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P41555

- ACEA_YARLI

UniProt

P41555 - ACEA_YARLI

Protein

Isocitrate lyase

Gene

ICL1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei203 – 2031PROSITE-ProRule annotation

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:ICL1
    Ordered Locus Names:YALI0C16885g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome C

    Subcellular locationi

    GO - Cellular componenti

    1. glyoxysome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Glyoxysome, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Isocitrate lyasePRO_0000068798Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi4952.P41555.

    Structurei

    3D structure databases

    ProteinModelPortaliP41555.
    SMRiP41555. Positions 3-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi538 – 5403Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2224.
    HOGENOMiHOG000238475.
    KOiK01637.
    OMAiWNILEKR.
    OrthoDBiEOG73Z331.

    Family and domain databases

    Gene3Di3.20.20.60. 2 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41555-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQQRFNNE VEEIKKWWSS PRWKHTKRVY SPEDIASRRG TIKVPQASSQ    50
    QADKLFKLLQ EHEKNHTASF TYGALDPVQV TQMAKYLDSI YVSGWQSSST 100
    ASTSNEPSPD LADYPMDTVP NKVEHLWFAQ LFHDRKQNEE RLSLPESERS 150
    KLPAPVDYLR PIIADADTGH GGLTAVVKLT KMFIERGAAG IHIEDQAPGT 200
    KKCGHMAGKV LVPIQEHINR LIAIRASADI FGSDLLAIAR TDSEAATLIT 250
    SSIDYRDHYF IAGATNKDAG HLVDVMVAAE LEGKQGAALQ AVEDEWNRKA 300
    GVKLFHEAFA DEVNAGSYSN KAELIAEFNK KVTPLSNTPA LEARALAARL 350
    LGKDIYFNWE AARVREGYYR YQGGTQCAVN RGIAYAPYAD LIWMESKLPD 400
    YAQAKEFAEG VKNAVPHQWL AYNLSPSFNW TTAMSPEDQE TYISRLAKLG 450
    YVWQFITLAG LHTNALISDK FAKAYSERGM KAYGGEIQQP EIDQGCEVVK 500
    HQKWSGAEYI DGILRMVTGG ITSTAAMGAG VTEDQFKSKL 540
    Length:540
    Mass (Da):60,049
    Last modified:October 11, 2004 - v3
    Checksum:i340B608321946098
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 742GA → AS in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti97 – 971S → C in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti107 – 1071P → S in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti112 – 1132AD → GG in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti134 – 1341D → E in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti149 – 1557RSKLPAP → PIQAPRAR in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti167 – 1671D → E in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti232 – 2343GSD → ALN in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti281 – 2888LEGKQGAA → ARGQAGAP in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti315 – 3151A → D in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti340 – 3456ALEARA → DIEDRY in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti383 – 3842IA → YS in CAA51362. (PubMed:8246896)Curated
    Sequence conflicti471 – 4722FA → SC in CAA51362. (PubMed:8246896)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72848 Genomic DNA. Translation: CAA51362.1.
    CR382129 Genomic DNA. Translation: CAG82243.1.
    RefSeqiXP_501923.1. XM_501923.1.

    Genome annotation databases

    EnsemblFungiiCAG82243; CAG82243; YALI0_C16885g.
    GeneIDi2909302.
    KEGGiyli:YALI0C16885g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72848 Genomic DNA. Translation: CAA51362.1 .
    CR382129 Genomic DNA. Translation: CAG82243.1 .
    RefSeqi XP_501923.1. XM_501923.1.

    3D structure databases

    ProteinModelPortali P41555.
    SMRi P41555. Positions 3-520.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.P41555.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG82243 ; CAG82243 ; YALI0_C16885g .
    GeneIDi 2909302.
    KEGGi yli:YALI0C16885g.

    Phylogenomic databases

    eggNOGi COG2224.
    HOGENOMi HOG000238475.
    KOi K01637.
    OMAi WNILEKR.
    OrthoDBi EOG73Z331.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 2 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the isocitrate lyase gene (ICL1) from Yarrowia lipolytica and characterization of the deduced protein."
      Barth G., Scheuber T.
      Mol. Gen. Genet. 241:422-430(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: B204-12C.
    2. Juretzek T.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIB 122 / E 150.

    Entry informationi

    Entry nameiACEA_YARLI
    AccessioniPrimary (citable) accession number: P41555
    Secondary accession number(s): Q6CBN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3