Reviewed, UniProtKB/Swiss-Prot P41578 (6PGD_SHIBO)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:

gnd

Organism

Shigella boydii

Taxonomic identifier

621 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	445 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›445	›445	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090048
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	445	1

Sequences

	Sequence		Length	Mass (Da)
	P41578-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: B90F886E7AD0CB0B	FASTA	445	48,833
	10 20 30 40 50 60 AVMGRNLALN IESRGYTVSI FNRSREKTEE VIAENPGKKL VPYYTVKEFV ESLETPRRIL 70 80 90 100 110 120 LMVKAGAGTD AAIDSLKPYL DKGDIIIDGG NTFFQDTIRR NRELSAEGFN FIGTGVSGGE 130 140 150 160 170 180 EGALKGPSIM PGGQKEAYEL VAPILTKIAA VAEDGEPCVT YIGADGAGHY VKMVHNGIEY 190 200 210 220 230 240 GDMQLIAEAY SLLKGGLNLS NEELAQTFTE WNNGELSSYL IDITKDIFTK KDEDGNYLVD 250 260 270 280 290 300 VILDEAANKG TGKWTSQSAL DLGEPLSLIT ESVFARYISS LKDQRVAASK VLSGPQAQPA 310 320 330 340 350 360 GNKAEFIEKV RRALYLGKIV SYAQGFSQLR AASEEYNWDL NYGEIAKIFR AGCIIRAQFL 370 380 390 400 410 420 QKITDAYAEN PQIANLLLAP YFKQIADDYQ QALRDVVAYA VQNGIPVPTF AAAVAYYDSY 430 440 RAAVLPANLI QAQRDYFGAH TYKRI

References

[1]

"Intergeneric transfer and recombination of the 6-phosphogluconate dehydrogenase gene (gnd) in enteric bacteria." Nelson K., Selander R.K. Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994) [PubMed: 7937867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 8700 / DSM 7532 / NCTC 12985.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U14469 Genomic DNA. Translation: AAC43820.1.
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.44. 96885.
Family and domain databases
InterPro	IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_SHIBO

Accession

Primary (citable) accession number: P41578

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)