Reviewed, UniProtKB/Swiss-Prot P41582 (6PGD_CITDI)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:

gnd

Organism

Citrobacter diversus

Taxonomic identifier

545 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Citrobacter

Protein attributes

Sequence length	445 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›445	›445	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090035
Natural variations
	Natural variant	31	1	V → G in strain: CT45.
	Natural variant	206	1	E → D in strain: CT42.
	Natural variant	300	1	A → E in strain: CT27.
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	445	1

Sequences

	Sequence		Length	Mass (Da)
	P41582-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 9DB96925EC40EDC4	FASTA	445	48,829
	10 20 30 40 50 60 AVMGRNLALN IESRGYTVSV FNRSREKTEE VIAENPGKKL VPYYTVKEFV ESLETPRRIL 70 80 90 100 110 120 LMVKAGAGTD AAIDSLKPYL DKGDIIIDGG NTFFQDTIRR NRELSAEGFN FIGTGVSGGE 130 140 150 160 170 180 EGALKGPSIM PGGQKEAYEL VAPILTKIAA VAEDGEPCVT YIGADGAGHY VKMVHNGIEY 190 200 210 220 230 240 GDMQLIAEAY SLLKGGLNLS NEELAETFTE WNKGELNSYL IDITKDIFTK KDEEGKYLVD 250 260 270 280 290 300 VILDEAANKG TGKWTSQSSL DLGEPLSLIT ESVFARYISS LKEQRVAASK VLSGPKAQLA 310 320 330 340 350 360 GDKAEFIEKV RRALYLGKIV SYAQGFSQLR AASDEYNWDL NYGEIAKIFR AGCIIRAQFL 370 380 390 400 410 420 QKITDAYAEN AGIANLLLAP YFKKIADDYQ QALRDVVAYA VQNGIPVPTF SAAVAYYDSY 430 440 RAAVLPANLI QAQRDYFGAH TYKRT

References

[1]

"Intergeneric transfer and recombination of the 6-phosphogluconate dehydrogenase gene (gnd) in enteric bacteria." Nelson K., Selander R.K. Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994) [PubMed: 7937867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CT19, CT27, CT4, CT42, CT45 and CT9.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U14424 Genomic DNA. Translation: AAC43774.1. U14425 Genomic DNA. Translation: AAC43775.1. U14427 Genomic DNA. Translation: AAC43776.1. U14428 Genomic DNA. Translation: AAC43777.1. U14429 Genomic DNA. Translation: AAC43778.1. U14432 Genomic DNA. Translation: AAC43779.1.
PIR	I40681. I40682. I40684. I40685.
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
ModBase	Search...
Family and domain databases
InterPro	IPR006183. 6-phosphogluconate_DHase. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DHase_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_CITDI

Accession

Primary (citable) accession number: P41582

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)