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Protein

Calcitonin

Gene

CALCA

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Gene namesi
Name:CALCA
Synonyms:CALC, CCALCI
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 21

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Propeptidei26 – 8257PRO_0000004038Add
BLAST
Peptidei85 – 11632CalcitoninPRO_0000004039Add
BLAST
Propeptidei121 – 13010By similarityPRO_0000004040

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421PhosphoserineBy similarity
Disulfide bondi85 ↔ 91By similarity
Modified residuei116 – 1161Proline amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP41547.

Expressioni

Tissue specificityi

Synthesized by C-cells of the thyroid gland.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012567.

Structurei

3D structure databases

ProteinModelPortaliP41547.
SMRiP41547. Positions 85-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7S. Eukaryota.
ENOG4111KS6. LUCA.
GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP41547.
KOiK12332.
OMAiCVLSAYW.
TreeFamiTF333069.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Calcitonin (identifier: P41547-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLWKSSPFL AFSILVLCQA GGLQAAPFRS ALEGLPDPTA LSEKEGRLLL
60 70 80 90 100
AALVKAYVQR KNELEQEQEQ ETEGSSLDSS RAKRCSNLST CVLGTYSKDL
110 120 130
NNFHTFSGIG FGAETPGKKR DIASGLERGR
Length:130
Mass (Da):14,051
Last modified:January 10, 2003 - v2
Checksum:i632F07397D9CFDA7
GO
Isoform Calcitonin-gene related peptide I (identifier: Q9MYV1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q9MYV1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):13,874
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451E → K AA sequence (PubMed:1758974).Curated
Sequence conflicti49 – 491L → N AA sequence (PubMed:1758974).Curated
Sequence conflicti64 – 641L → Q AA sequence (PubMed:1758974).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271090 Genomic DNA. Translation: CAB97486.1.
X56994 mRNA. Translation: CAA40311.1. Sequence problems.
PIRiA60063.
RefSeqiNP_001003266.1. NM_001003266.2. [P41547-1]
UniGeneiCfa.3806.
Cfa.45595.

Genome annotation databases

EnsembliENSCAFT00000013582; ENSCAFP00000012567; ENSCAFG00000008562. [P41547-1]
GeneIDi403946.
KEGGicfa:403946.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271090 Genomic DNA. Translation: CAB97486.1.
X56994 mRNA. Translation: CAA40311.1. Sequence problems.
PIRiA60063.
RefSeqiNP_001003266.1. NM_001003266.2. [P41547-1]
UniGeneiCfa.3806.
Cfa.45595.

3D structure databases

ProteinModelPortaliP41547.
SMRiP41547. Positions 85-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012567.

Proteomic databases

PaxDbiP41547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000013582; ENSCAFP00000012567; ENSCAFG00000008562. [P41547-1]
GeneIDi403946.
KEGGicfa:403946.

Organism-specific databases

CTDi796.

Phylogenomic databases

eggNOGiENOG410IX7S. Eukaryota.
ENOG4111KS6. LUCA.
GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP41547.
KOiK12332.
OMAiCVLSAYW.
TreeFamiTF333069.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular analysis and chromosomal assignment of the canine CALC-I/alpha-CGRP gene."
    Wende S., Krempler A., Breen M., Brunnberg L., Brenig B.
    Mamm. Genome 11:736-740(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Elucidation of the sequence of canine (pro)-calcitonin. A molecular biological and protein chemical approach."
    Mol J.A., Kwant M.M., Arnold I.C.J., Hazewinkel H.A.W.
    Regul. Pept. 35:189-195(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-50, NUCLEOTIDE SEQUENCE [MRNA] OF 64-130.
    Tissue: Thyroid.

Entry informationi

Entry nameiCALC_CANLF
AccessioniPrimary (citable) accession number: P41547
Secondary accession number(s): Q9MYV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 10, 2003
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.