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P41582

- 6PGD_CITKO

UniProt

P41582 - 6PGD_CITKO

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene
gnd
Organism
Citrobacter koseri (Citrobacter diversus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911NADP By similarity
Binding sitei91 – 911Substrate By similarity
Active sitei172 – 1721Proton acceptor By similarity
Active sitei179 – 1791Proton donor By similarity
Binding sitei180 – 1801Substrate By similarity
Binding sitei249 – 2491Substrate; via amide nitrogen By similarity
Binding sitei276 – 2761Substrate By similarity
Binding sitei434 – 4341Substrate; shared with dimeric partner By similarity
Binding sitei440 – 4401Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1 – 44NADP By similarity
Nucleotide bindingi22 – 243NADP By similarity
Nucleotide bindingi63 – 653NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
OrganismiCitrobacter koseri (Citrobacter diversus)
Taxonomic identifieri545 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›445›4456-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090035Add
BLAST

Proteomic databases

PRIDEiP41582.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP41582.
SMRiP41582. Positions 1-445.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 1193Substrate binding By similarity
Regioni175 – 1762Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P41582-1 [UniParc]FASTAAdd to Basket

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AVMGRNLALN IESRGYTVSV FNRSREKTEE VIAENPGKKL VPYYTVKEFV    50
ESLETPRRIL LMVKAGAGTD AAIDSLKPYL DKGDIIIDGG NTFFQDTIRR 100
NRELSAEGFN FIGTGVSGGE EGALKGPSIM PGGQKEAYEL VAPILTKIAA 150
VAEDGEPCVT YIGADGAGHY VKMVHNGIEY GDMQLIAEAY SLLKGGLNLS 200
NEELAETFTE WNKGELNSYL IDITKDIFTK KDEEGKYLVD VILDEAANKG 250
TGKWTSQSSL DLGEPLSLIT ESVFARYISS LKEQRVAASK VLSGPKAQLA 300
GDKAEFIEKV RRALYLGKIV SYAQGFSQLR AASDEYNWDL NYGEIAKIFR 350
AGCIIRAQFL QKITDAYAEN AGIANLLLAP YFKKIADDYQ QALRDVVAYA 400
VQNGIPVPTF SAAVAYYDSY RAAVLPANLI QAQRDYFGAH TYKRT 445
Length:445
Mass (Da):48,829
Last modified:November 1, 1995 - v1
Checksum:i9DB96925EC40EDC4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311V → G in strain: CT45.
Natural varianti206 – 2061E → D in strain: CT42.
Natural varianti300 – 3001A → E in strain: CT27.

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei445 – 4451

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14424 Genomic DNA. Translation: AAC43774.1.
U14425 Genomic DNA. Translation: AAC43775.1.
U14427 Genomic DNA. Translation: AAC43776.1.
U14428 Genomic DNA. Translation: AAC43777.1.
U14429 Genomic DNA. Translation: AAC43778.1.
U14432 Genomic DNA. Translation: AAC43779.1.
PIRiI40681.
I40682.
I40684.
I40685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14424 Genomic DNA. Translation: AAC43774.1 .
U14425 Genomic DNA. Translation: AAC43775.1 .
U14427 Genomic DNA. Translation: AAC43776.1 .
U14428 Genomic DNA. Translation: AAC43777.1 .
U14429 Genomic DNA. Translation: AAC43778.1 .
U14432 Genomic DNA. Translation: AAC43779.1 .
PIRi I40681.
I40682.
I40684.
I40685.

3D structure databases

ProteinModelPortali P41582.
SMRi P41582. Positions 1-445.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P41582.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Intergeneric transfer and recombination of the 6-phosphogluconate dehydrogenase gene (gnd) in enteric bacteria."
    Nelson K., Selander R.K.
    Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CT19, CT27, CT4, CT42, CT45 and CT9.

Entry informationi

Entry namei6PGD_CITKO
AccessioniPrimary (citable) accession number: P41582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 11, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3