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P41561 (IDH2_COLMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] 2

EC=1.1.1.42
Alternative name(s):
IDH-II
IDP-2
NADP(+)-specific ICDH 2
Oxalosuccinate decarboxylase 2
Gene names
Name:icd2
OrganismColwellia maris (Vibrio sp. (strain ABE-1))
Taxonomic identifier77524 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

Protein attributes

Sequence length743 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the monomeric-type IDH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 743742Isocitrate dehydrogenase [NADP] 2
PRO_0000083596

Regions

Nucleotide binding84 – 896NADP By similarity
Nucleotide binding586 – 5872NADP By similarity
Nucleotide binding602 – 6043NADP By similarity
Region134 – 1418Substrate binding By similarity

Sites

Metal binding3521Magnesium or manganese By similarity
Metal binding5501Magnesium or manganese By similarity
Metal binding5541Magnesium or manganese By similarity
Binding site1371NADP By similarity
Binding site1471Substrate By similarity
Binding site5491Substrate By similarity
Binding site5911NADP By similarity
Binding site6511NADP By similarity
Site2571Critical for catalysis By similarity
Site4221Critical for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P41561 [UniParc].

Last modified April 14, 2009. Version 3.
Checksum: DE1E71FF4B5A6E06

FASTA74380,882
        10         20         30         40         50         60 
MSTDNSKIIY TITDEAPALA TYSLLPIIQA YTASSGINVE TRDISLAGRI LANFPKYLTK 

        70         80         90        100        110        120 
EQRIDDALAE LGELAQTPEA NIIKLPNISA SIPQLEAVIK ELQAKGYDLP HYPAEPQNEA 

       130        140        150        160        170        180 
EESIKLTYAK ILGSAVNPVL REGNSDRRAP ASVKQYARNN PHSMGAWSKE SKSHVAHMAS 

       190        200        210        220        230        240 
GDFYGSEKSV TIDGATSVNI EFVAKNGDVT LLKSKLPLLD KEIIDASVMS KSALVEFFET 

       250        260        270        280        290        300 
EINKAKEEDV LLSLHLKATM MKVSDPVMFG HAVRVFYKDV FAKHAATFEQ LGVDADNGIG 

       310        320        330        340        350        360 
DVYAKIARLP AAQKEEIEAD LQAVYATRPE MAMVDSDKGI TNLHVPSDVI IDASMPAALR 

       370        380        390        400        410        420 
ASGMMWGPDG KQKDTKFMIP DRNYAGVFSA VVDFCRENGA FNPATMGTVP NVGLMAQKAE 

       430        440        450        460        470        480 
EYGSHDKTFT MKAAGTVRVV NSQGERLIEQ EVAQGDIYRM CQVKDAPIQD WVKLAVTRAR 

       490        500        510        520        530        540 
ATGTPTVFWL DENRGHDEQM IKKVNTYLAD HDTTGLDIQI LEPVKACEFT LARVAKGEDA 

       550        560        570        580        590        600 
ISVTGNVLRD YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQFEKENH 

       610        620        630        640        650        660 
LRWDSLGEFL ALAASLEHVA VTTGNARAQI LADTLDAATG KFLDTNKSPS RKVGELDNRG 

       670        680        690        700        710        720 
SHFYLAMYWA QALAAQTTDT ELQASFSSVA QALTKQEEKI VAELNAAQGP AIDLNGYYFA 

       730        740 
DTKLAEKAMR PSETFNTILS ALL 

« Hide

References

[1]"Genes encoding two isocitrate dehydrogenase isozymes of a psychrophilic bacterium, Vibrio sp. strain ABE-1."
Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
J. Bacteriol. 175:6873-6880(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 660-673.
[3]"Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4."
Fukunaga N., Imagawa S., Sahara T., Ishii A., Suzuki M.
J. Biochem. 112:849-855(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-39.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D14047 Genomic DNA. Translation: BAA03134.2.
PIRA49341.

3D structure databases

ProteinModelPortalP41561.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.718.10. 3 hits.
InterProIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamPF03971. IDH. 1 hit.
[Graphical view]
PIRSFPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsTIGR00178. monomer_idh. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIDH2_COLMA
AccessionPrimary (citable) accession number: P41561
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 14, 2009
Last modified: October 16, 2013
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families