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Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

Pth1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for parathyroid hormone and for parathyroid hormone-related peptide (PubMed:8197183). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.By similarity1 Publication

GO - Molecular functioni

  • parathyroid hormone receptor activity Source: MGI
  • peptide hormone binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein self-association Source: MGI

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  • aging Source: Ensembl
  • bone mineralization Source: MGI
  • bone resorption Source: MGI
  • cell maturation Source: MGI
  • cell surface receptor signaling pathway Source: InterPro
  • cellular calcium ion homeostasis Source: MGI
  • chondrocyte differentiation Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • ossification Source: MGI
  • osteoblast development Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of inositol phosphate biosynthetic process Source: Ensembl
  • skeletal system development Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alternative name(s):
PTH/PTHrP type I receptor
Short name:
PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name:
PTH1 receptor
Gene namesi
Name:Pth1r
Synonyms:Pthr, Pthr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97801 Pth1r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 188ExtracellularSequence analysisAdd BLAST162
Transmembranei189 – 212Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini213 – 219CytoplasmicSequence analysis7
Transmembranei220 – 239Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini240 – 282ExtracellularSequence analysisAdd BLAST43
Transmembranei283 – 306Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini307 – 320CytoplasmicSequence analysisAdd BLAST14
Transmembranei321 – 342Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini343 – 361ExtracellularSequence analysisAdd BLAST19
Transmembranei362 – 382Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini383 – 409CytoplasmicSequence analysisAdd BLAST27
Transmembranei410 – 428Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini429 – 440ExtracellularSequence analysisAdd BLAST12
Transmembranei441 – 463Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini464 – 591CytoplasmicSequence analysisAdd BLAST128

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075300

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001284627 – 591Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 117By similarity
Disulfide bondi108 ↔ 148By similarity
Disulfide bondi131 ↔ 170By similarity
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP41593
PaxDbiP41593
PRIDEiP41593

PTM databases

iPTMnetiP41593
PhosphoSitePlusiP41593

Expressioni

Tissue specificityi

Detected in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000032492
ExpressionAtlasiP41593 baseline and differential
GenevisibleiP41593 MM

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8197183). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202466, 1 interactor
IntActiP41593, 1 interactor
STRINGi10090.ENSMUSP00000006005

Structurei

3D structure databases

ProteinModelPortaliP41593
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi474 – 477Important for interaction with G proteinsBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008248
HOVERGENiHBG008318
InParanoidiP41593
KOiK04585
OMAiYAGCRVA
OrthoDBiEOG091G0NF8
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR002170 GPCR_2_parathyroid_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF24 PTHR12011:SF24, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00393 PTRHORMONER
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK
60 70 80 90 100
LLKEVLHTAA NIMESDKGWT PASTSGKPRK EKAPGKFYPE SKENKDVPTG
110 120 130 140 150
SRRRGRPCLP EWDNIVCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWEVVPGH NRTWANYSEC LKFMTNETRE REVFDRLGMI YTVGYSMSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK DAVLYSGFTL
260 270 280 290 300
DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG
360 370 380 390 400
CWDLSSGHKK WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLRST LVLVPLFGVH YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RAGLSLPLSP RLLPATTNGH SQLPGHAKPG APAIENETIP
560 570 580 590
VTMTVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M
Length:591
Mass (Da):66,372
Last modified:July 27, 2011 - v2
Checksum:iC2E6CCAF2ABAFEEF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 28DA → TS in AAA40011 (PubMed:8197183).Curated2
Sequence conflicti464 – 465Missing in AAA40011 (PubMed:8197183).Curated2
Sequence conflicti500 – 501VS → GA in CAA55536 (PubMed:7524627).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78936 mRNA Translation: CAA55536.1
L34611
, L34608, L34607, L34609, L34610 Genomic DNA Translation: AAA40011.1
BC051981 mRNA Translation: AAH51981.1
CCDSiCCDS52940.1
PIRiI59297
S44203
RefSeqiNP_001077404.1, NM_001083935.1
NP_001077405.1, NM_001083936.1
NP_035329.2, NM_011199.2
UniGeneiMm.3542

Genome annotation databases

EnsembliENSMUST00000006005; ENSMUSP00000006005; ENSMUSG00000032492
ENSMUST00000166716; ENSMUSP00000132064; ENSMUSG00000032492
ENSMUST00000198865; ENSMUSP00000143298; ENSMUSG00000032492
GeneIDi19228
KEGGimmu:19228
UCSCiuc009ruo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPTH1R_MOUSE
AccessioniPrimary (citable) accession number: P41593
Secondary accession number(s): Q62119, Q80WU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health