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Protein

Cholecystokinin

Gene

CCK

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

GO - Molecular functioni

  • neuropeptide hormone activity Source: UniProtKB

GO - Biological processi

  • axonogenesis Source: UniProtKB
  • eating behavior Source: UniProtKB
  • neuron migration Source: UniProtKB
  • response to food Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 10 chains:
Cholecystokinin-58
Short name:
CCK58
Alternative name(s):
(1-49)-CCK58
Cholecystokinin-39
Short name:
CCK39
Cholecystokinin-33
Short name:
CCK33
Cholecystokinin-25
Short name:
CCK25
Cholecystokinin-18
Short name:
CCK18
Cholecystokinin-12
Short name:
CCK12
Cholecystokinin-8
Short name:
CCK8
Cholecystokinin-7
Short name:
CCK7
Cholecystokinin-5
Short name:
CCK5
Gene namesi
Name:CCK
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB
  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 11595CholecystokininPRO_0000260763Add
BLAST
Propeptidei21 – 4424PRO_0000260764Add
BLAST
Peptidei46 – 10358Cholecystokinin-58PRO_0000010531Add
BLAST
Peptidei46 – 9449Cholecystokinin-58 desnonopeptideBy similarityPRO_0000306289Add
BLAST
Peptidei65 – 10339Cholecystokinin-39PRO_0000010532Add
BLAST
Peptidei71 – 10333Cholecystokinin-33PRO_0000010533Add
BLAST
Peptidei79 – 10325Cholecystokinin-25By similarityPRO_0000306290Add
BLAST
Peptidei86 – 10318Cholecystokinin-18By similarityPRO_0000306291Add
BLAST
Peptidei92 – 10312Cholecystokinin-12PRO_0000010534Add
BLAST
Peptidei96 – 1038Cholecystokinin-8PRO_0000010535
Peptidei97 – 1037Cholecystokinin-7By similarityPRO_0000306292
Peptidei99 – 1035Cholecystokinin-5By similarityPRO_0000306293
Propeptidei107 – 1159PRO_0000260765

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei97 – 971Sulfotyrosine1 Publication
Modified residuei103 – 1031Phenylalanine amide1 Publication
Modified residuei113 – 1131SulfotyrosineBy similarity

Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbiP41520.
PRIDEiP41520.

Interactioni

Subunit structurei

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: UniProtKB

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017320.

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiP41520.
KOiK05226.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRGVCLCLL MAVLAAGALA QPMPHADPTG PRAQQAEEAP RRQLRAVPRV
60 70 80 90 100
DDEPRAQLGA LLARYIQQAR KAPSGRMSVI KNLQSLDPSH RISDRDYMGW
110
MDFGRRSAEE FEYTS
Length:115
Mass (Da):12,835
Last modified:November 28, 2006 - v2
Checksum:iD90A4881E6D7120F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114184 mRNA. Translation: AAI14185.1.
PIRiA60315.
A60326.
RefSeqiNP_001040068.1. NM_001046603.2.
UniGeneiBt.30532.

Genome annotation databases

GeneIDi617510.
KEGGibta:617510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114184 mRNA. Translation: AAI14185.1.
PIRiA60315.
A60326.
RefSeqiNP_001040068.1. NM_001046603.2.
UniGeneiBt.30532.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017320.

Proteomic databases

PaxDbiP41520.
PRIDEiP41520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi617510.
KEGGibta:617510.

Organism-specific databases

CTDi885.

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiP41520.
KOiK05226.

Miscellaneous databases

NextBioi20900708.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.
  2. "Purification of bovine cholecystokinin-58 and sequencing of its N-terminus."
    Eng J., Li H.R., Yalow R.S.
    Regul. Pept. 30:15-19(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 46-74.
    Tissue: Brain.
  3. "Characterization of two novel forms of cholecystokinin isolated from bovine upper intestine."
    Carlquist M., Mutt V., Joernvall H.
    Regul. Pept. 11:27-34(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 65-103, SULFATION AT TYR-97, AMIDATION AT PHE-103.
    Tissue: Intestine.

Entry informationi

Entry nameiCCKN_BOVIN
AccessioniPrimary (citable) accession number: P41520
Secondary accession number(s): Q29RG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 28, 2006
Last modified: May 11, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.