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Reviewed, UniProtKB/Swiss-Prot P41586 (PACR_HUMAN)

Last modified November 25, 2008. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Pituitary adenylate cyclase-activating polypeptide type I receptor
      Short name=PACAP type I receptor
Alternative name(s):
    PACAP-R-1
Gene names
Name: ADCYAP1R1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 468448Pituitary adenylate cyclase-activating polypeptide type I receptor
PRO_0000012841

Regions

Topological domain21 – 155135Extracellular Potential
Transmembrane156 – 178231 Potential
Topological domain179 – 1868Cytoplasmic Potential
Transmembrane187 – 205192 Potential
Topological domain206 – 22722Extracellular Potential
Transmembrane228 – 253263 Potential
Topological domain254 – 26815Cytoplasmic Potential
Transmembrane269 – 291234 Potential
Topological domain292 – 30918Extracellular Potential
Transmembrane310 – 332235 Potential
Topological domain333 – 35018Cytoplasmic Potential
Transmembrane351 – 371216 Potential
Topological domain372 – 38514Extracellular Potential
Transmembrane386 – 405207 Potential
Topological domain406 – 46863Cytoplasmic Potential

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3751N-linked (GlcNAc...) Potential

Secondary structure

1 ........... 468
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P41586-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: BB515B84E9F28977

FASTA46853,314
        10         20         30         40         50         60 
MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN 

        70         80         90        100        110        120 
ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE 

       130        140        150        160        170        180 
DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK 

       190        200        210        220        230        240 
LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN 

       250        260        270        280        290        300 
YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN 

       310        320        330        340        350        360 
DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR LARSTLLLIP 

       370        380        390        400        410        420 
LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY CFLNGEVQAE IKRKWRSWKV 

       430        440        450        460 
NRYFAVDFKH RHPSLASSGV NGGTQLSILS KSSSQIRMSG LPADNLAT

« Hide

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References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor."
Ogi K., Miyamoto Y., Masuda Y., Habata Y., Hosoya M., Ohtaki T., Masuo Y., Onda H., Fujino M.
Biochem. Biophys. Res. Commun. 196:1511-1521(1993) [PubMed: 7902709] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
King M., Aronstam R.S., Sharma S.V.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7."
Stoffel M., Espinosa R., Trabb J.B., le Beau M.M., Bell G.I.
Genomics 23:697-699(1994) [PubMed: 7851900] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 418-468.
Tissue: Placenta.
+Additional computationally mapped references.

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Cross-references

Sequence databases

D17516 mRNA. Translation: BAA04466.1. Different initiation.
AB065700 Genomic DNA. Translation: BAC05923.1.
AY366498 mRNA. Translation: AAQ72806.1.
U09216 Genomic DNA. Translation: AAA19323.1.
PIRJN0902.
RefSeqNP_001109.2.
UniGeneHs.377783

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2JODNMR-A22-143[»]
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSG00000078549. Homo sapiens. [Contig view]
GeneID117.
KEGGhsa:117.

Organism-specific databases

H-InvDBHIX0006574.
HGNCHGNC:242. ADCYAP1R1.
HPACAB016341.
MIM102981. gene.
PharmGKBPA24565.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP41586.
HOVERGENP41586.

Enzyme and pathway databases

ReactomeREACT_11061. Signalling by NGF.

Gene expression databases

ArrayExpressP41586.
CleanExHS_ADCYAP1R1.
GermOnlineENSG00000078549. Homo sapiens.

Family and domain databases

InterProIPR001879. GPCR_2_extracellular.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
[Graphical view]
PANTHERPTHR12011:SF30. PAC_1_rcpt. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio455.
SOURCESearch...

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Entry information

Entry namePACR_HUMAN
AccessionPrimary (citable) accession number: P41586
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 25, 2008
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents