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Protein

Eukaryotic translation initiation factor 1

Gene

EIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • translation factor activity, RNA binding Source: ProtInc
  • translation initiation factor activity Source: ProtInc

GO - Biological processi

  • regulation of translational initiation Source: CACAO

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1
Short name:
eIF1
Alternative name(s):
A121
Protein translation factor SUI1 homolog
Sui1iso1
Gene namesi
Name:EIF1
Synonyms:SUI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173812.10
HGNCiHGNC:3249 EIF1
neXtProtiNX_P41567

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10209
OpenTargetsiENSG00000173812
PharmGKBiPA27683

Polymorphism and mutation databases

BioMutaiEIF1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001305542 – 113Eukaryotic translation initiation factor 1Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP41567
PaxDbiP41567
PeptideAtlasiP41567
PRIDEiP41567
ProteomicsDBi55464
TopDownProteomicsiP41567

PTM databases

iPTMnetiP41567
PhosphoSitePlusiP41567

Expressioni

Gene expression databases

BgeeiENSG00000173812
CleanExiHS_EIF1
ExpressionAtlasiP41567 baseline and differential
GenevisibleiP41567 HS

Interactioni

Subunit structurei

Interacts with RENT2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115504, 7 interactors
DIPiDIP-50783N
IntActiP41567, 7 interactors
MINTiP41567
STRINGi9606.ENSP00000419449

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 41Combined sources4
Beta strandi46 – 49Combined sources4
Helixi56 – 60Combined sources5
Helixi63 – 66Combined sources4
Beta strandi71 – 74Combined sources4
Turni77 – 79Combined sources3
Beta strandi80 – 87Combined sources8
Helixi90 – 100Combined sources11
Turni105 – 107Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IF1NMR-A1-113[»]
4KZXX-ray7.81l1-113[»]
4KZYX-ray7.01l1-113[»]
DisProtiDP00910
ProteinModelPortaliP41567
SMRiP41567
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41567

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

eggNOGiKOG1770 Eukaryota
COG0023 LUCA
GeneTreeiENSGT00390000015789
HOGENOMiHOG000279813
HOVERGENiHBG000295
InParanoidiP41567
KOiK03113
PhylomeDBiP41567
TreeFamiTF314417

Family and domain databases

CDDicd11566 eIF1_SUI1, 1 hit
InterProiView protein in InterPro
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR005874 SUI1_euk
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
PIRSFiPIRSF004499 SUI1_euk, 1 hit
SUPFAMiSSF55159 SSF55159, 1 hit
TIGRFAMsiTIGR01160 SUI1_MOF2, 1 hit
PROSITEiView protein in PROSITE
PS50296 SUI1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI
60 70 80 90 100
ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI
110
GLAKDDQLKV HGF
Length:113
Mass (Da):12,732
Last modified:November 1, 1995 - v1
Checksum:iA7BC7F9B53FFEB2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31I → V in AAD19900 (PubMed:10347211).Curated1
Sequence conflicti62A → P in AAD19900 (PubMed:10347211).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05250559L → P. Corresponds to variant dbSNP:rs3390Ensembl.1
Natural variantiVAR_05250690R → G. Corresponds to variant dbSNP:rs3387Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26247 mRNA Translation: AAA60602.1
AF083441 mRNA Translation: AAD52028.1
AF100737 mRNA Translation: AAD19900.1
BC005118 mRNA Translation: AAH05118.1
BC008710 mRNA Translation: AAH08710.1
CCDSiCCDS11403.1
PIRiJC2042
RefSeqiNP_005792.1, NM_005801.3
UniGeneiHs.150580

Genome annotation databases

EnsembliENST00000469257; ENSP00000419449; ENSG00000173812
GeneIDi10209
KEGGihsa:10209

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEIF1_HUMAN
AccessioniPrimary (citable) accession number: P41567
Secondary accession number(s): Q9UNQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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