Parathyroid hormone/parathyroid hormone-related peptide receptor precursor

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P41593 (PTH1R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 112. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor

Alternative name(s):
PTH/PTHrP type I receptor
Short name=PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name=PTH1 receptor

Gene names

Name:	Pth1r
Synonyms:	Pthr, Pthr1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	591 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Subunit structure	Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed by GNG2 and GNB1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-activating G-protein coupled receptor signaling pathway Inferred from mutant phenotype PubMed 9832460. Source: MGI aging Inferred from electronic annotation. Source: Compara bone mineralization Inferred from mutant phenotype PubMed 11606467 PubMed 9832460. Source: MGI bone resorption Inferred from mutant phenotype PubMed 9832460. Source: MGI cell maturation Inferred from mutant phenotype PubMed 12194850. Source: MGI cellular calcium ion homeostasis Inferred from mutant phenotype PubMed 9832460. Source: MGI chondrocyte differentiation Inferred from mutant phenotype PubMed 9832460. Source: MGI elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from mutant phenotype PubMed 12194850. Source: MGI osteoblast development Inferred from mutant phenotype PubMed 9832460. Source: MGI phospholipase C-activating G-protein coupled receptor signaling pathway Inferred from mutant phenotype PubMed 12194850. Source: MGI positive regulation of cell proliferation Inferred from genetic interaction PubMed 16476422. Source: MGI positive regulation of inositol phosphate biosynthetic process Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara basolateral plasma membrane Inferred from electronic annotation. Source: Compara brush border membrane Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from electronic annotation. Source: Compara intracellular Inferred from direct assay PubMed 8895385. Source: MGI nucleus Inferred from electronic annotation. Source: Compara receptor complex Inferred from electronic annotation. Source: Compara
Molecular_function	parathyroid hormone receptor activity Inferred from mutant phenotype PubMed 9832460. Source: MGI peptide hormone binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

Potential

Chain

27 – 591

565

Parathyroid hormone/parathyroid hormone-related peptide receptor

PRO_0000012846

Regions

Topological domain

27 – 188

162

Extracellular Potential

Transmembrane

189 – 212

Helical; Name=1; Potential

Topological domain

213 – 219

Cytoplasmic Potential

Transmembrane

220 – 239

Helical; Name=2; Potential

Topological domain

240 – 282

Extracellular Potential

Transmembrane

283 – 306

Helical; Name=3; Potential

Topological domain

307 – 320

Cytoplasmic Potential

Transmembrane

321 – 342

Helical; Name=4; Potential

Topological domain

343 – 361

Extracellular Potential

Transmembrane

362 – 382

Helical; Name=5; Potential

Topological domain

383 – 409

Cytoplasmic Potential

Transmembrane

410 – 428

Helical; Name=6; Potential

Topological domain

429 – 440

Extracellular Potential

Transmembrane

441 – 463

Helical; Name=7; Potential

Topological domain

464 – 591

128

Cytoplasmic Potential

Motif

474 – 477

Important for interaction with G proteins By similarity

Amino acid modifications

Glycosylation

151

N-linked (GlcNAc...) Potential

Glycosylation

161

N-linked (GlcNAc...) Potential

Glycosylation

166

N-linked (GlcNAc...) Potential

Glycosylation

176

N-linked (GlcNAc...) Potential

Disulfide bond

48 ↔ 117

By similarity

Disulfide bond

108 ↔ 148

By similarity

Disulfide bond

131 ↔ 170

By similarity

Experimental info

Sequence conflict

27 – 28

DA → TS in AAA40011. Ref.2

Sequence conflict

464 – 465

Missing in AAA40011. Ref.2

Sequence conflict

500 – 501

VS → GA in CAA55536. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P41593 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: C2E6CCAF2ABAFEEF
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FASTA

591

66,372

        10         20         30         40         50         60 
MGTARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK LLKEVLHTAA 

        70         80         90        100        110        120 
NIMESDKGWT PASTSGKPRK EKAPGKFYPE SKENKDVPTG SRRRGRPCLP EWDNIVCWPL 

       130        140        150        160        170        180 
GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR NGSWEVVPGH NRTWANYSEC LKFMTNETRE 

       190        200        210        220        230        240 
REVFDRLGMI YTVGYSMSLA SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK 

       250        260        270        280        290        300 
DAVLYSGFTL DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL 

       310        320        330        340        350        360 
VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG CWDLSSGHKK 

       370        380        390        400        410        420 
WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR QQYRKLLRST LVLVPLFGVH 

       430        440        450        460        470        480 
YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA 

       490        500        510        520        530        540 
LDFKRKARSG SSSYSYGPMV SHTSVTNVGP RAGLSLPLSP RLLPATTNGH SQLPGHAKPG 

       550        560        570        580        590 
APAIENETIP VTMTVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes." Karperien M., van Dijk T.B., Hoeijmakers T., Cremers F., Abou-Samra A.-B., Boonstra J., de Laat S.W., Defize L.H.K. Mech. Dev. 47:29-42(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C3H/HEHA.
[2]	"Molecular cloning of the gene encoding the mouse parathyroid hormone/parathyroid hormone-related peptide receptor." McCuaig K.A., Clarke J.C., White J.H. Proc. Natl. Acad. Sci. U.S.A. 91:5051-5055(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78936 mRNA. Translation: CAA55536.1. L34611 , L34608, L34607, L34609, L34610 Genomic DNA. Translation: AAA40011.1. BC051981 mRNA. Translation: AAH51981.1.
IPI	IPI00114634.
PIR	I59297. S44203.
RefSeq	NP_001077404.1. NM_001083935.1. NP_001077405.1. NM_001083936.1. NP_035329.2. NM_011199.2.
UniGene	Mm.3542.
3D structure databases
HSSP	HSSP built from PDB template 1BL1 based on UniProtKB Q03431.
ProteinModelPortal	P41593.
SMR	P41593. Positions 24-197.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P41593.
Proteomic databases
PaxDb	P41593.
PRIDE	P41593.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000006005; ENSMUSP00000006005; ENSMUSG00000032492. ENSMUST00000166716; ENSMUSP00000132064; ENSMUSG00000032492.
GeneID	19228.
KEGG	mmu:19228.
Organism-specific databases
CTD	5745.
MGI	MGI:97801. Pth1r.
Phylogenomic databases
eggNOG	NOG293423.
GeneTree	ENSGT00650000093116.
HOGENOM	HOG000008248.
HOVERGEN	HBG008318.
InParanoid	Q80WU8.
KO	K04585.
OMA	WIIQVPI.
OrthoDB	EOG4XWFXR.
Gene expression databases
Bgee	P41593.
Genevestigator	P41593.
GermOnline	ENSMUSG00000032492. Mus musculus.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular_dom. IPR002170. GPCR_2_parathyroid_rcpt. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. [Graphical view]
PANTHER	PTHR12011:SF24. PTHR12011:SF24. 1 hit.
Pfam	PF00002. 7tm_2. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN. PR00393. PTRHORMONER.
SMART	SM00008. HormR. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. 1 hit. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1075300.
NextBio	296024.
SOURCE	Search...

Entry information

Entry name

PTH1R_MOUSE

Accession

Primary (citable) accession number: P41593
Secondary accession number(s): Q62119, Q80WU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents