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P41560 (IDH1_COLMA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] 1
EC=1.1.1.42
Alternative name(s):
IDH-I
IDP-1
NADP(+)-specific ICDH 1
Oxalosuccinate decarboxylase 1
Gene names
Name:icdI
OrganismColwellia maris (Vibrio sp. (strain ABE-1))
Taxonomic identifier77524 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subunit structure

Homodimer.

Induction

By acetate.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 415414Isocitrate dehydrogenase [NADP] 1
PRO_0000083550

Regions

Nucleotide binding339 – 3457NADP By similarity

Sites

Metal binding3071Magnesium or manganese By similarity
Binding site1041NADP By similarity
Binding site1131Substrate By similarity
Binding site1151Substrate By similarity
Binding site1191Substrate By similarity
Binding site1291Substrate By similarity
Binding site1531Substrate By similarity
Binding site3521NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site3901NADP By similarity
Binding site3941NADP By similarity
Site1601Critical for catalysis By similarity
Site2301Critical for catalysis By similarity

Amino acid modifications

Modified residue1131Phosphoserine By similarity

Experimental info

Sequence conflict261N → G AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P41560 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 353EFF202824696E

FASTA41545,145
        10         20         30         40         50         60 
MTNKIIIPTT GDKITFIDGK LSVPNNPIIP YIEGDGIGVD VTPPMLKVVN AAVAKAYGGD 

        70         80         90        100        110        120 
RKIEWLEVYA GEKATKMYDS ETWLPEETLN ILQEYKVSIK GPLTTPVGGG MSSLNVAIRQ 

       130        140        150        160        170        180 
MLDLYVCQRP VQWFTGVPSP VKRPSEVDMV IFRENTEDIY AGIEYKAGSD KAKSVIKFLI 

       190        200        210        220        230        240 
EEMGASNIRF TENCGIGIKP VSKEGSQRLV RQAIQYAIDN NKDSVTLVHK GNIMKFTEGA 

       250        260        270        280        290        300 
FKDWGYELAI EEFGASLLHG GPWCSLKNPN TGKEIIIKDV IADAMLQQVL LRPAEYSVIA 

       310        320        330        340        350        360 
TLNLNGDYLS DALAAQVGGI GIAPGANLGD EVAVFEATHG TAPKYAGKNK VNPGSVILSA 

       370        380        390        400        410 
EMMLRHMGWL EADLLLKGMS GAIQAKTVTY DFERLMDDAT LVSCSAFGDC IIDHM

« Hide

References

[1]"Genes encoding two isocitrate dehydrogenase isozymes of a psychrophilic bacterium, Vibrio sp. strain ABE-1."
Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
J. Bacteriol. 175:6873-6880(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4."
Fukunaga N., Imagawa S., Sahara T., Ishii A., Suzuki M.
J. Biochem. 112:849-855(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-41.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D14047 Genomic DNA. Translation: BAA03135.1.
PIRB49341.

3D structure databases

ProteinModelPortalP41560.
SMRP41560. Positions 3-415.
ModBaseSearch...

Proteomic databases

PRIDEP41560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH1_COLMA
AccessionPrimary (citable) accession number: P41560
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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