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P41571 (G6PD_CERCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase
Short name=G6PD
EC=1.1.1.49
Alternative name(s):
Zwischenferment
Gene names
Name:ZW
OrganismCeratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Taxonomic identifier7213 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Tephritoidea › Tephritidae › Ceratitis › Ceratitis

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Glucose-6-phosphate 1-dehydrogenase
PRO_0000068090

Sites

Active site2761Proton acceptor By similarity
Binding site521NADP By similarity
Binding site841NADP By similarity
Binding site2141Substrate By similarity
Binding site2181Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P41571 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4047EBF7444C4917

FASTA52660,592
        10         20         30         40         50         60 
MATQHFTNGS ATDDGETALE HIIKSLETPT MKCEGTHFDS HVPHTFVIFG ASGDLAKKKI 

        70         80         90        100        110        120 
YPTLWWLYRD NLLPKSTKFC GYARSKLTIE ELRAKCHQYM KVQPDEQAKY EEFWQNHDYA 

       130        140        150        160        170        180 
AGSYDQRSDF VALKERLSSL ESCNCSCNRI FYLALPPSVF ERVTVNIKDI CLAERGWNRV 

       190        200        210        220        230        240 
IIEKPFGRDD VTSKKLSDHL ASLFHEDQLY RIDHYLGKEM VQNLMTIRFA NKILNSTWNR 

       250        260        270        280        290        300 
ENIASVLITF KEPFGTQGRG GYFDEFGIIR DVMQNHLLQI LSLVAMEKPT SCQPDDIRDE 

       310        320        330        340        350        360 
KVKVLKSIPA LTLDDMVLGQ YVGNPNGVGE QREGYLDDPT VSNDSNTPTY AQGVLRINNE 

       370        380        390        400        410        420 
RWDGVPFILR CGKALDERKA VVRIQYRDVP GDIFEGNSKR NELVIRVQPG EALYFKMMTK 

       430        440        450        460        470        480 
SPGITFDIEE TELDLTYEHR YKNSYLPDAY ERLILDVFCG SQMHFVRSDE LSEAWRIFTP 

       490        500        510        520 
VLNEIENNKV KPIPYVFGSR GPKEADQKTS ENNFKYYGSY KWIGKK

« Hide

References

[1]"Isolation of cDNAs encoding 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase from the mediterranean fruit fly Ceratitis capitata: correlating genetic and physical maps of chromosome 5."
Scott M.J., Kriticou D., Robinson A.S.
Insect Mol. Biol. 1:213-222(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S67872 mRNA. Translation: AAB29395.1.

3D structure databases

ProteinModelPortalP41571.
SMRP41571. Positions 44-518.
ModBaseSearch...

Proteomic databases

PRIDEP41571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_CERCA
AccessionPrimary (citable) accession number: P41571
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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