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Protein

Vasoactive intestinal polypeptide receptor 2

Gene

VIPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • vasoactive intestinal polypeptide receptor activity Source: Ensembl

GO - Biological processi

  • activation of adenylate cyclase activity Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • cell surface receptor signaling pathway Source: InterPro
  • negative regulation of smooth muscle cell proliferation Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106018-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 2
Short name:
VIP-R-2
Alternative name(s):
Helodermin-preferring VIP receptor
Pituitary adenylate cyclase-activating polypeptide type III receptor
Short name:
PACAP type III receptor
Short name:
PACAP-R-3
Short name:
PACAP-R3
VPAC2
Gene namesi
Name:VIPR2
Synonyms:VIP2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12695. VIPR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 126ExtracellularSequence analysisAdd BLAST103
Transmembranei127 – 151Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini152 – 158CytoplasmicSequence analysis7
Transmembranei159 – 178Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini179 – 203ExtracellularSequence analysisAdd BLAST25
Transmembranei204 – 227Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini228 – 240CytoplasmicSequence analysisAdd BLAST13
Transmembranei241 – 262Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini263 – 279ExtracellularSequence analysisAdd BLAST17
Transmembranei280 – 303Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini304 – 328CytoplasmicSequence analysisAdd BLAST25
Transmembranei329 – 348Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini349 – 360ExtracellularSequence analysisAdd BLAST12
Transmembranei361 – 380Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini381 – 438CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7434.
OpenTargetsiENSG00000106018.
Orphaneti3140. Schizophrenia.
PharmGKBiPA37314.

Chemistry databases

ChEMBLiCHEMBL4532.
GuidetoPHARMACOLOGYi372.

Polymorphism and mutation databases

BioMutaiVIPR2.
DMDMi2506490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001286024 – 438Vasoactive intestinal polypeptide receptor 2Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 611 Publication
Disulfide bondi52 ↔ 931 Publication
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi75 ↔ 1091 Publication
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi202 ↔ 271By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP41587.
PeptideAtlasiP41587.
PRIDEiP41587.

PTM databases

iPTMnetiP41587.
PhosphoSitePlusiP41587.

Expressioni

Tissue specificityi

Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78.1 Publication

Gene expression databases

BgeeiENSG00000106018.
CleanExiHS_VIPR2.
ExpressionAtlasiP41587. baseline and differential.
GenevisibleiP41587. HS.

Organism-specific databases

HPAiHPA062707.

Interactioni

Protein-protein interaction databases

BioGridi113275. 94 interactors.
IntActiP41587. 2 interactors.
STRINGi9606.ENSP00000262178.

Chemistry databases

BindingDBiP41587.

Structurei

Secondary structure

1438
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 44Combined sources19
Turni45 – 47Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi60 – 62Combined sources3
Beta strandi70 – 74Combined sources5
Helixi77 – 82Combined sources6
Beta strandi83 – 85Combined sources3
Beta strandi88 – 94Combined sources7
Helixi105 – 109Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X57X-ray2.10A/B/C26-118[»]
ProteinModelPortaliP41587.
SMRiP41587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP41587.
KOiK04590.
OMAiSEMFPDF.
PhylomeDBiP41587.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTLLPPALL TCWLLAPVNS IHPECRFHLE IQEEETKCAE LLRSQTEKHK
60 70 80 90 100
ACSGVWDNIT CWRPANVGET VTVPCPKVFS NFYSKAGNIS KNCTSDGWSE
110 120 130 140 150
TFPDFVDACG YSDPEDESKI TFYILVKAIY TLGYSVSLMS LATGSIILCL
160 170 180 190 200
FRKLHCTRNY IHLNLFLSFI LRAISVLVKD DVLYSSSGTL HCPDQPSSWV
210 220 230 240 250
GCKLSLVFLQ YCIMANFFWL LVEGLYLHTL LVAMLPPRRC FLAYLLIGWG
260 270 280 290 300
LPTVCIGAWT AARLYLEDTG CWDTNDHSVP WWVIRIPILI SIIVNFVLFI
310 320 330 340 350
SIIRILLQKL TSPDVGGNDQ SQYKRLAKST LLLIPLFGVH YMVFAVFPIS
360 370 380 390 400
ISSKYQILFE LCLGSFQGLV VAVLYCFLNS EVQCELKRKW RSRCPTPSAS
410 420 430
RDYRVCGSSF SRNGSEGALQ FHRGSRAQSF LQTETSVI
Length:438
Mass (Da):49,479
Last modified:November 1, 1997 - v2
Checksum:i265A43A70BE09699
GO
Isoform 2 (identifier: P41587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: MRTLLPPALL...TSDGWSETFP → MPLWEAPSDH...MDTVRRKHPE
     104-119: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):46,756
Checksum:iA05B08247F869DEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti424G → A in AAC37569 (PubMed:7811244).Curated1
Sequence conflicti424G → A in AAC41756 (PubMed:7811244).Curated1
Sequence conflicti424G → A in AAC50872 (PubMed:8933357).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01181139A → T.Corresponds to variant rs1062609dbSNPEnsembl.1
Natural variantiVAR_011812412R → H.Corresponds to variant rs1042620dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566841 – 103MRTLL…SETFP → MPLWEAPSDHPANPPATLQG HTSLPGCQEEPARDPQSGLP QITSESSSFSEGSLPSWSSG PAGAKLNASHEGIGSSSDGN GDSKAATERVVSAMDTVRRK HPE in isoform 2. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_056685104 – 119Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36566 mRNA. Translation: AAC37569.1.
L40764 Genomic DNA. Translation: AAC41756.1.
U18810 mRNA. Translation: AAC50872.1.
X95097 mRNA. Translation: CAA64474.1.
Y18423
, Y18424, Y18425, Y18426, Y18427, Y18428, Y18429, Y18430, Y18431 Genomic DNA. Translation: CAB41899.1.
BT007118 mRNA. Translation: AAP35782.1.
AK131406 mRNA. Translation: BAD18553.1.
AC004863 Genomic DNA. No translation available.
AC007269 Genomic DNA. No translation available.
AF027390 Genomic DNA. No translation available.
CH236954 Genomic DNA. Translation: EAL23936.1.
CH471149 Genomic DNA. Translation: EAX04596.1.
BC010569 mRNA. Translation: AAH10569.1.
CCDSiCCDS5950.1. [P41587-1]
CCDS78295.1. [P41587-2]
PIRiG02822.
RefSeqiNP_001291451.1. NM_001304522.1.
NP_001295188.1. NM_001308259.1. [P41587-2]
NP_003373.2. NM_003382.4. [P41587-1]
UniGeneiHs.585052.

