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P41576

- 6PGD_KLEPN

UniProt

P41576 - 6PGD_KLEPN

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021NADPBy similarity
    Binding sitei102 – 1021SubstrateBy similarity
    Active sitei183 – 1831Proton acceptorBy similarity
    Active sitei190 – 1901Proton donorBy similarity
    Binding sitei191 – 1911SubstrateBy similarity
    Binding sitei260 – 2601Substrate; via amide nitrogenBy similarity
    Binding sitei287 – 2871SubstrateBy similarity
    Binding sitei445 – 4451Substrate; shared with dimeric partnerBy similarity
    Binding sitei451 – 4511Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADPBy similarity
    Nucleotide bindingi33 – 353NADPBy similarity
    Nucleotide bindingi74 – 763NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    OrganismiKlebsiella pneumoniae
    Taxonomic identifieri573 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4684686-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090043Add
    BLAST

    Proteomic databases

    PRIDEiP41576.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP41576.
    SMRiP41576. Positions 1-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni128 – 1303Substrate bindingBy similarity
    Regioni186 – 1872Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41576-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKQQIGVVG MAVMGRNLAL NIESRGYTVS VFNRSREKTE EVIAENTGKK    50
    LVPYYTVQEF VESLETPRRI LLMVKAGAGT DSAIDSLKPY LDKGDIIIDG 100
    GNTFFQDTIR RNRELSAEGF NFIGTGVSGG EEGALKGPSI MPGGQKEAYE 150
    LVAPILKQIA AVAEDGEPCV TYIGADGAGH YVKMVHNGIE YGDMQLIAEA 200
    YALLKGGLAL SNEELAQTFT EWNEGELSSY LIDITKDIFT KKDEEGKYLV 250
    DVILDEAANK GTGKWTSQSS LDLGEPLSLI TESVFARYIS SLKDQRVAAS 300
    KVLSGPQAQP VGDKAGFIEK VRRALYLGKI VSYAQGFSQL RAASDEYNWD 350
    LNYGEIAKIF RAGCIIRAQF LQKITDAYAQ NAGIANLLLA PYFKQIADDY 400
    QQALRDVVAY AVQNGIPVPT VSAAIAYYDS YRSAVLPANL IQAQRDYFGA 450
    HTYKRTDKEG VFHTEWLE 468
    Length:468
    Mass (Da):51,328
    Last modified:November 1, 1997 - v2
    Checksum:iFF1EB5E7665FDC90
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti316 – 3161G → E in AAC43817. (PubMed:7937867)Curated
    Sequence conflicti421 – 4211V → F in AAC43817. (PubMed:7937867)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21242 Genomic DNA. Translation: BAA04786.1.
    U14471 Genomic DNA. Translation: AAC43817.1.
    PIRiD56146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21242 Genomic DNA. Translation: BAA04786.1 .
    U14471 Genomic DNA. Translation: AAC43817.1 .
    PIRi D56146.

    3D structure databases

    ProteinModelPortali P41576.
    SMRi P41576. Positions 1-466.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P41576.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid."
      Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M.
      J. Bacteriol. 177:1788-1796(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Chedid.
    2. "Intergeneric transfer and recombination of the 6-phosphogluconate dehydrogenase gene (gnd) in enteric bacteria."
      Nelson K., Selander R.K.
      Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-456.
      Strain: CW 7380.

    Entry informationi

    Entry namei6PGD_KLEPN
    AccessioniPrimary (citable) accession number: P41576
    Secondary accession number(s): Q48461
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3