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Protein

Vasoactive intestinal polypeptide receptor 2

Gene

Vipr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 2
Short name:
VIP-R-2
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type III receptor
Short name:
PACAP type III receptor
Short name:
PACAP-R-3
Short name:
PACAP-R3
Gene namesi
Name:Vipr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:107166. Vipr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 125103ExtracellularSequence analysisAdd
BLAST
Transmembranei126 – 15025Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini151 – 1577CytoplasmicSequence analysis
Transmembranei158 – 17720Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini178 – 20225ExtracellularSequence analysisAdd
BLAST
Transmembranei203 – 22624Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini227 – 23913CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26122Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini262 – 27817ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 30224Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini303 – 32725CytoplasmicSequence analysisAdd
BLAST
Transmembranei328 – 34720Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini348 – 35912ExtracellularSequence analysisAdd
BLAST
Transmembranei360 – 37920Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini380 – 43758CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 437415Vasoactive intestinal polypeptide receptor 2PRO_0000012861Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 60By similarity
Disulfide bondi51 ↔ 92By similarity
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi74 ↔ 108By similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi201 ↔ 270By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP41588.
PRIDEiP41588.

PTM databases

PhosphoSiteiP41588.

Expressioni

Tissue specificityi

Expressed at high levels in the MIN6 cells, at moderate levels in pancreatic islets, insulin-secreting cells, lung, brain, stomach, and colon, and at low levels in the heart.

Gene expression databases

BgeeiP41588.
CleanExiMM_VIPR2.
ExpressionAtlasiP41588. baseline and differential.
GenevisibleiP41588. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011315.

Structurei

3D structure databases

ProteinModelPortaliP41588.
SMRiP41588. Positions 25-113, 122-384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP41588.
KOiK04590.
OMAiPGNISKN.
OrthoDBiEOG7TF78W.
PhylomeDBiP41588.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRASVVLTCY CWLLVRVSSI HPECRFHLEI QEEETKCAEL LSSQTENQRA
60 70 80 90 100
CSGVWDNITC WRPADVGETV TVPCPKVFSN FYSRPGNISK NCTSDGWSET
110 120 130 140 150
FPDFIDACGY NDPEDESKIS FYILVKAIYT LGYSVSLMSL TTGSIIICLF
160 170 180 190 200
RKLHCTRNYI HLNLFLSFML RAISVLVKDS VLYSSSGLLR CHDQPASWVG
210 220 230 240 250
CKLSLVFFQY CIMANFYWLL VEGLYLHTLL VAILPPSRCF LAYLLIGWGI
260 270 280 290 300
PSVCIGAWTA TRLSLEDTGC WDTNDHSIPW WVIRMPILIS IVVNFALFIS
310 320 330 340 350
IVRILLQKLT SPDVGGNDQS QYKRLAKSTL LLIPLFGVHY MVFAAFPIGI
360 370 380 390 400
SSTYQILFEL CVGSFQGLVV AVLYCFLNSE VQCELKRRWR GLCLTQAGSR
410 420 430
DYRLHSWSMS RNGSESALQI HRGSRTQSFL QSETSVI
Length:437
Mass (Da):49,474
Last modified:November 1, 1995 - v1
Checksum:iCCC870A094F9DC90
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti397 – 3971A → P in AAN86758 (PubMed:8784257).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28132 mRNA. Translation: BAA05674.1.
S82966 Genomic DNA. Translation: AAN86758.1.
CCDSiCCDS26210.1.
PIRiA53471. JU0185.
RefSeqiNP_033537.1. NM_009511.2.
UniGeneiMm.395245.

Genome annotation databases

EnsembliENSMUST00000011315; ENSMUSP00000011315; ENSMUSG00000011171.
GeneIDi22355.
KEGGimmu:22355.
UCSCiuc007phe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28132 mRNA. Translation: BAA05674.1.
S82966 Genomic DNA. Translation: AAN86758.1.
CCDSiCCDS26210.1.
PIRiA53471. JU0185.
RefSeqiNP_033537.1. NM_009511.2.
UniGeneiMm.395245.

3D structure databases

ProteinModelPortaliP41588.
SMRiP41588. Positions 25-113, 122-384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011315.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP41588.

Proteomic databases

PaxDbiP41588.
PRIDEiP41588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000011315; ENSMUSP00000011315; ENSMUSG00000011171.
GeneIDi22355.
KEGGimmu:22355.
UCSCiuc007phe.2. mouse.

Organism-specific databases

CTDi7434.
MGIiMGI:107166. Vipr2.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP41588.
KOiK04590.
OMAiPGNISKN.
OrthoDBiEOG7TF78W.
PhylomeDBiP41588.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

NextBioi302655.
PROiP41588.
SOURCEiSearch...

Gene expression databases

BgeeiP41588.
CleanExiMM_VIPR2.
ExpressionAtlasiP41588. baseline and differential.
GenevisibleiP41588. MM.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells."
    Inagaki N., Yoshida H., Mizuta M., Mizuno N., Fujii Y., Gonoi T., Miyazaki J., Seino S.
    Proc. Natl. Acad. Sci. U.S.A. 91:2679-2683(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Differential expression of vasoactive intestinal peptide receptors 1 and 2 (VIP-R1 and VIP-R2) mRNA in murine lymphocytes."
    Delgado M., Martinez C., Johnson M.C., Gomariz R.P., Ganea D.
    J. Neuroimmunol. 68:27-38(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 149-407.
    Strain: BALB/cJ.
    Tissue: Thymus.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiVIPR2_MOUSE
AccessioniPrimary (citable) accession number: P41588
Secondary accession number(s): P97750
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.