P41563 (IDH3A_BOVIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 87.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial EC=1.1.1.41 Alternative name(s): Isocitrate dehydrogenase subunits 3/4 Isocitric dehydrogenase subunit alpha NAD(+)-specific ICDH subunit alpha | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) [Reference proteome] | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos![]() |
Protein attributes
| Sequence length | 366 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH. |
| Cofactor | Binds 1 magnesium or manganese ion per subunit By similarity. |
| Subunit structure | Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the isocitrate and isopropylmalate dehydrogenases family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Magnesium Manganese Metal-binding NAD |
| Molecular function | Oxidoreductase |
| PTM | Acetylation |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | mitochondrion Inferred from sequence or structural similarity. Source: AgBase |
| Molecular_function | NAD binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NAD+) activityInferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 27 | 27 | Mitochondrion | ||||||
| Chain | 28 – 366 | 339 | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | PRO_0000014435 | |||||
Sites | |||||||||
| Metal binding | 233 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 257 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 261 | 1 | Magnesium or manganese By similarity | ||||||
| Binding site | 115 | 1 | Substrate By similarity | ||||||
| Binding site | 125 | 1 | Substrate By similarity | ||||||
| Binding site | 146 | 1 | Substrate By similarity | ||||||
| Binding site | 233 | 1 | Substrate By similarity | ||||||
| Site | 153 | 1 | Critical for catalysis By similarity | ||||||
| Site | 200 | 1 | Critical for catalysis By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 343 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Isocitrate dehydrogenase from bovine heart: primary structure of subunit 3/4." Zeng Y., Weiss C., Yao T.T., Huang J., Siconolfi-Baez L., Hsu P., Rushbrook J.I. Biochem. J. 310:507-516(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart. |
| [2] | "Nicotinamide adenine dinucleotide dependent isocitrate dehydrogenase from beef heart: subunit heterogeneity and enzyme dissociation." Rushbrook J.I., Harvey R.A. Biochemistry 17:5339-5346(1978) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION. Tissue: Heart. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U07980 mRNA. Translation: AAC18425.1. |
| IPI | IPI00699016. |
| PIR | S58435. |
| RefSeq | NP_777069.1. NM_174644.2. |
| UniGene | Bt.3898. |
3D structure databases | |
| ProteinModelPortal | P41563. |
| SMR | P41563. Positions 26-362. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P41563. 1 interaction. |
| STRING | 9913.ENSBTAP00000008177. |
Proteomic databases | |
| PaxDb | P41563. |
| PRIDE | P41563. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 282446. |
| KEGG | bta:282446. |
Organism-specific databases | |
| CTD | 3419. |
Phylogenomic databases | |
| eggNOG | COG0473. |
| HOGENOM | HOG000021113. |
| HOVERGEN | HBG052080. |
| InParanoid | P41563. |
| KO | K00030. |
| OrthoDB | EOG4GMTX7. |
Family and domain databases | |
| Gene3D | 3.40.718.10. 1 hit. |
| InterPro | IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR004434. Isocitrate_DH_NAD. IPR024084. IsoPropMal-DH-like_dom. [Graphical view] |
| PANTHER | PTHR11835. PTHR11835. 1 hit. |
| Pfam | PF00180. Iso_dh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00175. mito_nad_idh. 1 hit. |
| PROSITE | PS00470. IDH_IMDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20806216. |
Entry information
| Entry name | IDH3A_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P41563 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
