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Protein

Protachykinin-1

Gene

TAC1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Names & Taxonomyi

Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 4 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Gene namesi
Name:TAC1
Synonyms:NKA, NKNA, TAC2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 5637Sequence analysisPRO_0000033557Add
BLAST
Peptidei58 – 6811Substance PPRO_0000033558Add
BLAST
Peptidei72 – 9221Neuropeptide gammaPRO_0000033559Add
BLAST
Peptidei83 – 9210Neurokinin APRO_0000033560
Peptidei96 – 11116C-terminal-flanking peptidePRO_0000033561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681Methionine amideBy similarity
Modified residuei92 – 921Methionine amide1 Publication

Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei59 – 602Cleavage; by FAPBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Structurei

Secondary structure

1
115
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi79 – 835Combined sources
Helixi84 – 874Combined sources
Turni88 – 914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MCENMR-A72-92[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000082514.
HOVERGENiHBG000127.
InParanoidiP41540.
KOiK05239.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: P41540-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILVALAVL ALVSTQLFAE DIRANDDLNY WSDWSDSDQI KEELPEPFEH
60 70 80 90 100
LLQRIARRPK PQQFFGLMGK RDAGHGQISH KRHKTDSFVG LMGKRALNSV
110
AYERSAMQNY ERRRK
Length:115
Mass (Da):13,370
Last modified:November 1, 1995 - v1
Checksum:i5EC76F7C9B10E1C6
GO
Isoform Alpha (identifier: P41540-2)

Sequence is not available
Length:
Mass (Da):
Isoform Gamma (identifier: P41540-4)

Sequence is not available
Length:
Mass (Da):
Isoform Delta (identifier: P41540-3)

Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62994 mRNA. Translation: CAA44728.1.
PIRiJN0709. SPRBG.
RefSeqiNP_001095168.1. NM_001101698.1. [P41540-1]
UniGeneiOcu.2078.

Genome annotation databases

GeneIDi100009275.
KEGGiocu:100009275.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62994 mRNA. Translation: CAA44728.1.
PIRiJN0709. SPRBG.
RefSeqiNP_001095168.1. NM_001101698.1. [P41540-1]
UniGeneiOcu.2078.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MCENMR-A72-92[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009275.
KEGGiocu:100009275.

Organism-specific databases

CTDi6863.

Phylogenomic databases

HOGENOMiHOG000082514.
HOVERGENiHBG000127.
InParanoidiP41540.
KOiK05239.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the rabbit gamma-preprotachykinin I cDNA."
    Maegert H.-J., Heitland A., Rose M., Forssmann W.-G.
    Biochem. Biophys. Res. Commun. 195:128-131(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Gamma-neuropeptide K: a peptide isolated from rabbit gut that is derived from gamma-preprotachykinin."
    Kage R., McGregor G.P., Thim L., Conlon J.M.
    Regul. Pept. 18:346-346(1987)
    Cited for: PROTEIN SEQUENCE OF 72-92, AMIDATION AT MET-92.

Entry informationi

Entry nameiTKN1_RABIT
AccessioniPrimary (citable) accession number: P41540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.