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P41567 (EIF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 1

Short name=eIF1
Alternative name(s):
A121
Protein translation factor SUI1 homolog
Sui1iso1
Gene names
Name:EIF1
Synonyms:SUI1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

Subunit structure

Interacts with RENT2. Ref.5

Sequence similarities

Belongs to the SUI1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 113112Eukaryotic translation initiation factor 1
PRO_0000130554

Amino acid modifications

Modified residue21N-acetylserine Ref.6 Ref.7 Ref.8
Modified residue91Phosphoserine Ref.8

Natural variations

Natural variant591L → P.
Corresponds to variant rs3390 [ dbSNP | Ensembl ].
VAR_052505
Natural variant901R → G.
Corresponds to variant rs3387 [ dbSNP | Ensembl ].
VAR_052506

Experimental info

Sequence conflict311I → V in AAD19900. Ref.3
Sequence conflict621A → P in AAD19900. Ref.3

Secondary structure

.................. 113
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P41567 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A7BC7F9B53FFEB2C

FASTA11312,732
        10         20         30         40         50         60 
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV 

        70         80         90        100        110 
KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI GLAKDDQLKV HGF 

« Hide

References

« Hide 'large scale' references
[1]"Expressed sequence tags identify a human isolog of the suil translation initiation factor."
Fields C.A., Adams M.D.
Biochem. Biophys. Res. Commun. 198:288-291(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Okadaic acid-responsive genes in malignant glioma cells identified by mRNA differential display."
Singh S.K., Murray S.F., Chin L.S.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1 (eIF1(A121/SUI1))."
Sheikh M.S., Fernandez-Salas E., Yu M., Hussain A., Dinman J.D., Peltz S.W., Huang Y., Fornace A.J. Jr.
J. Biol. Chem. 274:16487-16493(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Lung.
[5]"Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes."
Mendell J.T., Medghalchi S.M., Lake R.G., Noensie E.N., Dietz H.C.
Mol. Cell. Biol. 20:8944-8957(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RENT2.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Structure and interactions of the translation initiation factor eIF1."
Fletcher C.M., Pestova T.V., Hellen C.U., Wagner G.
EMBO J. 18:2631-2637(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L26247 mRNA. Translation: AAA60602.1.
AF083441 mRNA. Translation: AAD52028.1.
AF100737 mRNA. Translation: AAD19900.1.
BC005118 mRNA. Translation: AAH05118.1.
BC008710 mRNA. Translation: AAH08710.1.
PIRJC2042.
RefSeqNP_005792.1. NM_005801.3.
UniGeneHs.150580.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2IF1NMR-A1-113[»]
4KZXX-ray7.81l1-113[»]
4KZYX-ray7.01l1-113[»]
ProteinModelPortalP41567.
SMRP41567. Positions 1-113.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115504. 6 interactions.
DIPDIP-50783N.
IntActP41567. 5 interactions.
MINTMINT-1432975.
STRING9606.ENSP00000419449.

PTM databases

PhosphoSiteP41567.

Proteomic databases

PaxDbP41567.
PeptideAtlasP41567.
PRIDEP41567.

Protocols and materials databases

DNASU10209.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000469257; ENSP00000419449; ENSG00000173812.
GeneID10209.
KEGGhsa:10209.
UCSCuc002hxj.3. human.

Organism-specific databases

CTD10209.
GeneCardsGC17P039845.
HGNCHGNC:3249. EIF1.
HPAHPA043003.
neXtProtNX_P41567.
PharmGKBPA27683.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0023.
HOGENOMHOG000279813.
HOVERGENHBG000295.
InParanoidP41567.
KOK03113.
PhylomeDBP41567.
TreeFamTF314417.

Gene expression databases

ArrayExpressP41567.
BgeeP41567.
CleanExHS_EIF1.
GenevestigatorP41567.

Family and domain databases

Gene3D3.30.780.10. 1 hit.
InterProIPR005874. SUI1_euk.
IPR001950. TIF_SUI1.
[Graphical view]
PfamPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFPIRSF004499. SUI1_euk. 1 hit.
SUPFAMSSF55159. SSF55159. 1 hit.
TIGRFAMsTIGR01160. SUI1_MOF2. 1 hit.
PROSITEPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP41567.
GeneWikiEIF1.
GenomeRNAi10209.
NextBio38652.
PROP41567.

Entry information

Entry nameEIF1_HUMAN
AccessionPrimary (citable) accession number: P41567
Secondary accession number(s): Q9UNQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Translation initiation factors

List of translation initiation factor entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM