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P41582

- 6PGD_CITKO

UniProt

P41582 - 6PGD_CITKO

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Citrobacter koseri (Citrobacter diversus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911NADPBy similarity
Binding sitei91 – 911SubstrateBy similarity
Active sitei172 – 1721Proton acceptorBy similarity
Active sitei179 – 1791Proton donorBy similarity
Binding sitei180 – 1801SubstrateBy similarity
Binding sitei249 – 2491Substrate; via amide nitrogenBy similarity
Binding sitei276 – 2761SubstrateBy similarity
Binding sitei434 – 4341Substrate; shared with dimeric partnerBy similarity
Binding sitei440 – 4401Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1 – 44NADPBy similarity
Nucleotide bindingi22 – 243NADPBy similarity
Nucleotide bindingi63 – 653NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
OrganismiCitrobacter koseri (Citrobacter diversus)
Taxonomic identifieri545 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›445›4456-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090035Add
BLAST

Proteomic databases

PRIDEiP41582.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP41582.
SMRiP41582. Positions 1-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 1193Substrate bindingBy similarity
Regioni175 – 1762Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P41582-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AVMGRNLALN IESRGYTVSV FNRSREKTEE VIAENPGKKL VPYYTVKEFV
60 70 80 90 100
ESLETPRRIL LMVKAGAGTD AAIDSLKPYL DKGDIIIDGG NTFFQDTIRR
110 120 130 140 150
NRELSAEGFN FIGTGVSGGE EGALKGPSIM PGGQKEAYEL VAPILTKIAA
160 170 180 190 200
VAEDGEPCVT YIGADGAGHY VKMVHNGIEY GDMQLIAEAY SLLKGGLNLS
210 220 230 240 250
NEELAETFTE WNKGELNSYL IDITKDIFTK KDEEGKYLVD VILDEAANKG
260 270 280 290 300
TGKWTSQSSL DLGEPLSLIT ESVFARYISS LKEQRVAASK VLSGPKAQLA
310 320 330 340 350
GDKAEFIEKV RRALYLGKIV SYAQGFSQLR AASDEYNWDL NYGEIAKIFR
360 370 380 390 400
AGCIIRAQFL QKITDAYAEN AGIANLLLAP YFKKIADDYQ QALRDVVAYA
410 420 430 440
VQNGIPVPTF SAAVAYYDSY RAAVLPANLI QAQRDYFGAH TYKRT
Length:445
Mass (Da):48,829
Last modified:November 1, 1995 - v1
Checksum:i9DB96925EC40EDC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei445 – 4451

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311V → G in strain: CT45.
Natural varianti206 – 2061E → D in strain: CT42.
Natural varianti300 – 3001A → E in strain: CT27.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14424 Genomic DNA. Translation: AAC43774.1.
U14425 Genomic DNA. Translation: AAC43775.1.
U14427 Genomic DNA. Translation: AAC43776.1.
U14428 Genomic DNA. Translation: AAC43777.1.
U14429 Genomic DNA. Translation: AAC43778.1.
U14432 Genomic DNA. Translation: AAC43779.1.
PIRiI40681.
I40682.
I40684.
I40685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14424 Genomic DNA. Translation: AAC43774.1 .
U14425 Genomic DNA. Translation: AAC43775.1 .
U14427 Genomic DNA. Translation: AAC43776.1 .
U14428 Genomic DNA. Translation: AAC43777.1 .
U14429 Genomic DNA. Translation: AAC43778.1 .
U14432 Genomic DNA. Translation: AAC43779.1 .
PIRi I40681.
I40682.
I40684.
I40685.

3D structure databases

ProteinModelPortali P41582.
SMRi P41582. Positions 1-445.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P41582.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Intergeneric transfer and recombination of the 6-phosphogluconate dehydrogenase gene (gnd) in enteric bacteria."
    Nelson K., Selander R.K.
    Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CT19, CT27, CT4, CT42, CT45 and CT9.

Entry informationi

Entry namei6PGD_CITKO
AccessioniPrimary (citable) accession number: P41582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3