SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P41560

- IDH1_COLMA

UniProt

P41560 - IDH1_COLMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Isocitrate dehydrogenase [NADP] 1

Gene
icdI
Organism
Colwellia maris (Vibrio sp. (strain ABE-1))
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041NADP By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei115 – 1151Substrate By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei153 – 1531Substrate By similarity
Sitei160 – 1601Critical for catalysis By similarity
Sitei230 – 2301Critical for catalysis By similarity
Metal bindingi307 – 3071Magnesium or manganese By similarity
Binding sitei352 – 3521NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei390 – 3901NADP By similarity
Binding sitei394 – 3941NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi339 – 3457NADP By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] 1 (EC:1.1.1.42)
Alternative name(s):
IDH-I
IDP-1
NADP(+)-specific ICDH 1
Oxalosuccinate decarboxylase 1
Gene namesi
Name:icdI
OrganismiColwellia maris (Vibrio sp. (strain ABE-1))
Taxonomic identifieri77524 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 415414Isocitrate dehydrogenase [NADP] 1PRO_0000083550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP41560.

Expressioni

Inductioni

By acetate.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP41560.
SMRiP41560. Positions 3-415.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41560-1 [UniParc]FASTAAdd to Basket

« Hide

MTNKIIIPTT GDKITFIDGK LSVPNNPIIP YIEGDGIGVD VTPPMLKVVN    50
AAVAKAYGGD RKIEWLEVYA GEKATKMYDS ETWLPEETLN ILQEYKVSIK 100
GPLTTPVGGG MSSLNVAIRQ MLDLYVCQRP VQWFTGVPSP VKRPSEVDMV 150
IFRENTEDIY AGIEYKAGSD KAKSVIKFLI EEMGASNIRF TENCGIGIKP 200
VSKEGSQRLV RQAIQYAIDN NKDSVTLVHK GNIMKFTEGA FKDWGYELAI 250
EEFGASLLHG GPWCSLKNPN TGKEIIIKDV IADAMLQQVL LRPAEYSVIA 300
TLNLNGDYLS DALAAQVGGI GIAPGANLGD EVAVFEATHG TAPKYAGKNK 350
VNPGSVILSA EMMLRHMGWL EADLLLKGMS GAIQAKTVTY DFERLMDDAT 400
LVSCSAFGDC IIDHM 415
Length:415
Mass (Da):45,145
Last modified:January 23, 2007 - v2
Checksum:i353EFF202824696E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261N → G AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14047 Genomic DNA. Translation: BAA03135.1.
PIRiB49341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14047 Genomic DNA. Translation: BAA03135.1 .
PIRi B49341.

3D structure databases

ProteinModelPortali P41560.
SMRi P41560. Positions 3-415.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P41560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes encoding two isocitrate dehydrogenase isozymes of a psychrophilic bacterium, Vibrio sp. strain ABE-1."
    Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
    J. Bacteriol. 175:6873-6880(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4."
    Fukunaga N., Imagawa S., Sahara T., Ishii A., Suzuki M.
    J. Biochem. 112:849-855(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-41.

Entry informationi

Entry nameiIDH1_COLMA
AccessioniPrimary (citable) accession number: P41560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi