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Protein

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Gene

IDH3G

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Enzyme regulationi

Activated by increasing ADP/ATP ratios and by Ca2+.

GO - Molecular functioni

  • isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
  • magnesium ion binding Source: InterPro
  • NAD binding Source: InterPro

GO - Biological processi

  • isocitrate metabolic process Source: UniProtKB
  • tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit gamma
NAD(+)-specific ICDH subunit gamma
Gene namesi
Name:IDH3G
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›106›106Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialPRO_0000083592Add
BLAST

Proteomic databases

PaxDbiP41566.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013592.

Structurei

3D structure databases

ProteinModelPortaliP41566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0784. Eukaryota.
COG0473. LUCA.
InParanoidiP41566.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.

Sequencei

Sequence statusi: Fragments.

P41566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FSQQTIPPSA KYGGILTVTM SPGDGDGPEL MLTVXXXXXS ACVPVDFEEV
60 70 80 90 100
VVSSNADEED IRTSLDLYAN VIHCKLGDGL FLQCCKNIAN PTATLLASCM

MLDHLK
Length:106
Mass (Da):11,334
Last modified:November 1, 1995 - v1
Checksum:iAB0A66AB845C49AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi62 – 632Curated
Non-adjacent residuesi75 – 762Curated
Non-adjacent residuesi86 – 872Curated
Non-terminal residuei106 – 1061

Sequence databases

PIRiC35834.

Cross-referencesi

Sequence databases

PIRiC35834.

3D structure databases

ProteinModelPortaliP41566.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013592.

Proteomic databases

PaxDbiP41566.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0784. Eukaryota.
COG0473. LUCA.
InParanoidiP41566.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase."
    Huang Y.C., Colman R.F.
    Biochemistry 29:8266-8273(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Heart.
  2. "Cysteinyl peptide labeled by 3-bromo-2-ketoglutarate in the active site of pig heart NAD+-dependent isocitrate dehydrogenase."
    Saha A., Huang Y.C., Colman R.F.
    Biochemistry 28:8425-8431(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 40-62.
    Tissue: Heart.
  3. "Aspartyl peptide labeled by 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-diphosphate in the allosteric ADP site of pig heart NAD+-dependent isocitrate dehydrogenase."
    Huang Y.C., Colman R.F.
    J. Biol. Chem. 264:12208-12214(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 76-86.
    Tissue: Heart.

Entry informationi

Entry nameiIDH3G_PIG
AccessioniPrimary (citable) accession number: P41566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 9, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.