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P41565 (IDHG1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
EC=1.1.1.41
Alternative name(s):
Isocitric dehydrogenase subunit gamma
NAD(+)-specific ICDH subunit gamma
Gene names
Name:Idh3g
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Enzyme regulation

Activated by increasing ADP/ATP ratios and by Ca2+.

Subunit structure

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion By similarity
Chain40 – 393354Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
PRO_0000014452

Regions

Nucleotide binding56 – 8429NAD Potential
Nucleotide binding309 – 3168ATP Potential

Sites

Metal binding2541Magnesium or manganese By similarity
Binding site1361Substrate By similarity
Binding site1671Substrate By similarity
Binding site2541Substrate By similarity
Site1741Critical for catalysis By similarity
Site2211Critical for catalysis By similarity

Amino acid modifications

Modified residue3631Phosphothreonine By similarity

Experimental info

Sequence conflict71I → V in CAA52225. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P41565 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 890B1A4BE3543AE4

FASTA39342,851
        10         20         30         40         50         60 
MALKVAIAAG SAAKAIFKPA LLCRPWEVLA AHEAPRRSIS SQQTIPPSAK YGGRHTVTMI 

        70         80         90        100        110        120 
PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI RNAIMAIRRN RVALKGNIET 

       130        140        150        160        170        180 
NHDLPPSHKS RNNILRTSLD LYANVIHCKS LPGVVTRHKD IDILIVRENT EGEYSSLEHE 

       190        200        210        220        230        240 
SVAGVVESLK IITKAKSLRI AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA 

       250        260        270        280        290        300 
ARYPQITFDS MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 

       310        320        330        340        350        360 
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK AVLASMDNEN 

       370        380        390 
MHTPDIGGQG TTSQAIQDII RHIRIINGRA VEA

« Hide

References

[1]"Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse."
Brenner V., Nyakatura G., Rosenthal A., Platzer M.
Genomics 44:8-14(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24.
Strain: HAN/WIST.
[2]"Molecular cloning and deduced amino acid sequences of the gamma-subunits of rat and monkey NAD(+)-isocitrate dehydrogenases."
Nichols B.J., Hall L., Perry A.C.F., Denton R.M.
Biochem. J. 295:347-350(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-393.
Strain: Wistar.
Tissue: Epididymis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U63009 Genomic DNA. Translation: AAC53341.1.
X74125 mRNA. Translation: CAA52225.1.
IPIIPI00194047.
PIRS39064.
UniGeneRn.2837.

3D structure databases

ProteinModelPortalP41565.
SMRP41565. Positions 51-384.
ModBaseSearch...

Proteomic databases

PaxDbP41565.
PRIDEP41565.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD2863. Idh3g.

Phylogenomic databases

eggNOGCOG0473.
HOVERGENHBG052080.
InParanoidP41565.
OrthoDBEOG4M0F21.

Enzyme and pathway databases

SABIO-RKP41565.

Gene expression databases

ArrayExpressP41565.
GenevestigatorP41565.
GermOnlineENSRNOG00000037284. Rattus norvegicus.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00175. mito_nad_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDHG1_RAT
AccessionPrimary (citable) accession number: P41565
Secondary accession number(s): P70577
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 15, 1998
Last modified: April 3, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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