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P41563

- IDH3A_BOVIN

UniProt

P41563 - IDH3A_BOVIN

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Protein

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Gene
IDH3A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei115 – 1151Substrate By similarity
Binding sitei125 – 1251Substrate By similarity
Binding sitei146 – 1461Substrate By similarity
Sitei153 – 1531Critical for catalysis By similarity
Sitei200 – 2001Critical for catalysis By similarity
Metal bindingi233 – 2331Magnesium or manganese By similarity
Binding sitei233 – 2331Substrate By similarity
Metal bindingi257 – 2571Magnesium or manganese By similarity
Metal bindingi261 – 2611Magnesium or manganese By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitrate dehydrogenase subunits 3/4
Isocitric dehydrogenase subunit alpha
NAD(+)-specific ICDH subunit alpha
Gene namesi
Name:IDH3A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionAdd
BLAST
Chaini28 – 366339Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialPRO_0000014435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771N6-succinyllysine By similarity
Modified residuei223 – 2231N6-acetyllysine By similarity
Modified residuei343 – 3431N6-acetyllysine; alternate By similarity
Modified residuei343 – 3431N6-succinyllysine; alternate By similarity
Modified residuei350 – 3501N6-succinyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP41563.
PRIDEiP41563.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 By similarity.

Protein-protein interaction databases

IntActiP41563. 1 interaction.
STRINGi9913.ENSBTAP00000008177.

Structurei

3D structure databases

ProteinModelPortaliP41563.
SMRiP41563. Positions 26-362.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
HOGENOMiHOG000021113.
HOVERGENiHBG052080.
InParanoidiP41563.
KOiK00030.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41563-1 [UniParc]FASTAAdd to Basket

« Hide

MAGPAWISKV SRLLGAFHNQ KQVTRGFAGG VKTVTLIPGD GIGPEISAAV    50
MKIFDAAKAP IQWEERNVAA IQGPGGKWMI PPEAKESMDK NKMGLKGPLK 100
TPIAAGHPSM NLLLRKTFDL YANVRPCVSI EGYKTPYHDV NIVTIRENTE 150
GEYSGIEHVI VDGVVQSIKL ITEAASKRIA EFAFEYARNN HRSNVTAVHK 200
ANIMRMSDGL FLQKCREVAE NCKDIKFNEM YLDTVCLNMV QDPSQFDVLV 250
MPNLYGDILS DLCAGLIGGL GVTPSGNIGA NGVAIFESVH GTAPDIAGKD 300
MANPTALLLS AVMMLRHMGL FDHAAKIETA CFATIKDGKS LTKDLGGNSK 350
CSDFTEEICR RVKDLD 366
Length:366
Mass (Da):39,668
Last modified:November 1, 1995 - v1
Checksum:iB169D59B30E51C9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07980 mRNA. Translation: AAC18425.1.
PIRiS58435.
RefSeqiNP_777069.1. NM_174644.2.
UniGeneiBt.3898.

Genome annotation databases

GeneIDi282446.
KEGGibta:282446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07980 mRNA. Translation: AAC18425.1 .
PIRi S58435.
RefSeqi NP_777069.1. NM_174644.2.
UniGenei Bt.3898.

3D structure databases

ProteinModelPortali P41563.
SMRi P41563. Positions 26-362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P41563. 1 interaction.
STRINGi 9913.ENSBTAP00000008177.

Proteomic databases

PaxDbi P41563.
PRIDEi P41563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282446.
KEGGi bta:282446.

Organism-specific databases

CTDi 3419.

Phylogenomic databases

eggNOGi COG0473.
HOGENOMi HOG000021113.
HOVERGENi HBG052080.
InParanoidi P41563.
KOi K00030.

Miscellaneous databases

NextBioi 20806216.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isocitrate dehydrogenase from bovine heart: primary structure of subunit 3/4."
    Zeng Y., Weiss C., Yao T.T., Huang J., Siconolfi-Baez L., Hsu P., Rushbrook J.I.
    Biochem. J. 310:507-516(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Nicotinamide adenine dinucleotide dependent isocitrate dehydrogenase from beef heart: subunit heterogeneity and enzyme dissociation."
    Rushbrook J.I., Harvey R.A.
    Biochemistry 17:5339-5346(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Tissue: Heart.

Entry informationi

Entry nameiIDH3A_BOVIN
AccessioniPrimary (citable) accession number: P41563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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