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P41586 (PACR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor

Short name=PACAP type I receptor
Short name=PACAP-R-1
Short name=PACAP-R1
Gene names
Name:ADCYAP1R1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Subunit structure

Interacts (via N-terminal extracellular domain) with ADCYAP1.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence caution

The sequence BAA04466.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processDifferentiation
Spermatogenesis
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
G-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of adenylate cyclase activity

Traceable author statement. Source: Reactome

activation of phospholipase C activity

Inferred from electronic annotation. Source: Ensembl

cAMP-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

cell surface receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

development of primary female sexual characteristics

Inferred from electronic annotation. Source: Ensembl

multicellular organismal response to stress

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell death

Inferred from electronic annotation. Source: Ensembl

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

positive regulation of calcium ion transport into cytosol

Inferred from electronic annotation. Source: Ensembl

positive regulation of inositol phosphate biosynthetic process

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane receptor protein tyrosine kinase signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentcaveola

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from electronic annotation. Source: Ensembl

endosome

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

neuron projection

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

receptor complex

Inferred from direct assay PubMed 23382219. Source: MGI

rough endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

tight junction

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionneuropeptide binding

Inferred from electronic annotation. Source: Ensembl

receptor activity

Traceable author statement Ref.1. Source: ProtInc

vasoactive intestinal polypeptide receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform N (identifier: P41586-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform N-HOP1 (identifier: P41586-2)

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: Y → YFSCVQKCYCKPQRAQQHSCKMSELSTIT
Isoform S (identifier: P41586-3)

The sequence of this isoform differs from the canonical sequence as follows:
     89-109: Missing.
Isoform S-HOP1 (identifier: P41586-4)

The sequence of this isoform differs from the canonical sequence as follows:
     89-109: Missing.
     348-348: Y → YFSCVQKCYCKPQRAQQHSCKMSELSTIT
Isoform VS (identifier: P41586-5)

The sequence of this isoform differs from the canonical sequence as follows:
     53-88: Missing.
     89-109: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 468448Pituitary adenylate cyclase-activating polypeptide type I receptor
PRO_0000012841

Regions

Topological domain21 – 155135Extracellular Potential
Transmembrane156 – 17823Helical; Name=1; Potential
Topological domain179 – 1868Cytoplasmic Potential
Transmembrane187 – 20519Helical; Name=2; Potential
Topological domain206 – 22722Extracellular Potential
Transmembrane228 – 25326Helical; Name=3; Potential
Topological domain254 – 26815Cytoplasmic Potential
Transmembrane269 – 29123Helical; Name=4; Potential
Topological domain292 – 30918Extracellular Potential
Transmembrane310 – 33223Helical; Name=5; Potential
Topological domain333 – 35018Cytoplasmic Potential
Transmembrane351 – 37121Helical; Name=6; Potential
Topological domain372 – 38514Extracellular Potential
Transmembrane386 – 40520Helical; Name=7; Potential
Topological domain406 – 46863Cytoplasmic Potential
Region125 – 13915Important for ligand binding and specificity

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3751N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 63 Ref.10 Ref.11
Disulfide bond54 ↔ 118 Ref.10 Ref.11
Disulfide bond77 ↔ 134 Ref.10 Ref.11

Natural variations

Alternative sequence53 – 8836Missing in isoform VS.
VSP_042669
Alternative sequence89 – 10921Missing in isoform S, isoform S-HOP1 and isoform VS.
VSP_042670
Alternative sequence3481Y → YFSCVQKCYCKPQRAQQHSC KMSELSTIT in isoform N-HOP1 and isoform S-HOP1.
VSP_042671

Experimental info

Mutagenesis1141V → A: Reduced affinity for ADCYAP1. Ref.10
Mutagenesis1251E → R: Reduced affinity for ADCYAP1. Ref.10 Ref.11
Mutagenesis1281P → A: Reduced affinity for ADCYAP1. Ref.10
Mutagenesis1381E → R: Reduced affinity for ADCYAP1. Ref.10
Mutagenesis1391Y → A: Strongly reduced affinity for ADCYAP1. Ref.10
Isoform N-HOP1:
Sequence conflict3501Missing in AAI43680. Ref.7

Secondary structure

........... 468
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform N [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: BB515B84E9F28977

FASTA46853,314
        10         20         30         40         50         60 
MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN 

        70         80         90        100        110        120 
ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE 

       130        140        150        160        170        180 
DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK 

       190        200        210        220        230        240 
LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN 

       250        260        270        280        290        300 
YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN 

       310        320        330        340        350        360 
DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR LARSTLLLIP 

       370        380        390        400        410        420 
LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY CFLNGEVQAE IKRKWRSWKV 

       430        440        450        460 
NRYFAVDFKH RHPSLASSGV NGGTQLSILS KSSSQIRMSG LPADNLAT 

« Hide

Isoform N-HOP1 [UniParc].

