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P41586

- PACR_HUMAN

UniProt

P41586 - PACR_HUMAN

Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

ADCYAP1R1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

    GO - Molecular functioni

    1. neuropeptide binding Source: Ensembl
    2. protein binding Source: UniProtKB
    3. receptor activity Source: ProtInc
    4. vasoactive intestinal polypeptide receptor activity Source: InterPro

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: Reactome
    2. activation of phospholipase C activity Source: Ensembl
    3. cAMP-mediated signaling Source: Ensembl
    4. cell differentiation Source: UniProtKB-KW
    5. cell surface receptor signaling pathway Source: ProtInc
    6. development of primary female sexual characteristics Source: Ensembl
    7. multicellular organismal response to stress Source: Ensembl
    8. negative regulation of cell death Source: Ensembl
    9. neurotrophin TRK receptor signaling pathway Source: Reactome
    10. positive regulation of calcium ion transport into cytosol Source: Ensembl
    11. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
    12. response to drug Source: Ensembl
    13. response to estradiol Source: Ensembl
    14. response to ethanol Source: Ensembl
    15. spermatogenesis Source: UniProtKB-KW
    16. transmembrane receptor protein tyrosine kinase signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Enzyme and pathway databases

    ReactomeiREACT_11046. NGF-independant TRKA activation.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Protein family/group databases

    TCDBi9.A.14.4.8. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pituitary adenylate cyclase-activating polypeptide type I receptor
    Short name:
    PACAP type I receptor
    Short name:
    PACAP-R-1
    Short name:
    PACAP-R1
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:242. ADCYAP1R1.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. cell surface Source: Ensembl
    3. endosome Source: Ensembl
    4. integral component of plasma membrane Source: ProtInc
    5. neuron projection Source: Ensembl
    6. plasma membrane Source: Reactome
    7. receptor complex Source: MGI
    8. rough endoplasmic reticulum Source: Ensembl
    9. tight junction Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi114 – 1141V → A: Reduced affinity for ADCYAP1. 1 Publication
    Mutagenesisi125 – 1251E → R: Reduced affinity for ADCYAP1. 2 Publications
    Mutagenesisi128 – 1281P → A: Reduced affinity for ADCYAP1. 1 Publication
    Mutagenesisi138 – 1381E → R: Reduced affinity for ADCYAP1. 1 Publication
    Mutagenesisi139 – 1391Y → A: Strongly reduced affinity for ADCYAP1. 1 Publication

    Organism-specific databases

    PharmGKBiPA24565.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 468448Pituitary adenylate cyclase-activating polypeptide type I receptorPRO_0000012841Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 63
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi54 ↔ 118
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi77 ↔ 134
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP41586.
    PaxDbiP41586.
    PRIDEiP41586.

    PTM databases

    PhosphoSiteiP41586.

    Expressioni

    Tissue specificityi

    Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

    Gene expression databases

    ArrayExpressiP41586.
    BgeeiP41586.
    CleanExiHS_ADCYAP1R1.
    GenevestigatoriP41586.

    Organism-specific databases

    HPAiHPA049877.

    Interactioni

    Subunit structurei

    Interacts (via N-terminal extracellular domain) with ADCYAP1.1 Publication

    Protein-protein interaction databases

    DIPiDIP-42467N.
    MINTiMINT-1217291.
    STRINGi9606.ENSP00000306620.

    Structurei

    Secondary structure

    1
    468
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi24 – 263
    Helixi30 – 4415
    Turni48 – 503
    Beta strandi73 – 753
    Beta strandi114 – 1163

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2JODNMR-A22-143[»]
    3N94X-ray1.80A26-140[»]
    ProteinModelPortaliP41586.
    SMRiP41586. Positions 26-140, 150-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP41586.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 155135ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini179 – 1868CytoplasmicSequence Analysis
    Topological domaini206 – 22722ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini254 – 26815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 35018CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini372 – 38514ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini406 – 46863CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei156 – 17823Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20519Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 25326Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 29123Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 33223Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei386 – 40520Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 13915Important for ligand binding and specificityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330024.
    HOGENOMiHOG000008249.
    HOVERGENiHBG008318.
    KOiK04587.
    OrthoDBiEOG7TF78W.
    PhylomeDBiP41586.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002285. GPCR_2_PACAP_1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01156. PACAPRECEPTR.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform N (identifier: P41586-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS    50
    SPGCPGMWDN ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF 100
    GDSNSLDLSD MGVVSRNCTE DGWSEPFPHY FDACGFDEYE SETGDQDYYY 150
    LSVKALYTVG YSTSLVTLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA 200
    ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN YFWLFIEGLY 250
    LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN 300
    DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR 350
    LARSTLLLIP LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY 400
    CFLNGEVQAE IKRKWRSWKV NRYFAVDFKH RHPSLASSGV NGGTQLSILS 450
    KSSSQIRMSG LPADNLAT 468
    Length:468
    Mass (Da):53,314
    Last modified:November 1, 1995 - v1
    Checksum:iBB515B84E9F28977
    GO
    Isoform N-HOP1 (identifier: P41586-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         348-348: Y → YFSCVQKCYCKPQRAQQHSCKMSELSTIT

    Show »
    Length:496
    Mass (Da):56,531
    Checksum:iCBA040A9924D367A
    GO
    Isoform S (identifier: P41586-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         89-109: Missing.

    Show »
    Length:447
    Mass (Da):51,030
    Checksum:i71C127C1056CA6AD
    GO
    Isoform S-HOP1 (identifier: P41586-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         89-109: Missing.
         348-348: Y → YFSCVQKCYCKPQRAQQHSCKMSELSTIT

    Show »
    Length:475
    Mass (Da):54,248
    Checksum:i11ECA8F276CE00B9
    GO
    Isoform VS (identifier: P41586-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         53-88: Missing.
         89-109: Missing.

    Show »
    Length:411
    Mass (Da):46,957
    Checksum:i614BB6FB467ABD2A
    GO

    Sequence cautioni

    The sequence BAA04466.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform N-HOP1 (identifier: P41586-2)
    Sequence conflicti350 – 3501Missing in AAI43680. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei53 – 8836Missing in isoform VS. CuratedVSP_042669Add
    BLAST
    Alternative sequencei89 – 10921Missing in isoform S, isoform S-HOP1 and isoform VS. CuratedVSP_042670Add
    BLAST
    Alternative sequencei348 – 3481Y → YFSCVQKCYCKPQRAQQHSC KMSELSTIT in isoform N-HOP1 and isoform S-HOP1. 1 PublicationVSP_042671

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17516 mRNA. Translation: BAA04466.1. Different initiation.
    AB065700 Genomic DNA. Translation: BAC05923.1.
    AY366498 mRNA. Translation: AAQ72806.1.
    AK290046 mRNA. Translation: BAF82735.1.
    AC006466 Genomic DNA. No translation available.
    BC117116 mRNA. Translation: AAI17117.1.
    BC136267 mRNA. Translation: AAI36268.1.
    BC143679 mRNA. Translation: AAI43680.1.
    CH471073 Genomic DNA. Translation: EAW93978.1.
    U09216 Genomic DNA. Translation: AAA19323.1.
    CCDSiCCDS5433.1. [P41586-1]
    CCDS56480.1. [P41586-2]
    CCDS56481.1. [P41586-3]
    PIRiJN0902.
    RefSeqiNP_001109.2. NM_001118.4. [P41586-1]
    NP_001186564.1. NM_001199635.1. [P41586-2]
    NP_001186565.1. NM_001199636.1.
    NP_001186566.1. NM_001199637.1. [P41586-3]
    XP_005249675.1. XM_005249618.2. [P41586-5]
    XP_006715710.1. XM_006715647.1. [P41586-4]
    UniGeneiHs.377783.

    Genome annotation databases

    EnsembliENST00000304166; ENSP00000306620; ENSG00000078549. [P41586-1]
    ENST00000396211; ENSP00000379514; ENSG00000078549. [P41586-2]
    ENST00000409363; ENSP00000387335; ENSG00000078549. [P41586-3]
    GeneIDi117.
    KEGGihsa:117.
    UCSCiuc003tca.2. human. [P41586-1]
    uc003tcb.2. human. [P41586-3]
    uc003tce.2. human. [P41586-2]

    Polymorphism databases

    DMDMi1171986.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17516 mRNA. Translation: BAA04466.1 . Different initiation.
    AB065700 Genomic DNA. Translation: BAC05923.1 .
    AY366498 mRNA. Translation: AAQ72806.1 .
    AK290046 mRNA. Translation: BAF82735.1 .
    AC006466 Genomic DNA. No translation available.
    BC117116 mRNA. Translation: AAI17117.1 .
    BC136267 mRNA. Translation: AAI36268.1 .
    BC143679 mRNA. Translation: AAI43680.1 .
    CH471073 Genomic DNA. Translation: EAW93978.1 .
    U09216 Genomic DNA. Translation: AAA19323.1 .
    CCDSi CCDS5433.1. [P41586-1 ]
    CCDS56480.1. [P41586-2 ]
    CCDS56481.1. [P41586-3 ]
    PIRi JN0902.
    RefSeqi NP_001109.2. NM_001118.4. [P41586-1 ]
    NP_001186564.1. NM_001199635.1. [P41586-2 ]
    NP_001186565.1. NM_001199636.1.
    NP_001186566.1. NM_001199637.1. [P41586-3 ]
    XP_005249675.1. XM_005249618.2. [P41586-5 ]
    XP_006715710.1. XM_006715647.1. [P41586-4 ]
    UniGenei Hs.377783.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2JOD NMR - A 22-143 [» ]
    3N94 X-ray 1.80 A 26-140 [» ]
    ProteinModelPortali P41586.
    SMRi P41586. Positions 26-140, 150-410.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-42467N.
    MINTi MINT-1217291.
    STRINGi 9606.ENSP00000306620.

