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P41566

- IDH3G_PIG

UniProt

P41566 - IDH3G_PIG

Protein

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Gene

IDH3G

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

    Enzyme regulationi

    Activated by increasing ADP/ATP ratios and by Ca2+.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: UniProtKB
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC:1.1.1.41)
    Alternative name(s):
    Isocitric dehydrogenase subunit gamma
    NAD(+)-specific ICDH subunit gamma
    Gene namesi
    Name:IDH3G
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›106›106Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialPRO_0000083592Add
    BLAST

    Proteomic databases

    PaxDbiP41566.

    Interactioni

    Subunit structurei

    Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000013584.

    Structurei

    3D structure databases

    ProteinModelPortaliP41566.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0473.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.

    Sequencei

    Sequence statusi: Fragments.

    P41566-1 [UniParc]FASTAAdd to Basket

    « Hide

    FSQQTIPPSA KYGGILTVTM SPGDGDGPEL MLTVXXXXXS ACVPVDFEEV    50
    VVSSNADEED IRTSLDLYAN VIHCKLGDGL FLQCCKNIAN PTATLLASCM 100
    MLDHLK 106
    Length:106
    Mass (Da):11,334
    Last modified:November 1, 1995 - v1
    Checksum:iAB0A66AB845C49AB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-adjacent residuesi62 – 632Curated
    Non-adjacent residuesi75 – 762Curated
    Non-adjacent residuesi86 – 872Curated
    Non-terminal residuei106 – 1061

    Sequence databases

    PIRiC35834.

    Cross-referencesi

    Sequence databases

    PIRi C35834.

    3D structure databases

    ProteinModelPortali P41566.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000013584.

    Proteomic databases

    PaxDbi P41566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0473.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase."
      Huang Y.C., Colman R.F.
      Biochemistry 29:8266-8273(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Heart.
    2. "Cysteinyl peptide labeled by 3-bromo-2-ketoglutarate in the active site of pig heart NAD+-dependent isocitrate dehydrogenase."
      Saha A., Huang Y.C., Colman R.F.
      Biochemistry 28:8425-8431(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 40-62.
      Tissue: Heart.
    3. "Aspartyl peptide labeled by 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-diphosphate in the allosteric ADP site of pig heart NAD+-dependent isocitrate dehydrogenase."
      Huang Y.C., Colman R.F.
      J. Biol. Chem. 264:12208-12214(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 76-86.
      Tissue: Heart.

    Entry informationi

    Entry nameiIDH3G_PIG
    AccessioniPrimary (citable) accession number: P41566
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3