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Protein

Vasoactive intestinal polypeptide receptor 2

Gene

VIPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • vasoactive intestinal polypeptide receptor activity Source: Ensembl

GO - Biological processi

  • activation of adenylate cyclase activity Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • cell surface receptor signaling pathway Source: InterPro
  • negative regulation of smooth muscle cell proliferation Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 2
Short name:
VIP-R-2
Alternative name(s):
Helodermin-preferring VIP receptor
Pituitary adenylate cyclase-activating polypeptide type III receptor
Short name:
PACAP type III receptor
Short name:
PACAP-R-3
Short name:
PACAP-R3
VPAC2
Gene namesi
Name:VIPR2
Synonyms:VIP2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12695. VIPR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 126103ExtracellularSequence analysisAdd
BLAST
Transmembranei127 – 15125Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini152 – 1587CytoplasmicSequence analysis
Transmembranei159 – 17820Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini179 – 20325ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22724Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini228 – 24013CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26222Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini263 – 27917ExtracellularSequence analysisAdd
BLAST
Transmembranei280 – 30324Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini304 – 32825CytoplasmicSequence analysisAdd
BLAST
Transmembranei329 – 34820Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini349 – 36012ExtracellularSequence analysisAdd
BLAST
Transmembranei361 – 38020Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini381 – 43858CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti3140. Schizophrenia.
PharmGKBiPA37314.

Chemistry

ChEMBLiCHEMBL4532.
GuidetoPHARMACOLOGYi372.

Polymorphism and mutation databases

BioMutaiVIPR2.
DMDMi2506490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 438415Vasoactive intestinal polypeptide receptor 2PRO_0000012860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 611 Publication
Disulfide bondi52 ↔ 931 Publication
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Disulfide bondi75 ↔ 1091 Publication
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi202 ↔ 271By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP41587.
PeptideAtlasiP41587.
PRIDEiP41587.

PTM databases

iPTMnetiP41587.
PhosphoSiteiP41587.

Expressioni

Tissue specificityi

Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78.1 Publication

Gene expression databases

BgeeiP41587.
CleanExiHS_VIPR2.
ExpressionAtlasiP41587. baseline and differential.
GenevisibleiP41587. HS.

Organism-specific databases

HPAiHPA062707.

Interactioni

Protein-protein interaction databases

BioGridi113275. 94 interactions.
IntActiP41587. 2 interactions.
STRINGi9606.ENSP00000262178.

Chemistry

BindingDBiP41587.

Structurei

Secondary structure

1
438
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 4419Combined sources
Turni45 – 473Combined sources
Beta strandi55 – 573Combined sources
Beta strandi60 – 623Combined sources
Beta strandi70 – 745Combined sources
Helixi77 – 826Combined sources
Beta strandi83 – 853Combined sources
Beta strandi88 – 947Combined sources
Helixi105 – 1095Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X57X-ray2.10A/B/C26-118[»]
ProteinModelPortaliP41587.
SMRiP41587. Positions 26-114, 123-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP41587.
KOiK04590.
OMAiPLWEAPS.
PhylomeDBiP41587.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTLLPPALL TCWLLAPVNS IHPECRFHLE IQEEETKCAE LLRSQTEKHK
60 70 80 90 100
ACSGVWDNIT CWRPANVGET VTVPCPKVFS NFYSKAGNIS KNCTSDGWSE
110 120 130 140 150
TFPDFVDACG YSDPEDESKI TFYILVKAIY TLGYSVSLMS LATGSIILCL
160 170 180 190 200
FRKLHCTRNY IHLNLFLSFI LRAISVLVKD DVLYSSSGTL HCPDQPSSWV
210 220 230 240 250
GCKLSLVFLQ YCIMANFFWL LVEGLYLHTL LVAMLPPRRC FLAYLLIGWG
260 270 280 290 300
LPTVCIGAWT AARLYLEDTG CWDTNDHSVP WWVIRIPILI SIIVNFVLFI
310 320 330 340 350
SIIRILLQKL TSPDVGGNDQ SQYKRLAKST LLLIPLFGVH YMVFAVFPIS
360 370 380 390 400
ISSKYQILFE LCLGSFQGLV VAVLYCFLNS EVQCELKRKW RSRCPTPSAS
410 420 430
RDYRVCGSSF SRNGSEGALQ FHRGSRAQSF LQTETSVI
Length:438
Mass (Da):49,479
Last modified:November 1, 1997 - v2
Checksum:i265A43A70BE09699
GO
Isoform 2 (identifier: P41587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: MRTLLPPALL...TSDGWSETFP → MPLWEAPSDH...MDTVRRKHPE
     104-119: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):46,756
Checksum:iA05B08247F869DEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti424 – 4241G → A in AAC37569 (PubMed:7811244).Curated
Sequence conflicti424 – 4241G → A in AAC41756 (PubMed:7811244).Curated
Sequence conflicti424 – 4241G → A in AAC50872 (PubMed:8933357).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391A → T.
Corresponds to variant rs1062609 [ dbSNP | Ensembl ].
VAR_011811
Natural varianti412 – 4121R → H.
Corresponds to variant rs1042620 [ dbSNP | Ensembl ].
VAR_011812

