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P41581 (6PGD_CITAM) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating

EC=1.1.1.44
Gene names
Name:gnd
OrganismCitrobacter amalonaticus
Taxonomic identifier35703 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter

Protein attributes

Sequence length445 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›445›4456-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090034

Regions

Nucleotide binding1 – 44NADP By similarity
Nucleotide binding22 – 243NADP By similarity
Nucleotide binding63 – 653NADP By similarity
Region117 – 1193Substrate binding By similarity
Region175 – 1762Substrate binding By similarity

Sites

Active site1721Proton acceptor By similarity
Active site1791Proton donor By similarity
Binding site911NADP By similarity
Binding site911Substrate By similarity
Binding site1801Substrate By similarity
Binding site2491Substrate; via amide nitrogen By similarity
Binding site2761Substrate By similarity
Binding site4341Substrate; shared with dimeric partner By similarity
Binding site4401Substrate; shared with dimeric partner By similarity

Experimental info

Non-terminal residue11
Non-terminal residue4451

Sequences

Sequence LengthMass (Da)Tools
P41581 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A3771DFC9678EEF1

FASTA44548,887
        10         20         30         40         50         60 
AVMGRNLALN IESRGYTVSV FNRSREKTEE VIAENPGKKL VPYYTVQEFV ESLETPRRIL 

        70         80         90        100        110        120 
LMVKAGAGTD SAIDSLKPYL DKGDIIIDGG NTFFQDTIRR NRELSEEGFN FIGTGVSGGE 

       130        140        150        160        170        180 
EGALKGPSIM PGGQKEAYEL VAPILKQIAA VAEDGEPCVT YIGADGAGHY VKMVHNGIEY 

       190        200        210        220        230        240 
GDMQLIAEAY SLLKGGLNLS NEELATTFSE WNKGELSSYL IDITKDIFTK KDEEGKYLVD 

       250        260        270        280        290        300 
VILDEAANKG TGKWTSQSSL DLGEPLSLIT ESVFARYISS LKTQRVAASK VLTGPQAQPA 

       310        320        330        340        350        360 
GDKAEFIEKV RRALYLGKIV SYAQGFSQLR AASDEYNWDL NYGEIAKIFR AGCIIRAQFL 

       370        380        390        400        410        420 
QKITDAYAEN PAIANLLLAP YFKQIADDYQ QALRDVVSYA VQNGIPVPTF SAAVAYYDSY 

       430        440 
RAAVLPANLI QAQRDYFGAH TYKRT 

« Hide

References

[1]"Intergeneric transfer and recombination of the 6-phosphogluconate dehydrogenase gene (gnd) in enteric bacteria."
Nelson K., Selander R.K.
Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CT28.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14426 Genomic DNA. Translation: AAC43773.1.
PIRI40629.

3D structure databases

ProteinModelPortalP41581.
SMRP41581. Positions 1-445.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP41581.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00115; UER00410.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name6PGD_CITAM
AccessionPrimary (citable) accession number: P41581
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways