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P41565

- IDHG1_RAT

UniProt

P41565 - IDHG1_RAT

Protein

Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial

Gene

Idh3g

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Enzyme regulationi

    Activated by increasing ADP/ATP ratios and by Ca2+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei136 – 1361SubstrateBy similarity
    Binding sitei167 – 1671SubstrateBy similarity
    Sitei174 – 1741Critical for catalysisBy similarity
    Sitei221 – 2211Critical for catalysisBy similarity
    Metal bindingi254 – 2541Magnesium or manganeseBy similarity
    Binding sitei254 – 2541SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 8429NADSequence AnalysisAdd
    BLAST
    Nucleotide bindingi309 – 3168ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
    3. magnesium ion binding Source: InterPro
    4. NAD binding Source: InterPro

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: RGD
    2. isocitrate metabolic process Source: UniProtKB
    3. NADH metabolic process Source: RGD
    4. negative regulation of growth Source: RGD
    5. tricarboxylic acid cycle Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, NAD, Nucleotide-binding

    Enzyme and pathway databases

    SABIO-RKP41565.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (EC:1.1.1.41)
    Alternative name(s):
    Isocitric dehydrogenase subunit gamma
    NAD(+)-specific ICDH subunit gamma
    Gene namesi
    Name:Idh3g
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2863. Idh3g.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrial isocitrate dehydrogenase complex (NAD+) Source: RGD
    2. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionBy similarityAdd
    BLAST
    Chaini40 – 393354Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrialPRO_0000014452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei206 – 2061N6-acetyllysineBy similarity
    Modified residuei226 – 2261N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP41565.
    PRIDEiP41565.

    Expressioni

    Gene expression databases

    GenevestigatoriP41565.

    Interactioni

    Subunit structurei

    Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

    Structurei

    3D structure databases

    ProteinModelPortaliP41565.
    SMRiP41565. Positions 51-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0473.
    HOVERGENiHBG052080.
    InParanoidiP41565.
    PhylomeDBiP41565.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41565-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKVAIAAG SAAKAIFKPA LLCRPWEVLA AHEAPRRSIS SQQTIPPSAK    50
    YGGRHTVTMI PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI 100
    RNAIMAIRRN RVALKGNIET NHDLPPSHKS RNNILRTSLD LYANVIHCKS 150
    LPGVVTRHKD IDILIVRENT EGEYSSLEHE SVAGVVESLK IITKAKSLRI 200
    AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA ARYPQITFDS 250
    MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 300
    HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK 350
    AVLASMDNEN MHTPDIGGQG TTSQAIQDII RHIRIINGRA VEA 393
    Length:393
    Mass (Da):42,851
    Last modified:December 15, 1998 - v2
    Checksum:i890B1A4BE3543AE4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71I → V in CAA52225. (PubMed:8240232)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63009 Genomic DNA. Translation: AAC53341.1.
    X74125 mRNA. Translation: CAA52225.1.
    PIRiS39064.
    UniGeneiRn.2837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63009 Genomic DNA. Translation: AAC53341.1 .
    X74125 mRNA. Translation: CAA52225.1 .
    PIRi S39064.
    UniGenei Rn.2837.

    3D structure databases

    ProteinModelPortali P41565.
    SMRi P41565. Positions 51-384.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P41565.
    PRIDEi P41565.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2863. Idh3g.

    Phylogenomic databases

    eggNOGi COG0473.
    HOVERGENi HBG052080.
    InParanoidi P41565.
    PhylomeDBi P41565.

    Enzyme and pathway databases

    SABIO-RK P41565.

    Gene expression databases

    Genevestigatori P41565.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse."
      Brenner V., Nyakatura G., Rosenthal A., Platzer M.
      Genomics 44:8-14(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24.
      Strain: HAN/WIST.
    2. "Molecular cloning and deduced amino acid sequences of the gamma-subunits of rat and monkey NAD(+)-isocitrate dehydrogenases."
      Nichols B.J., Hall L., Perry A.C.F., Denton R.M.
      Biochem. J. 295:347-350(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-393.
      Strain: Wistar.
      Tissue: Epididymis.

    Entry informationi

    Entry nameiIDHG1_RAT
    AccessioniPrimary (citable) accession number: P41565
    Secondary accession number(s): P70577
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3