Reviewed, UniProtKB/Swiss-Prot P41571 (G6PD_CERCA)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49
Alternative name(s):
    Zwischenferment

Gene names

Name:

ZW

Organism

Ceratitis capitata (Mediterranean fruit fly)

Taxonomic identifier

7213 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Tephritoidea › Tephritidae › Ceratitis › Ceratitis

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068090
Sites
	Active site	276	1	Proton acceptor By similarity
	Binding site	52	1	NADP By similarity
	Binding site	84	1	NADP By similarity
	Binding site	214	1	Substrate By similarity
	Binding site	218	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41571-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4047EBF7444C4917	FASTA	526	60,592
	10 20 30 40 50 60 MATQHFTNGS ATDDGETALE HIIKSLETPT MKCEGTHFDS HVPHTFVIFG ASGDLAKKKI 70 80 90 100 110 120 YPTLWWLYRD NLLPKSTKFC GYARSKLTIE ELRAKCHQYM KVQPDEQAKY EEFWQNHDYA 130 140 150 160 170 180 AGSYDQRSDF VALKERLSSL ESCNCSCNRI FYLALPPSVF ERVTVNIKDI CLAERGWNRV 190 200 210 220 230 240 IIEKPFGRDD VTSKKLSDHL ASLFHEDQLY RIDHYLGKEM VQNLMTIRFA NKILNSTWNR 250 260 270 280 290 300 ENIASVLITF KEPFGTQGRG GYFDEFGIIR DVMQNHLLQI LSLVAMEKPT SCQPDDIRDE 310 320 330 340 350 360 KVKVLKSIPA LTLDDMVLGQ YVGNPNGVGE QREGYLDDPT VSNDSNTPTY AQGVLRINNE 370 380 390 400 410 420 RWDGVPFILR CGKALDERKA VVRIQYRDVP GDIFEGNSKR NELVIRVQPG EALYFKMMTK 430 440 450 460 470 480 SPGITFDIEE TELDLTYEHR YKNSYLPDAY ERLILDVFCG SQMHFVRSDE LSEAWRIFTP 490 500 510 520 VLNEIENNKV KPIPYVFGSR GPKEADQKTS ENNFKYYGSY KWIGKK

References

[1]

"Isolation of cDNAs encoding 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase from the mediterranean fruit fly Ceratitis capitata: correlating genetic and physical maps of chromosome 5." Scott M.J., Kriticou D., Robinson A.S. Insect Mol. Biol. 1:213-222(1993) [PubMed: 8269100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	S67872 mRNA. Translation: AAB29395.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_CERCA

Accession

Primary (citable) accession number: P41571

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)