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Protein

DNA-directed RNA polymerase subunit B'

Gene

rpoB1

Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The B (B''+B' and beta) subunits have been implicated in DNA promoter recognition and also in nucleotide binding.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri547 – 568Sequence analysisAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit B' (EC:2.7.7.6)
Gene namesi
Name:rpoB1
Synonyms:rpoB
Ordered Locus Names:Mevan_0672
OrganismiMethanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000481051 – 611DNA-directed RNA polymerase subunit B'Add BLAST611

Interactioni

Protein-protein interaction databases

STRINGi406327.Mevan_0672.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri547 – 568Sequence analysisAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiarCOG01762. Archaea.
COG0085. LUCA.
HOGENOMiHOG000222962.
KOiK03044.
OMAiQKLYHMV.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007646. RNA_pol_Rpb2_4.
IPR007647. RNA_pol_Rpb2_5.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
IPR019969. RNAP_B.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04566. RNA_pol_Rpb2_4. 1 hit.
PF04567. RNA_pol_Rpb2_5. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03670. rpoB_arch. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQANVYVN GKLIDTSKDP ENLVKSLRIQ RRSGKLSPNT SISFNEESND
60 70 80 90 100
IHISTDGGRA VRPLVVVENG FSKLTNELLE KVNNNELTFE YLVKTGVIEF
110 120 130 140 150
LDAEEEENAR IAMYNDEITF ENTHVEIDPL VILGIGAGVA PYPEHNSAPR
160 170 180 190 200
ITMAAAMGKQ SLGIPMANIK WRMDTRGHLL HYPQVPLVRT KHQEILGFDK
210 220 230 240 250
RPAGQNFVVA VMSYEGYNME DAFVINKASL ERGLGRSTFF RSYESFEKRY
260 270 280 290 300
PGGQLDKFEV PEKGVRGYRA EEAYRNLGDD GLIDLESEVR SGDVILGKTS
310 320 330 340 350
PPRFLEEQEI TLQTKSQRRD TSVTIRHGEE GVVDLVILSE TKEGNRLGKV
360 370 380 390 400
RVRDLRVPEF GDKFASRHGQ KGVIGLVVPQ EDLPFTEDGV IPDLIINPHA
410 420 430 440 450
IPSRMTIGQV LEMIGGKVGS LECRRVDGTI FSGEGEWALR HALENYGFTH
460 470 480 490 500
SGKETMYDGK TGRKLECEIF VGVAYYQKLH HLVAGKIHAR SRGPIQVLTR
510 520 530 540 550
QPTEGRAREG GLRFGEMERD VLVAHGAALL LKERLLDESD PHEDYVCAKC
560 570 580 590 600
GEIAIFDYKR GMKFCPVCGE SEDIQDNRKI PPVKIAYAFK LLLDELKSMG
610
IDPKLKLKDR A
Length:611
Mass (Da):68,481
Last modified:October 23, 2007 - v2
Checksum:iFDAC89B41896BE40
GO

Sequence cautioni

The sequence CAA51727 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73293 Genomic DNA. Translation: CAA51727.1. Different initiation.
CP000742 Genomic DNA. Translation: ABR54578.1.
PIRiS47161.
RefSeqiWP_011972480.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR54578; ABR54578; Mevan_0672.
GeneIDi5325059.
KEGGimvn:Mevan_0672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73293 Genomic DNA. Translation: CAA51727.1. Different initiation.
CP000742 Genomic DNA. Translation: ABR54578.1.
PIRiS47161.
RefSeqiWP_011972480.1. NC_009634.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi406327.Mevan_0672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR54578; ABR54578; Mevan_0672.
GeneIDi5325059.
KEGGimvn:Mevan_0672.

Phylogenomic databases

eggNOGiarCOG01762. Archaea.
COG0085. LUCA.
HOGENOMiHOG000222962.
KOiK03044.
OMAiQKLYHMV.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007646. RNA_pol_Rpb2_4.
IPR007647. RNA_pol_Rpb2_5.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
IPR019969. RNAP_B.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04566. RNA_pol_Rpb2_4. 1 hit.
PF04567. RNA_pol_Rpb2_5. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03670. rpoB_arch. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOB1_METVS
AccessioniPrimary (citable) accession number: P41557
Secondary accession number(s): A6UQ06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.