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Protein

Protachykinin-1

Gene

Tac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Enzyme and pathway databases

ReactomeiR-MMU-380095. Tachykinin receptors bind tachykinins.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 5 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Neuropeptide K
Short name:
NPK
Gene namesi
Name:Tac1
Synonyms:Nka, Nkna, Tac2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98474. Tac1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • cytosol Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: Ensembl
  • neuronal cell body Source: MGI
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 5637Sequence analysisPRO_0000033543Add
BLAST
Peptidei58 – 6811Substance PPRO_0000033544Add
BLAST
Peptidei72 – 10736Neuropeptide KPRO_0000033545Add
BLAST
Peptidei72 – 732Neuropeptide gamma, 1st partPRO_0000033546
Peptidei89 – 10719Neuropeptide gamma, 2nd partPRO_0000033547Add
BLAST
Peptidei98 – 10710Neurokinin APRO_0000033548
Peptidei111 – 12616C-terminal-flanking peptideBy similarityPRO_0000033549Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681Methionine amideBy similarity
Modified residuei107 – 1071Methionine amideBy similarity

Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei59 – 602Cleavage; by FAPBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

MaxQBiP41539.
PaxDbiP41539.
PRIDEiP41539.

PTM databases

iPTMnetiP41539.
PhosphoSiteiP41539.

Expressioni

Gene expression databases

BgeeiP41539.
CleanExiMM_TAC1.
MM_TAC2.
ExpressionAtlasiP41539. baseline and differential.
GenevisibleiP41539. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088175.

Structurei

3D structure databases

ProteinModelPortaliP41539.
SMRiP41539. Positions 72-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZZ. Eukaryota.
ENOG4112BW1. LUCA.
GeneTreeiENSGT00390000002457.
HOGENOMiHOG000082514.
HOVERGENiHBG000127.
InParanoidiP41539.
OMAiEMGANDD.
OrthoDBiEOG7C2R3N.
PhylomeDBiP41539.
TreeFamiTF333405.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: P41539-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILVAVAVF FLVSTQLFAE EIDANDDLNY WSDWSDSDQI KEAMPEPFEH
60 70 80 90 100
LLQRIARRPK PQQFFGLMGK RDADSSVEKQ VALLKALYGH GQISHKRHKT
110 120 130
DSFVGLMGKR ALNSVAYERS AMQNYERRRK
Length:130
Mass (Da):15,045
Last modified:November 1, 1995 - v1
Checksum:i7BE8DA15FDE72FF8
GO
Isoform Alpha (identifier: P41539-3)

Sequence is not available
Length:
Mass (Da):
Isoform Gamma (identifier: P41539-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Show »
Length:115
Mass (Da):13,399
Checksum:iAC32DE0CFC2C02C0
GO
Isoform Delta (identifier: P41539-4)

Sequence is not available
Length:
Mass (Da):

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 8815Missing in isoform Gamma. 1 PublicationVSP_006379Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17584 mRNA. Translation: BAA04508.1.
M68908 mRNA. Translation: AAA39969.1.
M68909 mRNA. Translation: AAA39970.1.
CCDSiCCDS19906.1. [P41539-1]
CCDS80486.1. [P41539-2]
PIRiI52526.
RefSeqiNP_033337.1. NM_009311.2. [P41539-1]
XP_006505090.1. XM_006505027.1. [P41539-1]
UniGeneiMm.1440.
Mm.410823.

Genome annotation databases

EnsembliENSMUST00000184986; ENSMUSP00000138818; ENSMUSG00000061762. [P41539-2]
ENSMUST00000185187; ENSMUSP00000139347; ENSMUSG00000061762. [P41539-1]
GeneIDi21333.
UCSCiuc009axc.1. mouse. [P41539-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17584 mRNA. Translation: BAA04508.1.
M68908 mRNA. Translation: AAA39969.1.
M68909 mRNA. Translation: AAA39970.1.
CCDSiCCDS19906.1. [P41539-1]
CCDS80486.1. [P41539-2]
PIRiI52526.
RefSeqiNP_033337.1. NM_009311.2. [P41539-1]
XP_006505090.1. XM_006505027.1. [P41539-1]
UniGeneiMm.1440.
Mm.410823.

3D structure databases

ProteinModelPortaliP41539.
SMRiP41539. Positions 72-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088175.

PTM databases

iPTMnetiP41539.
PhosphoSiteiP41539.

Proteomic databases

MaxQBiP41539.
PaxDbiP41539.
PRIDEiP41539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000184986; ENSMUSP00000138818; ENSMUSG00000061762. [P41539-2]
ENSMUST00000185187; ENSMUSP00000139347; ENSMUSG00000061762. [P41539-1]
GeneIDi21333.
UCSCiuc009axc.1. mouse. [P41539-1]

Organism-specific databases

CTDi6863.
MGIiMGI:98474. Tac1.

Phylogenomic databases

eggNOGiENOG410IWZZ. Eukaryota.
ENOG4112BW1. LUCA.
GeneTreeiENSGT00390000002457.
HOGENOMiHOG000082514.
HOVERGENiHBG000127.
InParanoidiP41539.
OMAiEMGANDD.
OrthoDBiEOG7C2R3N.
PhylomeDBiP41539.
TreeFamiTF333405.

Enzyme and pathway databases

ReactomeiR-MMU-380095. Tachykinin receptors bind tachykinins.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi300488.
PROiP41539.
SOURCEiSearch...

Gene expression databases

BgeeiP41539.
CleanExiMM_TAC1.
MM_TAC2.
ExpressionAtlasiP41539. baseline and differential.
GenevisibleiP41539. MM.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of mouse cDNAs encoding preprotachykinin A and B."
    Kako K., Munekata E., Hosaka M., Murakami K., Nakayama K.
    Biomed. Res. 14:253-259(1993)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
    Strain: ICR.
    Tissue: Brain.
  2. "Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis."
    Chiwakata C., Brackmann B., Hunt N., Davidoff M., Schulze W., Ivell R.
    Endocrinology 128:2441-2448(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-122 (ISOFORMS BETA AND GAMMA).
    Tissue: Brain.

Entry informationi

Entry nameiTKN1_MOUSE
AccessioniPrimary (citable) accession number: P41539
Secondary accession number(s): Q00073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.