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P41570

- 6PGD_CERCA

UniProt

P41570 - 6PGD_CERCA

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

Pgd

Organism
Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041NADPBy similarity
    Binding sitei104 – 1041SubstrateBy similarity
    Active sitei184 – 1841Proton acceptorBy similarity
    Active sitei191 – 1911Proton donorBy similarity
    Binding sitei192 – 1921SubstrateBy similarity
    Binding sitei259 – 2591Substrate; via amide nitrogenBy similarity
    Binding sitei286 – 2861SubstrateBy similarity
    Binding sitei445 – 4451Substrate; shared with dimeric partnerBy similarity
    Binding sitei451 – 4511Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADPBy similarity
    Nucleotide bindingi34 – 363NADPBy similarity
    Nucleotide bindingi76 – 783NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:Pgd
    OrganismiCeratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
    Taxonomic identifieri7213 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaTephritoideaTephritidaeCeratitisCeratitis

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4814816-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090068Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP41570.
    SMRiP41570. Positions 3-472.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1323Substrate bindingBy similarity
    Regioni187 – 1882Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41570-1 [UniParc]FASTAAdd to Basket

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    MSAKADIALI GLAVMGQNLV LNMNDKGFVV CAYNRTVEKV NQFLKNEAKG    50
    TNVIGATSLQ DMVNKLKLPR KIMLLVKAGS AVDDFIQQLV PLLSPGDVII 100
    DGGNSEYQDT ARRCDELRAK KILYVGSGVS GGEEGARHGP SLMPGGHPEA 150
    WPLIQPIFQS ICAKADKEPC CEWVGEGGAG HFVKMVHNGI EYGDMQLICE 200
    AYQIMKALGL SQAEMATEFE KWNSEELDSF LIEITRDILN YQDDRGYLLE 250
    RIRDTAGQKG TGKWTAISAL QYGVPVTLIG EAVFSRCLSA LKDERVAASK 300
    QLKGPNVNAK VEDLPKFLNH IKHALYCSKI VSYAQGFMLM REAAKENNWN 350
    LNYGGIALMW RGGCIIRSVF LGNIKDAYTR NPQLSNLLLD DFFKKAIEVG 400
    QNSWRQVVAN AFLWGIPVPA LSTALSFYDG YRTEKLPANL LQAQRDYFGA 450
    HTYELLGAEG KFVHTNWTGT GGNVSASTYQ A 481
    Length:481
    Mass (Da):52,964
    Last modified:November 1, 1995 - v1
    Checksum:iF0ABB506AD1B86D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67873 mRNA. Translation: AAB29396.1.
    RefSeqiNP_001266319.1. NM_001279390.1.

    Genome annotation databases

    GeneIDi101451876.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67873 mRNA. Translation: AAB29396.1 .
    RefSeqi NP_001266319.1. NM_001279390.1.

    3D structure databases

    ProteinModelPortali P41570.
    SMRi P41570. Positions 3-472.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101451876.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNAs encoding 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase from the mediterranean fruit fly Ceratitis capitata: correlating genetic and physical maps of chromosome 5."
      Scott M.J., Kriticou D., Robinson A.S.
      Insect Mol. Biol. 1:213-222(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry namei6PGD_CERCA
    AccessioniPrimary (citable) accession number: P41570
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3