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P41555 (ACEA_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate lyase
Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
Ordered Locus Names:YALI0C16885g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia ›

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Glyoxysome.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentGlyoxysome
Peroxisome
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentglyoxysome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Isocitrate lyase
PRO_0000068798

Regions

Motif538 – 5403Microbody targeting signal Potential

Sites

Active site2031 By similarity

Experimental info

Sequence conflict73 – 742GA → AS in CAA51362. Ref.1
Sequence conflict971S → C in CAA51362. Ref.1
Sequence conflict1071P → S in CAA51362. Ref.1
Sequence conflict112 – 1132AD → GG in CAA51362. Ref.1
Sequence conflict1341D → E in CAA51362. Ref.1
Sequence conflict149 – 1557RSKLPAP → PIQAPRAR in CAA51362. Ref.1
Sequence conflict1671D → E in CAA51362. Ref.1
Sequence conflict232 – 2343GSD → ALN in CAA51362. Ref.1
Sequence conflict281 – 2888LEGKQGAA → ARGQAGAP in CAA51362. Ref.1
Sequence conflict3151A → D in CAA51362. Ref.1
Sequence conflict340 – 3456ALEARA → DIEDRY in CAA51362. Ref.1
Sequence conflict383 – 3842IA → YS in CAA51362. Ref.1
Sequence conflict471 – 4722FA → SC in CAA51362. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P41555 [UniParc].

Last modified October 11, 2004. Version 3.
Checksum: 340B608321946098

FASTA54060,049
        10         20         30         40         50         60 
MSEQQRFNNE VEEIKKWWSS PRWKHTKRVY SPEDIASRRG TIKVPQASSQ QADKLFKLLQ 

        70         80         90        100        110        120 
EHEKNHTASF TYGALDPVQV TQMAKYLDSI YVSGWQSSST ASTSNEPSPD LADYPMDTVP 

       130        140        150        160        170        180 
NKVEHLWFAQ LFHDRKQNEE RLSLPESERS KLPAPVDYLR PIIADADTGH GGLTAVVKLT 

       190        200        210        220        230        240 
KMFIERGAAG IHIEDQAPGT KKCGHMAGKV LVPIQEHINR LIAIRASADI FGSDLLAIAR 

       250        260        270        280        290        300 
TDSEAATLIT SSIDYRDHYF IAGATNKDAG HLVDVMVAAE LEGKQGAALQ AVEDEWNRKA 

       310        320        330        340        350        360 
GVKLFHEAFA DEVNAGSYSN KAELIAEFNK KVTPLSNTPA LEARALAARL LGKDIYFNWE 

       370        380        390        400        410        420 
AARVREGYYR YQGGTQCAVN RGIAYAPYAD LIWMESKLPD YAQAKEFAEG VKNAVPHQWL 

       430        440        450        460        470        480 
AYNLSPSFNW TTAMSPEDQE TYISRLAKLG YVWQFITLAG LHTNALISDK FAKAYSERGM 

       490        500        510        520        530        540 
KAYGGEIQQP EIDQGCEVVK HQKWSGAEYI DGILRMVTGG ITSTAAMGAG VTEDQFKSKL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X72848 Genomic DNA. Translation: CAA51362.1.
CR382129 Genomic DNA. Translation: CAG82243.1.
RefSeqXP_501923.1. XM_501923.1.

3D structure databases

ProteinModelPortalP41555.
SMRP41555. Positions 3-520.
ModBaseSearch...

Protein-protein interaction databases

STRING4952.P41555.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2909302.
KEGGyli:YALI0C16885g.

Phylogenomic databases

eggNOGCOG2224.
HOGENOMHOG000238475.
KOK01637.
OMAMVTQMAK.
OrthoDBEOG4P5PJP.

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_YARLI
AccessionPrimary (citable) accession number: P41555
Secondary accession number(s): Q6CBN9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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