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Protein

Isocitrate dehydrogenase [NADP] 2

Gene

icd2

Organism
Colwellia maris (Vibrio sp. (strain ABE-1))
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137NADPBy similarity1
Binding sitei147SubstrateBy similarity1
Sitei257Critical for catalysisBy similarity1
Metal bindingi352Magnesium or manganeseBy similarity1
Sitei422Critical for catalysisBy similarity1
Binding sitei549SubstrateBy similarity1
Metal bindingi550Magnesium or manganeseBy similarity1
Metal bindingi554Magnesium or manganeseBy similarity1
Binding sitei591NADPBy similarity1
Binding sitei651NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 89NADPBy similarity6
Nucleotide bindingi586 – 587NADPBy similarity2
Nucleotide bindingi602 – 604NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] 2 (EC:1.1.1.42)
Alternative name(s):
IDH-II
IDP-2
NADP(+)-specific ICDH 2
Oxalosuccinate decarboxylase 2
Gene namesi
Name:icd2
OrganismiColwellia maris (Vibrio sp. (strain ABE-1))
Taxonomic identifieri77524 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000835962 – 743Isocitrate dehydrogenase [NADP] 2Add BLAST742

Proteomic databases

PRIDEiP41561.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP41561.
SMRiP41561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni134 – 141Substrate bindingBy similarity8

Sequence similaritiesi

Belongs to the monomeric-type IDH family.Curated

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41561-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTDNSKIIY TITDEAPALA TYSLLPIIQA YTASSGINVE TRDISLAGRI
60 70 80 90 100
LANFPKYLTK EQRIDDALAE LGELAQTPEA NIIKLPNISA SIPQLEAVIK
110 120 130 140 150
ELQAKGYDLP HYPAEPQNEA EESIKLTYAK ILGSAVNPVL REGNSDRRAP
160 170 180 190 200
ASVKQYARNN PHSMGAWSKE SKSHVAHMAS GDFYGSEKSV TIDGATSVNI
210 220 230 240 250
EFVAKNGDVT LLKSKLPLLD KEIIDASVMS KSALVEFFET EINKAKEEDV
260 270 280 290 300
LLSLHLKATM MKVSDPVMFG HAVRVFYKDV FAKHAATFEQ LGVDADNGIG
310 320 330 340 350
DVYAKIARLP AAQKEEIEAD LQAVYATRPE MAMVDSDKGI TNLHVPSDVI
360 370 380 390 400
IDASMPAALR ASGMMWGPDG KQKDTKFMIP DRNYAGVFSA VVDFCRENGA
410 420 430 440 450
FNPATMGTVP NVGLMAQKAE EYGSHDKTFT MKAAGTVRVV NSQGERLIEQ
460 470 480 490 500
EVAQGDIYRM CQVKDAPIQD WVKLAVTRAR ATGTPTVFWL DENRGHDEQM
510 520 530 540 550
IKKVNTYLAD HDTTGLDIQI LEPVKACEFT LARVAKGEDA ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQFEKENH
610 620 630 640 650
LRWDSLGEFL ALAASLEHVA VTTGNARAQI LADTLDAATG KFLDTNKSPS
660 670 680 690 700
RKVGELDNRG SHFYLAMYWA QALAAQTTDT ELQASFSSVA QALTKQEEKI
710 720 730 740
VAELNAAQGP AIDLNGYYFA DTKLAEKAMR PSETFNTILS ALL
Length:743
Mass (Da):80,882
Last modified:April 14, 2009 - v3
Checksum:iDE1E71FF4B5A6E06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14047 Genomic DNA. Translation: BAA03134.2.
PIRiA49341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14047 Genomic DNA. Translation: BAA03134.2.
PIRiA49341.

3D structure databases

ProteinModelPortaliP41561.
SMRiP41561.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP41561.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIDH2_COLMA
AccessioniPrimary (citable) accession number: P41561
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.