Checksum: CBA040A9924D367A
Show »

FASTA49656,531
Isoform S [UniParc].

Checksum: 71C127C1056CA6AD
Show »

FASTA44751,030
Isoform S-HOP1 [UniParc].

Checksum: 11ECA8F276CE00B9
Show »

FASTA47554,248
Isoform VS [UniParc].

Checksum: 614BB6FB467ABD2A
Show »

FASTA41146,957

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor."
Ogi K., Miyamoto Y., Masuda Y., Habata Y., Hosoya M., Ohtaki T., Masuo Y., Onda H., Fujino M.
Biochem. Biophys. Res. Commun. 196:1511-1521(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM N).
Tissue: Pituitary.
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
King M., Aronstam R.S., Sharma S.V.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N).
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N).
Tissue: Hippocampus.
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N-HOP1).
Tissue: Brain and Testis.
[8]"Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7."
Stoffel M., Espinosa R., Trabb J.B., le Beau M.M., Bell G.I.
Genomics 23:697-699(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 418-468.
Tissue: Placenta.
[9]"N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants."
Dautzenberg F.M., Mevenkamp G., Wille S., Hauger R.L.
J. Neuroendocrinol. 11:941-949(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
[10]"Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS."
Sun C., Song D., Davis-Taber R.A., Barrett L.W., Scott V.E., Richardson P.L., Pereda-Lopez A., Uchic M.E., Solomon L.R., Lake M.R., Walter K.A., Hajduk P.J., Olejniczak E.T.
Proc. Natl. Acad. Sci. U.S.A. 104:7875-7880(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 22-143 IN COMPLEX WITH ADCYAP1, MUTAGENESIS OF VAL-114; GLU-125; PRO-128; GLU-138 AND TYR-139, DISULFIDE BONDS.
[11]"Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors."
Kumar S., Pioszak A., Zhang C., Swaminathan K., Xu H.E.
PLoS ONE 6:E19682-E19682(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 26-140, MUTAGENESIS OF GLU-125, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D17516 mRNA. Translation: BAA04466.1. Different initiation.
AB065700 Genomic DNA. Translation: BAC05923.1.
AY366498 mRNA. Translation: AAQ72806.1.
AK290046 mRNA. Translation: BAF82735.1.
AC006466 Genomic DNA. No translation available.
BC117116 mRNA. Translation: AAI17117.1.
BC136267 mRNA. Translation: AAI36268.1.
BC143679 mRNA. Translation: AAI43680.1.
CH471073 Genomic DNA. Translation: EAW93978.1.
U09216 Genomic DNA. Translation: AAA19323.1.
PIRJN0902.
RefSeqNP_001109.2. NM_001118.4.
NP_001186564.1. NM_001199635.1.
NP_001186565.1. NM_001199636.1.
NP_001186566.1. NM_001199637.1.
XP_005249675.1. XM_005249618.2.
UniGeneHs.377783.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JODNMR-A22-143[»]
3N94X-ray1.80A26-140[»]
ProteinModelPortalP41586.
SMRP41586. Positions 26-140, 150-410.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1217291.
STRING9606.ENSP00000306620.

Chemistry

BindingDBP41586.
ChEMBLCHEMBL5399.
GuidetoPHARMACOLOGY370.

Protein family/group databases

TCDB9.A.14.4.8. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteP41586.

Polymorphism databases

DMDM1171986.

Proteomic databases

PaxDbP41586.
PRIDEP41586.

Protocols and materials databases

DNASU117.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304166; ENSP00000306620; ENSG00000078549. [P41586-1]
ENST00000396211; ENSP00000379514; ENSG00000078549. [P41586-2]
ENST00000409363; ENSP00000387335; ENSG00000078549. [P41586-3]
GeneID117.
KEGGhsa:117.
UCSCuc003tca.2. human. [P41586-1]
uc003tcb.2. human. [P41586-3]
uc003tce.2. human. [P41586-2]

Organism-specific databases

CTD117.
GeneCardsGC07P031058.
HGNCHGNC:242. ADCYAP1R1.
HPAHPA049877.
MIM102981. gene.
neXtProtNX_P41586.
PharmGKBPA24565.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG330024.
HOGENOMHOG000008249.
HOVERGENHBG008318.
KOK04587.
OrthoDBEOG7TF78W.
PhylomeDBP41586.
TreeFamTF315710.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP41586.
BgeeP41586.
CleanExHS_ADCYAP1R1.
GenevestigatorP41586.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERPTHR12011:SF30. PTHR12011:SF30. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSADCYAP1R1. human.
EvolutionaryTraceP41586.
GeneWikiADCYAP1R1.
GenomeRNAi117.
NextBio455.
PROP41586.
SOURCESearch...

Entry information

Entry namePACR_HUMAN
AccessionPrimary (citable) accession number: P41586
Secondary accession number(s): A8K1Y1 expand/collapse secondary AC list , B7ZLA7, B8ZZK3, Q17S10
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries