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P41561

- IDH2_COLMA

UniProt

P41561 - IDH2_COLMA

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Protein

Isocitrate dehydrogenase [NADP] 2

Gene

icd2

Organism
Colwellia maris (Vibrio sp. (strain ABE-1))
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371NADPBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Sitei257 – 2571Critical for catalysisBy similarity
Metal bindingi352 – 3521Magnesium or manganeseBy similarity
Sitei422 – 4221Critical for catalysisBy similarity
Binding sitei549 – 5491SubstrateBy similarity
Metal bindingi550 – 5501Magnesium or manganeseBy similarity
Metal bindingi554 – 5541Magnesium or manganeseBy similarity
Binding sitei591 – 5911NADPBy similarity
Binding sitei651 – 6511NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 896NADPBy similarity
Nucleotide bindingi586 – 5872NADPBy similarity
Nucleotide bindingi602 – 6043NADPBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] 2 (EC:1.1.1.42)
Alternative name(s):
IDH-II
IDP-2
NADP(+)-specific ICDH 2
Oxalosuccinate decarboxylase 2
Gene namesi
Name:icd2
OrganismiColwellia maris (Vibrio sp. (strain ABE-1))
Taxonomic identifieri77524 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 743742Isocitrate dehydrogenase [NADP] 2PRO_0000083596Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP41561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the monomeric-type IDH family.Curated

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41561-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTDNSKIIY TITDEAPALA TYSLLPIIQA YTASSGINVE TRDISLAGRI
60 70 80 90 100
LANFPKYLTK EQRIDDALAE LGELAQTPEA NIIKLPNISA SIPQLEAVIK
110 120 130 140 150
ELQAKGYDLP HYPAEPQNEA EESIKLTYAK ILGSAVNPVL REGNSDRRAP
160 170 180 190 200
ASVKQYARNN PHSMGAWSKE SKSHVAHMAS GDFYGSEKSV TIDGATSVNI
210 220 230 240 250
EFVAKNGDVT LLKSKLPLLD KEIIDASVMS KSALVEFFET EINKAKEEDV
260 270 280 290 300
LLSLHLKATM MKVSDPVMFG HAVRVFYKDV FAKHAATFEQ LGVDADNGIG
310 320 330 340 350
DVYAKIARLP AAQKEEIEAD LQAVYATRPE MAMVDSDKGI TNLHVPSDVI
360 370 380 390 400
IDASMPAALR ASGMMWGPDG KQKDTKFMIP DRNYAGVFSA VVDFCRENGA
410 420 430 440 450
FNPATMGTVP NVGLMAQKAE EYGSHDKTFT MKAAGTVRVV NSQGERLIEQ
460 470 480 490 500
EVAQGDIYRM CQVKDAPIQD WVKLAVTRAR ATGTPTVFWL DENRGHDEQM
510 520 530 540 550
IKKVNTYLAD HDTTGLDIQI LEPVKACEFT LARVAKGEDA ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQFEKENH
610 620 630 640 650
LRWDSLGEFL ALAASLEHVA VTTGNARAQI LADTLDAATG KFLDTNKSPS
660 670 680 690 700
RKVGELDNRG SHFYLAMYWA QALAAQTTDT ELQASFSSVA QALTKQEEKI
710 720 730 740
VAELNAAQGP AIDLNGYYFA DTKLAEKAMR PSETFNTILS ALL
Length:743
Mass (Da):80,882
Last modified:April 14, 2009 - v3
Checksum:iDE1E71FF4B5A6E06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14047 Genomic DNA. Translation: BAA03134.2.
PIRiA49341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14047 Genomic DNA. Translation: BAA03134.2 .
PIRi A49341.

3D structure databases

ProteinModelPortali P41561.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genes encoding two isocitrate dehydrogenase isozymes of a psychrophilic bacterium, Vibrio sp. strain ABE-1."
    Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
    J. Bacteriol. 175:6873-6880(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 660-673.
  3. "Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4."
    Fukunaga N., Imagawa S., Sahara T., Ishii A., Suzuki M.
    J. Biochem. 112:849-855(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-39.

Entry informationi

Entry nameiIDH2_COLMA
AccessioniPrimary (citable) accession number: P41561
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 14, 2009
Last modified: October 1, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3