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 103103MRTLL…SETFP → MPLWEAPSDHPANPPATLQG HTSLPGCQEEPARDPQSGLP QITSESSSFSEGSLPSWSSG PAGAKLNASHEGIGSSSDGN GDSKAATERVVSAMDTVRRK HPE in isoform 2. 1 PublicationVSP_056684Add
BLAST
Alternative sequencei104 – 11916Missing in isoform 2. 1 PublicationVSP_056685Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36566 mRNA. Translation: AAC37569.1.
L40764 Genomic DNA. Translation: AAC41756.1.
U18810 mRNA. Translation: AAC50872.1.
X95097 mRNA. Translation: CAA64474.1.
Y18423
, Y18424, Y18425, Y18426, Y18427, Y18428, Y18429, Y18430, Y18431 Genomic DNA. Translation: CAB41899.1.
BT007118 mRNA. Translation: AAP35782.1.
AK131406 mRNA. Translation: BAD18553.1.
AC004863 Genomic DNA. No translation available.
AC007269 Genomic DNA. No translation available.
AF027390 Genomic DNA. No translation available.
CH236954 Genomic DNA. Translation: EAL23936.1.
CH471149 Genomic DNA. Translation: EAX04596.1.
BC010569 mRNA. Translation: AAH10569.1.
CCDSiCCDS5950.1. [P41587-1]
CCDS78295.1. [P41587-2]
PIRiG02822.
RefSeqiNP_001291451.1. NM_001304522.1.
NP_001295188.1. NM_001308259.1. [P41587-2]
NP_003373.2. NM_003382.4. [P41587-1]
UniGeneiHs.585052.

Genome annotation databases

EnsembliENST00000262178; ENSP00000262178; ENSG00000106018. [P41587-1]
ENST00000377633; ENSP00000366860; ENSG00000106018. [P41587-2]
GeneIDi7434.
KEGGihsa:7434.
UCSCiuc064jts.1. human. [P41587-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36566 mRNA. Translation: AAC37569.1.
L40764 Genomic DNA. Translation: AAC41756.1.
U18810 mRNA. Translation: AAC50872.1.
X95097 mRNA. Translation: CAA64474.1.
Y18423
, Y18424, Y18425, Y18426, Y18427, Y18428, Y18429, Y18430, Y18431 Genomic DNA. Translation: CAB41899.1.
BT007118 mRNA. Translation: AAP35782.1.
AK131406 mRNA. Translation: BAD18553.1.
AC004863 Genomic DNA. No translation available.
AC007269 Genomic DNA. No translation available.
AF027390 Genomic DNA. No translation available.
CH236954 Genomic DNA. Translation: EAL23936.1.
CH471149 Genomic DNA. Translation: EAX04596.1.
BC010569 mRNA. Translation: AAH10569.1.
CCDSiCCDS5950.1. [P41587-1]
CCDS78295.1. [P41587-2]
PIRiG02822.
RefSeqiNP_001291451.1. NM_001304522.1.
NP_001295188.1. NM_001308259.1. [P41587-2]
NP_003373.2. NM_003382.4. [P41587-1]
UniGeneiHs.585052.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X57X-ray2.10A/B/C26-118[»]
ProteinModelPortaliP41587.
SMRiP41587. Positions 26-114, 123-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113275. 94 interactions.
IntActiP41587. 2 interactions.
STRINGi9606.ENSP00000262178.

Chemistry

BindingDBiP41587.
ChEMBLiCHEMBL4532.
GuidetoPHARMACOLOGYi372.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP41587.
PhosphoSiteiP41587.

Polymorphism and mutation databases

BioMutaiVIPR2.
DMDMi2506490.

Proteomic databases

PaxDbiP41587.
PeptideAtlasiP41587.
PRIDEiP41587.

Protocols and materials databases

DNASUi7434.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262178; ENSP00000262178; ENSG00000106018. [P41587-1]
ENST00000377633; ENSP00000366860; ENSG00000106018. [P41587-2]
GeneIDi7434.
KEGGihsa:7434.
UCSCiuc064jts.1. human. [P41587-1]

Organism-specific databases

CTDi7434.
GeneCardsiVIPR2.
H-InvDBHIX0095225.
HIX0167627.
HGNCiHGNC:12695. VIPR2.
HPAiHPA062707.
MIMi601970. gene.
neXtProtiNX_P41587.
Orphaneti3140. Schizophrenia.
PharmGKBiPA37314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP41587.
KOiK04590.
OMAiPLWEAPS.
PhylomeDBiP41587.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiVIPR2.
GenomeRNAii7434.
PROiP41587.
SOURCEiSearch...

Gene expression databases

BgeeiP41587.
CleanExiHS_VIPR2.
ExpressionAtlasiP41587. baseline and differential.
GenevisibleiP41587. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts."
    Svoboda M., Tastenoy M., van Rampelbergh J., Goossens J.-F., Neef P., Waelbroeck M., Robberecht P.
    Biochem. Biophys. Res. Commun. 205:1617-1624(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. "Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype."
    Mackay M., Fantes J., Scherer S., Boyle S., West K., Tsui L.-C., Belloni E., Lutz E., van Heyningen V., Harmar A.J.
    Genomics 37:345-353(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology."
    Wei Y., Mojsov S.
    J. Neuroendocrinol. 8:811-817(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Adipose tissue.
  4. "Structure of the human VIP2R gene for vasoactive intestinal peptide type 2 receptor."
    Lutz E.M., Shen S., Mackay M., West K., Harmar A.J.
    FEBS Lett. 458:197-203(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Heart.
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  11. "Predominant expression of type II vasoactive intestinal peptide receptors by human T lymphoblastoma cells: transduction of both Ca2+ and cyclic AMP signals."
    Xia M., Sreedharan S.P., Goetzl E.J.
    J. Clin. Immunol. 16:21-30(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-318 (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: T-cell.
  12. "Crystal structure of the extracellular domain of human vasoactive intestinal polypeptide receptor 2."
    Structural genomics consortium (SGC)
    Submitted (MAR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 26-118, DISULFIDE BONDS.

Entry informationi

Entry nameiVIPR2_HUMAN
AccessioniPrimary (citable) accession number: P41587
Secondary accession number(s): Q13053
, Q15870, Q53Y09, Q6ZN22, Q9UCW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.