SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P41555

- ACEA_YARLI

UniProt

P41555 - ACEA_YARLI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Isocitrate lyase

Gene
ICL1, YALI0C16885g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei203 – 2031 By similarity

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:ICL1
Ordered Locus Names:YALI0C16885g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome C

Subcellular locationi

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Isocitrate lyasePRO_0000068798Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi4952.P41555.

Structurei

3D structure databases

ProteinModelPortaliP41555.
SMRiP41555. Positions 3-520.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi538 – 5403Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2224.
HOGENOMiHOG000238475.
KOiK01637.
OMAiWNILEKR.
OrthoDBiEOG73Z331.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41555-1 [UniParc]FASTAAdd to Basket

« Hide

MSEQQRFNNE VEEIKKWWSS PRWKHTKRVY SPEDIASRRG TIKVPQASSQ    50
QADKLFKLLQ EHEKNHTASF TYGALDPVQV TQMAKYLDSI YVSGWQSSST 100
ASTSNEPSPD LADYPMDTVP NKVEHLWFAQ LFHDRKQNEE RLSLPESERS 150
KLPAPVDYLR PIIADADTGH GGLTAVVKLT KMFIERGAAG IHIEDQAPGT 200
KKCGHMAGKV LVPIQEHINR LIAIRASADI FGSDLLAIAR TDSEAATLIT 250
SSIDYRDHYF IAGATNKDAG HLVDVMVAAE LEGKQGAALQ AVEDEWNRKA 300
GVKLFHEAFA DEVNAGSYSN KAELIAEFNK KVTPLSNTPA LEARALAARL 350
LGKDIYFNWE AARVREGYYR YQGGTQCAVN RGIAYAPYAD LIWMESKLPD 400
YAQAKEFAEG VKNAVPHQWL AYNLSPSFNW TTAMSPEDQE TYISRLAKLG 450
YVWQFITLAG LHTNALISDK FAKAYSERGM KAYGGEIQQP EIDQGCEVVK 500
HQKWSGAEYI DGILRMVTGG ITSTAAMGAG VTEDQFKSKL 540
Length:540
Mass (Da):60,049
Last modified:October 11, 2004 - v3
Checksum:i340B608321946098
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 742GA → AS in CAA51362. 1 Publication
Sequence conflicti97 – 971S → C in CAA51362. 1 Publication
Sequence conflicti107 – 1071P → S in CAA51362. 1 Publication
Sequence conflicti112 – 1132AD → GG in CAA51362. 1 Publication
Sequence conflicti134 – 1341D → E in CAA51362. 1 Publication
Sequence conflicti149 – 1557RSKLPAP → PIQAPRAR in CAA51362. 1 Publication
Sequence conflicti167 – 1671D → E in CAA51362. 1 Publication
Sequence conflicti232 – 2343GSD → ALN in CAA51362. 1 Publication
Sequence conflicti281 – 2888LEGKQGAA → ARGQAGAP in CAA51362. 1 Publication
Sequence conflicti315 – 3151A → D in CAA51362. 1 Publication
Sequence conflicti340 – 3456ALEARA → DIEDRY in CAA51362. 1 Publication
Sequence conflicti383 – 3842IA → YS in CAA51362. 1 Publication
Sequence conflicti471 – 4722FA → SC in CAA51362. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72848 Genomic DNA. Translation: CAA51362.1.
CR382129 Genomic DNA. Translation: CAG82243.1.
RefSeqiXP_501923.1. XM_501923.1.

Genome annotation databases

EnsemblFungiiCAG82243; CAG82243; YALI0_C16885g.
GeneIDi2909302.
KEGGiyli:YALI0C16885g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72848 Genomic DNA. Translation: CAA51362.1 .
CR382129 Genomic DNA. Translation: CAG82243.1 .
RefSeqi XP_501923.1. XM_501923.1.

3D structure databases

ProteinModelPortali P41555.
SMRi P41555. Positions 3-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.P41555.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG82243 ; CAG82243 ; YALI0_C16885g .
GeneIDi 2909302.
KEGGi yli:YALI0C16885g.

Phylogenomic databases

eggNOGi COG2224.
HOGENOMi HOG000238475.
KOi K01637.
OMAi WNILEKR.
OrthoDBi EOG73Z331.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the isocitrate lyase gene (ICL1) from Yarrowia lipolytica and characterization of the deduced protein."
    Barth G., Scheuber T.
    Mol. Gen. Genet. 241:422-430(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: B204-12C.
  2. Juretzek T.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiACEA_YARLI
AccessioniPrimary (citable) accession number: P41555
Secondary accession number(s): Q6CBN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi