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P41554

- ACEA_RHOFA

UniProt

P41554 - ACEA_RHOFA

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Protein

Isocitrate lyase

Gene

icl

Organism
Rhodococcus fascians
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway (By similarity).By similarity

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei191 – 1911PROSITE-ProRule annotation

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:icl
OrganismiRhodococcus fascians
Taxonomic identifieri1828 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Isocitrate lyasePRO_0000068781Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP41554.
SMRiP41554. Positions 2-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 2 hits.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41554-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTTGTPKTT AEIQQDWDTN PRWKGVTRNF TAQQVSDLQG TVVEEATLAR
60 70 80 90 100
RGSEILWDLV NNEDYINSLG ALTGNQAVQQ IRAGLQAIYL SGWQVAGDAN
110 120 130 140 150
LSGHTYPDQS LYPANSVPSV VRRINNALLR ADEIAKIEGD TSVKNWVAPI
160 170 180 190 200
VADAEAGFGG ALNAYELQKA MIVAGAAGVH WEDQLASEKK CGHLGGKVLI
210 220 230 240 250
PTQQHIRTLT SARLASDVAD VPSVIIARTD AEAATLITSD VDERDREFLD
260 270 280 290 300
GTRTAEGFFG VKNGIEPCIA RAKAYAPYAD LIWMETGVPD LEVAKKFSES
310 320 330 340 350
VRSEFPDQLL AYNWSPSFNW KAHLDDATIA KFQKELGAMG FKFQFITLAG
360 370 380 390 400
FHSLNYGMFD LAHGYAREGM TAFVDLQERE FKAAEERGFT AIKHQREVGA
410 420
GYFDRIATTV DPNTSTAALK GSTEEGQFH
Length:429
Mass (Da):46,900
Last modified:November 1, 1995 - v1
Checksum:iEDBD9D5A2FF6BA0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29367 Genomic DNA. Translation: CAA82555.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29367 Genomic DNA. Translation: CAA82555.1 .

3D structure databases

ProteinModelPortali P41554.
SMRi P41554. Positions 2-428.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 1 hit.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 2 hits.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of the gene encoding isocitrate lyase from Rhodococcus fascians."
    Vereecke D., Villarroel R., van Montagu M., Desomer J.
    Gene 145:109-114(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: D188.

Entry informationi

Entry nameiACEA_RHOFA
AccessioniPrimary (citable) accession number: P41554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3