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P41567

- EIF1_HUMAN

UniProt

P41567 - EIF1_HUMAN

Protein

Eukaryotic translation initiation factor 1

Gene

EIF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. translation factor activity, nucleic acid binding Source: ProtInc
    3. translation initiation factor activity Source: UniProtKB

    GO - Biological processi

    1. dosage compensation by inactivation of X chromosome Source: Ensembl
    2. regulation of translational initiation Source: ProtInc
    3. response to stress Source: UniProtKB

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 1
    Short name:
    eIF1
    Alternative name(s):
    A121
    Protein translation factor SUI1 homolog
    Sui1iso1
    Gene namesi
    Name:EIF1
    Synonyms:SUI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:3249. EIF1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27683.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 113112Eukaryotic translation initiation factor 1PRO_0000130554Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications
    Modified residuei9 – 91Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP41567.
    PaxDbiP41567.
    PeptideAtlasiP41567.
    PRIDEiP41567.

    PTM databases

    PhosphoSiteiP41567.

    Expressioni

    Gene expression databases

    ArrayExpressiP41567.
    BgeeiP41567.
    CleanExiHS_EIF1.
    GenevestigatoriP41567.

    Organism-specific databases

    HPAiHPA043003.

    Interactioni

    Subunit structurei

    Interacts with RENT2.1 Publication

    Protein-protein interaction databases

    BioGridi115504. 6 interactions.
    DIPiDIP-50783N.
    IntActiP41567. 5 interactions.
    MINTiMINT-1432975.
    STRINGi9606.ENSP00000419449.

    Structurei

    Secondary structure

    1
    113
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi38 – 414
    Beta strandi46 – 494
    Helixi56 – 605
    Helixi63 – 664
    Beta strandi71 – 744
    Turni77 – 793
    Beta strandi80 – 878
    Helixi90 – 10011
    Turni105 – 1073

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IF1NMR-A1-113[»]
    4KZXX-ray7.81l1-113[»]
    4KZYX-ray7.01l1-113[»]
    ProteinModelPortaliP41567.
    SMRiP41567. Positions 1-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP41567.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SUI1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0023.
    HOGENOMiHOG000279813.
    HOVERGENiHBG000295.
    InParanoidiP41567.
    KOiK03113.
    PhylomeDBiP41567.
    TreeFamiTF314417.

    Family and domain databases

    Gene3Di3.30.780.10. 1 hit.
    InterProiIPR005874. SUI1_euk.
    IPR001950. TIF_SUI1.
    [Graphical view]
    PfamiPF01253. SUI1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004499. SUI1_euk. 1 hit.
    SUPFAMiSSF55159. SSF55159. 1 hit.
    TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
    PROSITEiPS50296. SUI1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41567-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI    50
    ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI 100
    GLAKDDQLKV HGF 113
    Length:113
    Mass (Da):12,732
    Last modified:November 1, 1995 - v1
    Checksum:iA7BC7F9B53FFEB2C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311I → V in AAD19900. (PubMed:10347211)Curated
    Sequence conflicti62 – 621A → P in AAD19900. (PubMed:10347211)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591L → P.
    Corresponds to variant rs3390 [ dbSNP | Ensembl ].
    VAR_052505
    Natural varianti90 – 901R → G.
    Corresponds to variant rs3387 [ dbSNP | Ensembl ].
    VAR_052506

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26247 mRNA. Translation: AAA60602.1.
    AF083441 mRNA. Translation: AAD52028.1.
    AF100737 mRNA. Translation: AAD19900.1.
    BC005118 mRNA. Translation: AAH05118.1.
    BC008710 mRNA. Translation: AAH08710.1.
    CCDSiCCDS11403.1.
    PIRiJC2042.
    RefSeqiNP_005792.1. NM_005801.3.
    UniGeneiHs.150580.

    Genome annotation databases

    EnsembliENST00000469257; ENSP00000419449; ENSG00000173812.
    GeneIDi10209.
    KEGGihsa:10209.
    UCSCiuc002hxj.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26247 mRNA. Translation: AAA60602.1 .
    AF083441 mRNA. Translation: AAD52028.1 .
    AF100737 mRNA. Translation: AAD19900.1 .
    BC005118 mRNA. Translation: AAH05118.1 .
    BC008710 mRNA. Translation: AAH08710.1 .
    CCDSi CCDS11403.1.
    PIRi JC2042.
    RefSeqi NP_005792.1. NM_005801.3.
    UniGenei Hs.150580.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IF1 NMR - A 1-113 [» ]
    4KZX X-ray 7.81 l 1-113 [» ]
    4KZY X-ray 7.01 l 1-113 [» ]
    ProteinModelPortali P41567.
    SMRi P41567. Positions 1-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115504. 6 interactions.
    DIPi DIP-50783N.
    IntActi P41567. 5 interactions.
    MINTi MINT-1432975.
    STRINGi 9606.ENSP00000419449.

    PTM databases

    PhosphoSitei P41567.

    Proteomic databases

    MaxQBi P41567.
    PaxDbi P41567.
    PeptideAtlasi P41567.
    PRIDEi P41567.

    Protocols and materials databases

    DNASUi 10209.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000469257 ; ENSP00000419449 ; ENSG00000173812 .
    GeneIDi 10209.
    KEGGi hsa:10209.
    UCSCi uc002hxj.3. human.

    Organism-specific databases

    CTDi 10209.
    GeneCardsi GC17P039845.
    HGNCi HGNC:3249. EIF1.
    HPAi HPA043003.
    neXtProti NX_P41567.
    PharmGKBi PA27683.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0023.
    HOGENOMi HOG000279813.
    HOVERGENi HBG000295.
    InParanoidi P41567.
    KOi K03113.
    PhylomeDBi P41567.
    TreeFami TF314417.

    Miscellaneous databases

    EvolutionaryTracei P41567.
    GeneWikii EIF1.
    GenomeRNAii 10209.
    NextBioi 38652.
    PROi P41567.

    Gene expression databases

    ArrayExpressi P41567.
    Bgeei P41567.
    CleanExi HS_EIF1.
    Genevestigatori P41567.

    Family and domain databases

    Gene3Di 3.30.780.10. 1 hit.
    InterProi IPR005874. SUI1_euk.
    IPR001950. TIF_SUI1.
    [Graphical view ]
    Pfami PF01253. SUI1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004499. SUI1_euk. 1 hit.
    SUPFAMi SSF55159. SSF55159. 1 hit.
    TIGRFAMsi TIGR01160. SUI1_MOF2. 1 hit.
    PROSITEi PS50296. SUI1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expressed sequence tags identify a human isolog of the suil translation initiation factor."
      Fields C.A., Adams M.D.
      Biochem. Biophys. Res. Commun. 198:288-291(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Okadaic acid-responsive genes in malignant glioma cells identified by mRNA differential display."
      Singh S.K., Murray S.F., Chin L.S.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1 (eIF1(A121/SUI1))."
      Sheikh M.S., Fernandez-Salas E., Yu M., Hussain A., Dinman J.D., Peltz S.W., Huang Y., Fornace A.J. Jr.
      J. Biol. Chem. 274:16487-16493(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Lung.
    5. "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes."
      Mendell J.T., Medghalchi S.M., Lake R.G., Noensie E.N., Dietz H.C.
      Mol. Cell. Biol. 20:8944-8957(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RENT2.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Structure and interactions of the translation initiation factor eIF1."
      Fletcher C.M., Pestova T.V., Hellen C.U., Wagner G.
      EMBO J. 18:2631-2637(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiEIF1_HUMAN
    AccessioniPrimary (citable) accession number: P41567
    Secondary accession number(s): Q9UNQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Translation initiation factors
      List of translation initiation factor entries
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3