyte differentiation Source: MGI
    8. negative regulation of cell proliferation Source: MGI
    9. ossification Source: MGI
    10. osteoblast development Source: MGI
    11. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
    12. positive regulation of cell proliferation Source: MGI
    13. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    14. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
    15. skeletal system development Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathyroid hormone/parathyroid hormone-related peptide receptor
    Alternative name(s):
    PTH/PTHrP type I receptor
    Short name:
    PTH/PTHr receptor
    Parathyroid hormone 1 receptor
    Short name:
    PTH1 receptor
    Gene namesi
    Name:Pth1r
    Synonyms:Pthr, Pthr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:97801. Pth1r.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. brush border membrane Source: Ensembl
    4. cytoplasm Source: Ensembl
    5. integral component of plasma membrane Source: Ensembl
    6. intracellular Source: MGI
    7. nucleus Source: Ensembl
    8. receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 591565Parathyroid hormone/parathyroid hormone-related peptide receptorPRO_0000012846Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi48 ↔ 117By similarity
    Disulfide bondi108 ↔ 148By similarity
    Disulfide bondi131 ↔ 170By similarity
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP41593.
    PRIDEiP41593.

    PTM databases

    PhosphoSiteiP41593.

    Expressioni

    Gene expression databases

    BgeeiP41593.
    GenevestigatoriP41593.

    Interactioni

    Subunit structurei

    Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed by GNG2 and GNB1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiP41593. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP41593.
    SMRiP41593. Positions 24-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 188162ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 2197CytoplasmicSequence Analysis
    Topological domaini240 – 28243ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini307 – 32014CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini343 – 36119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini383 – 40927CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini429 – 44012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini464 – 591128CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei189 – 21224Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 23920Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30624Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei321 – 34222Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei410 – 42819Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei441 – 46323Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi474 – 4774Important for interaction with G proteinsBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293423.
    GeneTreeiENSGT00750000117453.
    HOGENOMiHOG000008248.
    HOVERGENiHBG008318.
    InParanoidiQ80WU8.
    KOiK04585.
    OMAiWIIQVPI.
    OrthoDBiEOG7TF78W.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002170. GPCR_2_parathyroid_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PANTHERiPTHR12011:SF24. PTHR12011:SF24. 1 hit.
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR00393. PTRHORMONER.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41593-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK    50
    LLKEVLHTAA NIMESDKGWT PASTSGKPRK EKAPGKFYPE SKENKDVPTG 100
    SRRRGRPCLP EWDNIVCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR 150
    NGSWEVVPGH NRTWANYSEC LKFMTNETRE REVFDRLGMI YTVGYSMSLA 200
    SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK DAVLYSGFTL 250
    DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL 300
    VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG 350
    CWDLSSGHKK WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR 400
    QQYRKLLRST LVLVPLFGVH YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF 450
    QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA LDFKRKARSG SSSYSYGPMV 500
    SHTSVTNVGP RAGLSLPLSP RLLPATTNGH SQLPGHAKPG APAIENETIP 550
    VTMTVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M 591
    Length:591
    Mass (Da):66,372
    Last modified:July 27, 2011 - v2
    Checksum:iC2E6CCAF2ABAFEEF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 282DA → TS in AAA40011. (PubMed:8197183)Curated
    Sequence conflicti464 – 4652Missing in AAA40011. (PubMed:8197183)Curated
    Sequence conflicti500 – 5012VS → GA in CAA55536. (PubMed:7524627)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78936 mRNA. Translation: CAA55536.1.
    L34611
    , L34608, L34607, L34609, L34610 Genomic DNA. Translation: AAA40011.1.
    BC051981 mRNA. Translation: AAH51981.1.
    CCDSiCCDS52940.1.
    PIRiI59297.
    S44203.
    RefSeqiNP_001077404.1. NM_001083935.1.
    NP_001077405.1. NM_001083936.1.
    NP_035329.2. NM_011199.2.
    UniGeneiMm.3542.

    Genome annotation databases

    EnsembliENSMUST00000006005; ENSMUSP00000006005; ENSMUSG00000032492.
    ENSMUST00000166716; ENSMUSP00000132064; ENSMUSG00000032492.
    GeneIDi19228.
    KEGGimmu:19228.
    UCSCiuc009ruo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78936 mRNA. Translation: CAA55536.1 .
    L34611
    , L34608 , L34607 , L34609 , L34610 Genomic DNA. Translation: AAA40011.1 .
    BC051981 mRNA. Translation: AAH51981.1 .
    CCDSi CCDS52940.1.
    PIRi I59297.
    S44203.
    RefSeqi NP_001077404.1. NM_001083935.1.
    NP_001077405.1. NM_001083936.1.
    NP_035329.2. NM_011199.2.
    UniGenei Mm.3542.

    3D structure databases

    ProteinModelPortali P41593.
    SMRi P41593. Positions 24-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P41593. 1 interaction.

    Chemistry

    ChEMBLi CHEMBL1075300.
    GuidetoPHARMACOLOGYi 331.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P41593.

    Proteomic databases

    PaxDbi P41593.
    PRIDEi P41593.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006005 ; ENSMUSP00000006005 ; ENSMUSG00000032492 .
    ENSMUST00000166716 ; ENSMUSP00000132064 ; ENSMUSG00000032492 .
    GeneIDi 19228.
    KEGGi mmu:19228.
    UCSCi uc009ruo.1. mouse.

    Organism-specific databases

    CTDi 5745.
    MGIi MGI:97801. Pth1r.

    Phylogenomic databases

    eggNOGi NOG293423.
    GeneTreei ENSGT00750000117453.
    HOGENOMi HOG000008248.
    HOVERGENi HBG008318.
    InParanoidi Q80WU8.
    KOi K04585.
    OMAi WIIQVPI.
    OrthoDBi EOG7TF78W.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 296024.
    PROi P41593.
    SOURCEi Search...

    Gene expression databases

    Bgeei P41593.
    Genevestigatori P41593.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002170. GPCR_2_parathyroid_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    PANTHERi PTHR12011:SF24. PTHR12011:SF24. 1 hit.
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR00393. PTRHORMONER.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes."
      Karperien M., van Dijk T.B., Hoeijmakers T., Cremers F., Abou-Samra A.-B., Boonstra J., de Laat S.W., Defize L.H.K.
      Mech. Dev. 47:29-42(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H/HEHA.
    2. "Molecular cloning of the gene encoding the mouse parathyroid hormone/parathyroid hormone-related peptide receptor."
      McCuaig K.A., Clarke J.C., White J.H.
      Proc. Natl. Acad. Sci. U.S.A. 91:5051-5055(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPTH1R_MOUSE
    AccessioniPrimary (citable) accession number: P41593
    Secondary accession number(s): Q62119, Q80WU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3