Genome annotation databases

EnsembliENST00000262178; ENSP00000262178; ENSG00000106018. [P41587-1]
ENST00000377633; ENSP00000366860; ENSG00000106018. [P41587-2]
GeneIDi7434.
KEGGihsa:7434.
UCSCiuc064jts.1. human. [P41587-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36566 mRNA. Translation: AAC37569.1.
L40764 Genomic DNA. Translation: AAC41756.1.
U18810 mRNA. Translation: AAC50872.1.
X95097 mRNA. Translation: CAA64474.1.
Y18423
, Y18424, Y18425, Y18426, Y18427, Y18428, Y18429, Y18430, Y18431 Genomic DNA. Translation: CAB41899.1.
BT007118 mRNA. Translation: AAP35782.1.
AK131406 mRNA. Translation: BAD18553.1.
AC004863 Genomic DNA. No translation available.
AC007269 Genomic DNA. No translation available.
AF027390 Genomic DNA. No translation available.
CH236954 Genomic DNA. Translation: EAL23936.1.
CH471149 Genomic DNA. Translation: EAX04596.1.
BC010569 mRNA. Translation: AAH10569.1.
CCDSiCCDS5950.1. [P41587-1]
CCDS78295.1. [P41587-2]
PIRiG02822.
RefSeqiNP_001291451.1. NM_001304522.1.
NP_001295188.1. NM_001308259.1. [P41587-2]
NP_003373.2. NM_003382.4. [P41587-1]
UniGeneiHs.585052.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X57X-ray2.10A/B/C26-118[»]
ProteinModelPortaliP41587.
SMRiP41587.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113275. 94 interactors.
IntActiP41587. 2 interactors.
STRINGi9606.ENSP00000262178.

Chemistry databases

BindingDBiP41587.
ChEMBLiCHEMBL4532.
GuidetoPHARMACOLOGYi372.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP41587.
PhosphoSitePlusiP41587.

Polymorphism and mutation databases

BioMutaiVIPR2.
DMDMi2506490.

Proteomic databases

PaxDbiP41587.
PeptideAtlasiP41587.
PRIDEiP41587.

Protocols and materials databases

DNASUi7434.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262178; ENSP00000262178; ENSG00000106018. [P41587-1]
ENST00000377633; ENSP00000366860; ENSG00000106018. [P41587-2]
GeneIDi7434.
KEGGihsa:7434.
UCSCiuc064jts.1. human. [P41587-1]

Organism-specific databases

CTDi7434.
DisGeNETi7434.
GeneCardsiVIPR2.
H-InvDBHIX0095225.
HIX0167627.
HGNCiHGNC:12695. VIPR2.
HPAiHPA062707.
MIMi601970. gene.
neXtProtiNX_P41587.
OpenTargetsiENSG00000106018.
Orphaneti3140. Schizophrenia.
PharmGKBiPA37314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP41587.
KOiK04590.
OMAiSEMFPDF.
PhylomeDBiP41587.
TreeFamiTF315710.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106018-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiVIPR2.
GenomeRNAii7434.
PROiP41587.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106018.
CleanExiHS_VIPR2.
ExpressionAtlasiP41587. baseline and differential.
GenevisibleiP41587. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIPR2_HUMAN
AccessioniPrimary (citable) accession number: P41587
Secondary accession number(s): Q13053
, Q15870, Q53Y09, Q6ZN22, Q9UCW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.