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P41561

- IDH2_COLMA

UniProt

P41561 - IDH2_COLMA

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Protein
Isocitrate dehydrogenase [NADP] 2
Gene
icd2
Organism
Colwellia maris (Vibrio sp. (strain ABE-1))
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371NADP By similarity
Binding sitei147 – 1471Substrate By similarity
Sitei257 – 2571Critical for catalysis By similarity
Metal bindingi352 – 3521Magnesium or manganese By similarity
Sitei422 – 4221Critical for catalysis By similarity
Binding sitei549 – 5491Substrate By similarity
Metal bindingi550 – 5501Magnesium or manganese By similarity
Metal bindingi554 – 5541Magnesium or manganese By similarity
Binding sitei591 – 5911NADP By similarity
Binding sitei651 – 6511NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 896NADP By similarity
Nucleotide bindingi586 – 5872NADP By similarity
Nucleotide bindingi602 – 6043NADP By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] 2 (EC:1.1.1.42)
Alternative name(s):
IDH-II
IDP-2
NADP(+)-specific ICDH 2
Oxalosuccinate decarboxylase 2
Gene namesi
Name:icd2
OrganismiColwellia maris (Vibrio sp. (strain ABE-1))
Taxonomic identifieri77524 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 743742Isocitrate dehydrogenase [NADP] 2
PRO_0000083596Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP41561.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41561-1 [UniParc]FASTAAdd to Basket

« Hide

MSTDNSKIIY TITDEAPALA TYSLLPIIQA YTASSGINVE TRDISLAGRI    50
LANFPKYLTK EQRIDDALAE LGELAQTPEA NIIKLPNISA SIPQLEAVIK 100
ELQAKGYDLP HYPAEPQNEA EESIKLTYAK ILGSAVNPVL REGNSDRRAP 150
ASVKQYARNN PHSMGAWSKE SKSHVAHMAS GDFYGSEKSV TIDGATSVNI 200
EFVAKNGDVT LLKSKLPLLD KEIIDASVMS KSALVEFFET EINKAKEEDV 250
LLSLHLKATM MKVSDPVMFG HAVRVFYKDV FAKHAATFEQ LGVDADNGIG 300
DVYAKIARLP AAQKEEIEAD LQAVYATRPE MAMVDSDKGI TNLHVPSDVI 350
IDASMPAALR ASGMMWGPDG KQKDTKFMIP DRNYAGVFSA VVDFCRENGA 400
FNPATMGTVP NVGLMAQKAE EYGSHDKTFT MKAAGTVRVV NSQGERLIEQ 450
EVAQGDIYRM CQVKDAPIQD WVKLAVTRAR ATGTPTVFWL DENRGHDEQM 500
IKKVNTYLAD HDTTGLDIQI LEPVKACEFT LARVAKGEDA ISVTGNVLRD 550
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQFEKENH 600
LRWDSLGEFL ALAASLEHVA VTTGNARAQI LADTLDAATG KFLDTNKSPS 650
RKVGELDNRG SHFYLAMYWA QALAAQTTDT ELQASFSSVA QALTKQEEKI 700
VAELNAAQGP AIDLNGYYFA DTKLAEKAMR PSETFNTILS ALL 743
Length:743
Mass (Da):80,882
Last modified:April 14, 2009 - v3
Checksum:iDE1E71FF4B5A6E06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14047 Genomic DNA. Translation: BAA03134.2.
PIRiA49341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14047 Genomic DNA. Translation: BAA03134.2 .
PIRi A49341.

3D structure databases

ProteinModelPortali P41561.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genes encoding two isocitrate dehydrogenase isozymes of a psychrophilic bacterium, Vibrio sp. strain ABE-1."
    Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
    J. Bacteriol. 175:6873-6880(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 660-673.
  3. "Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4."
    Fukunaga N., Imagawa S., Sahara T., Ishii A., Suzuki M.
    J. Biochem. 112:849-855(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-39.

Entry informationi

Entry nameiIDH2_COLMA
AccessioniPrimary (citable) accession number: P41561
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 14, 2009
Last modified: October 16, 2013
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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