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Protein

Eukaryotic translation initiation factor 1

Gene

EIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • translation factor activity, RNA binding Source: ProtInc
  • translation initiation factor activity Source: UniProtKB

GO - Biological processi

  • dosage compensation by inactivation of X chromosome Source: Ensembl
  • regulation of translational initiation Source: CACAO
  • response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173812-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1
Short name:
eIF1
Alternative name(s):
A121
Protein translation factor SUI1 homolog
Sui1iso1
Gene namesi
Name:EIF1
Synonyms:SUI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:3249. EIF1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi10209.
OpenTargetsiENSG00000173812.
PharmGKBiPA27683.

Polymorphism and mutation databases

BioMutaiEIF1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001305542 – 113Eukaryotic translation initiation factor 1Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP41567.
PaxDbiP41567.
PeptideAtlasiP41567.
PRIDEiP41567.
TopDownProteomicsiP41567.

PTM databases

iPTMnetiP41567.
PhosphoSitePlusiP41567.

Expressioni

Gene expression databases

BgeeiENSG00000173812.
CleanExiHS_EIF1.
ExpressionAtlasiP41567. baseline and differential.
GenevisibleiP41567. HS.

Organism-specific databases

HPAiCAB012272.

Interactioni

Subunit structurei

Interacts with RENT2.1 Publication

Protein-protein interaction databases

BioGridi115504. 7 interactors.
DIPiDIP-50783N.
IntActiP41567. 5 interactors.
MINTiMINT-1432975.
STRINGi9606.ENSP00000419449.

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 41Combined sources4
Beta strandi46 – 49Combined sources4
Helixi56 – 60Combined sources5
Helixi63 – 66Combined sources4
Beta strandi71 – 74Combined sources4
Turni77 – 79Combined sources3
Beta strandi80 – 87Combined sources8
Helixi90 – 100Combined sources11
Turni105 – 107Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IF1NMR-A1-113[»]
4KZXX-ray7.81l1-113[»]
4KZYX-ray7.01l1-113[»]
ProteinModelPortaliP41567.
SMRiP41567.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41567.

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

eggNOGiKOG1770. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000015789.
HOGENOMiHOG000279813.
HOVERGENiHBG000295.
InParanoidiP41567.
KOiK03113.
PhylomeDBiP41567.
TreeFamiTF314417.

Family and domain databases

CDDicd11566. eIF1_SUI1. 1 hit.
Gene3Di3.30.780.10. 1 hit.
InterProiIPR001950. SUI1.
IPR005874. SUI1_euk.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI
60 70 80 90 100
ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI
110
GLAKDDQLKV HGF
Length:113
Mass (Da):12,732
Last modified:November 1, 1995 - v1
Checksum:iA7BC7F9B53FFEB2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31I → V in AAD19900 (PubMed:10347211).Curated1
Sequence conflicti62A → P in AAD19900 (PubMed:10347211).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05250559L → P.Corresponds to variant rs3390dbSNPEnsembl.1
Natural variantiVAR_05250690R → G.Corresponds to variant rs3387dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26247 mRNA. Translation: AAA60602.1.
AF083441 mRNA. Translation: AAD52028.1.
AF100737 mRNA. Translation: AAD19900.1.
BC005118 mRNA. Translation: AAH05118.1.
BC008710 mRNA. Translation: AAH08710.1.
CCDSiCCDS11403.1.
PIRiJC2042.
RefSeqiNP_005792.1. NM_005801.3.
UniGeneiHs.150580.

Genome annotation databases

EnsembliENST00000469257; ENSP00000419449; ENSG00000173812.
GeneIDi10209.
KEGGihsa:10209.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26247 mRNA. Translation: AAA60602.1.
AF083441 mRNA. Translation: AAD52028.1.
AF100737 mRNA. Translation: AAD19900.1.
BC005118 mRNA. Translation: AAH05118.1.
BC008710 mRNA. Translation: AAH08710.1.
CCDSiCCDS11403.1.
PIRiJC2042.
RefSeqiNP_005792.1. NM_005801.3.
UniGeneiHs.150580.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IF1NMR-A1-113[»]
4KZXX-ray7.81l1-113[»]
4KZYX-ray7.01l1-113[»]
ProteinModelPortaliP41567.
SMRiP41567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115504. 7 interactors.
DIPiDIP-50783N.
IntActiP41567. 5 interactors.
MINTiMINT-1432975.
STRINGi9606.ENSP00000419449.

PTM databases

iPTMnetiP41567.
PhosphoSitePlusiP41567.

Polymorphism and mutation databases

BioMutaiEIF1.

Proteomic databases

EPDiP41567.
PaxDbiP41567.
PeptideAtlasiP41567.
PRIDEiP41567.
TopDownProteomicsiP41567.

Protocols and materials databases

DNASUi10209.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000469257; ENSP00000419449; ENSG00000173812.
GeneIDi10209.
KEGGihsa:10209.

Organism-specific databases

CTDi10209.
DisGeNETi10209.
GeneCardsiEIF1.
HGNCiHGNC:3249. EIF1.
HPAiCAB012272.
neXtProtiNX_P41567.
OpenTargetsiENSG00000173812.
PharmGKBiPA27683.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1770. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000015789.
HOGENOMiHOG000279813.
HOVERGENiHBG000295.
InParanoidiP41567.
KOiK03113.
PhylomeDBiP41567.
TreeFamiTF314417.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173812-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP41567.
GeneWikiiEIF1.
GenomeRNAii10209.
PROiP41567.

Gene expression databases

BgeeiENSG00000173812.
CleanExiHS_EIF1.
ExpressionAtlasiP41567. baseline and differential.
GenevisibleiP41567. HS.

Family and domain databases

CDDicd11566. eIF1_SUI1. 1 hit.
Gene3Di3.30.780.10. 1 hit.
InterProiIPR001950. SUI1.
IPR005874. SUI1_euk.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEIF1_HUMAN
AccessioniPrimary (citable) accession number: P41567
Secondary accession number(s): Q9UNQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Translation initiation factors
    List of translation initiation factor entries
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.