Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P41567

- EIF1_HUMAN

UniProt

P41567 - EIF1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Eukaryotic translation initiation factor 1

Gene

EIF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. translation factor activity, nucleic acid binding Source: ProtInc
  3. translation initiation factor activity Source: UniProtKB

GO - Biological processi

  1. dosage compensation by inactivation of X chromosome Source: Ensembl
  2. regulation of translational initiation Source: ProtInc
  3. response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1
Short name:
eIF1
Alternative name(s):
A121
Protein translation factor SUI1 homolog
Sui1iso1
Gene namesi
Name:EIF1
Synonyms:SUI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:3249. EIF1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 113112Eukaryotic translation initiation factor 1PRO_0000130554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications
Modified residuei9 – 91Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP41567.
PaxDbiP41567.
PeptideAtlasiP41567.
PRIDEiP41567.

PTM databases

PhosphoSiteiP41567.

Expressioni

Gene expression databases

BgeeiP41567.
CleanExiHS_EIF1.
ExpressionAtlasiP41567. baseline and differential.
GenevestigatoriP41567.

Organism-specific databases

HPAiHPA043003.

Interactioni

Subunit structurei

Interacts with RENT2.1 Publication

Protein-protein interaction databases

BioGridi115504. 6 interactions.
DIPiDIP-50783N.
IntActiP41567. 5 interactions.
MINTiMINT-1432975.
STRINGi9606.ENSP00000419449.

Structurei

Secondary structure

1
113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi38 – 414
Beta strandi46 – 494
Helixi56 – 605
Helixi63 – 664
Beta strandi71 – 744
Turni77 – 793
Beta strandi80 – 878
Helixi90 – 10011
Turni105 – 1073

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IF1NMR-A1-113[»]
4KZXX-ray7.81l1-113[»]
4KZYX-ray7.01l1-113[»]
ProteinModelPortaliP41567.
SMRiP41567. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41567.

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

eggNOGiCOG0023.
HOGENOMiHOG000279813.
HOVERGENiHBG000295.
InParanoidiP41567.
KOiK03113.
PhylomeDBiP41567.
TreeFamiTF314417.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005874. SUI1_euk.
IPR001950. TIF_SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41567-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI
60 70 80 90 100
ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI
110
GLAKDDQLKV HGF
Length:113
Mass (Da):12,732
Last modified:November 1, 1995 - v1
Checksum:iA7BC7F9B53FFEB2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311I → V in AAD19900. (PubMed:10347211)Curated
Sequence conflicti62 – 621A → P in AAD19900. (PubMed:10347211)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591L → P.
Corresponds to variant rs3390 [ dbSNP | Ensembl ].
VAR_052505
Natural varianti90 – 901R → G.
Corresponds to variant rs3387 [ dbSNP | Ensembl ].
VAR_052506

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26247 mRNA. Translation: AAA60602.1.
AF083441 mRNA. Translation: AAD52028.1.
AF100737 mRNA. Translation: AAD19900.1.
BC005118 mRNA. Translation: AAH05118.1.
BC008710 mRNA. Translation: AAH08710.1.
CCDSiCCDS11403.1.
PIRiJC2042.
RefSeqiNP_005792.1. NM_005801.3.
UniGeneiHs.150580.

Genome annotation databases

EnsembliENST00000469257; ENSP00000419449; ENSG00000173812.
GeneIDi10209.
KEGGihsa:10209.
UCSCiuc002hxj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26247 mRNA. Translation: AAA60602.1 .
AF083441 mRNA. Translation: AAD52028.1 .
AF100737 mRNA. Translation: AAD19900.1 .
BC005118 mRNA. Translation: AAH05118.1 .
BC008710 mRNA. Translation: AAH08710.1 .
CCDSi CCDS11403.1.
PIRi JC2042.
RefSeqi NP_005792.1. NM_005801.3.
UniGenei Hs.150580.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2IF1 NMR - A 1-113 [» ]
4KZX X-ray 7.81 l 1-113 [» ]
4KZY X-ray 7.01 l 1-113 [» ]
ProteinModelPortali P41567.
SMRi P41567. Positions 1-113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115504. 6 interactions.
DIPi DIP-50783N.
IntActi P41567. 5 interactions.
MINTi MINT-1432975.
STRINGi 9606.ENSP00000419449.

PTM databases

PhosphoSitei P41567.

Proteomic databases

MaxQBi P41567.
PaxDbi P41567.
PeptideAtlasi P41567.
PRIDEi P41567.

Protocols and materials databases

DNASUi 10209.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000469257 ; ENSP00000419449 ; ENSG00000173812 .
GeneIDi 10209.
KEGGi hsa:10209.
UCSCi uc002hxj.3. human.

Organism-specific databases

CTDi 10209.
GeneCardsi GC17P039845.
HGNCi HGNC:3249. EIF1.
HPAi HPA043003.
neXtProti NX_P41567.
PharmGKBi PA27683.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0023.
HOGENOMi HOG000279813.
HOVERGENi HBG000295.
InParanoidi P41567.
KOi K03113.
PhylomeDBi P41567.
TreeFami TF314417.

Miscellaneous databases

EvolutionaryTracei P41567.
GeneWikii EIF1.
GenomeRNAii 10209.
NextBioi 38652.
PROi P41567.

Gene expression databases

Bgeei P41567.
CleanExi HS_EIF1.
ExpressionAtlasi P41567. baseline and differential.
Genevestigatori P41567.

Family and domain databases

Gene3Di 3.30.780.10. 1 hit.
InterProi IPR005874. SUI1_euk.
IPR001950. TIF_SUI1.
[Graphical view ]
Pfami PF01253. SUI1. 1 hit.
[Graphical view ]
PIRSFi PIRSF004499. SUI1_euk. 1 hit.
SUPFAMi SSF55159. SSF55159. 1 hit.
TIGRFAMsi TIGR01160. SUI1_MOF2. 1 hit.
PROSITEi PS50296. SUI1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expressed sequence tags identify a human isolog of the suil translation initiation factor."
    Fields C.A., Adams M.D.
    Biochem. Biophys. Res. Commun. 198:288-291(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Okadaic acid-responsive genes in malignant glioma cells identified by mRNA differential display."
    Singh S.K., Murray S.F., Chin L.S.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1 (eIF1(A121/SUI1))."
    Sheikh M.S., Fernandez-Salas E., Yu M., Hussain A., Dinman J.D., Peltz S.W., Huang Y., Fornace A.J. Jr.
    J. Biol. Chem. 274:16487-16493(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Lung.
  5. "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes."
    Mendell J.T., Medghalchi S.M., Lake R.G., Noensie E.N., Dietz H.C.
    Mol. Cell. Biol. 20:8944-8957(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RENT2.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Structure and interactions of the translation initiation factor eIF1."
    Fletcher C.M., Pestova T.V., Hellen C.U., Wagner G.
    EMBO J. 18:2631-2637(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiEIF1_HUMAN
AccessioniPrimary (citable) accession number: P41567
Secondary accession number(s): Q9UNQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Translation initiation factors
    List of translation initiation factor entries
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3