Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein SYS1

Gene

SYS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for the targeting of ARL3 to the Golgi. Involved in protein trafficking. May serve as a receptor for acetylated ARL3.

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • Golgi to endosome transport Source: SGD
  • Golgi to plasma membrane protein transport Source: SGD
  • protein localization to Golgi apparatus Source: SGD
  • vesicle organization Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31483-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SYS1
Gene namesi
Name:SYS1
Ordered Locus Names:YJL004C
ORF Names:J1402, YJR83.17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL004C
SGDiS000003541 SYS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 52HelicalSequence analysisAdd BLAST23
Topological domaini53 – 78LumenalSequence analysisAdd BLAST26
Transmembranei79 – 101HelicalSequence analysisAdd BLAST23
Topological domaini102 – 105CytoplasmicSequence analysis4
Transmembranei106 – 125HelicalSequence analysisAdd BLAST20
Topological domaini126 – 131LumenalSequence analysis6
Transmembranei132 – 154HelicalSequence analysisAdd BLAST23
Topological domaini155 – 203CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139421 – 203Protein SYS1Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei192PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP41544
PRIDEiP41544

PTM databases

iPTMnetiP41544

Interactioni

Protein-protein interaction databases

BioGridi33753, 379 interactors
DIPiDIP-2613N
IntActiP41544, 39 interactors
MINTiP41544
STRINGi4932.YJL004C

Structurei

3D structure databases

ProteinModelPortaliP41544
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SYS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000813
InParanoidiP41544
KOiK20318
OMAiRSKLAWD
OrthoDBiEOG092C51OF

Family and domain databases

InterProiView protein in InterPro
IPR019185 Integral_membrane_SYS1-rel
PANTHERiPTHR12952 PTHR12952, 1 hit
PfamiView protein in Pfam
PF09801 SYS1, 1 hit

Sequencei

Sequence statusi: Complete.

P41544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSIRRYLRV PNELKPSQIF KQDSLSPSKI GLQIVLLQIF YYTTAIVLFY
60 70 80 90 100
CWAKLAGYDL NIKEWLFSWE NIDFTNAYGL SISLLWLLDS LICVFFLTVI
110 120 130 140 150
VGRSKLAWDF AITIHAINFI VVFLYTRKFP SFSWFFLQIL SSLILIFLGT
160 170 180 190 200
WTTRWRELRD TFFEGLVDPN EGEVGLVTPS QQHSNHSELE QSPIQLKDLE

SQI
Length:203
Mass (Da):23,716
Last modified:November 1, 1995 - v1
Checksum:i78D398E84713732F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149 – 203GTWTT…LESQI → ALT in AAA85159 (PubMed:7720878).CuratedAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22326 Genomic DNA Translation: AAA85159.1
Z49279 Genomic DNA Translation: CAA89294.1
X87611 Genomic DNA Translation: CAA60918.1
AY558345 Genomic DNA Translation: AAS56671.1
X03449 Genomic DNA Translation: CAA27176.1
BK006943 Genomic DNA Translation: DAA08787.1
PIRiS55184
RefSeqiNP_012530.1, NM_001181438.1

Genome annotation databases

EnsemblFungiiYJL004C; YJL004C; YJL004C
GeneIDi853453
KEGGisce:YJL004C

Similar proteinsi

Entry informationi

Entry nameiSYS1_YEAST
AccessioniPrimary (citable) accession number: P41544
Secondary accession number(s): D6VWH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health