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P41571

- G6PD_CERCA

UniProt

P41571 - G6PD_CERCA

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

ZW

Organism
Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841NADP 1By similarity
    Binding sitei184 – 1841NADP 1; via carbonyl oxygenBy similarity
    Binding sitei184 – 1841SubstrateBy similarity
    Binding sitei252 – 2521SubstrateBy similarity
    Binding sitei271 – 2711SubstrateBy similarity
    Active sitei276 – 2761Proton acceptorBy similarity
    Binding sitei370 – 3701NADP 2By similarity
    Binding sitei373 – 3731SubstrateBy similarity
    Binding sitei378 – 3781SubstrateBy similarity
    Binding sitei379 – 3791NADP 2By similarity
    Binding sitei383 – 3831NADP 2By similarity
    Binding sitei406 – 4061NADP 2By similarity
    Binding sitei408 – 4081SubstrateBy similarity
    Binding sitei500 – 5001NADP 2By similarity
    Binding sitei516 – 5161NADP 2By similarity
    Binding sitei522 – 5221NADP 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 578NADP 1By similarity
    Nucleotide bindingi414 – 4163NADP 2By similarity
    Nucleotide bindingi434 – 4363NADP 2By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: UniProtKB
    2. NADP metabolic process Source: UniProtKB
    3. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Alternative name(s):
    Zwischenferment
    Gene namesi
    Name:ZW
    OrganismiCeratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
    Taxonomic identifieri7213 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaTephritoideaTephritidaeCeratitisCeratitis

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Glucose-6-phosphate 1-dehydrogenasePRO_0000068090Add
    BLAST

    Proteomic databases

    PRIDEiP41571.

    Structurei

    3D structure databases

    ProteinModelPortaliP41571.
    SMRiP41571. Positions 44-518.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni214 – 2185Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41571-1 [UniParc]FASTAAdd to Basket

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    MATQHFTNGS ATDDGETALE HIIKSLETPT MKCEGTHFDS HVPHTFVIFG    50
    ASGDLAKKKI YPTLWWLYRD NLLPKSTKFC GYARSKLTIE ELRAKCHQYM 100
    KVQPDEQAKY EEFWQNHDYA AGSYDQRSDF VALKERLSSL ESCNCSCNRI 150
    FYLALPPSVF ERVTVNIKDI CLAERGWNRV IIEKPFGRDD VTSKKLSDHL 200
    ASLFHEDQLY RIDHYLGKEM VQNLMTIRFA NKILNSTWNR ENIASVLITF 250
    KEPFGTQGRG GYFDEFGIIR DVMQNHLLQI LSLVAMEKPT SCQPDDIRDE 300
    KVKVLKSIPA LTLDDMVLGQ YVGNPNGVGE QREGYLDDPT VSNDSNTPTY 350
    AQGVLRINNE RWDGVPFILR CGKALDERKA VVRIQYRDVP GDIFEGNSKR 400
    NELVIRVQPG EALYFKMMTK SPGITFDIEE TELDLTYEHR YKNSYLPDAY 450
    ERLILDVFCG SQMHFVRSDE LSEAWRIFTP VLNEIENNKV KPIPYVFGSR 500
    GPKEADQKTS ENNFKYYGSY KWIGKK 526
    Length:526
    Mass (Da):60,592
    Last modified:November 1, 1995 - v1
    Checksum:i4047EBF7444C4917
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67872 mRNA. Translation: AAB29395.1.
    RefSeqiNP_001266304.1. NM_001279375.1.

    Genome annotation databases

    GeneIDi101453374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67872 mRNA. Translation: AAB29395.1 .
    RefSeqi NP_001266304.1. NM_001279375.1.

    3D structure databases

    ProteinModelPortali P41571.
    SMRi P41571. Positions 44-518.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P41571.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101453374.

    Organism-specific databases

    CTDi 32974.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNAs encoding 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase from the mediterranean fruit fly Ceratitis capitata: correlating genetic and physical maps of chromosome 5."
      Scott M.J., Kriticou D., Robinson A.S.
      Insect Mol. Biol. 1:213-222(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiG6PD_CERCA
    AccessioniPrimary (citable) accession number: P41571
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3