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P41560

- IDH1_COLMA

UniProt

P41560 - IDH1_COLMA

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Protein

Isocitrate dehydrogenase [NADP] 1

Gene

icdI

Organism
Colwellia maris (Vibrio sp. (strain ABE-1))
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041NADPBy similarity
Binding sitei113 – 1131SubstrateBy similarity
Binding sitei115 – 1151SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei129 – 1291SubstrateBy similarity
Binding sitei153 – 1531SubstrateBy similarity
Sitei160 – 1601Critical for catalysisBy similarity
Sitei230 – 2301Critical for catalysisBy similarity
Metal bindingi307 – 3071Magnesium or manganeseBy similarity
Binding sitei352 – 3521NADP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei390 – 3901NADPBy similarity
Binding sitei394 – 3941NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi339 – 3457NADPBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] 1 (EC:1.1.1.42)
Alternative name(s):
IDH-I
IDP-1
NADP(+)-specific ICDH 1
Oxalosuccinate decarboxylase 1
Gene namesi
Name:icdI
OrganismiColwellia maris (Vibrio sp. (strain ABE-1))
Taxonomic identifieri77524 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 415414Isocitrate dehydrogenase [NADP] 1PRO_0000083550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP41560.

Expressioni

Inductioni

By acetate.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP41560.
SMRiP41560. Positions 3-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41560-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNKIIIPTT GDKITFIDGK LSVPNNPIIP YIEGDGIGVD VTPPMLKVVN
60 70 80 90 100
AAVAKAYGGD RKIEWLEVYA GEKATKMYDS ETWLPEETLN ILQEYKVSIK
110 120 130 140 150
GPLTTPVGGG MSSLNVAIRQ MLDLYVCQRP VQWFTGVPSP VKRPSEVDMV
160 170 180 190 200
IFRENTEDIY AGIEYKAGSD KAKSVIKFLI EEMGASNIRF TENCGIGIKP
210 220 230 240 250
VSKEGSQRLV RQAIQYAIDN NKDSVTLVHK GNIMKFTEGA FKDWGYELAI
260 270 280 290 300
EEFGASLLHG GPWCSLKNPN TGKEIIIKDV IADAMLQQVL LRPAEYSVIA
310 320 330 340 350
TLNLNGDYLS DALAAQVGGI GIAPGANLGD EVAVFEATHG TAPKYAGKNK
360 370 380 390 400
VNPGSVILSA EMMLRHMGWL EADLLLKGMS GAIQAKTVTY DFERLMDDAT
410
LVSCSAFGDC IIDHM
Length:415
Mass (Da):45,145
Last modified:January 23, 2007 - v2
Checksum:i353EFF202824696E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261N → G AA sequence (PubMed:1295895)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14047 Genomic DNA. Translation: BAA03135.1.
PIRiB49341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14047 Genomic DNA. Translation: BAA03135.1 .
PIRi B49341.

3D structure databases

ProteinModelPortali P41560.
SMRi P41560. Positions 3-415.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P41560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes encoding two isocitrate dehydrogenase isozymes of a psychrophilic bacterium, Vibrio sp. strain ABE-1."
    Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.
    J. Bacteriol. 175:6873-6880(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4."
    Fukunaga N., Imagawa S., Sahara T., Ishii A., Suzuki M.
    J. Biochem. 112:849-855(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-41.

Entry informationi

Entry nameiIDH1_COLMA
AccessioniPrimary (citable) accession number: P41560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3