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Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

ADCYAP1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

GO - Molecular functioni

  • neuropeptide binding Source: Ensembl
  • receptor activity Source: ProtInc
  • vasoactive intestinal polypeptide receptor activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000078549-MONOMER.
ReactomeiR-HSA-187024. NGF-independant TRKA activation.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
SIGNORiP41586.

Protein family/group databases

TCDBi9.A.14.4.8. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Short name:
PACAP type I receptor
Short name:
PACAP-R-1
Short name:
PACAP-R1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:242. ADCYAP1R1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 155ExtracellularSequence analysisAdd BLAST135
Transmembranei156 – 178Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini179 – 186CytoplasmicSequence analysis8
Transmembranei187 – 205Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini206 – 227ExtracellularSequence analysisAdd BLAST22
Transmembranei228 – 253Helical; Name=3Sequence analysisAdd BLAST26
Topological domaini254 – 268CytoplasmicSequence analysisAdd BLAST15
Transmembranei269 – 291Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini292 – 309ExtracellularSequence analysisAdd BLAST18
Transmembranei310 – 332Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini333 – 350CytoplasmicSequence analysisAdd BLAST18
Transmembranei351 – 371Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini372 – 385ExtracellularSequence analysisAdd BLAST14
Transmembranei386 – 405Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini406 – 468CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

  • bicellular tight junction Source: Ensembl
  • caveola Source: Ensembl
  • cell surface Source: Ensembl
  • endosome Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • neuron projection Source: Ensembl
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
  • rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi114V → A: Reduced affinity for ADCYAP1. 1 Publication1
Mutagenesisi125E → R: Reduced affinity for ADCYAP1. 2 Publications1
Mutagenesisi128P → A: Reduced affinity for ADCYAP1. 1 Publication1
Mutagenesisi138E → R: Reduced affinity for ADCYAP1. 1 Publication1
Mutagenesisi139Y → A: Strongly reduced affinity for ADCYAP1. 1 Publication1

Organism-specific databases

DisGeNETi117.
OpenTargetsiENSG00000078549.
PharmGKBiPA24565.

Chemistry databases

ChEMBLiCHEMBL5399.
GuidetoPHARMACOLOGYi370.

Polymorphism and mutation databases

BioMutaiADCYAP1R1.
DMDMi1171986.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001284121 – 468Pituitary adenylate cyclase-activating polypeptide type I receptorAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 63
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi54 ↔ 118
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi77 ↔ 134
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1
Modified residuei434PhosphoserineBy similarity1
Modified residuei447PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP41586.
PeptideAtlasiP41586.
PRIDEiP41586.

PTM databases

iPTMnetiP41586.
PhosphoSitePlusiP41586.

Expressioni

Tissue specificityi

Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

Gene expression databases

BgeeiENSG00000078549.
CleanExiHS_ADCYAP1R1.
ExpressionAtlasiP41586. baseline and differential.
GenevisibleiP41586. HS.

Organism-specific databases

HPAiHPA049877.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with ADCYAP1.1 Publication

Protein-protein interaction databases

BioGridi106630. 1 interactor.
DIPiDIP-42467N.
MINTiMINT-1217291.

Chemistry databases

BindingDBiP41586.

Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 26Combined sources3
Helixi30 – 44Combined sources15
Turni48 – 50Combined sources3
Beta strandi73 – 75Combined sources3
Beta strandi114 – 116Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JODNMR-A22-143[»]
3N94X-ray1.80A26-140[»]
ProteinModelPortaliP41586.
SMRiP41586.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41586.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 139Important for ligand binding and specificityAdd BLAST15

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP41586.
KOiK04587.
PhylomeDBiP41586.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform N (identifier: P41586-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS
60 70 80 90 100
SPGCPGMWDN ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF
110 120 130 140 150
GDSNSLDLSD MGVVSRNCTE DGWSEPFPHY FDACGFDEYE SETGDQDYYY
160 170 180 190 200
LSVKALYTVG YSTSLVTLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA
210 220 230 240 250
ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN YFWLFIEGLY
260 270 280 290 300
LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN
310 320 330 340 350
DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR
360 370 380 390 400
LARSTLLLIP LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY
410 420 430 440 450
CFLNGEVQAE IKRKWRSWKV NRYFAVDFKH RHPSLASSGV NGGTQLSILS
460
KSSSQIRMSG LPADNLAT
Length:468
Mass (Da):53,314
Last modified:November 1, 1995 - v1
Checksum:iBB515B84E9F28977
GO
Isoform N-HOP1 (identifier: P41586-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: Y → YFSCVQKCYCKPQRAQQHSCKMSELSTIT

Show »
Length:496
Mass (Da):56,531
Checksum:iCBA040A9924D367A
GO
Isoform S (identifier: P41586-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-109: Missing.

Show »
Length:447
Mass (Da):51,030
Checksum:i71C127C1056CA6AD
GO
Isoform S-HOP1 (identifier: P41586-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-109: Missing.
     348-348: Y → YFSCVQKCYCKPQRAQQHSCKMSELSTIT

Show »
Length:475
Mass (Da):54,248
Checksum:i11ECA8F276CE00B9
GO
Isoform VS (identifier: P41586-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-88: Missing.
     89-109: Missing.

