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Protein

Vasoactive intestinal polypeptide receptor 2

Gene

Vipr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 2
Short name:
VIP-R-2
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type III receptor
Short name:
PACAP type III receptor
Short name:
PACAP-R-3
Short name:
PACAP-R3
Gene namesi
Name:Vipr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:107166 Vipr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 125ExtracellularSequence analysisAdd BLAST103
Transmembranei126 – 150Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini151 – 157CytoplasmicSequence analysis7
Transmembranei158 – 177Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini178 – 202ExtracellularSequence analysisAdd BLAST25
Transmembranei203 – 226Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini227 – 239CytoplasmicSequence analysisAdd BLAST13
Transmembranei240 – 261Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini262 – 278ExtracellularSequence analysisAdd BLAST17
Transmembranei279 – 302Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini303 – 327CytoplasmicSequence analysisAdd BLAST25
Transmembranei328 – 347Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini348 – 359ExtracellularSequence analysisAdd BLAST12
Transmembranei360 – 379Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini380 – 437CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001286123 – 437Vasoactive intestinal polypeptide receptor 2Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 60By similarity
Disulfide bondi51 ↔ 92By similarity
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi74 ↔ 108By similarity
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 270By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP41588
PRIDEiP41588

PTM databases

iPTMnetiP41588
PhosphoSitePlusiP41588
SwissPalmiP41588

Expressioni

Tissue specificityi

Expressed at high levels in the MIN6 cells, at moderate levels in pancreatic islets, insulin-secreting cells, lung, brain, stomach, and colon, and at low levels in the heart.

Gene expression databases

BgeeiENSMUSG00000011171
CleanExiMM_VIPR2
ExpressionAtlasiP41588 baseline and differential
GenevisibleiP41588 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011315

Structurei

3D structure databases

ProteinModelPortaliP41588
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008249
HOVERGENiHBG008318
InParanoidiP41588
KOiK04590
OMAiSEMFPDF
OrthoDBiEOG091G0NF8
PhylomeDBiP41588
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR001571 GPCR_2_VIP_rcpt
IPR002284 GPCR_2_VIP_rcpt_2
PANTHERiPTHR12011:SF27 PTHR12011:SF27, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00491 VASOACTVEIPR
PR01155 VIP2RECEPTOR
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRASVVLTCY CWLLVRVSSI HPECRFHLEI QEEETKCAEL LSSQTENQRA
60 70 80 90 100
CSGVWDNITC WRPADVGETV TVPCPKVFSN FYSRPGNISK NCTSDGWSET
110 120 130 140 150
FPDFIDACGY NDPEDESKIS FYILVKAIYT LGYSVSLMSL TTGSIIICLF
160 170 180 190 200
RKLHCTRNYI HLNLFLSFML RAISVLVKDS VLYSSSGLLR CHDQPASWVG
210 220 230 240 250
CKLSLVFFQY CIMANFYWLL VEGLYLHTLL VAILPPSRCF LAYLLIGWGI
260 270 280 290 300
PSVCIGAWTA TRLSLEDTGC WDTNDHSIPW WVIRMPILIS IVVNFALFIS
310 320 330 340 350
IVRILLQKLT SPDVGGNDQS QYKRLAKSTL LLIPLFGVHY MVFAAFPIGI
360 370 380 390 400
SSTYQILFEL CVGSFQGLVV AVLYCFLNSE VQCELKRRWR GLCLTQAGSR
410 420 430
DYRLHSWSMS RNGSESALQI HRGSRTQSFL QSETSVI
Length:437
Mass (Da):49,474
Last modified:November 1, 1995 - v1
Checksum:iCCC870A094F9DC90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti397A → P in AAN86758 (PubMed:8784257).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28132 mRNA Translation: BAA05674.1
S82966 Genomic DNA Translation: AAN86758.1
CCDSiCCDS26210.1
PIRiA53471 JU0185
RefSeqiNP_033537.1, NM_009511.2
UniGeneiMm.395245

Genome annotation databases

EnsembliENSMUST00000011315; ENSMUSP00000011315; ENSMUSG00000011171
GeneIDi22355
KEGGimmu:22355
UCSCiuc007phe.2 mouse

Similar proteinsi

Entry informationi

Entry nameiVIPR2_MOUSE
AccessioniPrimary (citable) accession number: P41588
Secondary accession number(s): P97750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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