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P41577

- 6PGD_RAOTE

UniProt

P41577 - 6PGD_RAOTE

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Raoultella terrigena (Klebsiella terrigena)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei91 – 911NADPBy similarity
    Binding sitei91 – 911SubstrateBy similarity
    Active sitei172 – 1721Proton acceptorBy similarity
    Active sitei179 – 1791Proton donorBy similarity
    Binding sitei180 – 1801SubstrateBy similarity
    Binding sitei249 – 2491Substrate; via amide nitrogenBy similarity
    Binding sitei276 – 2761SubstrateBy similarity
    Binding sitei434 – 4341Substrate; shared with dimeric partnerBy similarity
    Binding sitei440 – 4401Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1 – 44NADPBy similarity
    Nucleotide bindingi22 – 243NADPBy similarity
    Nucleotide bindingi63 – 653NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    OrganismiRaoultella terrigena (Klebsiella terrigena)
    Taxonomic identifieri577 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeRaoultella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›445›4456-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090044Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP41577.
    SMRiP41577. Positions 1-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 1193Substrate bindingBy similarity
    Regioni175 – 1762Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P41577-1 [UniParc]FASTAAdd to Basket

    « Hide

    AVMGRNLALN IESRGYTVSV FNRSREKTEE VIAENPGKKL VPHYTVKEFV    50
    ESLETPRRIL LMVKAGAGTD SAIDSLKPYL DKGDIIIDGG NTFFQDTIRR 100
    NRELSADGFN FIGTGVSGGE EGALKGPSIM PGGQKEAYEL VAPILEQIAA 150
    RAEDGEPCVA YIGADGAGHY VKMVHNGIEY GDMQLIAEAY ALLKGGLALS 200
    NEELATTFTE WNQGELSSYL IDITKDIFTK KDEEGKYLVD VILDEAANKG 250
    TGKWTSQSSL DLGEPLSLIT ESVFARYISS LKDQRVAASK VLTGPQAQPA 300
    SDKAEFIEKV RRALYLGKIV SYAQGFSQLR AASNEYSWDL NYGEIAKIFR 350
    AGCIIRAQFL QKITDAYEEN AGIANLLLAP YFKQIADEYQ QALRDVVAYA 400
    VQNGIPVPTF SAAIAYYDSY RSAVLPANLI QAQRDYFGAH TYKRT 445
    Length:445
    Mass (Da):48,834
    Last modified:November 1, 1995 - v1
    Checksum:i2FBD0E46CDAB69A8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei445 – 4451

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14473 Genomic DNA. Translation: AAC43819.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14473 Genomic DNA. Translation: AAC43819.1 .

    3D structure databases

    ProteinModelPortali P41577.
    SMRi P41577. Positions 1-445.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Intergeneric transfer and recombination of the 6-phosphogluconate dehydrogenase gene (gnd) in enteric bacteria."
      Nelson K., Selander R.K.
      Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 33257 / DSM 2687 / JCM 1687 / NBRC 14941 / NCTC 13038 / VTT-E-97854.

    Entry informationi

    Entry namei6PGD_RAOTE
    AccessioniPrimary (citable) accession number: P41577
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3