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P41565

- IDHG1_RAT

UniProt

P41565 - IDHG1_RAT

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Protein
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
Gene
Idh3g
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Enzyme regulationi

Activated by increasing ADP/ATP ratios and by Ca2+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361Substrate By similarity
Binding sitei167 – 1671Substrate By similarity
Sitei174 – 1741Critical for catalysis By similarity
Sitei221 – 2211Critical for catalysis By similarity
Metal bindingi254 – 2541Magnesium or manganese By similarity
Binding sitei254 – 2541Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 8429NAD Reviewed prediction
Add
BLAST
Nucleotide bindingi309 – 3168ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD binding Source: InterPro
  3. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
  4. magnesium ion binding Source: InterPro

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: RGD
  2. NADH metabolic process Source: RGD
  3. isocitrate metabolic process Source: UniProtKB
  4. negative regulation of growth Source: RGD
  5. tricarboxylic acid cycle Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKP41565.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit gamma
NAD(+)-specific ICDH subunit gamma
Gene namesi
Name:Idh3g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2863. Idh3g.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrial isocitrate dehydrogenase complex (NAD+) Source: RGD
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939Mitochondrion By similarity
Add
BLAST
Chaini40 – 393354Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
PRO_0000014452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061N6-acetyllysine By similarity
Modified residuei226 – 2261N6-succinyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP41565.
PRIDEiP41565.

Expressioni

Gene expression databases

GenevestigatoriP41565.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

Structurei

3D structure databases

ProteinModelPortaliP41565.
SMRiP41565. Positions 51-384.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
HOVERGENiHBG052080.
InParanoidiP41565.
PhylomeDBiP41565.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41565-1 [UniParc]FASTAAdd to Basket

« Hide

MALKVAIAAG SAAKAIFKPA LLCRPWEVLA AHEAPRRSIS SQQTIPPSAK    50
YGGRHTVTMI PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI 100
RNAIMAIRRN RVALKGNIET NHDLPPSHKS RNNILRTSLD LYANVIHCKS 150
LPGVVTRHKD IDILIVRENT EGEYSSLEHE SVAGVVESLK IITKAKSLRI 200
AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA ARYPQITFDS 250
MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 300
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK 350
AVLASMDNEN MHTPDIGGQG TTSQAIQDII RHIRIINGRA VEA 393
Length:393
Mass (Da):42,851
Last modified:December 15, 1998 - v2
Checksum:i890B1A4BE3543AE4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71I → V in CAA52225. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63009 Genomic DNA. Translation: AAC53341.1.
X74125 mRNA. Translation: CAA52225.1.
PIRiS39064.
UniGeneiRn.2837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63009 Genomic DNA. Translation: AAC53341.1 .
X74125 mRNA. Translation: CAA52225.1 .
PIRi S39064.
UniGenei Rn.2837.

3D structure databases

ProteinModelPortali P41565.
SMRi P41565. Positions 51-384.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P41565.
PRIDEi P41565.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2863. Idh3g.

Phylogenomic databases

eggNOGi COG0473.
HOVERGENi HBG052080.
InParanoidi P41565.
PhylomeDBi P41565.

Enzyme and pathway databases

SABIO-RK P41565.

Gene expression databases

Genevestigatori P41565.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse."
    Brenner V., Nyakatura G., Rosenthal A., Platzer M.
    Genomics 44:8-14(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24.
    Strain: HAN/WIST.
  2. "Molecular cloning and deduced amino acid sequences of the gamma-subunits of rat and monkey NAD(+)-isocitrate dehydrogenases."
    Nichols B.J., Hall L., Perry A.C.F., Denton R.M.
    Biochem. J. 295:347-350(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-393.
    Strain: Wistar.
    Tissue: Epididymis.

Entry informationi

Entry nameiIDHG1_RAT
AccessioniPrimary (citable) accession number: P41565
Secondary accession number(s): P70577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 15, 1998
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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