Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein SYS1

Gene

SYS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the targeting of ARL3 to the Golgi. Involved in protein trafficking. May serve as a receptor for acetylated ARL3.

GO - Biological processi

  • Golgi to endosome transport Source: SGD
  • Golgi to plasma membrane protein transport Source: SGD
  • protein targeting to Golgi Source: SGD
  • vesicle organization Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SYS1
Gene namesi
Name:SYS1
Ordered Locus Names:YJL004C
ORF Names:J1402, YJR83.17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL004C.
SGDiS000003541. SYS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 52HelicalSequence analysisAdd BLAST23
Topological domaini53 – 78LumenalSequence analysisAdd BLAST26
Transmembranei79 – 101HelicalSequence analysisAdd BLAST23
Topological domaini102 – 105CytoplasmicSequence analysis4
Transmembranei106 – 125HelicalSequence analysisAdd BLAST20
Topological domaini126 – 131LumenalSequence analysis6
Transmembranei132 – 154HelicalSequence analysisAdd BLAST23
Topological domaini155 – 203CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

  • cytosol Source: GOC
  • integral component of Golgi membrane Source: SGD
  • trans-Golgi network Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139421 – 203Protein SYS1Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei192PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP41544.

PTM databases

iPTMnetiP41544.

Interactioni

Protein-protein interaction databases

BioGridi33753. 229 interactors.
DIPiDIP-2613N.
IntActiP41544. 39 interactors.
MINTiMINT-423473.

Structurei

3D structure databases

ProteinModelPortaliP41544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SYS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000813.
InParanoidiP41544.
KOiK20318.
OMAiWIFSWEL.
OrthoDBiEOG092C51OF.

Family and domain databases

InterProiIPR019185. Integral_membrane_SYS1-rel.
[Graphical view]
PfamiPF09801. SYS1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSIRRYLRV PNELKPSQIF KQDSLSPSKI GLQIVLLQIF YYTTAIVLFY
60 70 80 90 100
CWAKLAGYDL NIKEWLFSWE NIDFTNAYGL SISLLWLLDS LICVFFLTVI
110 120 130 140 150
VGRSKLAWDF AITIHAINFI VVFLYTRKFP SFSWFFLQIL SSLILIFLGT
160 170 180 190 200
WTTRWRELRD TFFEGLVDPN EGEVGLVTPS QQHSNHSELE QSPIQLKDLE

SQI
Length:203
Mass (Da):23,716
Last modified:November 1, 1995 - v1
Checksum:i78D398E84713732F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149 – 203GTWTT…LESQI → ALT in AAA85159 (PubMed:7720878).CuratedAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22326 Genomic DNA. Translation: AAA85159.1.
Z49279 Genomic DNA. Translation: CAA89294.1.
X87611 Genomic DNA. Translation: CAA60918.1.
AY558345 Genomic DNA. Translation: AAS56671.1.
X03449 Genomic DNA. Translation: CAA27176.1.
BK006943 Genomic DNA. Translation: DAA08787.1.
PIRiS55184.
RefSeqiNP_012530.1. NM_001181438.1.

Genome annotation databases

EnsemblFungiiYJL004C; YJL004C; YJL004C.
GeneIDi853453.
KEGGisce:YJL004C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22326 Genomic DNA. Translation: AAA85159.1.
Z49279 Genomic DNA. Translation: CAA89294.1.
X87611 Genomic DNA. Translation: CAA60918.1.
AY558345 Genomic DNA. Translation: AAS56671.1.
X03449 Genomic DNA. Translation: CAA27176.1.
BK006943 Genomic DNA. Translation: DAA08787.1.
PIRiS55184.
RefSeqiNP_012530.1. NM_001181438.1.

3D structure databases

ProteinModelPortaliP41544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33753. 229 interactors.
DIPiDIP-2613N.
IntActiP41544. 39 interactors.
MINTiMINT-423473.

PTM databases

iPTMnetiP41544.

Proteomic databases

PRIDEiP41544.

Protocols and materials databases

DNASUi853453.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL004C; YJL004C; YJL004C.
GeneIDi853453.
KEGGisce:YJL004C.

Organism-specific databases

EuPathDBiFungiDB:YJL004C.
SGDiS000003541. SYS1.

Phylogenomic databases

HOGENOMiHOG000000813.
InParanoidiP41544.
KOiK20318.
OMAiWIFSWEL.
OrthoDBiEOG092C51OF.

Enzyme and pathway databases

BioCyciYEAST:G3O-31483-MONOMER.

Miscellaneous databases

PROiP41544.

Family and domain databases

InterProiIPR019185. Integral_membrane_SYS1-rel.
[Graphical view]
PfamiPF09801. SYS1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYS1_YEAST
AccessioniPrimary (citable) accession number: P41544
Secondary accession number(s): D6VWH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.