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P41571

- G6PD_CERCA

UniProt

P41571 - G6PD_CERCA

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
ZW
Organism
Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841NADP 1 By similarity
Binding sitei184 – 1841NADP 1; via carbonyl oxygen By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei252 – 2521Substrate By similarity
Binding sitei271 – 2711Substrate By similarity
Active sitei276 – 2761Proton acceptor By similarity
Binding sitei370 – 3701NADP 2 By similarity
Binding sitei373 – 3731Substrate By similarity
Binding sitei378 – 3781Substrate By similarity
Binding sitei379 – 3791NADP 2 By similarity
Binding sitei383 – 3831NADP 2 By similarity
Binding sitei406 – 4061NADP 2 By similarity
Binding sitei408 – 4081Substrate By similarity
Binding sitei500 – 5001NADP 2 By similarity
Binding sitei516 – 5161NADP 2 By similarity
Binding sitei522 – 5221NADP 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 578NADP 1 By similarity
Nucleotide bindingi414 – 4163NADP 2 By similarity
Nucleotide bindingi434 – 4363NADP 2 By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. NADP metabolic process Source: UniProtKB
  2. glucose 6-phosphate metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Alternative name(s):
Zwischenferment
Gene namesi
Name:ZW
OrganismiCeratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Taxonomic identifieri7213 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaTephritoideaTephritidaeCeratitisCeratitis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068090Add
BLAST

Proteomic databases

PRIDEiP41571.

Structurei

3D structure databases

ProteinModelPortaliP41571.
SMRiP41571. Positions 44-518.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni214 – 2185Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41571-1 [UniParc]FASTAAdd to Basket

« Hide

MATQHFTNGS ATDDGETALE HIIKSLETPT MKCEGTHFDS HVPHTFVIFG    50
ASGDLAKKKI YPTLWWLYRD NLLPKSTKFC GYARSKLTIE ELRAKCHQYM 100
KVQPDEQAKY EEFWQNHDYA AGSYDQRSDF VALKERLSSL ESCNCSCNRI 150
FYLALPPSVF ERVTVNIKDI CLAERGWNRV IIEKPFGRDD VTSKKLSDHL 200
ASLFHEDQLY RIDHYLGKEM VQNLMTIRFA NKILNSTWNR ENIASVLITF 250
KEPFGTQGRG GYFDEFGIIR DVMQNHLLQI LSLVAMEKPT SCQPDDIRDE 300
KVKVLKSIPA LTLDDMVLGQ YVGNPNGVGE QREGYLDDPT VSNDSNTPTY 350
AQGVLRINNE RWDGVPFILR CGKALDERKA VVRIQYRDVP GDIFEGNSKR 400
NELVIRVQPG EALYFKMMTK SPGITFDIEE TELDLTYEHR YKNSYLPDAY 450
ERLILDVFCG SQMHFVRSDE LSEAWRIFTP VLNEIENNKV KPIPYVFGSR 500
GPKEADQKTS ENNFKYYGSY KWIGKK 526
Length:526
Mass (Da):60,592
Last modified:November 1, 1995 - v1
Checksum:i4047EBF7444C4917
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67872 mRNA. Translation: AAB29395.1.
RefSeqiNP_001266304.1. NM_001279375.1.

Genome annotation databases

GeneIDi101453374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67872 mRNA. Translation: AAB29395.1 .
RefSeqi NP_001266304.1. NM_001279375.1.

3D structure databases

ProteinModelPortali P41571.
SMRi P41571. Positions 44-518.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P41571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101453374.

Organism-specific databases

CTDi 32974.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of cDNAs encoding 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase from the mediterranean fruit fly Ceratitis capitata: correlating genetic and physical maps of chromosome 5."
    Scott M.J., Kriticou D., Robinson A.S.
    Insect Mol. Biol. 1:213-222(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiG6PD_CERCA
AccessioniPrimary (citable) accession number: P41571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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