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P41544

- SYS1_YEAST

UniProt

P41544 - SYS1_YEAST

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Protein
Protein SYS1
Gene
SYS1, YJL004C, J1402, YJR83.17
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Necessary for the targeting of ARL3 to the Golgi. Involved in protein trafficking. May serve as a receptor for acetylated ARL3.

GO - Biological processi

  1. Golgi to endosome transport Source: SGD
  2. Golgi to plasma membrane protein transport Source: SGD
  3. protein targeting to Golgi Source: SGD
  4. vesicle organization Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SYS1
Gene namesi
Name:SYS1
Ordered Locus Names:YJL004C
ORF Names:J1402, YJR83.17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL004c.
SGDiS000003541. SYS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei30 – 5223Helical; Reviewed prediction
Add
BLAST
Topological domaini53 – 7826Lumenal Reviewed prediction
Add
BLAST
Transmembranei79 – 10123Helical; Reviewed prediction
Add
BLAST
Topological domaini102 – 1054Cytoplasmic Reviewed prediction
Transmembranei106 – 12520Helical; Reviewed prediction
Add
BLAST
Topological domaini126 – 1316Lumenal Reviewed prediction
Transmembranei132 – 15423Helical; Reviewed prediction
Add
BLAST
Topological domaini155 – 20349Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of Golgi membrane Source: SGD
  2. trans-Golgi network Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Protein SYS1
PRO_0000213942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki15 – 15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei192 – 1921Phosphoserine1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP41544.

Expressioni

Gene expression databases

GenevestigatoriP41544.

Interactioni

Protein-protein interaction databases

BioGridi33753. 225 interactions.
DIPiDIP-2613N.
IntActiP41544. 39 interactions.
MINTiMINT-423473.
STRINGi4932.YJL004C.

Structurei

3D structure databases

ProteinModelPortaliP41544.

Family & Domainsi

Sequence similaritiesi

Belongs to the SYS1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237580.
HOGENOMiHOG000000813.
OMAiYSTRWKE.
OrthoDBiEOG72G1KR.

Family and domain databases

InterProiIPR019185. Integral_membrane_SYS1-rel.
[Graphical view]
PfamiPF09801. SYS1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41544-1 [UniParc]FASTAAdd to Basket

« Hide

MVSIRRYLRV PNELKPSQIF KQDSLSPSKI GLQIVLLQIF YYTTAIVLFY    50
CWAKLAGYDL NIKEWLFSWE NIDFTNAYGL SISLLWLLDS LICVFFLTVI 100
VGRSKLAWDF AITIHAINFI VVFLYTRKFP SFSWFFLQIL SSLILIFLGT 150
WTTRWRELRD TFFEGLVDPN EGEVGLVTPS QQHSNHSELE QSPIQLKDLE 200
SQI 203
Length:203
Mass (Da):23,716
Last modified:November 1, 1995 - v1
Checksum:i78D398E84713732F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 20355GTWTT…LESQI → ALT in AAA85159. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22326 Genomic DNA. Translation: AAA85159.1.
Z49279 Genomic DNA. Translation: CAA89294.1.
X87611 Genomic DNA. Translation: CAA60918.1.
AY558345 Genomic DNA. Translation: AAS56671.1.
X03449 Genomic DNA. Translation: CAA27176.1.
BK006943 Genomic DNA. Translation: DAA08787.1.
PIRiS55184.
RefSeqiNP_012530.1. NM_001181438.1.

Genome annotation databases

EnsemblFungiiYJL004C; YJL004C; YJL004C.
GeneIDi853453.
KEGGisce:YJL004C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22326 Genomic DNA. Translation: AAA85159.1 .
Z49279 Genomic DNA. Translation: CAA89294.1 .
X87611 Genomic DNA. Translation: CAA60918.1 .
AY558345 Genomic DNA. Translation: AAS56671.1 .
X03449 Genomic DNA. Translation: CAA27176.1 .
BK006943 Genomic DNA. Translation: DAA08787.1 .
PIRi S55184.
RefSeqi NP_012530.1. NM_001181438.1.

3D structure databases

ProteinModelPortali P41544.
ModBasei Search...

Protein-protein interaction databases

BioGridi 33753. 225 interactions.
DIPi DIP-2613N.
IntActi P41544. 39 interactions.
MINTi MINT-423473.
STRINGi 4932.YJL004C.

Proteomic databases

PaxDbi P41544.

Protocols and materials databases

DNASUi 853453.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL004C ; YJL004C ; YJL004C .
GeneIDi 853453.
KEGGi sce:YJL004C.

Organism-specific databases

CYGDi YJL004c.
SGDi S000003541. SYS1.

Phylogenomic databases

eggNOGi NOG237580.
HOGENOMi HOG000000813.
OMAi YSTRWKE.
OrthoDBi EOG72G1KR.

Enzyme and pathway databases

BioCyci YEAST:G3O-31483-MONOMER.

Miscellaneous databases

NextBioi 974017.
PROi P41544.

Gene expression databases

Genevestigatori P41544.

Family and domain databases

InterProi IPR019185. Integral_membrane_SYS1-rel.
[Graphical view ]
Pfami PF09801. SYS1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The essential yeast NLT1 gene encodes the 64 kDa glycoprotein subunit of the oligosaccharyl transferase."
    Pathak R., Parker C.S., Imperiali B.
    FEBS Lett. 362:229-234(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Yeast adenylate cyclase catalytic domain is carboxy terminal."
    Masson P., Lenzen G., Jacquemin J.M., Danchin A.
    Curr. Genet. 10:343-352(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-203.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
    Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-15.
  8. "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p."
    Behnia R., Panic B., Whyte J.R.C., Munro S.
    Nat. Cell Biol. 6:405-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARL3.
  9. "Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p."
    Setty S.R., Strochlic T.I., Tong A.H., Boone C., Burd C.G.
    Nat. Cell Biol. 6:414-419(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARL3.
  10. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYS1_YEAST
AccessioniPrimary (citable) accession number: P41544
Secondary accession number(s): D6VWH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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