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P41561

- IDH2_COLMA

UniProt

P41561 - IDH2_COLMA

Protein

Isocitrate dehydrogenase [NADP] 2

Gene

icd2

Organism
Colwellia maris (Vibrio sp. (strain ABE-1))
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 3 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei137 – 1371NADPBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Sitei257 – 2571Critical for catalysisBy similarity
    Metal bindingi352 – 3521Magnesium or manganeseBy similarity
    Sitei422 – 4221Critical for catalysisBy similarity
    Binding sitei549 – 5491SubstrateBy similarity
    Metal bindingi550 – 5501Magnesium or manganeseBy similarity
    Metal bindingi554 – 5541Magnesium or manganeseBy similarity
    Binding sitei591 – 5911NADPBy similarity
    Binding sitei651 – 6511NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi84 – 896NADPBy similarity
    Nucleotide bindingi586 – 5872NADPBy similarity
    Nucleotide bindingi602 – 6043NADPBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] 2 (EC:1.1.1.42)
    Alternative name(s):
    IDH-II
    IDP-2
    NADP(+)-specific ICDH 2
    Oxalosuccinate decarboxylase 2
    Gene namesi
    Name:icd2
    OrganismiColwellia maris (Vibrio sp. (strain ABE-1))
    Taxonomic identifieri77524 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 743742Isocitrate dehydrogenase [NADP] 2PRO_0000083596Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP41561.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the monomeric-type IDH family.Curated

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41561-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTDNSKIIY TITDEAPALA TYSLLPIIQA YTASSGINVE TRDISLAGRI    50
    LANFPKYLTK EQRIDDALAE LGELAQTPEA NIIKLPNISA SIPQLEAVIK 100
    ELQAKGYDLP HYPAEPQNEA EESIKLTYAK ILGSAVNPVL REGNSDRRAP 150
    ASVKQYARNN PHSMGAWSKE SKSHVAHMAS GDFYGSEKSV TIDGATSVNI 200
    EFVAKNGDVT LLKSKLPLLD KEIIDASVMS KSALVEFFET EINKAKEEDV 250
    LLSLHLKATM MKVSDPVMFG HAVRVFYKDV FAKHAATFEQ LGVDADNGIG 300
    DVYAKIARLP AAQKEEIEAD LQAVYATRPE MAMVDSDKGI TNLHVPSDVI 350
    IDASMPAALR ASGMMWGPDG KQKDTKFMIP DRNYAGVFSA VVDFCRENGA 400
    FNPATMGTVP NVGLMAQKAE EYGSHDKTFT MKAAGTVRVV NSQGERLIEQ 450
    EVAQGDIYRM CQVKDAPIQD WVKLAVTRAR ATGTPTVFWL DENRGHDEQM 500
    IKKVNTYLAD HDTTGLDIQI LEPVKACEFT LARVAKGEDA ISVTGNVLRD 550
    YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQFEKENH 600
    LRWDSLGEFL ALAASLEHVA VTTGNARAQI LADTLDAATG KFLDTNKSPS 650
    RKVGELDNRG SHFYLAMYWA QALAAQTTDT ELQASFSSVA QALTKQEEKI 700
    VAELNAAQGP AIDLNGYYFA DTKLAEKAMR PSETFNTILS ALL 743
    Length:743
    Mass (Da):80,882
    Last modified:April 14, 2009 - v3
    Checksum:iDE1E71FF4B5A6E06
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14047 Genomic DNA. Translation: BAA03134.2.
    PIRiA49341.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14047 Genomic DNA. Translation: BAA03134.2 .
    PIRi A49341.

    3D structure databases

    ProteinModelPortali P41561.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genes encoding two isocitrate dehydrogenase isozymes of a psychrophilic bacterium, Vibrio sp. strain ABE-1."
      Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
      J. Bacteriol. 175:6873-6880(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 660-673.
    3. "Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4."
      Fukunaga N., Imagawa S., Sahara T., Ishii A., Suzuki M.
      J. Biochem. 112:849-855(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-39.

    Entry informationi

    Entry nameiIDH2_COLMA
    AccessioniPrimary (citable) accession number: P41561
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 71 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3