    Chemistry

    BindingDBi P41586.
    ChEMBLi CHEMBL5399.
    GuidetoPHARMACOLOGYi 370.

    Protein family/group databases

    TCDBi 9.A.14.4.8. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei P41586.

    Polymorphism databases

    DMDMi 1171986.

    Proteomic databases

    MaxQBi P41586.
    PaxDbi P41586.
    PRIDEi P41586.

    Protocols and materials databases

    DNASUi 117.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304166 ; ENSP00000306620 ; ENSG00000078549 . [P41586-1 ]
    ENST00000396211 ; ENSP00000379514 ; ENSG00000078549 . [P41586-2 ]
    ENST00000409363 ; ENSP00000387335 ; ENSG00000078549 . [P41586-3 ]
    GeneIDi 117.
    KEGGi hsa:117.
    UCSCi uc003tca.2. human. [P41586-1 ]
    uc003tcb.2. human. [P41586-3 ]
    uc003tce.2. human. [P41586-2 ]

    Organism-specific databases

    CTDi 117.
    GeneCardsi GC07P031058.
    HGNCi HGNC:242. ADCYAP1R1.
    HPAi HPA049877.
    MIMi 102981. gene.
    neXtProti NX_P41586.
    PharmGKBi PA24565.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330024.
    HOGENOMi HOG000008249.
    HOVERGENi HBG008318.
    KOi K04587.
    OrthoDBi EOG7TF78W.
    PhylomeDBi P41586.
    TreeFami TF315710.

    Enzyme and pathway databases

    Reactomei REACT_11046. NGF-independant TRKA activation.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    ChiTaRSi ADCYAP1R1. human.
    EvolutionaryTracei P41586.
    GeneWikii ADCYAP1R1.
    GenomeRNAii 117.
    NextBioi 455.
    PROi P41586.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41586.
    Bgeei P41586.
    CleanExi HS_ADCYAP1R1.
    Genevestigatori P41586.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002285. GPCR_2_PACAP_1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01156. PACAPRECEPTR.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor."
      Ogi K., Miyamoto Y., Masuda Y., Habata Y., Hosoya M., Ohtaki T., Masuo Y., Onda H., Fujino M.
      Biochem. Biophys. Res. Commun. 196:1511-1521(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM N).
      Tissue: Pituitary.
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M., Aronstam R.S., Sharma S.V.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N).
      Tissue: Hippocampus.
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N-HOP1).
      Tissue: Brain and Testis.
    8. "Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7."
      Stoffel M., Espinosa R., Trabb J.B., le Beau M.M., Bell G.I.
      Genomics 23:697-699(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 418-468.
      Tissue: Placenta.
    9. "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants."
      Dautzenberg F.M., Mevenkamp G., Wille S., Hauger R.L.
      J. Neuroendocrinol. 11:941-949(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    10. "Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS."
      Sun C., Song D., Davis-Taber R.A., Barrett L.W., Scott V.E., Richardson P.L., Pereda-Lopez A., Uchic M.E., Solomon L.R., Lake M.R., Walter K.A., Hajduk P.J., Olejniczak E.T.
      Proc. Natl. Acad. Sci. U.S.A. 104:7875-7880(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 22-143 IN COMPLEX WITH ADCYAP1, MUTAGENESIS OF VAL-114; GLU-125; PRO-128; GLU-138 AND TYR-139, DISULFIDE BONDS.
    11. "Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors."
      Kumar S., Pioszak A., Zhang C., Swaminathan K., Xu H.E.
      PLoS ONE 6:E19682-E19682(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 26-140, MUTAGENESIS OF GLU-125, DISULFIDE BONDS.

    Entry informationi

    Entry nameiPACR_HUMAN
    AccessioniPrimary (citable) accession number: P41586
    Secondary accession number(s): A8K1Y1
    , B7ZLA7, B8ZZK3, Q17S10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3