Show »
Length:411
Mass (Da):46,957
Checksum:i614BB6FB467ABD2A
GO

Sequence cautioni

The sequence BAA04466 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform N-HOP1 (identifier: P41586-2)
Sequence conflicti350Missing in AAI43680 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04266953 – 88Missing in isoform VS. CuratedAdd BLAST36
Alternative sequenceiVSP_04267089 – 109Missing in isoform S, isoform S-HOP1 and isoform VS. CuratedAdd BLAST21
Alternative sequenceiVSP_042671348Y → YFSCVQKCYCKPQRAQQHSC KMSELSTIT in isoform N-HOP1 and isoform S-HOP1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17516 mRNA. Translation: BAA04466.1. Different initiation.
AB065700 Genomic DNA. Translation: BAC05923.1.
AY366498 mRNA. Translation: AAQ72806.1.
AK290046 mRNA. Translation: BAF82735.1.
AC006466 Genomic DNA. No translation available.
BC117116 mRNA. Translation: AAI17117.1.
BC136267 mRNA. Translation: AAI36268.1.
BC143679 mRNA. Translation: AAI43680.1.
CH471073 Genomic DNA. Translation: EAW93978.1.
U09216 Genomic DNA. Translation: AAA19323.1.
CCDSiCCDS5433.1. [P41586-1]
CCDS56480.1. [P41586-2]
CCDS56481.1. [P41586-3]
PIRiJN0902.
RefSeqiNP_001109.2. NM_001118.4. [P41586-1]
NP_001186564.1. NM_001199635.1. [P41586-2]
NP_001186565.1. NM_001199636.1.
NP_001186566.1. NM_001199637.1. [P41586-3]
XP_005249675.1. XM_005249618.4. [P41586-5]
XP_016867226.1. XM_017011737.1. [P41586-4]
UniGeneiHs.377783.

Genome annotation databases

EnsembliENST00000304166; ENSP00000306620; ENSG00000078549. [P41586-1]
ENST00000396211; ENSP00000379514; ENSG00000078549. [P41586-2]
ENST00000409363; ENSP00000387335; ENSG00000078549. [P41586-3]
ENST00000614107; ENSP00000483721; ENSG00000078549. [P41586-2]
GeneIDi117.
KEGGihsa:117.
UCSCiuc003tca.3. human. [P41586-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17516 mRNA. Translation: BAA04466.1. Different initiation.
AB065700 Genomic DNA. Translation: BAC05923.1.
AY366498 mRNA. Translation: AAQ72806.1.
AK290046 mRNA. Translation: BAF82735.1.
AC006466 Genomic DNA. No translation available.
BC117116 mRNA. Translation: AAI17117.1.
BC136267 mRNA. Translation: AAI36268.1.
BC143679 mRNA. Translation: AAI43680.1.
CH471073 Genomic DNA. Translation: EAW93978.1.
U09216 Genomic DNA. Translation: AAA19323.1.
CCDSiCCDS5433.1. [P41586-1]
CCDS56480.1. [P41586-2]
CCDS56481.1. [P41586-3]
PIRiJN0902.
RefSeqiNP_001109.2. NM_001118.4. [P41586-1]
NP_001186564.1. NM_001199635.1. [P41586-2]
NP_001186565.1. NM_001199636.1.
NP_001186566.1. NM_001199637.1. [P41586-3]
XP_005249675.1. XM_005249618.4. [P41586-5]
XP_016867226.1. XM_017011737.1. [P41586-4]
UniGeneiHs.377783.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JODNMR-A22-143[»]
3N94X-ray1.80A26-140[»]
ProteinModelPortaliP41586.
SMRiP41586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106630. 1 interactor.
DIPiDIP-42467N.
MINTiMINT-1217291.

Chemistry databases

BindingDBiP41586.
ChEMBLiCHEMBL5399.
GuidetoPHARMACOLOGYi370.

Protein family/group databases

TCDBi9.A.14.4.8. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP41586.
PhosphoSitePlusiP41586.

Polymorphism and mutation databases

BioMutaiADCYAP1R1.
DMDMi1171986.

Proteomic databases

MaxQBiP41586.
PeptideAtlasiP41586.
PRIDEiP41586.

Protocols and materials databases

DNASUi117.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304166; ENSP00000306620; ENSG00000078549. [P41586-1]
ENST00000396211; ENSP00000379514; ENSG00000078549. [P41586-2]
ENST00000409363; ENSP00000387335; ENSG00000078549. [P41586-3]
ENST00000614107; ENSP00000483721; ENSG00000078549. [P41586-2]
GeneIDi117.
KEGGihsa:117.
UCSCiuc003tca.3. human. [P41586-1]

Organism-specific databases

CTDi117.
DisGeNETi117.
GeneCardsiADCYAP1R1.
HGNCiHGNC:242. ADCYAP1R1.
HPAiHPA049877.
MIMi102981. gene.
neXtProtiNX_P41586.
OpenTargetsiENSG00000078549.
PharmGKBiPA24565.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP41586.
KOiK04587.
PhylomeDBiP41586.
TreeFamiTF315710.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000078549-MONOMER.
ReactomeiR-HSA-187024. NGF-independant TRKA activation.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
SIGNORiP41586.

Miscellaneous databases

ChiTaRSiADCYAP1R1. human.
EvolutionaryTraceiP41586.
GeneWikiiADCYAP1R1.
GenomeRNAii117.
PROiP41586.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000078549.
CleanExiHS_ADCYAP1R1.
ExpressionAtlasiP41586. baseline and differential.
GenevisibleiP41586. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPACR_HUMAN
AccessioniPrimary (citable) accession number: P41586
Secondary accession number(s): A8K1Y1
, B7ZLA7, B8ZZK3, Q17S10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.