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Protein

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Gene

IDH3G

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Enzyme regulationi

Activated by increasing ADP/ATP ratios and by Ca2+.

GO - Molecular functioni

  • isocitrate dehydrogenase (NAD+) activity Source: UniProtKB

GO - Biological processi

  • isocitrate metabolic process Source: UniProtKB
  • tricarboxylic acid cycle Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit gamma
NAD(+)-specific ICDH subunit gamma
Gene namesi
Name:IDH3G
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835921 – ›106Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialAdd BLAST›106

Proteomic databases

PaxDbiP41566.
PeptideAtlasiP41566.
PRIDEiP41566.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013592.

Structurei

3D structure databases

ProteinModelPortaliP41566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0784. Eukaryota.
COG0473. LUCA.
InParanoidiP41566.

Sequencei

Sequence statusi: Fragments.

P41566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FSQQTIPPSA KYGGILTVTM SPGDGDGPEL MLTVXXXXXS ACVPVDFEEV
60 70 80 90 100
VVSSNADEED IRTSLDLYAN VIHCKLGDGL FLQCCKNIAN PTATLLASCM

MLDHLK
Length:106
Mass (Da):11,334
Last modified:November 1, 1995 - v1
Checksum:iAB0A66AB845C49AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-adjacent residuesi62 – 63Curated2
Non-adjacent residuesi75 – 76Curated2
Non-adjacent residuesi86 – 87Curated2
Non-terminal residuei1061

Sequence databases

PIRiC35834.
UniGeneiSsc.16670.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIDH3G_PIG
AccessioniPrimary (citable) accession number: P41566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families