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P41563

- IDH3A_BOVIN

UniProt

P41563 - IDH3A_BOVIN

Protein

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Gene

IDH3A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei115 – 1151SubstrateBy similarity
    Binding sitei125 – 1251SubstrateBy similarity
    Binding sitei146 – 1461SubstrateBy similarity
    Sitei153 – 1531Critical for catalysisBy similarity
    Sitei200 – 2001Critical for catalysisBy similarity
    Metal bindingi233 – 2331Magnesium or manganeseBy similarity
    Binding sitei233 – 2331SubstrateBy similarity
    Metal bindingi257 – 2571Magnesium or manganeseBy similarity
    Metal bindingi261 – 2611Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC:1.1.1.41)
    Alternative name(s):
    Isocitrate dehydrogenase subunits 3/4
    Isocitric dehydrogenase subunit alpha
    NAD(+)-specific ICDH subunit alpha
    Gene namesi
    Name:IDH3A
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: AgBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionAdd
    BLAST
    Chaini28 – 366339Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialPRO_0000014435Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei77 – 771N6-succinyllysineBy similarity
    Modified residuei223 – 2231N6-acetyllysineBy similarity
    Modified residuei343 – 3431N6-acetyllysine; alternateBy similarity
    Modified residuei343 – 3431N6-succinyllysine; alternateBy similarity
    Modified residuei350 – 3501N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP41563.
    PRIDEiP41563.

    Interactioni

    Subunit structurei

    Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

    Protein-protein interaction databases

    IntActiP41563. 1 interaction.
    STRINGi9913.ENSBTAP00000008177.

    Structurei

    3D structure databases

    ProteinModelPortaliP41563.
    SMRiP41563. Positions 26-362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0473.
    HOGENOMiHOG000021113.
    HOVERGENiHBG052080.
    InParanoidiP41563.
    KOiK00030.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41563-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPAWISKV SRLLGAFHNQ KQVTRGFAGG VKTVTLIPGD GIGPEISAAV    50
    MKIFDAAKAP IQWEERNVAA IQGPGGKWMI PPEAKESMDK NKMGLKGPLK 100
    TPIAAGHPSM NLLLRKTFDL YANVRPCVSI EGYKTPYHDV NIVTIRENTE 150
    GEYSGIEHVI VDGVVQSIKL ITEAASKRIA EFAFEYARNN HRSNVTAVHK 200
    ANIMRMSDGL FLQKCREVAE NCKDIKFNEM YLDTVCLNMV QDPSQFDVLV 250
    MPNLYGDILS DLCAGLIGGL GVTPSGNIGA NGVAIFESVH GTAPDIAGKD 300
    MANPTALLLS AVMMLRHMGL FDHAAKIETA CFATIKDGKS LTKDLGGNSK 350
    CSDFTEEICR RVKDLD 366
    Length:366
    Mass (Da):39,668
    Last modified:November 1, 1995 - v1
    Checksum:iB169D59B30E51C9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07980 mRNA. Translation: AAC18425.1.
    PIRiS58435.
    RefSeqiNP_777069.1. NM_174644.2.
    UniGeneiBt.3898.

    Genome annotation databases

    GeneIDi282446.
    KEGGibta:282446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07980 mRNA. Translation: AAC18425.1 .
    PIRi S58435.
    RefSeqi NP_777069.1. NM_174644.2.
    UniGenei Bt.3898.

    3D structure databases

    ProteinModelPortali P41563.
    SMRi P41563. Positions 26-362.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P41563. 1 interaction.
    STRINGi 9913.ENSBTAP00000008177.

    Proteomic databases

    PaxDbi P41563.
    PRIDEi P41563.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282446.
    KEGGi bta:282446.

    Organism-specific databases

    CTDi 3419.

    Phylogenomic databases

    eggNOGi COG0473.
    HOGENOMi HOG000021113.
    HOVERGENi HBG052080.
    InParanoidi P41563.
    KOi K00030.

    Miscellaneous databases

    NextBioi 20806216.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isocitrate dehydrogenase from bovine heart: primary structure of subunit 3/4."
      Zeng Y., Weiss C., Yao T.T., Huang J., Siconolfi-Baez L., Hsu P., Rushbrook J.I.
      Biochem. J. 310:507-516(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Nicotinamide adenine dinucleotide dependent isocitrate dehydrogenase from beef heart: subunit heterogeneity and enzyme dissociation."
      Rushbrook J.I., Harvey R.A.
      Biochemistry 17:5339-5346(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Tissue: Heart.

    Entry informationi

    Entry nameiIDH3A_BOVIN
    AccessioniPrimary (citable) accession number: P41563
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3