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Protein

Protachykinin-1

Gene

TAC1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Names & Taxonomyi

Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 4 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Gene namesi
Name:TAC1
Synonyms:NKA, NKNA, TAC2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003355720 – 56Sequence analysisAdd BLAST37
PeptideiPRO_000003355858 – 68Substance PAdd BLAST11
PeptideiPRO_000003355972 – 92Neuropeptide gammaAdd BLAST21
PeptideiPRO_000003356083 – 92Neurokinin A10
PeptideiPRO_000003356196 – 111C-terminal-flanking peptideAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68Methionine amideBy similarity1
Modified residuei92Methionine amide1 Publication1

Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiP41540.

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi79 – 83Combined sources5
Helixi84 – 87Combined sources4
Turni88 – 91Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MCENMR-A72-92[»]
SMRiP41540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000082514.
HOVERGENiHBG000127.
InParanoidiP41540.
KOiK05239.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: P41540-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILVALAVL ALVSTQLFAE DIRANDDLNY WSDWSDSDQI KEELPEPFEH
60 70 80 90 100
LLQRIARRPK PQQFFGLMGK RDAGHGQISH KRHKTDSFVG LMGKRALNSV
110
AYERSAMQNY ERRRK
Length:115
Mass (Da):13,370
Last modified:November 1, 1995 - v1
Checksum:i5EC76F7C9B10E1C6
GO
Isoform Alpha (identifier: P41540-2)
Sequence is not available
Length:
Mass (Da):
Isoform Gamma (identifier: P41540-4)
Sequence is not available
Length:
Mass (Da):
Isoform Delta (identifier: P41540-3)
Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62994 mRNA. Translation: CAA44728.1.
PIRiJN0709. SPRBG.
RefSeqiNP_001095168.1. NM_001101698.1. [P41540-1]
UniGeneiOcu.2078.

Genome annotation databases

GeneIDi100009275.
KEGGiocu:100009275.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62994 mRNA. Translation: CAA44728.1.
PIRiJN0709. SPRBG.
RefSeqiNP_001095168.1. NM_001101698.1. [P41540-1]
UniGeneiOcu.2078.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MCENMR-A72-92[»]
SMRiP41540.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP41540.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009275.
KEGGiocu:100009275.

Organism-specific databases

CTDi6863.

Phylogenomic databases

HOGENOMiHOG000082514.
HOVERGENiHBG000127.
InParanoidiP41540.
KOiK05239.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTKN1_RABIT
AccessioniPrimary (citable) accession number: P41540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.