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P41571 (G6PD_CERCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Alternative name(s):
Zwischenferment
Gene names
Name:ZW
OrganismCeratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Taxonomic identifier7213 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaTephritoideaTephritidaeCeratitisCeratitis

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068090

Regions

Nucleotide binding50 – 578NADP 1 By similarity
Nucleotide binding414 – 4163NADP 2 By similarity
Nucleotide binding434 – 4363NADP 2 By similarity
Region214 – 2185Substrate binding By similarity

Sites

Active site2761Proton acceptor By similarity
Binding site841NADP 1 By similarity
Binding site1841NADP 1; via carbonyl oxygen By similarity
Binding site1841Substrate By similarity
Binding site2521Substrate By similarity
Binding site2711Substrate By similarity
Binding site3701NADP 2 By similarity
Binding site3731Substrate By similarity
Binding site3781Substrate By similarity
Binding site3791NADP 2 By similarity
Binding site3831NADP 2 By similarity
Binding site4061NADP 2 By similarity
Binding site4081Substrate By similarity
Binding site5001NADP 2 By similarity
Binding site5161NADP 2 By similarity
Binding site5221NADP 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P41571 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4047EBF7444C4917

FASTA52660,592
        10         20         30         40         50         60 
MATQHFTNGS ATDDGETALE HIIKSLETPT MKCEGTHFDS HVPHTFVIFG ASGDLAKKKI 

        70         80         90        100        110        120 
YPTLWWLYRD NLLPKSTKFC GYARSKLTIE ELRAKCHQYM KVQPDEQAKY EEFWQNHDYA 

       130        140        150        160        170        180 
AGSYDQRSDF VALKERLSSL ESCNCSCNRI FYLALPPSVF ERVTVNIKDI CLAERGWNRV 

       190        200        210        220        230        240 
IIEKPFGRDD VTSKKLSDHL ASLFHEDQLY RIDHYLGKEM VQNLMTIRFA NKILNSTWNR 

       250        260        270        280        290        300 
ENIASVLITF KEPFGTQGRG GYFDEFGIIR DVMQNHLLQI LSLVAMEKPT SCQPDDIRDE 

       310        320        330        340        350        360 
KVKVLKSIPA LTLDDMVLGQ YVGNPNGVGE QREGYLDDPT VSNDSNTPTY AQGVLRINNE 

       370        380        390        400        410        420 
RWDGVPFILR CGKALDERKA VVRIQYRDVP GDIFEGNSKR NELVIRVQPG EALYFKMMTK 

       430        440        450        460        470        480 
SPGITFDIEE TELDLTYEHR YKNSYLPDAY ERLILDVFCG SQMHFVRSDE LSEAWRIFTP 

       490        500        510        520 
VLNEIENNKV KPIPYVFGSR GPKEADQKTS ENNFKYYGSY KWIGKK 

« Hide

References

[1]"Isolation of cDNAs encoding 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase from the mediterranean fruit fly Ceratitis capitata: correlating genetic and physical maps of chromosome 5."
Scott M.J., Kriticou D., Robinson A.S.
Insect Mol. Biol. 1:213-222(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S67872 mRNA. Translation: AAB29395.1.
RefSeqNP_001266304.1. NM_001279375.1.

3D structure databases

ProteinModelPortalP41571.
SMRP41571. Positions 44-518.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP41571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101453374.

Organism-specific databases

CTD32974.

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_CERCA
AccessionPrimary (citable) accession number: P41571
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways